Tap av tumor suppressorgener ved utvikling av kreft i tykktarm
- Prosjektnummer
- 2008096
- Ansvarlig person
- Edgar Rivedal
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
The gap junction channel protein connexin 43 is covalently modified and regulated by SUMOylation.
J Biol Chem 2012 May;287(19):15851-61. Epub 2012 mar 12
PMID: 22411987 - Inngår i doktorgradsavhandlingen
Smad ubiquitination regulatory factor-2 controls gap junction intercellular communication by modulating endocytosis and degradation of connexin43.
J Cell Sci 2012 Sep;125(Pt 17):3966-76. Epub 2012 mai 23
PMID: 22623726 - Inngår i doktorgradsavhandlingen
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
Cell Signal 2013 Jan;25(1):12-8. Epub 2012 sep 5
PMID: 22974840
Connexin43 acts as a colorectal cancer tumor suppressor and predicts disease outcome.
Int J Cancer 2012 Aug;131(3):570-81. Epub 2011 okt 20
PMID: 21866551
Endocytosis and post-endocytic sorting of connexins.
Biochim Biophys Acta 2012 Aug;1818(8):1870-9. Epub 2011 okt 4
PMID: 21996040
Norepinephrine inhibits intercellular coupling in rat cardiomyocytes by ubiquitination of connexin43 gap junctions.
Cell Commun Adhes 2011 Aug;18(4):57-65. Epub 2011 sep 21
PMID: 21936631
Quantitative validation of GJC1 promoter hypermethylation in benign and malignant colorectal tumors.
Endocr Relat Cancer 2011 Oct;18(6):C31-4. Epub 2011 okt 27
PMID: 21868474
Cargo-dependent degradation of ESCRT-I as a feedback mechanism to modulate endosomal sorting.
Traffic 2011 Sep;12(9):1211-26. Epub 2011 jun 13
PMID: 21564451
DNA methylation analyses of the connexin gene family reveal silencing of GJC1 (Connexin45) by promoter hypermethylation in colorectal cancer.
Epigenetics 2011 May;6(5):602-9. Epub 2011 mai 1
PMID: 21406965
Inhibition of connexin 43 gap junction channels by the endocrine disruptor ioxynil.
Toxicol Appl Pharmacol 2010 Aug;247(1):10-7. Epub 2010 mai 25
PMID: 20510257
Regulation of gap junction intercellular communication by the ubiquitin system.
Cell Signal 2010 Sep;22(9):1267-73. Epub 2010 mar 4
PMID: 20206687
Gap junction intercellular communication and benzene toxicity.
Chem Biol Interact 2010 Mar;184(1-2):229-32. Epub 2009 nov 22
PMID: 19932693
Interplay between PKC and the MAP kinase pathway in Connexin43 phosphorylation and inhibition of gap junction intercellular communication.
Biochem Biophys Res Commun 2009 Apr;382(1):41-5. Epub 2009 mar 1
PMID: 19258009
Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.
J Cell Sci 2009 Nov;122(Pt 21):3883-93. Epub 2009 okt 6
PMID: 19808888
The benzene metabolite trans,trans-muconaldehyde blocks gap junction intercellular communication by cross-linking connexin43.
Toxicol Appl Pharmacol 2008 Nov;232(3):463-8. Epub 2008 aug 6
PMID: 18723040
The detergent resistance of Connexin43 is lost upon TPA or EGF treatment and is an early step in gap junction endocytosis.
Biochem Biophys Res Commun 2008 Sep;373(4):597-601. Epub 2008 jul 2
PMID: 18601906
Posttranslational modification of the tumor suppressor protein connexin43 - implications for cell communication and cancer
- Disputert:
- juni 2012
- Hovedveileder:
- Edgar Rivedal og Edward Leithe
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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