Persontilpasset medisin for barn og voksne med diabetes - PERSON-MED-DIA
- Prosjektnummer
- 912010
- Ansvarlig person
- Pål Njølstad
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Strategisk satsing - persontilpasset medisin
- Helsekategori
- Metabolic and Endocrine
- Forskningsaktivitet
- 4. Detection and Diagnosis, 5. Treatment Developement
Leder for Diabetesforbundet Bjørnar Allgot var i 2017 invitert til et møte i vårt nettverk under en sesjon om brukermedvirkning der Allgot hadde hovedinnlegget om brukermedvirkning sett fra deres side. Prosjektleder har i mange år vært medlem av Diabetesforbundets ekspertutvalg. Videre har prosjektleder ca hvert år reist ut til et medlemsmøte for Nordhordlands lag av Norges Diabetesforbund og hatt et eget innlegg der fokus er hva vår forskning betyr for de med diabetes og hva de synes om vår forskning sett fra deres side. Det er lagt vekt på resultater fra forskningen når det gjelder behandling. Kontaktperson er Bibbi Pletten. Nordhordlands lag av Norges Diabetesforbund synes veldig fornøyd med våre resultater og gir jevnlig en gavesjekk på vel 100 000 kr som de skaffer gjennom strikking ("Strikkedamene"). Sist tildeling var i desember og to fra Nordhordland ble invitert til vår juleavslutning. Et pågående prosjekt er å teste ut tablettbehandling hos personer som er antatt å ha type 1 diabetes og å trenge insulin resten av livet. Vi har funnet to pasienter som vi har klart å skifte til tablettbehandling. Her har foreldrene vært i tett dialog med oss mht. hvordan vi skal gå frem når det gjelder praktiske prosedyrer og oppfølging av metabolsk kontroll i ettertid. Vi har således et meget tett og godt forhold til brukerne.
Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases.
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1455.
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Early manifestations of genetic risk for neurodevelopmental disorders.
J Child Psychol Psychiatry 2022 Jul;63(7):810. Epub 2021 okt 4
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Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring.
Alcohol Clin Exp Res 2021 10;45(10):2090-2102. Epub 2021 sep 6
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Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.
Behav Genet 2021 09;51(5):592-606. Epub 2021 aug 14
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Does Current Diabetes Technology Improve Metabolic Control? A Cross-Sectional Study on the Use of Insulin Pumps and Continuous Glucose Monitoring Devices in a Nationwide Pediatric Population.
Diabetes Ther 2021 Sep;12(9):2571-2583. Epub 2021 aug 13
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Impact of overweight on glucose homeostasis in MODY2 and MODY3.
Diabet Med 2021 Oct;38(10):e14649. Epub 2021 aug 5
PMID: 34269485
Prediction of Type 1 Diabetes at Birth: Cord Blood Metabolites vs Genetic Risk Score in the Norwegian Mother, Father, and Child Cohort.
J Clin Endocrinol Metab 2021 09 27;106(10):e4062-e4071.
PMID: 34086903
The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity.
J Biol Chem 2021 Jan-Jun;296():100661. Epub 2021 apr 14
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Genetic Liability for Schizophrenia and Childhood Psychopathology in the General Population.
Schizophr Bull 2021 07 08;47(4):1179-1189.
PMID: 33561255
SeeCiTe: a method to assess CNV calls from SNP arrays using trio data.
Bioinformatics 2021 Jan 18. Epub 2021 jan 18
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Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios.
Hum Mol Genet 2021 02 04;29(23):3845-3858.
PMID: 33291140
Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated
Diabetes Care 2021 01;44(1):35-42. Epub 2020 nov 12
PMID: 33184150
Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro.
J Inherit Metab Dis 2021 01;44(1):240-252. Epub 2020 sep 28
PMID: 32876354
Population prevalence and inheritance pattern of recurrent CNVs associated with neurodevelopmental disorders in 12,252 newborns and their parents.
Eur J Hum Genet 2021 01;29(1):205-215. Epub 2020 aug 10
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Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice.
Arterioscler Thromb Vasc Biol 2021 10;41(10):2563-2574. Epub 2021 aug 5
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Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.
Nutr Res 2021 08;92():72-83. Epub 2021 jun 12
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Meal patterns associated with energy intake in people with obesity.
Br J Nutr 2021 Jul 12. Epub 2021 jul 12
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Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study.
Clin Nutr 2021 05;40(5):2556-2575. Epub 2021 apr 3
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A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density.
Cell Metab 2021 03 02;33(3):615-628.e13. Epub 2021 jan 28
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Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance.
Diabetes 2021 03;70(3):680-695. Epub 2021 jan 6
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Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial.
Eur J Nutr 2021 Jun;60(4):2231-2248. Epub 2020 okt 27
PMID: 33108521
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
Nat Commun 2021 08 20;12(1):5068. Epub 2021 aug 20
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Activity-Based Anorexia Induces Browning of Adipose Tissue Independent of Hypothalamic AMPK.
Front Endocrinol (Lausanne) 2021;12():669980. Epub 2021 jun 2
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Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner.
Redox Biol 2021 05;41():101945. Epub 2021 mar 13
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Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance.
Int J Mol Sci 2021 Jan 31;22(3). Epub 2021 jan 31
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κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance.
Int J Mol Sci 2021 Feb 03;22(4). Epub 2021 feb 3
PMID: 33546289
Setting analytical performance specifications using HbA1c as a model measurand.
Clin Chim Acta 2021 Dec;523():407-414. Epub 2021 okt 16
PMID: 34666026
High adherence to recommended diabetes follow-up procedures by general practitioners is associated with lower estimated cardiovascular risk.
Diabet Med 2021 Aug;38(8):e14586. Epub 2021 mai 7
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Factors associated with treatment in primary versus specialist care: A population-based study of people with type 2 and type 1 diabetes.
Diabet Med 2021 Jul;38(7):e14580. Epub 2021 mai 5
PMID: 33834523
Factors associated with potential over- and undertreatment of hyperglycaemia and annual measurement of HbA
Diabet Med 2021 Aug;38(8):e14500. Epub 2021 jan 7
PMID: 33354827
Variation between general practitioners in type 2 diabetes processes of care.
Prim Care Diabetes 2021 06;15(3):495-501. Epub 2021 jan 19
PMID: 33349599
Personalized Reference Intervals in Laboratory Medicine: A New Model Based on Within-Subject Biological Variation.
Clin Chem 2021 01 30;67(2):374-384.
PMID: 33188412
Personalized reference intervals - statistical approaches and considerations.
Clin Chem Lab Med 2021 Dec 13. Epub 2021 des 13
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Iodine Nutrition and Iodine Supplement Initiation in Association with Thyroid Function in Mildly-to-Moderately Iodine-Deficient Pregnant and Postpartum Women.
J Nutr 2021 Oct 01;151(10):3187-3196.
PMID: 34255063
Left ventricular myocardial oxygen demand and subclinical dysfunction in patients with severe obesity referred for bariatric surgery.
Nutr Metab Cardiovasc Dis 2021 02 08;31(2):666-674. Epub 2020 okt 17
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A fast wavelet-based functional association analysis replicates several susceptibility loci for birth weight in a Norwegian population.
BMC Genomics 2021 May 02;22(1):321. Epub 2021 mai 2
PMID: 33932983
GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility.
Nat Commun 2021 02 11;12(1):959. Epub 2021 feb 11
PMID: 33574239
KRAS mutation analysis by droplet digital PCR of duodenal juice from patients with MODY8 and other pancreatic diseases.
Pancreatology 2021 Dec;21(8):1460-1465. Epub 2021 sep 21
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Aetiological risk factors are associated with distinct imaging findings in patients with chronic pancreatitis: A study of 959 cases from the Scandinavian Baltic Pancreatic Club (SBPC) imaging database.
Pancreatology 2021 Jun;21(4):688-697. Epub 2021 mar 3
PMID: 33707113
Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis.
Eur J Gastroenterol Hepatol 2021 06 01;33(6):839-843.
PMID: 33079780
The genetic architecture of sporadic and multiple consecutive miscarriage.
Nat Commun 2020 11 25;11(1):5980. Epub 2020 nov 25
PMID: 33239672
How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa).
