Inflammatory markers in opioid maintenance therapy. The role of major depression and psychosocial stressors
Inflammatory markers in opioid maintenance therapy (OMT). The role of major depression and psychosocial stressors.
This research project is translational and has scientific and clinical relevance. It could contribute to our understanding of the etiology and pathogenesis of major depressive disorder amongst patients in opioid maintenance treatment (OMT), and give clues for the choice of treatment.
Patients on opioid maintenance therapy (OMT) have a high prevalence of major depression and somatic co morbidity such as hepatitis C virus infection (HCV). In addition, they are subjected to a high level of psychosocial stressors, all of which are known to increase the level of inflammatory markers. OMT formulations containing either buprenorphine or methadone have different pharmacokinetic properties with different impact on the immune –and central nervous system. Buprenorphine has ?-receptor antagonistic properties causing anti-depressant-like effect with a different impact on the immune system as compared to methadone. However, studies thus far have only investigated limited amount of cytokines and their association with major depression, HCV and psychosocial stressors, respectively, and none have incorporated all of these factors in patient on OMT. The aim of this project is to investigate the role inflammatory markers play in patients on OMT with HCV on depression and psychosocial stressors. The study is a cross-sectional study where patients on OMT with HCV will undergo blood-sampling analyzing 27 different cytokines using a multiplex approach and psychometric evaluation using SF-36, Scl-90 and Europ-ASI. Each patient will be matched with non-OMT controls with HCV matched for age and gender. Prosjektet er fortsatt i datainnsamlingsfasen. det er sdnart inkludert 100 pasienter og skal i alt inkluderes ca 120. Vi regner med at det er gjort før sommeren. Da vil analysen av data starte opp.