The role of complement in the inflammatory reaction
- Prosjektnummer
- SFP1085-13
- Ansvarlig person
- Tom Eirik Mollnes
- Institusjon
- Nordlandssykehuset HF
- Prosjektkategori
- Flerårig forskningsprosjekt
- Helsekategori
- Inflammatory and immune system
- Forskningsaktivitet
- 5. Treatment Development
Complement activation patterns in atypical haemolytic uraemic syndrome during acute phase and in remission.
Clin Exp Immunol 2015 Aug;181(2):306-13.
PMID: 25079699
Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo.
Clin Exp Immunol 2015 Feb;179(2):294-9.
PMID: 25174443
High ficolin-3 level at the time of transplantation is an independent risk factor for graft loss in kidney transplant recipients.
Transplantation 2015 Apr;99(4):791-6.
PMID: 25222012
Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma.
Biomaterials 2015 Jan;36():55-65. Epub 2014 okt 5
PMID: 25292422
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn.
Immunobiology 2015 Apr;220(4):452-9. Epub 2014 nov 13
PMID: 25468724
A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases.
Mol Immunol 2015 Mar;64(1):170-6. Epub 2014 des 19
PMID: 25534848
Plasma cytokine expression in adolescent chronic fatigue syndrome.
Brain Behav Immun 2015 May;46():80-6. Epub 2014 des 31
PMID: 25555530
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray.
PLoS One 2015;10(2):e0117261. Epub 2015 feb 23
PMID: 25706641
Meconium aspiration syndrome: possible pathophysiological mechanisms and future potential therapies.
Neonatology 2015;107(3):225-30.
PMID: 25721501
The anti-inflammatory effect of combined complement and CD14 inhibition is preserved during escalating bacterial load.
Clin Exp Immunol 2015 Sep;181(3):457-67. Epub 2015 jul 19
PMID: 25907631
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14.
Immunobiology 2015 Aug;220(8):999-1005. Epub 2015 apr 27
PMID: 25956456
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.
J Infect Dis 2015 Dec 1;212(11):1835-40. Epub 2015 mai 15
PMID: 25980034
Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood.
Innate Immun 2014 Jan;20(1):68-77. Epub 2013 mai 13
PMID: 23669326
Electroluminescent TCC, C3dg and fB/Bb epitope assays for profiling complement cascade activation in vitro using an activated complement serum calibration standard.
J Immunol Methods 2014 Jan 15;402(1-2):50-6. Epub 2013 nov 25
PMID: 24287422
A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers.
PLoS One 2014;9(1):e85604. Epub 2014 jan 9
PMID: 24416431
Combined inhibition of complement and CD14 efficiently attenuated the inflammatory response induced by Staphylococcus aureus in a human whole blood model.
J Immunol 2014 Mar 15;192(6):2857-64. Epub 2014 feb 10
PMID: 24516199
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease.
Inflamm Bowel Dis 2014 Jun;20(6):995-1003.
PMID: 24739633
Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice.
J Immunol 2014 Jun 1;192(11):5324-31. Epub 2014 apr 30
PMID: 24790148
A novel method for direct measurement of complement convertases activity in human serum.
Clin Exp Immunol 2014 Oct;178(1):142-53.
PMID: 24853370
High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders.
CNS Neurosci Ther 2014 Oct;20(10):898-904. Epub 2014 jul 3
PMID: 24995667
A vital role for complement in heart disease.
Mol Immunol 2014 Oct;61(2):126-34. Epub 2014 jul 16
PMID: 25037633
Cholesterol crystal-induced endothelial cell activation is complement-dependent and mediated by TNF.
Immunobiology 2014 Oct;219(10):786-92. Epub 2014 jul 5
PMID: 25053140
Seventy-two hours of mild hypothermia after cardiac arrest is associated with a lowered inflammatory response during rewarming in a prospective observational study.
Crit Care 2014 Oct 11;18(5):546. Epub 2014 okt 11
PMID: 25304549
Cytokine Network in Adults with Falciparum Malaria and HIV-1: Increased IL-8 and IP-10 Levels Are Associated with Disease Severity.
PLoS One 2014;9(12):e114480. Epub 2014 des 11
PMID: 25503583
Activation of coagulation and platelets by candidate membranes of implantable devices in a whole blood model without soluble anticoagulant.
J Biomed Mater Res A 2013 Feb;101(2):575-81. Epub 2012 sep 4
PMID: 22949225
The induction of cytokines by polycation containing microspheres by a complement dependent mechanism.
Biomaterials 2013 Jan;34(3):621-30. Epub 2012 okt 24
PMID: 23103159
C1-inhibitor efficiently inhibits Escherichia?coli-induced tissue factor mRNA up-regulation, monocyte tissue factor expression and coagulation activation in human whole blood.
Clin Exp Immunol 2013 Aug;173(2):217-29.
PMID: 23607270
Primary complement C5 deficiencies - molecular characterization and clinical review of two families.
Immunobiology 2013 Oct;218(10):1304-10. Epub 2013 mai 14
PMID: 23743184
Atrial fibrillation: inflammation in disguise?
Scand J Immunol 2013 Aug;78(2):112-9.
PMID: 23672430
An international serum standard for application in assays to detect human complement activation products.
Mol Immunol 2013 Dec 15;56(3):232-9. Epub 2013 jun 17
PMID: 23787367
Increased systemic and local interleukin 9 levels in patients with carotid and coronary atherosclerosis.
PLoS One 2013;8(8):e72769. Epub 2013 aug 30
PMID: 24023645
Chimeric anti-CD14 IGG2/4 Hybrid antibodies for therapeutic intervention in pig and human models of inflammation.
J Immunol 2013 Nov 1;191(9):4769-77. Epub 2013 sep 23
PMID: 24062486
COMP-C3b complexes in rheumatoid arthritis with severe extraarticular manifestations.
J Rheumatol 2013 Dec;40(12):2001-5. Epub 2013 nov 1
PMID: 24187101
Staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults.
Pediatr Res 2013 Mar;73(3):294-300. Epub 2012 des 11
PMID: 23232670
The effects of selective complement and CD14 inhibition on the E. coli-induced tissue factor mRNA upregulation, monocyte tissue factor expression, and tissue factor functional activity in human whole blood.
Adv Exp Med Biol 2013;735():123-36.
PMID: 23402023
- Terje Espevik Prosjektdeltaker
- Knut Tore Lappegård Prosjektdeltaker
- Corinna Lau Prosjektdeltaker
- Ole Lars Brekke Prosjektdeltaker
- Erik Waage Nielsen Prosjektdeltaker
- Tom Eirik Mollnes Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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