BMC Med 2020 10 27;18(1):284. Epub 2020 okt 27
PMID: 33106172
Unsupervised Clustering of Missense Variants in HNF1A Using Multidimensional Functional Data Aids Clinical Interpretation.
Am J Hum Genet 2020 10 01;107(4):670-682. Epub 2020 sep 9
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Inhibition of the PI 3-kinase pathway disrupts the unfolded protein response and reduces sensitivity to ER stress-dependent apoptosis.
FASEB J 2020 Sep;34(9):12521-12532. Epub 2020 aug 3
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Maternal and child gluten intake and association with type 1 diabetes: The Norwegian Mother and Child Cohort Study.
PLoS Med 2020 03;17(3):e1003032. Epub 2020 mar 2
PMID: 32119659
Functional Analyses of HNF1A-MODY Variants Refine the Interpretation of Identified Sequence Variants.
J Clin Endocrinol Metab 2020 04 01;105(4).
PMID: 32017842
Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis.
Pancreatology 2020 Apr;20(3):377-384. Epub 2020 jan 20
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Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells.
Cells 2020 01 18;9(1). Epub 2020 jan 18
PMID: 31963687
Intellectual Disability in K
Diabetes Care 2020 03;43(3):526-533. Epub 2020 jan 13
PMID: 31932458
The homeobox factor Irx3 maintains adipogenic identity.
Metabolism 2020 02;103():154014. Epub 2019 nov 18
PMID: 31751577
Introducing M-GCTA a Software Package to Estimate Maternal (or Paternal) Genetic Effects on Offspring Phenotypes.
Behav Genet 2020 01;50(1):51-66. Epub 2019 sep 6
PMID: 31493278
Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding.
Hum Mutat 2020 Nov;41(11):1967-1978. Epub 2020 sep 9
PMID: 32906201
COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1.
Sci Rep 2020 11 19;10(1):20164. Epub 2020 nov 19
PMID: 33214660
A MicroRNA Linking Human Positive Selection and Metabolic Disorders.
Cell 2020 Oct 29;183(3):684-701.e14. Epub 2020 okt 14
PMID: 33058756
Hormone References for Ultrasound Breast Staging and Endocrine Profiling to Detect Female Onset of Puberty.
J Clin Endocrinol Metab 2020 Dec 01;105(12).
PMID: 32961560
3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism.
Diabetes 2020 09;69(9):1903-1916. Epub 2020 jun 25
PMID: 32586980
Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: a randomised trial.
Br J Nutr 2020 02 28;123(4):419-427. Epub 2019 nov 25
PMID: 31760958
Testicular Ultrasound to Stratify Hormone References in a Cross-Sectional Norwegian Study of Male Puberty.
J Clin Endocrinol Metab 2020 Jun 01;105(6).
PMID: 31697832
Natural Killer Cells as Sensors of Adipose Tissue Stress.
Trends Endocrinol Metab 2020 01;31(1):3-12. Epub 2019 okt 6
PMID: 31597606
TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity.
Eur J Nutr 2020 Aug;59(5):2249-2259. Epub 2019 aug 10
PMID: 31401679
Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study.
Eur J Nutr 2020 Apr;59(3):1013-1029. Epub 2019 apr 10
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An Ultrasensitive Routine LC-MS/MS Method for Estradiol and Estrone in the Clinically Relevant Sub-Picomolar Range.
J Endocr Soc 2020 Jun 01;4(6):bvaa047. Epub 2020 apr 21
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European Association for the Study of Obesity Position Statement on the Global COVID-19 Pandemic.
Obes Facts 2020;13(2):292-296. Epub 2020 apr 27
PMID: 32340020
Critical appraisal and meta-analysis of biological variation estimates for kidney related analytes.
Clin Chem Lab Med 2020 Oct 03. Epub 2020 okt 3
PMID: 32970605
The total prevalence of diagnosed diabetes and the quality of diabetes care for the adult population in Salten, Norway.
Scand J Public Health 2020 Aug 27. Epub 2020 aug 27
PMID: 32854596
Analytical Performance Specifications for Lipoprotein(a), Apolipoprotein B-100, and Apolipoprotein A-I Using the Biological Variation Model in the EuBIVAS Population.
Clin Chem 2020 05 01;66(5):727-736.
PMID: 32353129
Availability and analytical quality of hemoglobin A1c point-of-care testing in general practitioners' offices are associated with better glycemic control in type 2 diabetes.
Clin Chem Lab Med 2020 Jul 28;58(8):1349-1356.
PMID: 32229656
Performance of Afinion HbA1c measurements in general practice as judged by external quality assurance data.
Clin Chem Lab Med 2020 03 26;58(4):588-596.
PMID: 31821164
Variation in the achievement of HbA
Diabet Med 2020 09;37(9):1471-1481. Epub 2019 nov 15
PMID: 31651045
Factors associated with glycaemic control in adults with Type 1 diabetes: a registry-based analysis including 7601 individuals from 34 centres in Norway.
Diabet Med 2020 05;37(5):828-837. Epub 2019 okt 18
PMID: 31469928
Leptin Receptor Signaling Regulates Protein Synthesis Pathways and Neuronal Differentiation in Pluripotent Stem Cells.
Stem Cell Reports 2020 Nov 10;15(5):1067-1079. Epub 2020 okt 29
PMID: 33125875
Bioinformatic Analyses of miRNA-mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation.
Biomedicines 2020 Jun 27;8(7). Epub 2020 jun 27
PMID: 32605028
Matrix decoded - A pancreatic extracellular matrix with organ specific cues guiding human iPSC differentiation.
Biomaterials 2020 06;244():119766. Epub 2020 mar 6
PMID: 32199284
Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism.
Front Cell Dev Biol 2020;8():109. Epub 2020 feb 25
PMID: 32161757
Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling.
Sci Rep 2020 01 15;10(1):414. Epub 2020 jan 15
PMID: 31942009
In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress.
Acta Physiol (Oxf) 2020 04;228(4):e13433. Epub 2020 jan 8
PMID: 31872528
Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors.
Stem Cells 2020 04;38(4):542-555. Epub 2020 jan 22
PMID: 31828876
Anatomy and evolution of database search engines-a central component of mass spectrometry based proteomic workflows.
Mass Spectrom Rev 2020 05;39(3):292-306. Epub 2017 sep 13
PMID: 28902424
Effect of a telemedicine intervention for diabetes-related foot ulcers on health, well-being and quality of life: secondary outcomes from a cluster randomized controlled trial (DiaFOTo).
BMC Endocr Disord 2020 Oct 21;20(1):157. Epub 2020 okt 21
PMID: 33087074
Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth.
Nat Commun 2019 10 01;10(1):4448. Epub 2019 okt 1
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A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.
Hum Mol Genet 2019 10 01;28(19):3327-3338.
PMID: 31504550
Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.
Nat Commun 2019 09 02;10(1):3927. Epub 2019 sep 2
PMID: 31477735
PathwayMatcher: proteoform-centric network construction enables fine-granularity multiomics pathway mapping.
Gigascience 2019 08 01;8(8).
PMID: 31363752
Maternal microchimerism in cord blood and risk of childhood-onset type 1 diabetes.
Pediatr Diabetes 2019 09;20(6):728-735. Epub 2019 jun 19
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Roadmap for a precision-medicine initiative in the Nordic region.
Nat Genet 2019 06;51(6):924-930.
PMID: 30988515
Maternal and Newborn Vitamin D-Binding Protein, Vitamin D Levels, Vitamin D Receptor Genotype, and Childhood Type 1 Diabetes.
Diabetes Care 2019 04;42(4):553-559. Epub 2019 jan 28
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IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.
Int J Obes (Lond) 2019 11;43(11):2151-2162. Epub 2018 des 11
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Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability.
Stem Cells Int 2019;2019():8036035. Epub 2019 nov 18
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Ethnic and gender differences in the management of type 2 diabetes: a cross-sectional study from Norwegian general practice.
BMC Health Serv Res 2019 Nov 28;19(1):904. Epub 2019 nov 28
PMID: 31779621
The Rho GTPase RND3 regulates adipocyte lipolysis.
Metabolism 2019 Dec;101():153999. Epub 2019 okt 28
PMID: 31672447
Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis.
Sci Rep 2019 Oct 15;9(1):14817. Epub 2019 okt 15
PMID: 31616017
Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys.
Br J Nutr 2019 Aug 14;122(3):262-273. Epub 2019 aug 9
PMID: 31397239
Retained NK Cell Phenotype and Functionality in Non-alcoholic Fatty Liver Disease.
Front Immunol 2019;10():1255. Epub 2019 jun 4
PMID: 31214196
HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells.
iScience 2019 Jun 28;16():192-205. Epub 2019 mai 27
PMID: 31195238
The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation.
Front Endocrinol (Lausanne) 2019;10():293. Epub 2019 mai 8
PMID: 31139151
Biological variation data for lipid cardiovascular risk assessment biomarkers. A systematic review applying the biological variation data critical appraisal checklist (BIVAC).
Clin Chim Acta 2019 Aug;495():467-475. Epub 2019 mai 16
PMID: 31103621
Exploring the relationship between coronary heart disease and type 2 diabetes: a cross-sectional study of secondary prevention among diabetes patients.
BJGP Open 2019 Apr;3(1):bjgpopen18X101636. Epub 2019 mar 20
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The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis.
Pancreatology 2019 Jun;19(4):531-534. Epub 2019 apr 26
PMID: 31036489
Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice.
Sci Rep 2019 Mar 15;9(1):4614. Epub 2019 mar 15
PMID: 30874564
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.
Nature 2019 03;567(7746):43-48. Epub 2019 feb 13
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Population, general practitioner and practice characteristics are associated with screening procedures for microvascular complications in Type 2 diabetes care in Norway.
Diabet Med 2019 11;36(11):1431-1443. Epub 2018 nov 27
PMID: 30343522
The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2
J Biol Chem 2018 Dec 14;293(50):19476-19491. Epub 2018 okt 12
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ISPAD Clinical Practice Consensus Guidelines 2018: The diagnosis and management of monogenic diabetes in children and adolescents.
Pediatr Diabetes 2018 Oct;19 Suppl 27():47-63.
PMID: 30225972
The E3 SUMO ligase PIASγ is a novel interaction partner regulating the activity of diabetes associated hepatocyte nuclear factor-1α.
Sci Rep 2018 Aug 24;8(1):12780. Epub 2018 aug 24
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Parental Smoking and Risk of Childhood-onset Type 1 Diabetes.
Epidemiology 2018 11;29(6):848-856.
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Sonographic pancreas echogenicity in cystic fibrosis compared to exocrine pancreatic function and pancreas fat content at Dixon-MRI.
PLoS One 2018;13(7):e0201019. Epub 2018 jul 26
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Prenatal iron exposure and childhood type 1 diabetes.
Sci Rep 2018 Jun 13;8(1):9067. Epub 2018 jun 13
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Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study.
Lancet Diabetes Endocrinol 2018 Aug;6(8):637-646. Epub 2018 jun 4
PMID: 29880308
Antibiotics, acetaminophen and infections during prenatal and early life in relation to type 1 diabetes.
Int J Epidemiol 2018 Oct 01;47(5):1538-1548.
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Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes.
Diabetes 2018 07;67(7):1297-1309. Epub 2018 mai 3
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Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes.
Int J Epidemiol 2018 04 01;47(2):417-426.
PMID: 29415279
Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.
Hum Mol Genet 2018 02 15;27(4):742-756.
PMID: 29309628
Plasma immunological markers in pregnancy and cord blood: A possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes.
Am J Reprod Immunol 2018 03;79(3). Epub 2017 des 20
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The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.
Pancreatology 2018 Jan;18(1):12-19. Epub 2017 des 5
PMID: 29233499
Lack of Association Between Maternal or Neonatal Vitamin D Status and Risk of Childhood Type 1 Diabetes: A Scandinavian Case-Cohort Study.
Am J Epidemiol 2018 Jun 01;187(6):1174-1181.
PMID: 29186303
Targets and teamwork: Understanding differences in pediatric diabetes centers treatment outcomes.
Pediatr Diabetes 2018 05;19(3):559-565. Epub 2017 nov 20
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Salmon Fillet Intake Led to Higher Serum Triacylglycerol in Obese Zucker Fa/Fa Rats But Not in Normolipidemic Long-Evans Rats.
Nutrients 2018 Oct 08;10(10). Epub 2018 okt 8
PMID: 30297656
Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain
Nutrients 2018 Jun 28;10(7). Epub 2018 jun 28
PMID: 29958397
Daily Intake of Protein from Cod Residual Material Lowers Serum Concentrations of Nonesterified Fatty Acids in Overweight Healthy Adults: A Randomized Double-Blind Pilot Study.
Mar Drugs 2018 Jun 05;16(6). Epub 2018 jun 5
PMID: 29874805
The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults.
Nutrients 2018 May 11;10(5). Epub 2018 mai 11
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Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats.
J Am Soc Hypertens 2018 Apr;12(4):294-302. Epub 2018 feb 2
PMID: 29472029
The Short Cosyntropin Test Revisited: New Normal Reference Range Using LC-MS/MS.
J Clin Endocrinol Metab 2018 04 01;103(4):1696-1703.
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Inflammatory markers, the tryptophan-kynurenine pathway, and vitamin B status after bariatric surgery.
PLoS One 2018;13(2):e0192169. Epub 2018 feb 5
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The HNF1A mutant Ala180Val: Clinical challenges in determining causality of a rare HNF1A variant in familial diabetes.
Diabetes Res Clin Pract 2017 Nov;133():142-149. Epub 2017 sep 1
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Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation.
Mol Cell Endocrinol 2017 Oct 15;454():146-157. Epub 2017 jun 22
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Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase.
Invest Ophthalmol Vis Sci 2017 Jun 01;58(7):3100-3106.
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The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease.
Diabetologia 2017 Sep;60(9):1712-1721. Epub 2017 jun 13
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Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts.
Diabetes Care 2017 07;40(7):920-927. Epub 2017 mai 9
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PeptideMapper: efficient and versatile amino acid sequence and tag mapping.
Bioinformatics 2017 Jul 01;33(13):2042-2044.
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Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris.
J Am Heart Assoc 2017 Feb 03;6(2). Epub 2017 feb 3
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Targeted next-generation sequencing reveals MODY in up to 6.5% of antibody-negative diabetes cases listed in the Norwegian Childhood Diabetes Registry.
Diabetologia 2017 Apr;60(4):625-635. Epub 2016 des 2
PMID: 27913849
Functional Investigations of HNF1A Identify Rare Variants as Risk Factors for Type 2 Diabetes in the General Population.
Diabetes 2017 02;66(2):335-346. Epub 2016 nov 29
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Secretin-stimulated MRI assessment of exocrine pancreatic function in patients with cystic fibrosis and healthy controls.
Abdom Radiol (NY) 2017 Mar;42(3):890-899.
PMID: 27832324
Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer.
Pancreatology 2017 Jan - Feb;17(1):83-88. Epub 2016 okt 11
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Causes of death in childhood-onset Type 1 diabetes: long-term follow-up.
Diabet Med 2017 Jan;34(1):56-63. Epub 2016 apr 7
PMID: 26996105
High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: a randomised trial.
Br J Nutr 2017 May;117(10):1368-1378. Epub 2017 jun 13
PMID: 28606215
Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery.
Transl Res 2017 Jun;184():35-44.e4. Epub 2017 mar 9
PMID: 28347650
Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: a randomized controlled trial.
Am J Clin Nutr 2017 Jan;105(1):85-99. Epub 2016 nov 30
PMID: 27903520
Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis.
PLoS One 2016;11(11):e0165567. Epub 2016 nov 1
PMID: 27802312
Analysis of protein-coding genetic variation in 60,706 humans.
Nature 2016 08 18;536(7616):285-91.
PMID: 27535533
Common and rare forms of diabetes mellitus: towards a continuum of diabetes subtypes.
Nat Rev Endocrinol 2016 Jul;12(7):394-406. Epub 2016 apr 15
PMID: 27080136
Prospective Associations of Systemic and Urinary Choline Metabolites with Incident Type 2 Diabetes.
Clin Chem 2016 May;62(5):755-65. Epub 2016 mar 15
PMID: 26980210
PI3-kinase mutation linked to insulin and growth factor resistance in vivo.
J Clin Invest 2016 Apr 01;126(4):1401-12. Epub 2016 mar 14
PMID: 26974159
The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice.
Diabetes 2016 Jun;65(6):1672-8. Epub 2016 mar 7
PMID: 26953163
Structure-function studies of HNF1A (MODY3) gene mutations in South Indian patients with monogenic diabetes.
Clin Genet 2016 Dec;90(6):486-495. Epub 2016 mar 4
PMID: 26853433
The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus.
Mol Cell Endocrinol 2016 Jan 05;419():83-91. Epub 2015 okt 9
PMID: 26450151
DNA Topoisomerase IIa contributes to the early steps of adipogenesis in 3T3-L1 cells.
Cell Signal 2016 Oct;28(10):1593-603. Epub 2016 jul 9
PMID: 27404349
High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: a randomised trial.
Br J Nutr 2016 Aug;116(4):648-57. Epub 2016 jul 1
PMID: 27363518
Lean Seafood Intake Reduces Postprandial C-peptide and Lactate Concentrations in Healthy Adults in a Randomized Controlled Trial with a Crossover Design.
J Nutr 2016 May;146(5):1027-34. Epub 2016 apr 20
PMID: 27099232
Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study.
Mol Nutr Food Res 2016 Jul;60(7):1661-72. Epub 2016 mai 4
PMID: 26873789
The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORa and SRC-2 coactivator transcriptional activity.
Mol Cell Endocrinol 2016 Jan 05;419():92-101. Epub 2015 okt 9
PMID: 26455881
Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design.
Am J Clin Nutr 2015 Sep;102(3):582-92. Epub 2015 jul 29
PMID: 26224298
Classifying insulin regimens--difficulties and proposal for comprehensive new definitions.
Pediatr Diabetes 2015 Sep;16(6):402-6. Epub 2015 apr 10
PMID: 25865149
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
N Engl J Med 2015 Sep 3;373(10):895-907. Epub 2015 aug 19
PMID: 26287746
Glycogenin-2 is dispensable for liver glycogen synthesis and glucagon-stimulated glucose release.
J Clin Endocrinol Metab 2015 May;100(5):E767-75. Epub 2015 mar 9
PMID: 25751106
A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis.
Nat Genet 2015 May;47(5):518-22. Epub 2015 mar 16
PMID: 25774637
High Incidence of Heterozygous ABCC8 and HNF1A Mutations in Czech Patients With Congenital Hyperinsulinism.
J Clin Endocrinol Metab 2015 Dec;100(12):E1540-9. Epub 2015 okt 2
PMID: 26431509
All-cause mortality in a nationwide cohort of childhood-onset diabetes in Norway 1973-2013.
Diabetologia 2015 Aug;58(8):1779-86. Epub 2015 mai 14
PMID: 25972232
The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey).
Int J Endocrinol 2015;2015():164652. Epub 2015 mai 18
PMID: 26089876
Infant Growth and Risk of Childhood-Onset Type 1 Diabetes in Children From 2 Scandinavian Birth Cohorts.
JAMA Pediatr 2015 Dec 7;169(12):e153759. Epub 2015 des 7
PMID: 26642117
Novel adipose genes in substrate- and depot-dependent lipid accumulation
- Disputert:
- juni 2021
- Hovedveileder:
- Simon E Nitter Dankel
Interleukin-2 receptor in the pathogenesis of diabetic complications and Sjögren's syndrome
- Disputert:
- desember 2021
- Hovedveileder:
- Valeriya Lyssenko
Family-based genetic association models
- Disputert:
- juni 2020
- Hovedveileder:
- Håkon Gjessing, Rolv Terje Lie, Pål Rasmus Njølstad
Regulation of adipogenesis and fat storage by IRX3 and IRX5
- Disputert:
- april 2020
- Hovedveileder:
- Gunnar Mellgren, Simon Dankel, Jørn Sagen, Pål Rasmus Njølstad
Parental and Environmental Effects in the Genetics of Neurodevelopmental Disorders and Related Traits
- Disputert:
- desember 2020
- Hovedveileder:
- Stefan Johansson, Tetyana Zayats og Jan Håvik.
Precision medicine in MODY-diabetes: Unraveling the disease causality of gene variants and new regulatory mechanisms
- Disputert:
- oktober 2019
- Hovedveileder:
- Ingvild Aukrust, Pål R. Njølstad, Lise Bjørkhaug Gundersen
In vitro modelling of monogenic diabetes using human induced pluripotent stem cells
- Disputert:
- desember 2019
- Hovedveileder:
- Helge Ræder, Simona Chera
In vitro modulation of pancreatic islet cell fate characterized by mass spectrometry-based proteomics
- Disputert:
- mai 2019
- Hovedveileder:
- Helge Ræder, Simona Chera
Carboxyl-ester lipase in human pancreatic disease: A study with focus on genetics, glycosylation and ABO blood groups
- Disputert:
- september 2018
- Hovedveileder:
- Anders Molven
PI3-kinase regulation of mice and men: Novel aspects of insulin and growth factor signaling
- Disputert:
- april 2018
- Hovedveileder:
- Pål Rasmus Njølstad
Genetic and cellular studies of carboxyl-ester lipase (CEL), a protein involved in exocrine and endocrine pancreatic disease
- Disputert:
- september 2018
- Hovedveileder:
- Anders Molven
Role of rare HNF1A variants function in monogenic and type 2 diabetes
- Disputert:
- oktober 2018
- Hovedveileder:
- Lise Bj. Gundersen
Targeted clinical and genetic investigations to identify monogenic diabetes
- Disputert:
- oktober 2017
- Hovedveileder:
- Pål Rasmus Njølstad
Components of the choline oxidation pathway in relation to acute myocardial infarction, type 2 diabetes and mortality.
- Disputert:
- april 2016
- Hovedveileder:
- Gunnar Mellgren
- Janne Molnes Prosjektdeltaker
- Aishwarya Pavithram Ph.d.-kandidat
- Pernille Svalastoga Ph.d.-kandidat
- Laura Kind Ph.d.-kandidat
- Heidrun Vethne Ph.d.-kandidat
- Yngvild Bjørlykke Ph.d.-kandidat
- Alba Kaci Ph.d.-kandidat
- Svein Skeie Leder av forskningsgruppe
- Johan Fernø Postdoktor
- Jan-Inge Bjune Ph.d.-kandidat
- Gunnar Mellgren Leder av forskningsgruppe
- Sverre Sandberg Leder av forskningsgruppe
- Stefan Johansson Leder av forskningsgruppe
- Anders Molven Leder av forskningsgruppe
- John Cooper Leder av forskningsgruppe
- Bjørn Gunnar Nedrebø Leder av forskningsgruppe
- Jørn V. Sagen Leder av forskningsgruppe
- Øyvind Helgeland Ph.d.-kandidat
- Rolv Terje Lie Prosjektdeltaker
- Bente Berg Johansson Postdoktor
- Inge Jonassen Prosjektdeltaker
- Ingfrid S Haldorsen Prosjektdeltaker
- Georg Gjorgji Dimcevski Prosjektdeltaker
- Eirik Søfteland Prosjektdeltaker
- Kenneth Hugdahl Prosjektdeltaker
- Erling Tjora Postdoktor
- Helge Ræder Prosjektdeltaker
- Simon E Nitter Dankel Prosjektdeltaker
- Dag Jone Stokke Fadnes Prosjektdeltaker
- Villy Våge Prosjektdeltaker
- Arne-Christian Mohn Prosjektdeltaker
- Jonathan D Bland Prosjektdeltaker
- Heiko Bratke Prosjektdeltaker
- Jan Inge Sørheim Prosjektdeltaker
- Per Helge Kvistad Prosjektdeltaker
- Camilla Tøndel Prosjektdeltaker
- Bjørn Tore Gjertsen Prosjektdeltaker
- Marit Graue Prosjektdeltaker
- Pål Rasmus Njølstad Prosjektleder
- John Bland Prosjektdeltaker
- Henrik Underthun Irgens Ph.d.-kandidat
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