Novel biomarkers for lung cancer by metabolic profiling within the multicenter Lung cancer cohort consortium (LC3)
- Prosjektnummer
- 911875
- Ansvarlig person
- Per Magne Ueland
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Cancer
- Forskningsaktivitet
- 2. Aetiology, 4. Detection and Diagnosis
Det vil være ugjennomførbart å implementere norsk brukermedvirkning i et internasjonalt prosjekt som inkluderer 20 sentra I USA, EU, og Asia, og der personer fra Norge utgjør kun noen få prosent av den totale kohort.
Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease.
Eur J Nutr 2017 Feb;56(1):261-272. Epub 2015 okt 19
PMID: 26482150
DNA Methylation Score as a Biomarker in Newborns for Sustained Maternal Smoking during Pregnancy.
Environ Health Perspect 2017 Apr;125(4):760-766. Epub 2016 jun 21
PMID: 27323799
Maternal Folate Intake during Pregnancy and Childhood Asthma in a Population-based Cohort.
Am J Respir Crit Care Med 2017 Jan 15;195(2):221-228.
PMID: 27518161
Increased Bronchial Hyperresponsiveness and Higher Asymmetric Dimethylarginine Levels after Fetal Growth Restriction.
Am J Respir Cell Mol Biol 2017 Jan;56(1):83-89.
PMID: 27574738
Midpregnancy and cord blood immunologic biomarkers, HLA genotype, and pediatric celiac disease.
J Allergy Clin Immunol 2017 May;139(5):1696-1698. Epub 2016 nov 16
PMID: 27865861
Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis.
Sci Rep 2017 Feb 24;7():43434. Epub 2017 feb 24
PMID: 28233834
Dietary Choline Intake Is Directly Associated with Bone Mineral Density in the Hordaland Health Study.
J Nutr 2017 04;147(4):572-578. Epub 2017 mar 8
PMID: 28275104
Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status.
Am J Clin Nutr 2017 Apr;105(4):897-904. Epub 2017 mar 8
PMID: 28275126
Vitamin B-12 status in infancy is positively associated with development and cognitive functioning 5 y later in Nepalese children.
Am J Clin Nutr 2017 May;105(5):1122-1131. Epub 2017 mar 22
PMID: 28330909
Ratios of One-Carbon Metabolites Are Functional Markers of B-Vitamin Status in a Norwegian Coronary Angiography Screening Cohort.
J Nutr 2017 06;147(6):1167-1173. Epub 2017 apr 5
PMID: 28381531
Circulating concentrations of biomarkers and metabolites related to vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations.
Am J Clin Nutr 2017 Jun;105(6):1314-1326. Epub 2017 apr 19
PMID: 28424186
Tryptophan catabolism and immune activation in primary and chronic HIV infection.
BMC Infect Dis 2017 May 16;17(1):349. Epub 2017 mai 16
PMID: 28511640
B Vitamins and Hip Fracture: Secondary Analyses and Extended Follow-Up of Two Large Randomized Controlled Trials.
J Bone Miner Res 2017 Oct;32(10):1981-1989. Epub 2017 jun 28
PMID: 28574605
Unmetabolized Folic Acid, Tetrahydrofolate, and Colorectal Adenoma Risk.
Cancer Prev Res (Phila) 2017 Aug;10(8):451-458. Epub 2017 jun 9
PMID: 28600398
The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease.
Diabetologia 2017 Sep;60(9):1712-1721. Epub 2017 jun 13
PMID: 28612106
Vitamin B12 deficiency.
Nat Rev Dis Primers 2017 Jun 29;3():17040. Epub 2017 jun 29
PMID: 28660890
Comparable Performance Characteristics of Plasma Thiamine and Erythrocyte Thiamine Diphosphate in Response to Thiamine Fortification in Rural Cambodian Women.
Nutrients 2017 Jun 29;9(7). Epub 2017 jun 29
PMID: 28661435
Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A.
Atherosclerosis 2017 Oct;265():325-330. Epub 2017 jul 21
PMID: 28774484
Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris.
J Nutr 2017 09;147(9):1658-1668. Epub 2017 aug 9
PMID: 28794210
Kynurenine Pathway Metabolites in Alzheimer's Disease.
J Alzheimers Dis 2017;60(2):495-504.
PMID: 28869479
Amino acid profile and metabolic syndrome in a male Mediterranean population: A cross-sectional study.
Nutr Metab Cardiovasc Dis 2017 Nov;27(11):1021-1030. Epub 2017 jul 25
PMID: 28958693
Neopterin as an Effect Modifier of the Cardiovascular Risk Predicted by Total Homocysteine: A Prospective 2-Cohort Study.
J Am Heart Assoc 2017 Nov 02;6(11). Epub 2017 nov 2
PMID: 29097387
Impaired functional vitamin B6 status is associated with increased risk of lung cancer.
Int J Cancer 2018 06 15;142(12):2425-2434. Epub 2018 jan 4
PMID: 29238985
Amniotic Fluid Arginine from Gestational Weeks 13 to 15 Is a Predictor of Birth Weight, Length, and Head Circumference.
Nutrients 2017 Dec 14;9(12). Epub 2017 des 14
PMID: 29240677
Plasma immunological markers in pregnancy and cord blood: A possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes.
Am J Reprod Immunol 2018 03;79(3). Epub 2017 des 20
PMID: 29266506
Genotype, B-vitamin status, and androgens affect spaceflight-induced ophthalmic changes.
FASEB J 2016 Jan;30(1):141-8. Epub 2015 aug 27
PMID: 26316272
Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status.
J Nutr 2016 Jan;146(1):1-8. Epub 2015 nov 11
PMID: 26561410
Cosinor modelling of seasonal variation in 25-hydroxyvitamin D concentrations in cardiovascular patients in Norway.
Eur J Clin Nutr 2016 Apr;70(4):517-22. Epub 2015 nov 25
PMID: 26603883
Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats.
Nutrients 2016 Jan 05;8(1). Epub 2016 jan 5
PMID: 26742069
B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris.
Nutr Metab Cardiovasc Dis 2016 Jun;26(6):495-501. Epub 2015 des 23
PMID: 26803590
Plasma Biomarkers of Inflammation, the Kynurenine Pathway, and Risks of All-Cause, Cancer, and Cardiovascular Disease Mortality: The Hordaland Health Study.
Am J Epidemiol 2016 Feb 15;183(4):249-58. Epub 2016 jan 27
PMID: 26823439
Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns.
Nat Commun 2016 Feb 10;7():10577. Epub 2016 feb 10
PMID: 26861414
Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.
Immun Ageing 2016;13():5. Epub 2016 feb 25
PMID: 26918023
Serum trans fatty acids, asymmetric dimethylarginine and risk of acute myocardial infarction and mortality in patients with suspected coronary heart disease: a prospective cohort study.
Lipids Health Dis 2016 Feb 27;15():38. Epub 2016 feb 27
PMID: 26920731
Prospective Associations of Systemic and Urinary Choline Metabolites with Incident Type 2 Diabetes.
Clin Chem 2016 May;62(5):755-65. Epub 2016 mar 15
PMID: 26980210
Vitamin Status among Breastfed Infants in Bhaktapur, Nepal.
Nutrients 2016 Mar 08;8(3):149. Epub 2016 mar 8
PMID: 27005657
Circulating Folate and Vitamin B12 and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls.
Eur Urol 2016 Dec;70(6):941-951. Epub 2016 apr 6
PMID: 27061263
A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin.
Am J Hum Genet 2016 May 05;98(5):869-82. Epub 2016 apr 28
PMID: 27132595
Vitamin B-6 catabolism and long-term mortality risk in patients with coronary artery disease.
Am J Clin Nutr 2016 Jun;103(6):1417-25. Epub 2016 mai 11
PMID: 27169836
Maternal plasma total neopterin and kynurenine/tryptophan levels during pregnancy in relation to asthma development in the offspring.
J Allergy Clin Immunol 2016 Nov;138(5):1319-1325.e4. Epub 2016 apr 20
PMID: 27221136
Nutritional Intake and Status of Cobalamin and Folate among Non-Pregnant Women of Reproductive Age in Bhaktapur, Nepal.
Nutrients 2016 Jun 22;8(6). Epub 2016 jun 22
PMID: 27338469
Components of One-carbon Metabolism Other than Folate and Colorectal Cancer Risk.
Epidemiology 2016 Nov;27(6):787-96.
PMID: 27367522
Serum Immune System Biomarkers Neopterin and Interleukin-10 Are Strongly Related to Tryptophan Metabolism in Healthy Young Adults.
J Nutr 2016 Sep;146(9):1801-6. Epub 2016 aug 3
PMID: 27489009
Plasma IP-10 Is Increased in Immunological NonResponders and Associated With Activated Regulatory T Cells and Persisting Low CD4 Counts.
J Acquir Immune Defic Syndr 2016 Oct 01;73(2):138-48.
PMID: 27632144
Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy.
Nutrients 2016 Oct 09;8(10). Epub 2016 okt 9
PMID: 27735840
Combined Measurement of 6 Fat-Soluble Vitamins and 26 Water-Soluble Functional Vitamin Markers and Amino Acids in 50 µL of Serum or Plasma by High-Throughput Mass Spectrometry.
Anal Chem 2016 Nov 01;88(21):10427-10436. Epub 2016 okt 17
PMID: 27715010
Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort.
Sci Rep 2016 Nov 04;6():36017. Epub 2016 nov 4
PMID: 27812016
Serum B6 vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations.
Cancer Causes Control 2016 Dec;27(12):1447-1456. Epub 2016 nov 9
PMID: 27830400
MTHFD1 Polymorphisms Modify the Associations of Plasma Glycine and Serine with Risk of AMI in Patients with Stable Angina Pectoris in WENBIT.
Circ Cardiovasc Genet 2016 Nov 21. Epub 2016 nov 21
PMID: 27872106
Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero.
BMC Genomics 2016 Nov 25;17(1):976. Epub 2016 nov 25
PMID: 27887572
Impact of Pre-Pregnancy BMI on B Vitamin and Inflammatory Status in Early Pregnancy: An Observational Cohort Study.
Nutrients 2016 Nov 30;8(12). Epub 2016 nov 30
PMID: 27916904
Vitamin levels in adults with ADHD.
BJPsych Open 2016 Nov;2(6):377-384. Epub 2016 des 13
PMID: 27990293
Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers.
Nutrients 2016 Dec 21;8(12). Epub 2016 des 21
PMID: 28009810
Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome.
JCI Insight 2016 Dec 22;1(21):e89376. Epub 2016 des 22
PMID: 28018972
Inflammation, vitamin B6 and related pathways.
Mol Aspects Med 2016 Sep 01. Epub 2016 sep 1
PMID: 27593095
Markers of vitamin B6 status and metabolism as predictors of incident cancer: the Hordaland Health Study.
Int J Cancer 2015 Jun 15;136(12):2932-9. Epub 2014 nov 26
PMID: 25404109
Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris.
Arterioscler Thromb Vasc Biol 2015 Feb;35(2):455-62. Epub 2014 des 18
PMID: 25524770
Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes.
J Nutr 2015 Jan;145(1):87-95. Epub 2014 nov 19
PMID: 25527663
Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread.
Br J Nutr 2015 Feb 14;113(3):445-53. Epub 2015 jan 13
PMID: 25585164
Plasma dimethylglycine, nicotine exposure and risk of low bone mineral density and hip fracture: the Hordaland Health Study.
Osteoporos Int 2015 May;26(5):1573-83. Epub 2015 jan 24
PMID: 25616506
A prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.
J Natl Cancer Inst 2015 Apr;107(4). Epub 2015 feb 23
PMID: 25713165
Glycated hemoglobin and long-term prognosis in patients with suspected stable angina pectoris without diabetes mellitus: a prospective cohort study.
Atherosclerosis 2015 May;240(1):115-20. Epub 2015 feb 28
PMID: 25770690
Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults.
J Nutr 2015 Apr;145(4):701-7. Epub 2015 feb 18
PMID: 25833774
Kynurenines as predictors of acute coronary events in the Hordaland Health Study.
Int J Cardiol 2015;189():18-24. Epub 2015 mar 30
PMID: 25885868
Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5'-Phosphate Concentration in Healthy Adults.
J Nutr 2015 Jul;145(7):1386-93. Epub 2015 mai 13
PMID: 25972531
Direct and Functional Biomarkers of Vitamin B6 Status.
Annu Rev Nutr 2015;35():33-70. Epub 2015 mai 13
PMID: 25974692
Circulating 25-hydroxyvitamin D3 and survival after diagnosis with kidney cancer.
Cancer Epidemiol Biomarkers Prev 2015 Aug;24(8):1277-81. Epub 2015 mai 28
PMID: 26021552
Circulating B-vitamins and smoking habits are associated with serum polyunsaturated Fatty acids in patients with suspected coronary heart disease: a cross-sectional study.
PLoS One 2015;10(6):e0129049. Epub 2015 jun 3
PMID: 26039046
Increased Tryptophan Catabolism is Associated with Increased Frequency of CD161+Tc17/MAIT Cells, and Lower CD4+ T cell Count in HIV-1 infected Patients on cART after Two Years of Follow-up.
J Acquir Immune Defic Syndr 2015 Jul 11. Epub 2015 jul 11
PMID: 26181815
Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
Am J Clin Nutr 2015 Sep;102(3):616-25. Epub 2015 jul 22
PMID: 26201817
Reduced Levels of D-dimer and Changes in Gut Microbiota Composition After Probiotic Intervention in HIV-Infected Individuals on Stable ART.
J Acquir Immune Defic Syndr 2015 Dec 1;70(4):329-37.
PMID: 26258571
Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials.
Am J Clin Nutr 2015 Oct;102(4):837-47. Epub 2015 sep 9
PMID: 26354531
Biomarkers of Nutrition for Development-Folate Review.
J Nutr 2015 Jul;145(7):1636S-1680S. Epub 2015 jun 3
PMID: 26451605
Increased Tryptophan Catabolism Is Associated With Increased Frequency of CD161+Tc17/MAIT Cells and Lower CD4+ T-Cell Count in HIV-1 Infected Patients on cART After 2 Years of Follow-Up.
J Acquir Immune Defic Syndr 2015 Nov 1;70(3):228-35.
PMID: 26470032
Circulating Concentrations of Vitamin B6 and Kidney Cancer Prognosis: A Prospective Case-Cohort Study.
PLoS One 2015;10(10):e0140677. Epub 2015 okt 27
PMID: 26506437
Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case-control study.
Behav Brain Funct 2015;11(1):36. Epub 2015 nov 5
PMID: 26542774
Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial.
BMC Pediatr 2015;15(1):218. Epub 2015 des 18
PMID: 26678525
Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris.
J Am Heart Assoc 2015;5(1). Epub 2015 des 31
PMID: 26722126
Interactions between plasma concentrations of folate and markers of vitamin B(12) status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study.
Br J Nutr 2014 Mar 28;111(6):1085-95. Epub 2013 nov 11
PMID: 24229560
Circulating biomarkers of tryptophan and the kynurenine pathway and lung cancer risk.
Cancer Epidemiol Biomarkers Prev 2014 Mar;23(3):461-8. Epub 2013 des 19
PMID: 24357106
Vitamin D status was not associated with 'one-year' progression of coronary artery disease, assessed by coronary angiography in statin-treated patients.
Eur J Prev Cardiol 2014 Jan 30. Epub 2014 jan 30
PMID: 24480878
Folic acid supplementation and interpregnancy interval.
Paediatr Perinat Epidemiol 2014 May;28(3):270-4. Epub 2014 feb 10
PMID: 24506308
One-carbon metabolite levels in mid-pregnancy and risks of conotruncal heart defects.
Birth Defects Res A Clin Mol Teratol 2014 Feb;100(2):107-15. Epub 2014 feb 15
PMID: 24532477
Neonatal genome-wide methylation patterns in relation to birth weight in the Norwegian Mother and Child Cohort.
Am J Epidemiol 2014 Apr 1;179(7):834-42. Epub 2014 feb 20
PMID: 24561991
Plasma choline, smoking, and long-term prognosis in patients with stable angina pectoris.
Eur J Prev Cardiol 2014 Mar 4. Epub 2014 mar 4
PMID: 24595862
Most blood biomarkers related to vitamin status, one-carbon metabolism, and the kynurenine pathway show adequate preanalytical stability and within-person reproducibility to allow assessment of exposure or nutritional status in healthy women and cardiovascular patients.
J Nutr 2014 May;144(5):784-90. Epub 2014 mar 19
PMID: 24647388
Smoking and body fat mass in relation to bone mineral density and hip fracture: the Hordaland Health Study.
PLoS One 2014;9(3):e92882. Epub 2014 mar 25
PMID: 24667849
Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease.
Eur J Prev Cardiol 2015 Jun;22(6):743-52. Epub 2014 mar 26
PMID: 24671904
Maternal smoking and DNA methylation in newborns: in utero effect or epigenetic inheritance?
Cancer Epidemiol Biomarkers Prev 2014 Jun;23(6):1007-17. Epub 2014 apr 16
PMID: 24740201
Evidence for increased catabolism of vitamin B-6 during systemic inflammation.
Am J Clin Nutr 2014 May 7;100(1):250-255. Epub 2014 mai 7
PMID: 24808485
Interferon gamma (IFN-?)-mediated inflammation and the kynurenine pathway in relation to risk of hip fractures: the Hordaland Health Study.
Osteoporos Int 2014 Aug;25(8):2067-75. Epub 2014 mai 10
PMID: 24817202
Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
Ann Oncol 2014 Aug;25(8):1609-15. Epub 2014 mai 14
PMID: 24827130
Targeted quantification of C-reactive protein and cystatin c and its variants by immuno-MALDI-MS.
Anal Chem 2014 Jun 17;86(12):5807-14. Epub 2014 mai 28
PMID: 24848523
Interferon-?-induced inflammatory markers and the risk of cancer: the Hordaland Health Study.
Cancer 2014 Nov 1;120(21):3370-7. Epub 2014 jun 19
PMID: 24948355
Low folate levels are associated with reduced risk of colorectal cancer in a population with low folate status.
Cancer Epidemiol Biomarkers Prev 2014 Oct;23(10):2136-44. Epub 2014 jul 25
PMID: 25063522
Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-?-mediated immune activation in the community-based Hordaland Health Study.
Br J Nutr 2014 Oct 14;112(7):1065-72. Epub 2014 aug 8
PMID: 25105221
Circulating 25-hydroxyvitamin D3 in relation to renal cell carcinoma incidence and survival in the EPIC cohort.
Am J Epidemiol 2014 Oct 15;180(8):810-20. Epub 2014 sep 8
PMID: 25205830
Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.
Am J Clin Nutr 2014 Oct;100(4):1069-74. Epub 2014 aug 13
PMID: 25240073
Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine.
Genes Nutr 2014 Nov;9(6):435. Epub 2014 okt 17
PMID: 25322900
Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival.
J Natl Cancer Inst 2014 Dec;106(12). Epub 2014 nov 5
PMID: 25376861
- Stein Emil Vollset Prosjektdeltaker
- Lars Johan Vatten Prosjektdeltaker
- Matias Johansson Prosjektleder
- Hui Zuo Prosjektdeltaker
- Paul Brennan Leder av forskningsgruppe
- Despoina Theofylaktopoulou Prosjektdeltaker
- Per Magne Ueland Prosjektleder
- Mattias Johansson Prosjektleder
- Per Bakke Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest