Preklinisk stråleterapi
- Prosjektnummer
- 2008009
- Ansvarlig person
- Einar K. Rofstad
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Magnetic resonance imaging identifies early effects of sunitinib treatment in human melanoma xenografts.
J Exp Clin Cancer Res 2013;32(1):93. Epub 2013 nov 19
PMID: 24245934
DCE-MRI of the hypoxic fraction, radioresponsiveness, and metastatic propensity of cervical carcinoma xenografts.
Radiother Oncol 2014 Feb;110(2):335-41. Epub 2013 nov 11
PMID: 24231244
The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI.
Transl Oncol 2013;6(5):607-17. Epub 2013 okt 1
PMID: 24151541
The efficacy of CHK1 inhibitors is not altered by hypoxia, but is enhanced after reoxygenation.
Mol Cancer Ther 2013 May;12(5):705-16. Epub 2013 mai 1
PMID: 23635654
Tumors exposed to acute cyclic hypoxia show increased vessel density and delayed blood supply.
Microvasc Res 2013 Jan;85():10-5. Epub 2012 nov 12
PMID: 23154277
Tumor-line specific causes of intertumor heterogeneity in blood supply in human melanoma xenografts.
Microvasc Res 2013 Jan;85():16-23. Epub 2012 nov 10
PMID: 23149341 - Inngår i doktorgradsavhandlingen
Assessment of the interstitial fluid pressure of tumors by dynamic contrast-enhanced magnetic resonance imaging with contrast agents of different molecular weights.
Acta Oncol 2013 Apr;52(3):627-35. Epub 2012 nov 6
PMID: 23126523
Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of tumors: a preclinical study of cervical carcinoma and melanoma xenografts.
Acta Oncol 2013 Apr;52(3):604-11. Epub 2012 jun 7
PMID: 22671573
Preclinical evaluation of Gd-DTPA and gadomelitol as contrast agents in DCE-MRI of cervical carcinoma interstitial fluid pressure.
BMC Cancer 2012;12():544. Epub 2012 nov 22
PMID: 23173554
Interstitial fluid pressure and associated lymph node metastasis revealed in tumors by dynamic contrast-enhanced MRI.
Cancer Res 2012 Oct;72(19):4899-908.
PMID: 23027087
Vascular abnormalities associated with acute hypoxia in human melanoma xenografts.
Radiother Oncol 2012 Oct;105(1):72-8. Epub 2012 sep 27
PMID: 23022175 - Inngår i doktorgradsavhandlingen
Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts.
BMC Cancer 2012;12():388. Epub 2012 sep 4
PMID: 22947392 - Inngår i doktorgradsavhandlingen
High interstitial fluid pressure is associated with tumor-line specific vascular abnormalities in human melanoma xenografts.
PLoS One 2012;7(6):e40006. Epub 2012 jun 29
PMID: 22768196 - Inngår i doktorgradsavhandlingen
Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of melanoma xenografts.
Int J Radiat Oncol Biol Phys 2012 May;83(1):e121-7. Epub 2012 feb 28
PMID: 22381901
A novel application of dorsal window chambers: repetitive imaging of tumor-associated lymphatics.
Microvasc Res 2012 May;83(3):360-5. Epub 2012 feb 9
PMID: 22342351 - Inngår i doktorgradsavhandlingen
Microenvironment-associated lymph node metastasis of human cervical carcinoma xenografts.
Acta Oncol 2012 Apr;51(4):465-72. Epub 2012 jan 31
PMID: 22292610
pO2 fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts.
Int J Radiat Oncol Biol Phys 2012 Jul;83(4):1317-23. Epub 2012 jan 21
PMID: 22270159
Assessment of hypoxia and radiation response in intramuscular experimental tumors by dynamic contrast-enhanced magnetic resonance imaging.
Radiother Oncol 2012 Mar;102(3):429-35. Epub 2011 des 24
PMID: 22197352
Dynamic contrast-enhanced-MRI of tumor hypoxia.
Magn Reson Med 2012 Feb;67(2):519-30. Epub 2011 jun 9
PMID: 21661044
Assessment of tumor hypoxia and interstitial fluid pressure by gadomelitol-based dynamic contrast-enhanced magnetic resonance imaging.
Radiother Oncol 2011 Oct;101(1):217-22. Epub 2011 aug 15
PMID: 21840612
Assessment of tumor radioresponsiveness and metastatic potential by dynamic contrast-enhanced magnetic resonance imaging.
Int J Radiat Oncol Biol Phys 2011 Sep;81(1):255-61.
PMID: 21816291
Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging.
Radiother Oncol 2011 Mar;98(3):360-4. Epub 2011 jan 22
PMID: 21262548
Interstitial fluid pressure and vascularity of intradermal and intramuscular human tumor xenografts.
Int J Radiat Oncol Biol Phys 2011 May;80(1):258-64. Epub 2011 jan 20
PMID: 21255944
Magnetic resonance imaging of tumor necrosis.
Acta Oncol 2011 Apr;50(3):427-34. Epub 2010 okt 18
PMID: 20950229
Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia.
Neoplasia 2010 Nov;12(11):889-98.
PMID: 21076614
Quantitative assessment of hypoxia in melanoma xenografts by dynamic contrast-enhanced magnetic resonance imaging: intradermal versus intramuscular tumors.
Radiother Oncol 2010 Nov;97(2):233-8. Epub 2010 okt 9
PMID: 20934767
Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: pharmacokinetic analysis and correlation to tumor histomorphology.
Radiother Oncol 2010 Nov;97(2):217-24. Epub 2010 jul 23
PMID: 20656365
Development of hypoxia in a preclinical model of tumor micrometastases.
Int J Radiat Oncol Biol Phys 2010 Mar;76(3):879-88.
PMID: 20159362 - Inngår i doktorgradsavhandlingen
Associations between radiocurability and interstitial fluid pressure in human tumor xenografts without hypoxic tissue.
Clin Cancer Res 2010 Feb;16(3):936-45. Epub 2010 jan 26
PMID: 20103667
Tumors exposed to acute cyclic hypoxic stress show enhanced angiogenesis, perfusion and metastatic dissemination.
Int J Cancer 2010 Oct;127(7):1535-46.
PMID: 20091868
Dynamic contrast-enhanced magnetic resonance imaging of tumor interstitial fluid pressure.
Radiother Oncol 2009 Apr;91(1):107-13. Epub 2008 okt 28
PMID: 18973959
Photochemical internalization of bleomycin is superior to photodynamic therapy due to the therapeutic effect in the tumor periphery.
Photochem Photobiol 2009 May-Jun;85(3):740-9. Epub 2008 des 8
PMID: 19076314
Human cervical carcinoma xenograft models for studies of the physiological microenvironment of tumors.
J Cancer Res Clin Oncol 2009 Sep;135(9):1177-84. Epub 2009 feb 13
PMID: 19214568
Assessment of hypoxia in human cervical carcinoma xenografts by dynamic contrast-enhanced magnetic resonance imaging.
Int J Radiat Oncol Biol Phys 2009 Mar;73(3):838-45.
PMID: 19215820
Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries.
Neoplasia 2009 Mar;11(3):277-85.
PMID: 19242609
Dynamic contrast-enhanced magnetic resonance imaging of tumors: preclinical validation of parametric images.
Radiat Res 2009 Sep;172(3):339-47.
PMID: 19708783
Radiocurability is associated with interstitial fluid pressure in human tumor xenografts.
Neoplasia 2009 Nov;11(11):1243-51.
PMID: 19881960
A novel method for mapping the heterogeneity in blood supply to normal and malignant tissues in the mouse dorsal window chamber.
Microvasc Res 2008 Mar;75(2):179-87. Epub 2007 aug 6
PMID: 17688890
Assessment of extravascular extracellular space fraction in human melanoma xenografts by DCE-MRI and kinetic modeling.
Magn Reson Imaging 2008 Feb;26(2):160-70. Epub 2007 aug 9
PMID: 17692490
Tumor vascularity assessed by magnetic resonance imaging and intravital microscopy imaging.
Neoplasia 2008 Apr;10(4):354-62.
PMID: 18392132
Assessment of fraction of hypoxic cells in human tumor xenografts with necrotic regions by dynamic contrast-enhanced MRI.
Radiat Res 2008 Jun;169(6):689-99.
PMID: 18494552
Temporal heterogeneity in blood supply in human tumor xenografts.
Neoplasia 2008 Jul;10(7):727-35.
PMID: 18592011
Detection of different hypoxic cell subpopulations in human melanoma xenografts by pimonidazole immunohistochemistry.
Radiat Res 2008 Nov;170(5):638-50.
PMID: 18959463
Limitations of dynamic contrast-enhanced MRI in monitoring radiation-induced changes in the fraction of radiobiologically hypoxic cells in human melanoma xenografts.
J Magn Reson Imaging 2008 Nov;28(5):1209-18.
PMID: 18972344
Interstitial fluid pressure of tumors as a function of parameters derived by dynamic contrast-enhanced magnetic resonance imagin
Radiotherapy and Oncology, 94, 385-386, 2010.
Intravital microscopy of the physiological microenvironment of human melanoma xenografts
- Disputert:
- februar 2013
- Hovedveileder:
- Einar K Rofstad
Preclinical studies of the physiological microenvironment of cervical carcinoma
- Disputert:
- mai 2012
- Hovedveileder:
- Einar K. Rofstad
Tumor blood perfusion assessed by DCE-MRI and intravital microscopy.
- Disputert:
- desember 2009
- Hovedveileder:
- Einar K. Rofstad
The Dynamics of Tumor Hypoxia: Implications for Cancer Treatment
- Disputert:
- februar 2008
- Hovedveileder:
- Einar K. Rofstad
Dynamic Gd-DTPA-Enhanced MRI of the Physiological Microenvironment of Human Melanoma Xenografts
- Disputert:
- juni 2008
- Hovedveileder:
- Einar K. Rofstad
- Kanthi Galappathi Prosjektdeltaker
- Berit Synnøve Mathiesen Prosjektdeltaker
- Trude Golimo Simonsen Doktorgradsstipendiat
- Kirsti marie Øvrebø Prosjektdeltaker
- Tord Hompland Prosjektdeltaker
- Christine Ellingsen Prosjektdeltaker
- Jon-Vidar Gaustad Prosjektdeltaker
- Einar K Rofstad Prosjektleder
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