Membrandomener involvert i kontroll av signalisering fra reseptortyrosinkinaser
- Prosjektnummer
- 2008097
- Ansvarlig person
- Espen Stang
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis.
Exp Cell Res 2012 Dec;318(20):2578-91. Epub 2012 sep 11
PMID: 22975728
The oncoprotein ErbB3 is endocytosed in the absence of added ligand in a clathrin-dependent manner.
Carcinogenesis 2012 May;33(5):1031-9. Epub 2012 mar 20
PMID: 22436610
Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations.
J Immunother 2011 Sep;34(7):550-5.
PMID: 21760527
CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor.
Exp Cell Res 2011 Aug;317(13):1804-16. Epub 2011 mai 20
PMID: 21635887
A chimeric pre-ubiquitinated EGF receptor is constitutively endocytosed in a clathrin-dependent, but kinase-independent manner.
Traffic 2011 Apr;12(4):507-20. Epub 2011 feb 8
PMID: 21226813
Internalization and intracellular sorting of the EGF receptor: a model for understanding the mechanisms of receptor trafficking.
J Cell Sci 2009 Oct;122(Pt 19):3433-9.
PMID: 19759283
Pertuzumab increases epidermal growth factor receptor down-regulation by counteracting epidermal growth factor receptor-ErbB2 heterodimerization.
Mol Cancer Ther 2009 Jul;8(7):1885-92. Epub 2009 jul 7
PMID: 19584234
Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2.
Mol Cancer Res 2009 Feb;7(2):275-84. Epub 2009 feb 10
PMID: 19208749
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits.
Traffic 2009 Feb;10(2):235-45. Epub 2008 nov 20
PMID: 19054389
An endosomally localized isoform of Eps15 interacts with Hrs to mediate degradation of epidermal growth factor receptor.
J Cell Biol 2008 Mar;180(6):1205-18.
PMID: 18362181
Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent.
Mol Cancer Res 2008 Mar;6(3):491-500.
PMID: 18337455
Dysregulation of Ack1 inhibits down-regulation of the EGF receptor.
Exp Cell Res 2008 Apr;314(6):1292-300. Epub 2008 jan 5
PMID: 18262180
Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Tras
Pharamaceuticals, 5(7), 674-689
Expression of EGFR or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2
Mol Cancer Res 2009 In press
Mechanisms underlying the downregulation of receptor tyrosine kinases EGFR and ErbB2
- Disputert:
- november 2012
- Hovedveileder:
- Inger Helene Madshus
Ubiquitination in Control of EGF Receptor Endocytosis
- Disputert:
- januar 2009
- Hovedveileder:
- Inger Helene Madshus
Mechanisms Involved in Endocytosis of ErbB Proteins
- Disputert:
- mai 2008
- Hovedveileder:
- Inger Helene Madshus
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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