Targeted therapy against metastatic malignant melanoma
- Prosjektnummer
- 2008099
- Ansvarlig person
- Gunhild Mari Mælandsmo
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Human malignant melanoma harbours a large fraction of highly clonogenic cells that do not express markers associated with cancer stem cells.
Pigment Cell Melanoma Res 2010 Jun;23(3):449-51. Epub 2010 mar 13
PMID: 20236249
Aldehyde dehydrogenase (ALDH) activity does not select for cells with enhanced aggressive properties in malignant melanoma.
PLoS One 2010;5(5):e10731. Epub 2010 mai 20
PMID: 20505780
Species-specific in vivo engraftment of the human BL melanoma cell line results in an invasive dedifferentiated phenotype not present in xenografts.
Cancer Res 2009 May;69(9):3746-54. Epub 2009 apr 21
PMID: 19383913
Growth of cancer cell lines under stem cell-like conditions has the potential to unveil therapeutic targets.
Exp Cell Res 2008 Jun;314(10):2110-22. Epub 2008 mar 20
PMID: 18423605
In vivo imaging and molecular characterization of site-specific growth of malignant melanoma: a study of melanoma metastasis...
AACR 102nd Annual Meeting, Orlando, 2-6 April 2011
Imaging and molecular characterization of site-specific growth of malignant melanoma in experimental metastasis models in vivo
New Concepts in Cancer Metastasis, Lisboa 25-28 June, 2011
S100A4 and osteopontin as mediators in cancer invasion
New Concepts in Cancer Metastasis, Lisboa 25-28 June, 2011
Metastatic melanoma contains frequent cells with high activity of aldehyde dehydrogenase (ALDH) and potential for self-renewal i
2009 International Melanoma Congress, Boston
Malignant melanoma cells with tumourigenic properties are common and can not be distinguished by the stem cell marker ALDH
Second Norwegian Cancer Symposium 2009 (Fronties in Cancer Stem Cell Research), Oslo
Human malignant melanoma harbours a large fraction of highly clonogenic cells that can not be distinguished by proposed markers
Under Review in Pigment Cell & Melanoma Research
Aldehyde Dehydrogenase (ALDH) Activity does not Select for Cells with Enhanced Aggressive Properties in Malignant Melanoma
Submitted to PLoS ONE
Evaluation of stem cell-associated charcteristics and metastatic potential of melanoma cells derived from patient biopsies
Proceedings AACR Annual Meeting 2008
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport