Translational research with goal to identify T-cells that induce and support B cell malignancies in mice and humans
- Prosjektnummer
- 2008067
- Ansvarlig person
- Ludvig A Munthe
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Blood, Inflammatory and Immune System
- Forskningsaktivitet
- 2. Aetiology, 5. Treatment Developement
Systemic Lupus Erythematosus: Molecular Mimicry between Anti-dsDNA CDR3 Idiotype, Microbial and Self Peptides-As Antigens for Th Cells.
Front Immunol 2015;6():382. Epub 2015 jul 28
PMID: 26284067
Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model.
Gene Ther 2015 May;22(5):391-403. Epub 2015 feb 5
PMID: 25652098
Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-? by a T-bet-dependent mechanism.
J Immunol 2015 Jan 15;194(2):827-35. Epub 2014 des 10
PMID: 25505279
Idiotype-specific Th cells support oligoclonal expansion of anti-dsDNA B cells in mice with lupus.
J Immunol 2014 Sep 15;193(6):2691-8. Epub 2014 aug 15
PMID: 25127856
Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells.
J Immunol 2014 May 1;192(9):4174-83. Epub 2014 apr 4
PMID: 24706724
Targeted DNA vaccines eliciting crossreactive anti-idiotypic antibody responses against human B cell malignancies in mice.
J Transl Med 2014;12():207. Epub 2014 jul 25
PMID: 25059102
Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells.
Cell Rep 2013 Aug 15;4(3):566-77. Epub 2013 aug 8
PMID: 23933259
The cellular mechanism by which complementary Id+ and anti-Id antibodies communicate: T cells integrated into idiotypic regulation.
Immunol Cell Biol 2010 Jul;88(5):515-22. Epub 2010 jan 12
PMID: 20066000
The idiotype connection: linking infection and multiple sclerosis.
Trends Immunol 2010 Feb;31(2):56-62. Epub 2009 des 2
PMID: 19962346
Tracking early autoimmune disease by bioluminescent imaging of NF-kappaB activation reveals pathology in multiple organ systems.
Am J Pathol 2009 Apr;174(4):1358-67. Epub 2009 mar 12
PMID: 19286564
Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA).
Cell Signal 2009 Feb;21(2):274-81. Epub 2008 okt 29
PMID: 19000925
What makes the B cell lymphomas grow?
Global Academic Programs - (GAP). MD Anderson Cancer Center. Oslo, May 2012. Lecture.
Leukemic B Cells Can Collaborate with Antigen-specific T Helper Cells and Receive Help to Proliferate
12th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2012), in Vancouver, Canada, June 2012, poster presentation
Leukemic B Cells Can Collaborate with Antigen-specific T Helper Cells and Receive Help to Proliferate
12th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2012), in Vancouver, Canada, June 2012, poster presentation
T cells in CLL
UK-CLL forum, London March 2012. Invited lecture
Leukemic B cells receive help from autologous T helper cells through a mechanism involving recognition of endogenous antigen
World Immune Regulation Meeting V, Davos, Switzerland, March 2012, poster presentation
Shrödingers katt
16. april. NRK1, 19.31-19.37, (ca 7 minutter)
NRK1 Shrödingers katt. Episode publisert på NRK nettsider.
http://www1.nrk.no/nett-tv/indeks/167690
Intervju, biomedisinsk forskning, mus.
2.15 minutter. http://www1.nrk.no/nett-tv/klipp/485219
The idiotype connection: linking infection and multiple sclerosis
Trends Immunol, Epub 2009 des 2. PMID: 19962346
T cells specific for endogenous B cell antigen: Consequences for autoimmunity and mature B cell malignancies
- Disputert:
- desember 2011
- Hovedveileder:
- Bjarne Bogen
Dr Med
- Disputert:
- oktober 2009
- Hovedveileder:
- Bjarne Bogen
- Ane Funderud Prosjektdeltaker
- Kristin Aas-Hanssen Doktorgradsstipendiat
- Ludvig Andre Munthe Prosjektleder
- Kristin Ass-Hansen Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport