Gamma Knife Surgery for Brain Cancer – Radiosensitizers and Imaging techniques to improve treatment Efficacy - Experimental and Clinical research
- Prosjektnummer
- 912042
- Ansvarlig person
- Bente Sandvei Skeie
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Cancer, Neurological
- Forskningsaktivitet
- 5. Treatment Developement, 6. Treatment Evaluation
Dette ble redegjort for i søknad om postdoktorstipend i 2015: The projects end-users include patients with primary or metastatic intracranial tumours suitable for gamma knife treatment; and their families recruited from a national reference area. In 2014 160 patients with BM and 30 with glioma were treated with GKS. The number of users has increased exponentially since the start in 1988 but varies considerably between different regions of the country. The indications for GKS are expanding. In 2014 the number of BMs in single patients considered suitable for GKS increased from 3 to 10. Thus more patients will benefit from GKS in the future. User involvement in the planning and the implementation of the project is only indirect. Our prospective QOL-study included close follow-up of 100 BM patients. These patients self-reported QoL, satisfaction and complaints related to treatment and the uncertainties evaluating MRI during follow-up, are the main inspiration behind this project.
A simple score to estimate the likelihood of pseudoprogression vs. recurrence following stereotactic radiosurgery for brain metastases: The Bergen Criteria.
Neurooncol Adv 2020 Jan-Dec;2(1):vdaa026. Epub 2020 mar 10
PMID: 32642686
A prospective study of the natural history of incidental meningioma-Hold your horses!
Neurooncol Pract 2019 Dec;6(6):438-450. Epub 2019 apr 17
PMID: 31832214
Predictors of quality of life and survival following Gamma Knife surgery for lung cancer brain metastases: a prospective study.
J Neurosurg 2018 Jul;129(1):71-83. Epub 2017 aug 18
PMID: 28820304
Drug repurposing in cancer.
Pharmacol Res 2017 Oct;124():74-91. Epub 2017 jul 13
PMID: 28712971
Colony Stimulating Factor-1 Receptor Inhibitors-A 4 for 1 Deal in the Desire to Improve Glioma Radiotherapy.
Neurosurgery 2017 Sep 01;81(3):N27-N28.
PMID: 28859456
Quality of life is maintained using Gamma Knife radiosurgery: a prospective study of a brain metastases patient cohort.
J Neurosurg 2017 Mar;126(3):708-725. Epub 2016 apr 8
PMID: 27058206
Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models.
BMC Cancer 2016 Aug 19;16():657. Epub 2016 aug 19
PMID: 27542970
Treatment with the PI3K inhibitor buparlisib (NVP-BKM120) suppresses the growth of established patient-derived GBM xenografts and prolongs survival in nude rats.
J Neurooncol 2016 Aug;129(1):57-66. Epub 2016 jun 9
PMID: 27283525
- Christopher Filippi Prosjektdeltaker
- Øystein Vesterli Tveiten Prosjektdeltaker
- Maziar Behbahani Prosjektdeltaker
- Sidsel Marit Bragstad Prosjektdeltaker
- Jonas Anders Lind Prosjektdeltaker
- Dorota Goplen Prosjektdeltaker
- Charles Valery Prosjektdeltaker
- Jonathan Knisely Prosjektdeltaker
- Ernest Dodoo Prosjektdeltaker
- Halfdan Sørbye Prosjektdeltaker
- Thomas Schwarzlmüller Prosjektleder
- Eli Renate Gruner Prosjektdeltaker
- Bente Sandvei Skeie Postdoktor
- Jan Ingemann Heggdal Prosjektdeltaker
- Geir Egil Eide Prosjektdeltaker
- Paal-Henning Pedersen Prosjektdeltaker
- Per Øyvind Enger Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest