Pathogenic role of inflammatory mechanisms in chronic heart failure
- Prosjektnummer
- 2008076
- Ansvarlig person
- Pål Aukrust
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 2. Aetiology
Disturbed carnitine regulation in chronic heart failure--increased plasma levels of palmitoyl-carnitine are associated with poor prognosis.
Int J Cardiol 2013 Sep 1;167(5):1892-9. Epub 2012 mai 22
PMID: 22622056
Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure: analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Circ Heart Fail 2013 Jan;6(1):91-8. Epub 2012 des 10
PMID: 23230311
Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction.
Int J Cardiol 2013 Sep 20;168(1):212-8. Epub 2012 okt 6
PMID: 23046599
Prognostic value of CXCL16 in patients with left ventricular systolic dysfunction and heart failure.
Int J Cardiol 2013 Oct 9;168(4):4427-9. Epub 2013 mai 26
PMID: 23714594
Association of ficolin-3 with severity and outcome of chronic heart failure.
PLoS One 2013;8(4):e60976. Epub 2013 apr 15
PMID: 23596511
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Cardiovasc Res 2013 Jul 1;99(1):164-74. Epub 2013 apr 10
PMID: 23580606
CCL21 is associated with fatal outcomes in chronic heart failure: data from CORONA and GISSI-HF trials.
Eur J Heart Fail 2013 Jul;15(7):747-55. Epub 2013 mar 13
PMID: 23487539
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse.
J Appl Physiol (1985) 2013 Apr;114(8):988-97. Epub 2013 feb 14
PMID: 23412898
Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH.
Circ Heart Fail 2013 Mar;6(2):219-26. Epub 2013 feb 8
PMID: 23395934
Cardiac resynchronization therapy improves minute ventilation/carbon dioxide production slope and skeletal muscle capillary density without reversal of skeletal muscle pathology or inflammation.
Europace 2013 Jun;15(6):857-64. Epub 2013 jan 15
PMID: 23322010
Tetradecylthioacetic acid increases fat metabolism and improves cardiac function in experimental heart failure.
Lipids 2013 Feb;48(2):139-54. Epub 2012 des 25
PMID: 23266898
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.
J Intern Med 2014 Jun;275(6):621-30. Epub 2014 jan 9
PMID: 24330105
The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*.
J Intern Med 2012 May;271(5):436-43. Epub 2012 jan 16
PMID: 22211640
Increased interleukin-1ß levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
J Intern Med 2012 Sep;272(3):267-76. Epub 2012 feb 26
PMID: 22243053
Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology.
Eur J Heart Fail 2012 Mar;14(3):268-77. Epub 2012 feb 2
PMID: 22302661
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle.
J Appl Physiol 2012 Apr;112(8):1372-82. Epub 2012 feb 16
PMID: 22345433
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure.
PLoS One 2012;7(3):e33038. Epub 2012 mar 12
PMID: 22427939
TNF revisited: osteoprotegerin and TNF-related molecules in heart failure.
Curr Heart Fail Rep 2012 Jun;9(2):92-100.
PMID: 22453763
Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Eur Heart J 2012 Sep;33(18):2290-6. Epub 2012 apr 17
PMID: 22513778
Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure.
PLoS One 2012;7(5):e36815. Epub 2012 mai 15
PMID: 22615818
Inflammatory cytokines in heart failure: mediators and markers.
Cardiology 2012;122(1):23-35. Epub 2012 jun 12
PMID: 22699305
Pentraxin-3 in chronic heart failure: the CORONA and GISSI-HF trials.
Eur J Heart Fail 2012 Sep;14(9):992-9. Epub 2012 jun 27
PMID: 22740508
Heart failure biomarkers: focus on interleukin-1 receptor-like 1-based blood tests.
Drugs Today (Barc) 2012 Jul;48(7):479-91.
PMID: 22844659
The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Am Heart J 2012 Dec;164(6):878-83. Epub 2012 okt 29
PMID: 23194488
Secreted wnt modulators in symptomatic aortic stenosis.
J Am Heart Assoc 2012 Dec;1(6):e002261. Epub 2012 des 19
PMID: 23316316
Osteoprotegerin predicts progression of chronic heart failure: results from CORONA.
Circ Heart Fail 2011 Mar;4(2):145-52. Epub 2011 jan 7
PMID: 21216833
Elevated serum osteoprotegerin levels measured early after acute ST-elevation myocardial infarction predict final infarct size.
Heart 2011 Mar;97(6):460-5. Epub 2011 jan 26
PMID: 21270073
Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure.
Clin Sci (Lond) 2011 Aug;121(3):119-27.
PMID: 21294711
No inflammatory response related to pulmonary hemodynamics in children with systemic to pulmonary shunts.
Congenit Heart Dis 2011 Jul-Aug;6(4):338-46. Epub 2011 mar 31
PMID: 21450032
Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation.
Diabetes 2011 May;60(5):1544-51. Epub 2011 apr 4
PMID: 21464440
Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality.
J Intern Med 2011 Sep;270(3):263-72. Epub 2011 mai 3
PMID: 21466599
Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation.
Am J Physiol Lung Cell Mol Physiol 2011 Jul;301(1):L50-9. Epub 2011 apr 15
PMID: 21498626
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.
PLoS One 2011;6(4):e18668. Epub 2011 apr 18
PMID: 21533157
Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis.
J Intern Med 2011 Nov;270(5):452-60. Epub 2011 mai 30
PMID: 21623962
Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial.
Transplantation 2011 Jul;92(2):235-43.
PMID: 21677600
Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy.
Am Heart J 2011 Jun;161(6):1031-7. Epub 2011 mai 11
PMID: 21641347
Galectin-3 in heart failure: high levels are associated with all-cause mortality.
Int J Cardiol 2011 Aug;150(3):361-4. Epub 2011 jun 8
PMID: 21641051
Perfusion temperature, thyroid hormones and inflammation during pediatric cardiac surgery.
Interact Cardiovasc Thorac Surg 2010 Jan;10(1):76-80. Epub 2009 okt 12
PMID: 19822605
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure.
Basic Res Cardiol 2010 Jan;105(1):89-98.
PMID: 19823891
Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors.
BMC Cancer 2010;10():6. Epub 2010 jan 6
PMID: 20053285
Systemic markers of inflammation are associated with cardiac allograft vasculopathy and an increased intimal inflammatory component.
Am J Transplant 2010 Jun;10(6):1428-36. Epub 2010 mai 10
PMID: 20486911
Activin A in carcinoid heart disease: a possible role in diagnosis and pathogenesis.
Neuroendocrinology 2010;92(3):168-77. Epub 2010 aug 18
PMID: 20720391
Activation of Notch signaling in cardiomyocytes during post-infarction remodeling.
Scand Cardiovasc J 2010 Dec;44(6):359-66. Epub 2010 aug 30
PMID: 20799913
Undercarboxylated matrix Gla protein is associated with indices of heart failure and mortality in symptomatic aortic stenosis.
J Intern Med 2010 Nov;268(5):483-92.
PMID: 20804515
Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.
Circ Res 2009 Jan;104(1):60-8. Epub 2008 nov 20
PMID: 19023130
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
Eur J Heart Fail 2009 Feb;11(2):119-29.
PMID: 19168509
Elevated levels of activin A in clinical and experimental pulmonary hypertension.
J Appl Physiol 2009 Apr;106(4):1356-64. Epub 2009 feb 5
PMID: 19196915
C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction.
Eur Heart J 2009 May;30(10):1180-6. Epub 2009 mar 19
PMID: 19299430
Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993-2003.
Arterioscler Thromb Vasc Biol 2009 Jun;29(6):975-80. Epub 2009 mar 26
PMID: 19325145
Up-regulation of myocardial DNA base excision repair activities in experimental heart failure.
Mutat Res 2009 Jun;666(1-2):32-8. Epub 2009 mar 31
PMID: 19481677
Increased systemic and myocardial expression of neutrophil gelatinase-associated lipocalin in clinical and experimental heart failure.
Eur Heart J 2009 May;30(10):1229-36. Epub 2009 mar 26
PMID: 19329498
Patients with pulmonary hypertension related to congenital systemic-to-pulmonary shunts are characterized by inflammation involving endothelial cell activation and platelet-mediated inflammation.
Congenit Heart Dis 2009 May;4(3):153-9.
PMID: 19489942
Dickkopf-1 enhances inflammatory interaction between platelets and endothelial cells and shows increased expression in atherosclerosis.
Arterioscler Thromb Vasc Biol 2009 Aug;29(8):1228-34. Epub 2009 jun 4
PMID: 19498175
Soluble CXCL16 predicts long-term mortality in acute coronary syndromes.
Circulation 2009 Jun;119(25):3181-8. Epub 2009 jun 15
PMID: 19528340
The prognostic importance of modifiable risk factors after heart transplantation.
Am Heart J 2009 Sep;158(3):431-6. Epub 2009 jul 15
PMID: 19699867
Testosterone: a novel therapeutic approach in chronic heart failure?
J Am Coll Cardiol 2009 Sep;54(10):928-9.
PMID: 19712803
Elevated serum uric acid levels following heart transplantation predict all-cause and cardiac mortality.
Eur J Heart Fail 2009 Oct;11(10):1005-13. Epub 2009 sep 8
PMID: 19737803
The tumour necrosis factor superfamily ligand APRIL (TNFSF13) is released upon platelet activation and expressed in atherosclerosis.
Thromb Haemost 2009 Oct;102(4):704-10.
PMID: 19806256
The chemokine network in relation to infarct size and left ventricular remodeling following acute myocardial infarction.
Am J Cardiol 2009 Nov;104(9):1179-83. Epub 2009 sep 16
PMID: 19840558
Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling.
Circ Heart Fail 2009 Nov;2(6):624-32. Epub 2009 sep 22
PMID: 19919988
Cytokine expression profiling of the myocardium reveals a role for CX3CL1 (fractalkine) in heart failure.
J Mol Cell Cardiol 2008 Aug;45(2):261-9. Epub 2008 mai 28
PMID: 18585734
Increased expression of LIGHT/TNFSF14 and its receptors in experimental and clinical heart failure.
Eur J Heart Fail 2008 Apr;10(4):352-9. Epub 2008 mar 18
PMID: 18353719
Greater symptom duration predicts response to immunomodulatory therapy in dilated cardiomyopathy.
Int J Cardiol 2008 Aug;128(1):38-41. Epub 2007 aug 16
PMID: 17707091
Chemokines and cardiovascular risk.
Arterioscler Thromb Vasc Biol 2008 Nov;28(11):1909-19. Epub 2008 jul 31
PMID: 18669888
High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins.
Cardiovasc Res 2008 Jul;79(1):195-203. Epub 2008 mar 13
PMID: 18339644
Exercise training decreases plasma levels of soluble CD40 ligand and P-selectin in patients with chronic heart failure.
Eur J Cardiovasc Prev Rehabil 2008 Feb;15(1):43-8.
PMID: 18277184
Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromes.
J Am Coll Cardiol 2008 Feb;51(6):627-33.
PMID: 18261681
Inflammatory responses after intracoronary injection of autologous mononuclear bone marrow cells in patients with acute myocardial infarction.
Am Heart J 2008 Jan;155(1):55.e1-9.
PMID: 18082489
Raised LIGHT levels in pulmonary arterial hypertension: potential role in thrombus formation.
Am J Respir Crit Care Med 2008 Jan;177(2):202-7. Epub 2007 okt 25
PMID: 17962639
Inflammatory cytokines in heart failure. Potential roles as mediators and biomarkers
- Disputert:
- desember 2010
- Hovedveileder:
- Lars Gullestad
- Lars Gullestad Prosjektdeltaker
- Thor Ueland Forskningsgruppeleder
- Arne Yndestad Forskningsgruppeleder
- Pål Aukrust Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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