Transport into cells:lessons learned from plant and bacterial toxins
- Prosjektnummer
- 2008055
- Ansvarlig person
- Kirsten Sandvig
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
The ether lipid precursor hexadecylglycerol causes major changes in the lipidome of HEp-2 cells.
PLoS One 2013;8(9):e75904. Epub 2013 sep 30
PMID: 24098742
Cell density-induced changes in lipid composition and intracellular trafficking.
Cell Mol Life Sci 2014 Mar;71(6):1097-116. Epub 2013 aug 7
PMID: 23921715
Retrograde transport of protein toxins through the Golgi apparatus.
Histochem Cell Biol 2013 Sep;140(3):317-26. Epub 2013 jun 14
PMID: 23765164
Genetic blockage of endocytic pathways reveals differences in the intracellular processing of non-viral gene delivery systems.
J Control Release 2012 Nov;163(3):385-95. Epub 2012 okt 4
PMID: 23041276
Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells.
Biochim Biophys Acta 2012 Nov-Dec;1819(11-12):1154-63. Epub 2012 sep 8
PMID: 22982408
Shiga toxins.
Toxicon 2012 Nov;60(6):1085-107. Epub 2012 aug 16
PMID: 22960449
Flotillins as regulators of ErbB2 levels in breast cancer.
Oncogene 2013 Jul 18;32(29):3443-51. Epub 2012 aug 6
PMID: 22869152
Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism.
J Nanobiotechnology 2012;10():33. Epub 2012 jul 31
PMID: 22849338
Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin.
PLoS One 2012;7(7):e40429. Epub 2012 jul 6
PMID: 22792315
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.
J Biol Chem 2012 Jun;287(26):21992-2003. Epub 2012 apr 26
PMID: 22539349
Proteomic analysis of microvesicles released by the human prostate cancer cell line PC-3.
Mol Cell Proteomics 2012 Jul;11(7):M111.012914. Epub 2012 mar 28
PMID: 22457534
Inhibitors of intravesicular acidification protect against Shiga toxin in a pH-independent manner.
Traffic 2012 Mar;13(3):443-54. Epub 2011 des 21
PMID: 22132807
Role of phospholipase a(2) in retrograde transport of ricin.
Toxins (Basel) 2011 Sep;3(9):1203-19. Epub 2011 sep 23
PMID: 22069763
Comment on "short ligands affect modes of QD uptake and elimination in human cells".
ACS Nano 2011 Oct;5(10):7690; author reply 7691-2.
PMID: 22023400
Protein C mutation (A267T) results in ER retention and unfolded protein response activation.
PLoS One 2011;6(8):e24009. Epub 2011 aug 25
PMID: 21901152
Clathrin- and dynamin-independent endocytosis of FGFR3--implications for signalling.
PLoS One 2011;6(7):e21708. Epub 2011 jul 14
PMID: 21779335
Derlin-dependent retrograde transport from endosomes to the Golgi apparatus.
Traffic 2011 Oct;12(10):1417-31. Epub 2011 jul 27
PMID: 21722281
Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity.
Biochem Biophys Res Commun 2011 May;408(3):405-10. Epub 2011 apr 12
PMID: 21513701
Clathrin-independent endocytosis: mechanisms and function.
Curr Opin Cell Biol 2011 Aug;23(4):413-20. Epub 2011 apr 3
PMID: 21466956
A single point mutation in ricin A-chain increases toxin degradation and inhibits EDEM1-dependent ER retrotranslocation.
Biochem J 2011 Jun;436(2):371-85.
PMID: 21388347
Shiga toxin and its use in targeted cancer therapy and imaging.
Microb Biotechnol 2011 Jan;4(1):32-46.
PMID: 21255370
Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells.
FEMS Immunol Med Microbiol 2011 Feb;61(1):63-75. Epub 2010 nov 3
PMID: 21054580
Functional characterization of the protein C A267T mutation: evidence for impaired secretion due to defective intracellular transport.
