Critical research program on the association between anti-dsDNA antibodies and SLE nephritis
Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities.
Exp Dermatol 2010 Aug;19(8):e265-74.
Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis.
PLoS One 2010;5(8). Epub 2010 aug 10
Alterations in Wnt pathway activity in serum and kidneys during lupus development.
Arthritis Rheum 2010 Nov. Epub 2010 nov 4
Heparin exerts a dual effect on murine lupus nephritis by enhancing enzymatic chromatin degradation and preventing chromatin binding in glomerular membranes.
Arthritis Rheum 2011 Apr;63(4):1065-75.
Pure anti-dsDNA mAbs need chromatin structures to promote glomerular mesangial deposits in BALB/c mice.
Autoimmunity 2010 Mar;43(2):179-88.
Nuclease deficiencies promote end-stage lupus nephritis but not nephritogenic autoimmunity in (NZB × NZW) F1 mice.
Immunol Cell Biol. Epub 2010 Jun 15.
Alterations in the renal microenvironmentduring development of lupus nephritis
- desember 2010
- Ole Petter Rekvig