Influence of emerging contaminants on endocrine functions and T2DM risk
Annual report for "Influence of emerging contaminants on endocrine functions and T2DM risk"
We are investigating the relationship between POPs, emerging contaminants, obesity, weight change, dyslipidemia, endocrine functions and T2DM in the Tromsø study. This is a prospective nested case-control design, with four repeated blood samples from 150 individuals; three samples prior to T2DM diagnosis and one blood sample after T2DM diagnosis.
The Tromsø study are currently rearranging their biobank and evaluating remaining volumes of biological samples from all participants and study periods. The scientific board of the Tromsø study has therefore decided to temporarily stop the delivery of biological specimens to all projects until they have received an overview of the biobank. Accordingly, delivery of biological specimens for analyses of POPs and hormones in this project is delayed but our request for samples is pending, and we expect to receive samples during the summer or autumn 2017. While awaiting samples from the Tromsø study, the postdoctoral fellow and project leader are conducting a pilot study covering the original hypotheses but using a different biobank (the biobank of the Norwegian Women and Cancer study) with available biological specimen from two time points; one prior to T2DM diagnosis and one after. This pilot study will be finalized during spring 2017 and will result in 3 scientific articles. The results will be used to optimize the study design of the main project in order to answer the research questions in the best possible way. Additionally, during 2016 the postoctoral fellow completed two statistical courses (at UIT and UIO) to prepare for the statistical methods required for the main project as well as the pilot study. Further, the postdoctoral fellow has been working on a prediction model for POPs using a subpopulation of the NOWAC cohort. The aim is to build a statistical model that predicts POP concentrations in large populations based on demographics and information extracted from food frequency questionnaires. The model can replace the time consuming and expensive analyses of POPs in blood, and will be useful in investigating the risk of T2DM according to POP concentrations in large epidemiological studies. A publication will be completed during 2017, and the model will be further applied (by the postdoctoral fellow or a master/phd student) for investigating the association between POPs and T2DM risk in a larger sample of the NOWAC cohort (N=70 000). In addition to this, the postdoctoral fellow, the project manager and collaborators, have measured the emerging contaminants “PFASs” in 30 year-old male participants from the Tromsø Study at four different time points (our research group received these specimens before the temporary delivery stop). These results will increase our knowledge on temporal trends of PFASs in regards to birth year, BMI and age and will be very useful for the study of time-trends of PFAS in the main project. Results are expected to be published during 2017.