Molecular Mechanisms of Heart Failure - Deciphering Function of GRK Isoforms in the Heart
- Prosjektnummer
- 2008124
- Ansvarlig person
- Håvard Attramadal
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning
Connective tissue growth factor/CCN2 attenuates ß-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes.
Mol Pharmacol 2013 Sep;84(3):372-83. Epub 2013 jun 18
PMID: 23778361
Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload.
Am J Physiol Heart Circ Physiol 2012 Jul;303(1):H66-74. Epub 2012 apr 27
PMID: 22542621
CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3ß signaling pathway.
J Cell Commun Signal 2013 Mar;7(1):31-47. Epub 2012 des 4
PMID: 23208610 - Inngår i doktorgradsavhandlingen
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury.
Am J Physiol Heart Circ Physiol 2011 Apr;300(4):H1291-302. Epub 2010 des 24
PMID: 21186275
Hypertension: Are we beta-ARKing up the right tree?
Hypertension 2009 Jul;54(1):27-8. Epub 2009 jun 1
PMID: 19487585
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure.
Am J Physiol Regul Integr Comp Physiol 2010 Mar;298(3):R808-14. Epub 2009 des 23
PMID: 20032264
Prokineticins and the heart: diverging actions elicited by signalling through prokineticin receptor-1 or -2.
Cardiovasc Res 2009 Jan;81(1):3-4. Epub 2008 nov 12
PMID: 19008213
Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness.
J Biol Chem 2008 Apr;283(16):10601-10. Epub 2007 des 29
PMID: 18165681
Molecular Mechanisms of Myocardial Hypertrophy and Heart Failure
- Disputert:
- september 2009
- Hovedveileder:
- Håvard Attramadal
- Tuyet Anh Thi Pham Doktorgradsstipendiat
- Thomas Gero von Lueder Forsker (annen finansiering)
- Jørgen A. Gravning Forsker (annen finansiering)
- Ingvild Tronstad Moe Doktorgradsstipendiat
- Muhammad Shakil Ahmed Medveileder
- Håvard Attramadal Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport