Persontilpassa kreftbehandling - biomarkørar og kliniske studiar
- Prosjektnummer
- 912009
- Ansvarlig person
- Bjørn Tore Gjertsen
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Strategisk satsing - persontilpasset medisin
- Helsekategori
- Blood, Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
Prosjektet skal utvikle nye analysar på materiale fra kliniske studier som kvar for seg er godkjente av Regional Etisk Komité og Statens legemiddelverk dersom påkrevd. Dei kliniske studiene tilhøyrer prosjekter der brukermedverkning med pasientar er etablert eller under utarbeiding. Siden prosjektet er regionalt vil vi kontakte Regionalt brukerutvalg for å presentere prosjektet i løpet av 2018. Samarbeidande legar og laboratorium ved andre helseforetak er en meir direkte brukarside. Desse oppsøkes og rådføres, og det er for 2018 planlagt ein rundtur ved ulike helseforetak for å teste prøve-logistikk mellom foretaka. Logistikk er i aukande grad ei utfordring ved persontilpassa kreftbehandling.
Single Cell Detection of the p53 Protein by Mass Cytometry.
Cancers (Basel) 2020 Dec 09;12(12). Epub 2020 des 9
PMID: 33317179
Partial Response to Sorafenib in a Child With a Myeloid/Lymphoid Neoplasm, Eosinophilia, and a ZMYM2-FLT3 Fusion.
J Pediatr Hematol Oncol 2020 Aug 26. Epub 2020 aug 26
PMID: 32852395
The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles.
Cancers (Basel) 2020 Jun 04;12(6). Epub 2020 jun 4
PMID: 32512867
Pure Red Cell Aplasia with Del(20q) Sensitive for Immunosuppressive Treatment.
Case Rep Hematol 2020;2020():1262038. Epub 2020 jan 20
PMID: 32082654
Effects of replacing PSA with Stockholm3 for diagnosis of clinically significant prostate cancer in a healthcare system - the Stavanger experience.
Scand J Prim Health Care 2020 Sep;38(3):315-322. Epub 2020 aug 8
PMID: 32772613
Dual Pro- and Anti-Inflammatory Features of Monocyte-Derived Dendritic Cells.
Front Immunol 2020;11():438. Epub 2020 mar 27
PMID: 32292402
AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer.
iScience 2020 Nov 20;23(11):101649. Epub 2020 okt 7
PMID: 33103086
Dose Reduction of Preoperative Radiotherapy in Myxoid Liposarcoma: A Nonrandomized Controlled Trial.
JAMA Oncol 2021 Jan 01;7(1):e205865. Epub 2021 jan 21
PMID: 33180100
Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis.
Pancreatology 2020 Apr;20(3):377-384. Epub 2020 jan 20
PMID: 32007358
High Constitutive Cytokine Release by Primary Human Acute Myeloid Leukemia Cells Is Associated with a Specific Intercellular Communication Phenotype.
J Clin Med 2019 Jul 04;8(7). Epub 2019 jul 4
PMID: 31277464
Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia.
J Cancer Res Clin Oncol 2019 Jul;145(7):1729-1749. Epub 2019 mai 20
PMID: 31111215
ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab.
Sci Rep 2019 Nov 25;9(1):17471. Epub 2019 nov 25
PMID: 31767937
Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma.
BMC Cancer 2019 Jan 05;19(1):11. Epub 2019 jan 5
PMID: 30611220
Trisomy 8 in acute myeloid leukemia.
Expert Rev Hematol 2019 Nov;12(11):947-958. Epub 2019 sep 26
PMID: 31422708
Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: a case report.
J Med Case Rep 2019 Jun 10;13(1):177. Epub 2019 jun 10
PMID: 31177991
Clinical Trials of Repurposing Medicines in Acute Myeloid Leukemia: Limitations and Possibilities in the Age of Precision Therapy.
Cancer J 2019 Mar/Apr;25(2):153-163.
PMID: 30896540
Influence of p53 Isoform Expression on Survival in High-Grade Serous Ovarian Cancers.
Sci Rep 2019 Mar 27;9(1):5244. Epub 2019 mar 27
PMID: 30918304
Titrating Complex Mass Cytometry Panels.
Cytometry A 2019 Jul;95(7):792-796. Epub 2019 apr 9
PMID: 30964237
GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells.
Haematologica 2019 May;104(5):e229.
PMID: 31040234
Intracellular Signaling in Key Pathways Is Induced by Treatment with Ultrasound and Microbubbles in a Leukemia Cell Line, but Not in Healthy Peripheral Blood Mononuclear Cells.
Pharmaceutics 2019 Jul 06;11(7). Epub 2019 jul 6
PMID: 31284599
Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia.
Haematologica 2020 03;105(3):708-720. Epub 2019 jul 11
PMID: 31296572
Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival.
Cancers (Basel) 2019 07 17;11(7). Epub 2019 jul 17
PMID: 31319548
Pembrolizumab plus pomalidomide and dexamethasone for patients with relapsed or refractory multiple myeloma (KEYNOTE-183): a randomised, open-label, phase 3 trial.
Lancet Haematol 2019 Sep;6(9):e459-e469. Epub 2019 jul 18
PMID: 31327687
Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival.
Br J Cancer 2019 Oct;121(7):545-555. Epub 2019 aug 15
PMID: 31413318
Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line.
Oncoimmunology 2019;8(9):e1638210. Epub 2019 jul 13
PMID: 31428530
Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types.
Haematologica 2020 Jun;105(6):1527-1538. Epub 2019 aug 22
PMID: 31439679
Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy.
Cells 2019 Oct 10;8(10). Epub 2019 okt 10
PMID: 31658693
Detection of disseminated tumor cells in bone marrow predict late recurrences in operable breast cancer patients.
BMC Cancer 2019 Nov 21;19(1):1131. Epub 2019 nov 21
PMID: 31752747
Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma.
Clin Cancer Res 2019 01 01;25(1):334-345. Epub 2018 nov 15
PMID: 30442683
Fragment size and level of cell-free DNA provide prognostic information in patients with advanced pancreatic cancer.
J Transl Med 2018 Nov 06;16(1):300. Epub 2018 nov 6
PMID: 30400802
The Prognostic Relevance of Sentinel Lymph Node Metastases Assessed by PHGR1 mRNA Quantification in Stage I to III Colon Cancer.
Transl Oncol 2018 Apr;11(2):436-443. Epub 2018 feb 21
PMID: 29475140
Expression profiling and intracellular localization studies of the novel Proline-, Histidine-, and Glycine-rich protein 1 suggest an essential role in gastro-intestinal epithelium and a potential clinical application in colorectal cancer diagnostics.
BMC Gastroenterol 2018 Feb 07;18(1):26. Epub 2018 feb 7
PMID: 29415677
Circulating tumour cells and DNA as liquid biopsies in gastrointestinal cancer.
Br J Surg 2018 01;105(2):e110-e120.
PMID: 29341153
Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial.
Stem Cell Res Ther 2018 Aug 09;9(1):213. Epub 2018 aug 9
PMID: 30092840
High expression of the p53 isoform γ is associated with reduced progression-free survival in uterine serous carcinoma.
BMC Cancer 2018 Jun 25;18(1):684. Epub 2018 jun 25
PMID: 29940909
Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia.
J Proteomics 2018 Feb 20;173():32-41. Epub 2017 nov 21
PMID: 29175091
Targeting Wnt/β-Catenin Signaling for Cancer Immunotherapy.
Trends Pharmacol Sci 2018 07;39(7):648-658. Epub 2018 apr 17
PMID: 29678298
Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer.
PLoS One 2018;13(11):e0206665. Epub 2018 nov 1
PMID: 30383835
Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis.
Biomark Res 2018;6():33. Epub 2018 nov 21
PMID: 30479769
IG-
Blood 2018 Nov 22;132(21):2280-2285. Epub 2018 okt 3
PMID: 30282799
A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation.
Clin Exp Immunol 2018 Jul;193(1):130-141. Epub 2018 apr 1
PMID: 29513361
Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib.
Haematologica 2017 Aug;102(8):1361-1367. Epub 2017 mai 18
PMID: 28522574
Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia.
J Clin Oncol 2017 Jan 10;35(2):175-184. Epub 2016 nov 7
PMID: 28056193
Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma.
N Engl J Med 2017 11 09;377(19):1824-1835. Epub 2017 sep 10
PMID: 28891423
Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years.
JAMA Intern Med 2017 Dec 01;177(12):1774-1780.
PMID: 29114736
Single-cell mRNA profiling reveals transcriptional heterogeneity among pancreatic circulating tumour cells.
BMC Cancer 2017 May 31;17(1):390. Epub 2017 mai 31
PMID: 28569190
Prognostic relevance of an epigenetic biomarker panel in sentinel lymph nodes from colon cancer patients.
Clin Epigenetics 2017;9():97. Epub 2017 sep 5
PMID: 28878843
Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells.
BMC Cancer 2017 Sep 06;17(1):630. Epub 2017 sep 6
PMID: 28877686
MINDEC-An Enhanced Negative Depletion Strategy for Circulating Tumour Cell Enrichment.
Sci Rep 2016 Jul 19;6():28929. Epub 2016 jul 19
PMID: 27432216
Clinical relevance of circulating KRAS mutated DNA in plasma from patients with advanced pancreatic cancer.
Mol Oncol 2016 Apr;10(4):635-43. Epub 2015 des 15
PMID: 26725968
Pure red cell aplasia with del(20q)-sensitive for immunsuppresive treatment
Case Reports Hematology, 2020
Interferon alpha and tyrosine kinase inhibitors increase tunneling nanotubes (TNT) formation and cell adhesion in chronic myeliod leukemia (CML) cell lines
FASEB Journal, 2020
Early response evaluation in AML using mass cytometry
Eurupean Hematology Association Abstract 2019
Mass cytoemtry reveal early signaling responses to induction therapy in immunophenotypically defined leukemic cell subsets that predict survival in AML
Eurupean Hematology Association Abstract 2019
Biomarker Panels and Contemporary practice in Clinical Trial of Targeted Therapy
Biomarkes of the Tumour Microenvironment (2017)
Identification of Responders by Gene Expression Profiling of Pretreatment Leukemic Cells
2016
Clinical Relevance of Circulating Tumor Cells and Circulating Tumor DNA in Patients with Advanced Pancreatic Cancer
- Disputert:
- september 2017
- Hovedveileder:
- Oddmund Nordgård
- Maria Winther Gunnes Prosjektdeltaker
- Tor Kristian Jenssen Prosjektdeltaker
- Leonardo Zepeda Meza Prosjektdeltaker
- Bjørn Henning Grønberg Prosjektdeltaker
- Anne Margrete Øyan Prosjektdeltaker
- Liv Cecilie Vestrheim Thomsen Prosjektdeltaker
- Kjersti Tjensvoll Prosjektdeltaker
- Benedict Man Hung Choi Prosjektdeltaker
- Anders Molven Leder av forskningsgruppe
- Sigrun Margrethe Hjelle Prosjektdeltaker
- Trude Høysæter Prosjektdeltaker
- Rakel Brendsdal Forthun Prosjektdeltaker
- Morten Lapin Prosjektdeltaker
- Reidun Kristin Kopperud Prosjektdeltaker
- Kristin Bentung Lygre Prosjektdeltaker
- Sonia Gavasso Prosjektdeltaker
- Nina Louise Jebsen Prosjektdeltaker
- Frank Pfeffer Prosjektdeltaker
- Oddmund Nordgård Leder av forskningsgruppe
- Karl-Henning Kalland Leder av forskningsgruppe
- James Lorens Leder av forskningsgruppe
- Oddbjørn Straume Leder av forskningsgruppe
- Randi Hovland Leder av forskningsgruppe
- Odd Helge Gilja Leder av forskningsgruppe
- Bjørnar Gilje Leder av forskningsgruppe
- Bjørn Tore Gjertsen Prosjektleder
- Helga Birgitte Salvesen Leder av forskningsgruppe
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest