Regenerating bone defects using stem cells: experimental and clinical studies
User involvement in development and planning of the project: Patients are eligible to be treated will be offered the participation in the surgical trials. The treatment will be an alternative to treatment with an autologous or allogenic bone grafts. Patients’ acceptance for follow-ups will also be asked. Detailed information of the intervention will be explained and discussed with the patients and their families. Written consents approved by the Regional Ethics Authority and the Medicine Agencies in Norway will be discussed and signed by the patients. The involvement of patients (users) in the study is important to assess the safety and efficiency of the treatment by assessing the acceptability of this approach postoperatively, by evaluating its morbidity, its impact on the patient’s quality of life and other patient reported outcomes. The study design and protocols will be discussed with the leaders in each institute and with the surgeons and surgical staff . User involvement in dissemination and implementation of the results: The dissemination activities will help to promote the project’s results, to increase more widely the impact, to disseminate experiences and good practices in advanced therapy medicinal products based on cultured autologous mesenchymal stem cells for bone regeneration to the general public, scientific community and clinicians, as well as regulatory and government agencies.
Efficacy of Humanized Mesenchymal Stem Cell Cultures for Bone Tissue Engineering: A Systematic Review with a Focus on Platelet Derivatives.
Tissue Eng Part B Rev 2017 Dec;23(6):552-569. Epub 2017 jul 28
Cytocompatibility of Wood-Derived Cellulose Nanofibril Hydrogels with Different Surface Chemistry.
Biomacromolecules 2017 04 10;18(4):1238-1248. Epub 2017 mar 16
A Copolymer Scaffold Functionalized with Nanodiamond Particles Enhances Osteogenic Metabolic Activity and Bone Regeneration.
Macromol Biosci 2017 Jun;17(6). Epub 2017 jan 24
A copolymer scaffold functionalized with nanodiamond particles enhances 1 osteogenic metabolic activity and bone regeneration
Accepted in Macromolecular Bioscience
Efficacy of humanized MSC cell cultures for bone tissue engineering: a systematic review with a focus on platelet-derivatives
Submitted to Biomaterials
Cytocompatibility of Wood-derived Cellulose nanofibril Hydrogels with Different Surface Chemistry
Submitted to Biomacromolecules
Stem cells in bone regeneration, a systematic approach and an observational first-in-human trial