Regenerating bone defects using stem cells: experimental and clinical studies
- Prosjektnummer
- 912048
- Ansvarlig person
- Kamal Mustafa
- Institusjon
- Helse Bergen HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Musculoskeletal
- Forskningsaktivitet
- 5. Treatment Developement
User involvement in development and planning of the project: Patients are eligible to be treated will be offered the participation in the surgical trials. The treatment will be an alternative to treatment with an autologous or allogenic bone grafts. Patients’ acceptance for follow-ups will also be asked. Detailed information of the intervention will be explained and discussed with the patients and their families. Written consents approved by the Regional Ethics Authority and the Medicine Agencies in Norway will be discussed and signed by the patients. The involvement of patients (users) in the study is important to assess the safety and efficiency of the treatment by assessing the acceptability of this approach postoperatively, by evaluating its morbidity, its impact on the patient’s quality of life and other patient reported outcomes. The study design and protocols will be discussed with the leaders in each institute and with the surgeons and surgical staff . User involvement in dissemination and implementation of the results: The dissemination activities will help to promote the project’s results, to increase more widely the impact, to disseminate experiences and good practices in advanced therapy medicinal products based on cultured autologous mesenchymal stem cells for bone regeneration to the general public, scientific community and clinicians, as well as regulatory and government agencies.
Impact of humanised isolation and culture conditions on stemness and osteogenic potential of bone marrow derived mesenchymal stromal cells.
Sci Rep 2019 Nov 05;9(1):16031. Epub 2019 nov 5
PMID: 31690774
Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration.
J Tissue Eng 2019 Jan-Dec;10():2041731419852703. Epub 2019 mai 31
PMID: 31210921
Adenoviral mediated mono delivery of BMP2 is superior to the combined delivery of BMP2 and VEGFA in bone regeneration in a critical-sized rat calvarial bone defect.
Bone Rep 2019 Jun;10():100205. Epub 2019 apr 11
PMID: 31193299
Wood-based nanocellulose and bioactive glass modified gelatin-alginate bioinks for 3D bioprinting of bone cells.
Biofabrication 2019 04 26;11(3):035010. Epub 2019 apr 26
PMID: 30754034
Inflammatory responses and tissue reactions to wood-Based nanocellulose scaffolds.
Mater Sci Eng C Mater Biol Appl 2019 Apr;97():208-221. Epub 2018 des 2
PMID: 30678905
Cell therapy for orofacial bone regeneration: A systematic review and meta-analysis.
J Clin Periodontol 2019 06;46 Suppl 21():162-182.
PMID: 30623455
Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison.
Stem Cell Res Ther 2018 Jun 19;9(1):168. Epub 2018 jun 19
PMID: 29921311
In vitro cytotoxicity assessment of nanodiamond particles and their osteogenic potential.
J Biomed Mater Res A 2018 Jun;106(6):1697-1707. Epub 2018 mar 8
PMID: 29451353
Coating 3D Printed Polycaprolactone Scaffolds with Nanocellulose Promotes Growth and Differentiation of Mesenchymal Stem Cells.
Biomacromolecules 2018 Nov 12;19(11):4307-4319. Epub 2018 okt 18
PMID: 30296827
Efficacy of Humanized Mesenchymal Stem Cell Cultures for Bone Tissue Engineering: A Systematic Review with a Focus on Platelet Derivatives.
Tissue Eng Part B Rev 2017 Dec;23(6):552-569. Epub 2017 jul 28
PMID: 28610481
Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry.
Biomacromolecules 2017 04 10;18(4):1238-1248. Epub 2017 mar 16
PMID: 28263573
A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration.
Macromol Biosci 2017 Jun;17(6). Epub 2017 jan 24
PMID: 28116858
3D-Printable polycaprolactone-gelatin blends characterized for in vitro osteogenic potency
Reactive and Functional Polymers, 2019
Inflammatory Responses and Host Tissue Reactions to Wood-Based Nanocellulose Scaffolds
Accepted in Materials Science & Engineering C (2019)
Cell therapy for orofacial bone regeneration: a systematic review and meta-analysis
Accepted in J Clin Periodontol (2019)
Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry
Biomacromolecules 2017 Apr 10;18(4):1238-1248. doi: 10.1021/acs.biomac.6b01911. Epub (2017).
Patient experience following iliac crest-derived alveolar bone grafting and implant placement
Submitted manuscript, 2019
Optimising humanised culture conditions for expansion of mesenchymal stromal cells for bone regeneration
Submitted manuscript, 2019
Stem cells in mandibular bone regeneration, a 3 years follow-up
Manuscript, 2019
A copolymer scaffold functionalized with nanodiamond particles enhances 1 osteogenic metabolic activity and bone regeneration
Accepted in Macromolecular Bioscience
Efficacy of humanized MSC cell cultures for bone tissue engineering: a systematic review with a focus on platelet-derivatives
Submitted to Biomaterials
Cytocompatibility of Wood-derived Cellulose nanofibril Hydrogels with Different Surface Chemistry
Submitted to Biomacromolecules
Stem cells in bone regeneration, a systematic approach and an observational first-in-human trial
Manuscript
- Markus Rojewski Prosjektdeltaker
- Anna Finne Wistrand Prosjektdeltaker
- Hubert Schrezenmeier Prosjektdeltaker
- Pål Høvding Prosjektdeltaker
- Tor Hervig Prosjektdeltaker
- Mohammed Ahmed Alamin Yousif Yassin Postdoktor
- Jan E. Brinchmann Prosjektdeltaker
- Bjørn Tore Gjertsen Prosjektdeltaker
- Siddharth Shanbhag Ph.d.-kandidat
- Kristin Syverud Prosjektdeltaker
- Salwa Suliman Postdoktor
- Ahmad Rashad Saad Mohamed Elsebahy Ph.d.-kandidat
- Cecilie Gudveig Gjerde Ph.d.-kandidat
- Kamal Babikeir Eln Mustafa Prosjektleder
- Yngvar Krukhaug Prosjektdeltaker
- Maryam Alizadeh Gharaei Ph.d.-kandidat
- Siddharth Shanbhag Ph.d.-kandidat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til Faglig rapportering, Helse Vest