Persisterende immunaktivering som klinisk prognostisk faktor i behandling av HIV
- Prosjektnummer
- 2007056
- Ansvarlig person
- Dag Kvale
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Forskningsprosjekt
- Helsekategori
- Infection
- Forskningsaktivitet
- 7. Disease Management
Mitochondrial toxicity in HIV-infected patients both off and on antiretroviral treatment: a continuum or distinct underlying mechanisms?
J Antimicrob Chemother 2009 Nov;64(5):901-9. Epub 2009 sep 9
PMID: 19740910
Interleukin-10-secreting T cells define a suppressive subset within the HIV-1-specific T-cell population.
Eur J Immunol 2009 May;39(5):1280-7.
PMID: 19384871
PD-1 predicts CD4 loss rate in chronic HIV-1 infection better than HIV RNA and CD38 but not in cryopreserved samples.
Curr HIV Res 2008 Jan;6(1):49-58.
PMID: 18288975
Distinct mechanisms for mitochondrial DNA loss in T and B lymphocytes from HIV-infected patients exposed to nucleoside reverse-transcriptase inhibitors and those naive to antiretroviral treatment.
J Infect Dis 2008 Nov;198(10):1474-81.
PMID: 18851688
Insulin resistance is affected by increased levels of plasma lactate but not mitochondrial alterations in skeletal muscle in NRTI-exposed HIV-infected patients.
HIV Clin Trials 2007 Sep-Oct;8(5):345-53.
PMID: 17956836
CD4 loss rate in untreated chronic HIV type 1 infection may be better predict by PD-1 than HIV RNA and CD38.
Abstract # 336, 15th Conference on Retroviruses and Opportunistic Infections, 3-6 Feb 2008, Boston, USA.
Mitochondrial DNA loss is related to CD38 and PD-1 reflecting persistent immune activation in HIV-infected treatment-naïve patie
XVII International AIDS Conference, Mexico City, 3-8 August 2008.
IFN-g- and IL-10-producing HIV-specific T cells have suppressive properties.
Abstr. # 436, Keystone Symposium “Molecular and cellular determinants of HIV pathogenesis”, Whistler, BC, Canada, 25-30 March, 2007.
Differential mitochondrial DNA loss in T cell subsets of HIV-infected treatment-naive and NRTI-exposed patients.
11th European AIDS Conference / EACS, 24-27 October 2007, Madrid, Spain, Abstract 9.5/0.1.
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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