Gamma Knife Surgery for Brain Cancer – Radiosensitizers and Imaging techniques to improve treatment Efficacy - Experimental and Clinical research
Dette ble redegjort for i søknad om postdoktorstipend i 2015: The projects end-users include patients with primary or metastatic intracranial tumours suitable for gamma knife treatment; and their families recruited from a national reference area. In 2014 160 patients with BM and 30 with glioma were treated with GKS. The number of users has increased exponentially since the start in 1988 but varies considerably between different regions of the country. The indications for GKS are expanding. In 2014 the number of BMs in single patients considered suitable for GKS increased from 3 to 10. Thus more patients will benefit from GKS in the future. User involvement in the planning and the implementation of the project is only indirect. Our prospective QOL-study included close follow-up of 100 BM patients. These patients self-reported QoL, satisfaction and complaints related to treatment and the uncertainties evaluating MRI during follow-up, are the main inspiration behind this project.
Predictors of quality of life and survival following Gamma Knife surgery for lung cancer brain metastases: a prospective study.
J Neurosurg 2017 Aug 18. Epub 2017 aug 18
Drug repurposing in cancer.
Pharmacol Res 2017 Oct;124():74-91. Epub 2017 jul 13
Colony Stimulating Factor-1 Receptor Inhibitors-A 4 for 1 Deal in the Desire to Improve Glioma Radiotherapy.
Neurosurgery 2017 Sep 01;81(3):N27-N28.
Quality of life is maintained using Gamma Knife radiosurgery: a prospective study of a brain metastases patient cohort.
J Neurosurg 2017 Mar;126(3):708-725. Epub 2016 apr 8
Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models.
BMC Cancer 2016 Aug 19;16():657. Epub 2016 aug 19
Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats.
J Neurooncol 2016 Aug;129(1):57-66. Epub 2016 jun 9