The role of autophagy and Alfy in degradation of protein aggregates associated with cancer and neurodegenerative disease
- Prosjektnummer
- 2008083
- Ansvarlig person
- Harald Stenmark
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
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The role of ALFY in selective autophagy.
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Alfy-dependent elimination of aggregated proteins by macroautophagy: can there be too much of a good thing?
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The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration.
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Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein.
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The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.
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Fighting disease by selective autophagy of aggregate-prone proteins.
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p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.
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Autophagic degradation of an oncoprotein.
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PhD
- Disputert:
- oktober 2011
- Hovedveileder:
- Anne Simonsen
Mechanisms of autophagic protein degradation
- Disputert:
- desember 2009
- Hovedveileder:
- Anne Simonsen
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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