The Role of Complement in Human Disease - Targets for Therapeutic Inhibition
- Prosjektnummer
- SFP1217-15
- Ansvarlig person
- Tom Eirik Mollnes
- Institusjon
- Nordlandssykehuset
- Prosjektkategori
- Flerårig forskningsprosjekt
- Helsekategori
- Inflammatory and immune system
- Forskningsaktivitet
- 2. Aetiology
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.
J Leukoc Biol 2017 01;101(1):193-204. Epub 2016 aug 31
PMID: 27581539
Complement activation by cholesterol crystals triggers a subsequent cytokine response.
Mol Immunol 2017 Apr;84():43-50. Epub 2016 sep 28
PMID: 27692470
Plasma Levels of Marine n-3 Fatty Acids Are Inversely Correlated With Proinflammatory Markers sTNFR1 and IL-6 in Renal Transplant Recipients.
J Ren Nutr 2017 May;27(3):161-168. Epub 2016 nov 9
PMID: 27838193
Systemic inflammation in acute intermittent porphyria: a case-control study.
Clin Exp Immunol 2017 Mar;187(3):466-479. Epub 2016 des 15
PMID: 27859020
Properdin binding to complement activating surfaces depends on initial C3b deposition.
Proc Natl Acad Sci U S A 2017 Jan 24;114(4):E534-E539. Epub 2017 jan 9
PMID: 28069958
The alternative complement pathway is dysregulated in patients with chronic heart failure.
Sci Rep 2017 Feb 14;7():42532. Epub 2017 feb 14
PMID: 28195242
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function.
Basic Res Cardiol 2017 May;112(3):20. Epub 2017 mar 3
PMID: 28258298
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis.
J Intensive Care 2017;5():21. Epub 2017 feb 27
PMID: 28261486
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report.
Medicine (Baltimore) 2017 Mar;96(11):e6338.
PMID: 28296762
Plasma complement and vascular complement deposition in patients with coronary artery disease with and without inflammatory rheumatic diseases.
PLoS One 2017;12(3):e0174577. Epub 2017 mar 31
PMID: 28362874
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes.
Nat Nanotechnol 2017 Jul;12(6):589-594. Epub 2017 apr 10
PMID: 28396605
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring.
Mol Immunol 2017 Sep;89():10-21. Epub 2017 mai 31
PMID: 28576323
Alginate microbeads are coagulation compatible, while alginate microcapsules activate coagulation secondary to complement or directly through FXII.
Acta Biomater 2017 Aug;58():158-167. Epub 2017 mai 30
PMID: 28576714
Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model.
Int J Nanomedicine 2017;12():3927-3940. Epub 2017 mai 23
PMID: 28579778
Effect of the anticoagulant, storage time and temperature of blood samples on the concentrations of 27 multiplex assayed cytokines - Consequences for defining reference values in healthy humans.
Cytokine 2017 Sep;97():86-95. Epub 2017 jun 6
PMID: 28595117
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses.
Mol Immunol 2017 Sep;89():111-114. Epub 2017 jun 10
PMID: 28610663
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis.
Proc Natl Acad Sci U S A 2017 Jul 18. Epub 2017 jul 18
PMID: 28720697
Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy.
Clin Proteomics 2017;14():30. Epub 2017 aug 14
PMID: 28814945
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.
J Immunol 2017 10 15;199(8):2910-2920. Epub 2017 aug 30
PMID: 28855312
Transforming growth factor beta (TGF-β) in adolescent chronic fatigue syndrome.
J Transl Med 2017 Dec 04;15(1):245. Epub 2017 des 4
PMID: 29202780
Reduced inflammatory response by transcatheter, as compared to surgical aortic valve replacement.
Scand Cardiovasc J 2017 Dec 12. Epub 2017 des 12
PMID: 29233022
Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery.
Blood 2016 Jan 21;127(3):365-7. Epub 2015 des 7
PMID: 26644452
Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1ß Secondarily to Activation of C5 and CD14 in Whole Blood.
J Immunol 2016 Mar 01;196(5):2293-9. Epub 2016 jan 22
PMID: 26800874
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome.
Rheumatology (Oxford) 2016 Jul;55(7):1337-9. Epub 2016 apr 22
PMID: 27105662
Combined Inhibition of Complement and CD14 Attenuates Bacteria-Induced Inflammation in Human Whole Blood More Efficiently Than Antagonizing the Toll-like Receptor 4-MD2 Complex.
J Infect Dis 2016 Jul 01;214(1):140. Epub 2016 mar 14
PMID: 26977050
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation.
J Control Release 2016 May 10;229():58-69. Epub 2016 mar 16
PMID: 26993426
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis.
J Immunol 2016 Jun 15;196(12):5064-74. Epub 2016 mai 16
PMID: 27183610
C1-inhibitor efficiently delays clot development in normal human whole blood and inhibits Escherichia coli-induced coagulation measured by thromboelastometry.
Thromb Res 2016 Jul;143():63-70. Epub 2016 apr 28
PMID: 27197075
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo.
Clin Microbiol Infect 2016 Aug;22(8):734.e1-6. Epub 2016 mai 20
PMID: 27217049
LDL apheresis activates the complement system and the cytokine network, whereas PCSK9 inhibition with evolocumab induces no inflammatory response.
J Clin Lipidol 2016 Nov - Dec;10(6):1481-1487. Epub 2016 sep 13
PMID: 27919366
Low level of MAp44, an inhibitor of the lectin complement pathway, and long-term graft and patient survival; a cohort study of 382 kidney recipients.
BMC Nephrol 2016 Oct 18;17(1):148. Epub 2016 okt 18
PMID: 27760523
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis.
Atherosclerosis 2015 Aug;241(2):480-94. Epub 2015 jun 5
PMID: 26086357
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation.
J Immunol 2015 Jul 1;195(1):257-64. Epub 2015 mai 29
PMID: 26026058
TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-ß Production via a TAK1-IKKß-IRF5 Signaling Pathway.
J Immunol 2015 Aug 1;195(3):1100-11. Epub 2015 jun 17
PMID: 26085680
Effect of Cardiac Resynchronization Therapy on Inflammation in Congestive Heart Failure: A Review.
Scand J Immunol 2015 Sep;82(3):191-8.
PMID: 26099323
Sensitive, reliable and easy-performed laboratory monitoring of eculizumab therapy in atypical hemolytic uremic syndrome.
Clin Immunol 2015 Oct;160(2):237-43. Epub 2015 jun 23
PMID: 26111482
Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo.
Blood 2015 Jul 9;126(2):278-9.
PMID: 26160188
The key roles of complement and tissue factor in Escherichia coli-induced coagulation in human whole blood.
Clin Exp Immunol 2015 Oct;182(1):81-9. Epub 2015 aug 2
PMID: 26241501
Massive Organ Inflammation in Experimental and in Clinical Meningococcal Septic Shock.
Shock 2015 Nov;44(5):458-69.
PMID: 26473439
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response.
Genom Data 2015 Sep;5():176-83. Epub 2015 mai 30
PMID: 26484252
Therapeutic complement inhibition – from experimental to clinical medicine.
Tidsskr Nor Laegeforen 2015 Oct 20;135(19):1745-9. Epub 2015 okt 20
PMID: 26486669
Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases: Data From the Oslo-CoMet Trial.
Medicine (Baltimore) 2015 Oct;94(42):e1786.
PMID: 26496309
Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis.
Crit Care 2015;19():415. Epub 2015 nov 27
PMID: 26612199
Chronic fatigue syndrome/myalgic encephalo-myelitis - pathophysiology, diagnosis and treatment.
Tidsskr Nor Laegeforen 2015 Dec;135(23-24):2172-2175. Epub 2015 des 15
PMID: 26674040
Harnessing Innate Immunity
- Disputert:
- november 2017
- Hovedveileder:
- Tom Eirik Mollnes
Teaming up to fight inflammation
- Disputert:
- juni 2016
- Hovedveileder:
- Tom Eirik Mollnes
- Tom Eirik Mollnes Prosjektleder
- John-Bjarne Hansen Prosjektdeltaker
- Pål Aukrust Prosjektdeltaker
- Terje Espevik Prosjektdeltaker
- Knut Tore Lappegård Prosjektdeltaker
- Ole Lars Brekke Prosjektdeltaker
- Erik Waage Nielsen Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport, Helse Nord