Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) Study
- Prosjektnummer
- 2008005
- Ansvarlig person
- Anne Bjørhovde Rossebø
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 7. Disease Management
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Association of Annual N-Terminal Pro-Brain Natriuretic Peptide Measurements With Clinical Events in Patients With Asymptomatic Nonsevere Aortic Stenosis: A Post Hoc Substudy of the SEAS Trial.
JAMA Cardiol 2022 Apr 01;7(4):435.
PMID: 35171199
Prognosis in asymptomatic patients with discordantly graded aortic valve stenosis based on pressure recovery adjusted valve area.
Open Heart 2022 Nov;9(2).
PMID: 36428084
Sudden cardiac death in asymptomatic patients with aortic stenosis.
Heart 2020 Nov;106(21):1646-1650. Epub 2020 jul 31
PMID: 32737125
Prognostic impact of impaired left ventricular midwall function during progression of aortic stenosis.
Echocardiography 2020 Nov 04. Epub 2020 nov 4
PMID: 33146452
Higher left ventricular mass-wall stress-heart rate product and outcome in aortic valve stenosis.
Heart 2019 Nov;105(21):1629-1633. Epub 2019 jun 1
PMID: 31154431
Antihypertensive Treatment With β-Blockade in Patients With Asymptomatic Aortic Stenosis and Association With Cardiovascular Events.
J Am Heart Assoc 2017 Nov 27;6(12). Epub 2017 nov 27
PMID: 29180457
Impact of stroke volume on cardiovascular risk during progression of aortic valve stenosis.
Heart 2017 09;103(18):1443-1448. Epub 2017 apr 28
PMID: 28455295
Relation of Left Ventricular Mass to Prognosis in Initially Asymptomatic Mild to Moderate Aortic Valve Stenosis.
Circ Cardiovasc Imaging 2015 Nov;8(11):e003644; discussion e003644.
PMID: 26489804 - Inngår i doktorgradsavhandlingen
Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis: the SEAS study.
Int J Cardiol 2015 Feb 1;180():122-8. Epub 2014 nov 26
PMID: 25438232
High sensitivity C reactive protein as a prognostic marker in patients with mild to moderate aortic valve stenosis during lipid-lowering treatment: an SEAS substudy.
Open Heart 2015;2(1):e000152. Epub 2015 feb 4
PMID: 25685360
Effect of Randomized Lipid Lowering With Simvastatin and Ezetimibe on Cataract Development (from the Simvastatin and Ezetimibe in Aortic Stenosis Study).
Am J Cardiol 2015 Dec 15;116(12):1840-4. Epub 2015 okt 3
PMID: 26602073
Indexing aortic valve area by body surface area increases the prevalence of severe aortic stenosis.
Heart 2014 Jan;100(1):28-33. Epub 2013 aug 22
PMID: 23969478
Stroke in patients with aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis study.
Stroke 2014 Jul;45(7):1939-46. Epub 2014 jun 5
PMID: 24903982
Renin-angiotensin system inhibition is not associated with increased sudden cardiac death, cardiovascular mortality or all-cause mortality in patients with aortic stenosis.
Int J Cardiol 2014 Aug 20;175(3):492-8. Epub 2014 jun 28
PMID: 25012498
Usefulness of the electrocardiogram in predicting cardiovascular mortality in asymptomatic adults with aortic stenosis (from the Simvastatin and Ezetimibe in Aortic Stenosis Study).
Am J Cardiol 2014 Sep 1;114(5):751-6. Epub 2014 jun 21
PMID: 25048345
Velocity ratio predicts outcomes in patients with low gradient severe aortic stenosis and preserved EF.
Heart 2014 Dec;100(24):1946-53. Epub 2014 sep 12
PMID: 25217488
Left atrial size and function as predictors of new-onset of atrial fibrillation in patients with asymptomatic aortic stenosis: the simvastatin and ezetimibe in aortic stenosis study.
Int J Cardiol 2013 Oct 3;168(3):2322-7. Epub 2013 feb 14
PMID: 23416018
Prognostic importance of atrial fibrillation in asymptomatic aortic stenosis: the Simvastatin and Ezetimibe in Aortic Stenosis study.
Int J Cardiol 2013 Jun 5;166(1):72-6. Epub 2011 okt 11
PMID: 21996417
A risk score for predicting mortality in patients with asymptomatic mild to moderate aortic stenosis.
Heart 2011 Dec. Epub 2011 des 8
PMID: 22155702
Differences in cardiovascular risk profile between electrocardiographic hypertrophy versus strain in asymptomatic patients with aortic stenosis (from SEAS data).
Am J Cardiol 2011 Aug;108(4):541-7. Epub 2011 mai 31
PMID: 21624542
Outcome of patients with low-gradient "severe" aortic stenosis and preserved ejection fraction.
Circulation 2011 Mar;123(8):887-95. Epub 2011 feb 14
PMID: 21321152
Impact of baseline severity of aortic valve stenosis on effect of intensive lipid lowering therapy (from the SEAS study).
Am J Cardiol 2010 Dec;106(11):1634-9. Epub 2010 okt 14
PMID: 21094366 - Inngår i doktorgradsavhandlingen
Observed and predicted reduction of ischemic cardiovascular events in the Simvastatin and Ezetimibe in Aortic Stenosis trial.
Am J Cardiol 2010 Jun;105(12):1802-8. Epub 2010 mar 16
PMID: 20538134
Effect of obesity on left ventricular mass and systolic function in patients with asymptomatic aortic stenosis (a Simvastatin Ezetimibe in Aortic Stenosis [SEAS] substudy).
Am J Cardiol 2010 May;105(10):1456-60. Epub 2010 mar 30
PMID: 20451694
Impact of hypertension on left ventricular structure in patients with asymptomatic aortic valve stenosis (a SEAS substudy).
J Hypertens 2010 Feb;28(2):377-83.
PMID: 19844185
Aortic valve stenosis.
Lancet 2009 Jun;373(9680):2022-3; author reply 2023.
PMID: 19524771
Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.
N Engl J Med 2008 Sep;359(13):1343-56. Epub 2008 sep 2
PMID: 18765433
Left ventricular systolic and diastolic function in asymptomatic patients with moderate aortic stenosis.
Am J Cardiol 2008 Oct;102(7):897-901. Epub 2008 aug 26
PMID: 18805118
Factors influencing left ventricular structure and stress-corrected systolic function in men and women with asymptomatic aortic valve stenosis (a SEAS Substudy).
Am J Cardiol 2008 Feb;101(4):510-5. Epub 2007 des 20
PMID: 18312768
Impact of baseline severity og aortic valve stenosis on effect of intensive lipid lowering therapy. Insights from the SEAS study
Submitted, under revision for re-submittance
Lipid lowering by simvastatin and ezetimibe predicts the reduction of ischemic cardiovascular events in patients with asymp.....
Accepted Am J Cardiol dec2009, in press (expected June2010)
Outcome of Asymptomatic Patients with Low Gradient Severe Aortic Stenosis and Preserved Ejection Fraction – Results from the ...
Submitted NEJM Jan 2010
A longitudinal perspective of LV systolic and diastolic function in patients with moderate aortic stenosis. A tissue Doppler ...
Submitted, under revision Cardiology
Impact of Obesity on Left Ventricular Mass and Systolic Function in Patients with Asymptomatic Aortic Stenosis (a SEAS Substudy)
Accepted Am J Cardiol Dec 2009, in press
Impact of hypertension on left ventricular structure in patients with asymptomatic aortic valve stenosis (a SEAS substudy).
online first Oct19, 2009. doi:10.1097/HJH.0b013e328332fa44
Lipid Lowering Treatment in Mild to Moderate Aortic Stenosis
- Disputert:
- september 2016
- Hovedveileder:
- Terje Rolf Pedersen
Lege, PhD
- Disputert:
- mai 2009
- Hovedveileder:
- Eva Gerdts
Lege, PhD
- Disputert:
- november 2009
- Hovedveileder:
- Kenneth Egstrup
- Anne Bjørhovde Rossebø Postdoktorstipendiat (finansiert av denne bevilgning)
- Dan Atar Medveileder
- Terje Rolf Pedersen Hovedveileder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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