BMC Cell Biol 2010;11():67. Epub 2010 sep 6
PMID: 20815936
Clostridium botulinum C2 toxin is internalized by clathrin- and Rho-dependent mechanisms.
Cell Microbiol 2010 Dec;12(12):1809-20.
PMID: 20690924
Shiga toxin increases formation of clathrin-coated pits through Syk kinase.
PLoS One 2010;5(7):e10944. Epub 2010 jul 27
PMID: 20668539
New metal-based nanoparticles for intravenous use: requirements for clinical success with focus on medical imaging.
Nanomedicine 2010 Dec;6(6):730-7. Epub 2010 mai 26
PMID: 20570639
Protein toxins from plants and bacteria: probes for intracellular transport and tools in medicine.
FEBS Lett 2010 Jun;584(12):2626-34. Epub 2010 apr 10
PMID: 20385131
Interplay between toxin transport and flotillin localization.
PLoS One 2010;5(1):e8844. Epub 2010 jan 22
PMID: 20107503
Endocytosis and retrograde transport of Shiga toxin.
Toxicon 2010 Dec;56(7):1181-5. Epub 2009 nov 29
PMID: 19951719
Ligand-specific induction of endocytosis in taste receptor cells.
J Exp Biol 2009 Jan;212(Pt 1):42-9.
PMID: 19088209
beta-arrestins attenuate p38 mediated endosome to Golgi transport.
Cell Microbiol 2009 Jan. Epub 2009 jan 21
PMID: 19159388
Characterization of clathrin and Syk interaction upon Shiga toxin binding.
Cell Signal 2009 Jul;21(7):1161-8. Epub 2009 mar 13
PMID: 19289168
Glycosphingolipid requirements for endosome-to-Golgi transport of Shiga toxin.
Traffic 2009 Jul;10(7):868-82. Epub 2009 mai 6
PMID: 19453975
SNX4 in complex with clathrin and dynein: implications for endosome movement.
PLoS One 2009;4(6):e5935. Epub 2009 jun 16
PMID: 19529763
Sorting nexin 8 regulates endosome-to-Golgi transport.
Biochem Biophys Res Commun 2009 Dec;390(1):109-14. Epub 2009 sep 24
PMID: 19782049
Cellular trafficking of quantum dot-ligand bioconjugates and their induction of changes in normal routing of unconjugated ligands.
Nano Lett 2008 Jul;8(7):1858-65. Epub 2008 jun 21
PMID: 18570482
Cell biology: Viruses in camouflage.
Nature 2008 May;453(7194):466-7.
PMID: 18497813
Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity.
Histochem Cell Biol 2008 Mar;129(3):267-76. Epub 2008 jan 12
PMID: 18193449
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking.
Mol Biol Cell 2008 Jan;19(1):95-104. Epub 2007 okt 24
PMID: 17959827
The intracellular journey of Shiga toxins
The Open Toxinology Journal 2010, 3, 3-12
Shiga toxin and its use in targeted cancer therapy and imaging
Microbial Biotechnology, 2010 In Press.
Endocytosis and intracellular trafficking of quantum dot-ligand bioconjugates.
In: Organelle-specific Pharmaceutical Nanotechnology, pp. 55-72, ISBN 978-0-470-63165-2
Investigations of membrane dynamics in cancer cells by following Shiga toxin
- Disputert:
- september 2013
- Hovedveileder:
- Kirsten Sandvig
Endocytosis and retrograde transport of Shiga toxin and ricin
- Disputert:
- juni 2009
- Hovedveileder:
- Kirsten Sandvig
Mechanisms in intracellular transport of toxins
- Disputert:
- januar 2009
- Hovedveileder:
- Kirsten Sandvig
- Tore Skotland Forsker (annen finansiering)
- Roger Simm Prosjektdeltaker
- Simona Kavaliauskiene Doktorgradsstipendiat
- Kirsten Sandvig Forskningsgruppeleder
- Jonas Bergan Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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