Betydning av mikroRNA og komplementsystemet for inflammasjon i en human fullblodsmodell for sepsis
- Prosjektnummer
- SFP1143-14
- Ansvarlig person
- Ole-Lars Brekke
- Institusjon
- Nordlandssykehuset
- Prosjektkategori
- flerårig forskningsprosjekt som omfatter flere forskere
- Helsekategori
- Cardiovascular, Infection, Inflammatory and immune system
- Forskningsaktivitet
- 2. Aetiology, 4. Detection and Diagnosis
Brukerne som er friske blodgivere som har samtykket til å gi ferskt venøst blod i prosjektet har hatt mulighet til å påvirke, utvikle og endre prosjektet. De har også fått informasjon om resultater i studien
Brukere har hatt mulighet til å påvirke prosjektet
A mitochondrial long noncoding RNA in atlantic cod harbors complex heteroplasmic tandem repeat motifs.
Mitochondrial DNA A DNA Mapp Seq Anal 2019 03;30(2):307-311. Epub 2018 sep 10
PMID: 30198386
Lifestyle factors including diet and biochemical biomarkers in acute intermittent porphyria: Results from a case-control study in northern Norway.
Mol Genet Metab 2019 Nov;128(3):254-270. Epub 2018 des 10
PMID: 30583995
Key role of the number of complement receptor 1 on erythrocytes for binding of Escherichia coli to erythrocytes and for leukocyte phagocytosis and oxidative burst in human whole blood.
Mol Immunol 2019 10;114():139-148. Epub 2019 jul 25
PMID: 31352230
Mitochondrial genome variation of Atlantic cod.
BMC Res Notes 2018 Jun 19;11(1):397. Epub 2018 jun 19
PMID: 29921324
Elucidating the Small Regulatory RNA Repertoire of the Sea Anemone Anemonia viridis Based on Whole Genome and Small RNA Sequencing.
Genome Biol Evol 2018 02 01;10(2):410-426.
PMID: 29385567
Staphylococcus aureus-induced complement activation promotes tissue factor-mediated coagulation.
J Thromb Haemost 2018 May;16(5):905-918. Epub 2018 mar 23
PMID: 29437288
Associations between complement pathways activity, mannose-binding lectin, and odds of unprovoked venous thromboembolism.
Thromb Res 2018 09;169():50-56. Epub 2018 jun 30
PMID: 30015228
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
Clin Exp Immunol 2019 04;196(1):97-110. Epub 2018 des 19
PMID: 30444525
Systemic inflammation in acute intermittent porphyria: a case-control study.
Clin Exp Immunol 2017 Mar;187(3):466-479. Epub 2016 des 15
PMID: 27859020
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII.
Acta Biomater 2017 Aug;58():158-167. Epub 2017 mai 30
PMID: 28576714
Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines - Consequences for defining reference values in healthy humans.
Cytokine 2017 Sep;97():86-95. Epub 2017 jun 6
PMID: 28595117
Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release.
J Immunol 2014 Mar 15;192(6):2837-45. Epub 2014 feb 19
PMID: 24554772
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn.
Immunobiology 2015 Apr;220(4):452-9. Epub 2014 nov 13
PMID: 25468724
Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor
J Immunol. 2019 Aug 15; 203(4): 853–863
Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli‐induced coagulation accompanied by Toll‐like receptor 4
Clin Exp Immunol. 2019 Apr; 196(1): 97–110
Systemic inflammation in acute intermittent porphyria: a case control study
Clinical and Experimental Immunology, 2016
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood
Genom Data. 2015 September; 5: 176–183. Published online 2015 May 30. doi: 10.1016/j.gdata.2015.05.019
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
Crit Care. 2015; 19: 415. Published online 2015 November 27. doi: 10.1186/s13054-015-1129-9
CD14 and Complement Crosstalk and Largely Mediate the Transcriptional Response to Escherichia coli in Human Whole Blood
PLoS One. 2015; 10(2): e0117261. Published online 2015 February 23. doi: 10.1371/journal.pone.0117261
- Bård Ove Karlsen Postdoktorstipendiat
- Steinar Daae Johansen Prosjektdeltaker
- Tom Eirik Mollnes Forskningsgruppeleder
- Ole-Lars Brekke Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport, Helse Nord