Proton beam therapy in treatment of breast cancer
Prosjekt
- Prosjektnummer
- SFP1158-14
- Ansvarlig person
- Rune Sundset
- Institusjon
- Universitetssykehuset Nord-Norge HF
- Prosjektkategori
- Ph.d.-stipend
- Helsekategori
- Cancer and neoplasms
- Forskningsaktivitet
- 5. Treatment Development
Rapporter
I 2015 har det ikke vært fremdrift i dette prosjektet. -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I 2015 har det ikke vært fremdrift i dette prosjektet. -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
The present project is focusing on the most common cancer form among females, breast cancer, where RT is an important treatment modality. Proton therapy has a considerable potential to improve outcome for breast cancer, but this requires careful investigations to deliver optimal proton therapy to appropriately selected patients.I started my project in March 2014. I moved to Bergen and established myself at Haukeland Universitets Sykehus (HUS) since the project was tightly connected to the group in Bergen. The group in Bergen has since several years back been involved in development of particle therapy in Norway and has the highest national competence regarding this area. Hence it was evaluated most beneficial for my project to work from Bergen in order to access the existing competence here.
Since March 2014 I have learned to work with the treatment planning research work station (Tbox) available at HUS, with proton dose planning using the latest system delivered by Varian. I have learned treatment planning with different proton modalities (scattering/scanning) in Tbox. We decided to use a scanning modality, Intensity Modulated Proton Therapy (IMPT), for dose planning of my project. Since this technique is relative new and have shown some advantages in patient treatment.
I had already agreed with radiation therapy department in Tromsø to use data from breast cancer patients treated in Tromsø in Deep Inspiration Breath Hold (DIBH). I had previously in my clinical work in Tromsø implemented DIBH technique for treatment of left-sided breast cancer patients. 20 patients were scanned in CT in free breathing (FB) and in DIBH. These patients where sent to me from Tromsø (in anonymized form) and then entered them into the Tbox.
These patients were treatment planned with IMPT in Tbox. I tried to find an optimal field set-up which could be most beneficial regarding target (breast) coverage and dose to organ at risk (OAR); meaning the coverage to target volume to be kept as close to prescribed dose as possible while keeping the radiation dose to OAR as low as possible. Result of this study has been accepted for presentation at the main European RT conference (Estro) in april 2015.
During 2014 I have attended the Estro meeting in Wien, PTCOG 2014 and a seminar in Uppsala. I also have participated in a Monte Carlo course in Oxford. I have visited Aarhus and established collaboration with the radiation oncology department at Aarhus universitetshospital. The 20 patietns from Tromsø have now been delineated with new Estro guidelines for breast contouring in Aarhus in order to evaluate usage of IMPT for more clinical complicated cases.
Since the knowledge within proton therapy and proton treatment planning is limited in Norway, I have also visited University of Florida Proton Therapy Institute (UFPTI) and Massachusetts General Hospital (MGH) in order to gather more information and evaluate the created proton dose plans. These visits have been very useful and have had a major part in further developing and optimizing my research.
My project study during 2014 has shown the benefits of IMPT in treatment of breast cancer. I have come to conclusion that DIBH is not necessarily the optimum technique in treatment of breast cancer with proton therapy.
In 2015 I have planned to attend even more courses related to my project and participate in more conferences by submitting my work so far. At least three of these courses will be attended in Tromsø. My supervisor in Tromsø and I will organized a seminar in Tromsø in order to share the knowledge achieved so far in proton treatment planning. I will develop my project further and start a new study in 4DCT in order to study the effect of breathing motion and robustness of IMPT plans.
Deltagere
- Ludvig Paul Muren Prosjektleder
- Mana Rasi Doktorgradsstipendiat
- Rune Sundset Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport, Helse Nord