CCN2/CTGF: A Novel Cardioprotective Factor in Myocardial Ischemia/Reperfusion Injury and Heart Failure
- Prosjektnummer
- 2009086
- Ansvarlig person
- Håvard Attramadal
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
Exercise training promotes cardioprotection through oxygen-sparing action in high fat-fed mice.
Am J Physiol Heart Circ Physiol 2015 Apr 15;308(8):H823-9. Epub 2015 jan 30
PMID: 25637547
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.
PLoS One 2015;10(10):e0139715. Epub 2015 okt 13
PMID: 26461521
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.
Am J Physiol Heart Circ Physiol 2015 Aug 1;309(3):H434-49. Epub 2015 jun 8
PMID: 26055793
The matricellular "cysteine-rich protein 61" is released from activated platelets and increased in the circulation during experimentally induced sepsis.
Shock 2014 Mar;41(3):233-40.
PMID: 24430538
Connective tissue growth factor induces tube formation and IL-8 production in first trimester human placental trophoblast cells.
Eur J Obstet Gynecol Reprod Biol 2014 Oct;181():183-8. Epub 2014 aug 7
PMID: 25150958
Connective tissue growth factor/CCN2 attenuates ß-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes.
Mol Pharmacol 2013 Sep;84(3):372-83. Epub 2013 jun 18
PMID: 23778361
CCN2/CTGF attenuates myocardial hypertrophy and cardiac dysfunction upon chronic pressure-overload.
Int J Cardiol 2013 Oct 3;168(3):2049-56. Epub 2013 feb 26
PMID: 23452880
CCN2 exerts direct cytoprotective actions in adult cardiac myocytes by activation of the PI3-kinase/Akt/GSK-3ß signaling pathway.
J Cell Commun Signal 2013 Mar;7(1):31-47. Epub 2012 des 4
PMID: 23208610
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.
J Intern Med 2014 Jun;275(6):621-30. Epub 2014 jan 9
PMID: 24330105
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) Attenuates Left Ventricular Remodeling after Myocardial Infarction.
PLoS One 2012;7(12):e52120. Epub 2012 des 20
PMID: 23284892
Protecting the heart through delivering DNA encoding for heme oxygenase-1 into skeletal muscle.
Life Sci 2012 Oct;91(17-18):828-36. Epub 2012 aug 17
PMID: 22917518
The matri-cellular proteins 'cysteine-rich, angiogenic-inducer, 61' and 'connective tissue growth factor' are regulated in experimentally-induced sepsis with multiple organ dysfunction.
Innate Immun 2012 Oct;18(5):717-26. Epub 2012 feb 14
PMID: 22334618
Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury.
Am J Physiol Heart Circ Physiol 2011 Apr;300(4):H1291-302. Epub 2010 des 24
PMID: 21186275
Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo.
Life Sci 2011 Mar;88(11-12):543-50. Epub 2011 jan 14
PMID: 21238463
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.
PLoS One 2011;6(4):e18668. Epub 2011 apr 18
PMID: 21533157
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload.
Eur Heart J 2011 Jan;32(2):236-45. Epub 2010 jun 5
PMID: 20525982
Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors.
BMC Cancer 2010;10():6. Epub 2010 jan 6
PMID: 20053285
Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure.
Basic Res Cardiol 2010 Jan;105(1):89-98.
PMID: 19823891
Prokineticins and the heart: diverging actions elicited by signalling through prokineticin receptor-1 or -2.
Cardiovasc Res 2009 Jan;81(1):3-4. Epub 2008 nov 12
PMID: 19008213
Hypertension: Are we beta-ARKing up the right tree?
Hypertension 2009 Jul;54(1):27-8. Epub 2009 jun 1
PMID: 19487585
Separate mechanisms cause anemia in ischemic vs. nonischemic murine heart failure.
Am J Physiol Regul Integr Comp Physiol 2010 Mar;298(3):R808-14. Epub 2009 des 23
PMID: 20032264
The Matricellular Protein CCN2/CTGF Alters Remodeling and Fibrotic Response Following Myocardial Infarction in Mice
Circulation. 2012;126:A14287 (Abstract 14287, Scientific Sessions 2012)
CCN2/CTGF as a Novel Stimulator of Proliferation and Survival of Cardiac Progenitor Cells/Stem Cells
American Heart Association Scientific Sessions 2010, Circulation (Abstract Suppl. 2010)
Myocardial Connective Tissue Growth Factor (CCN2/CTGF) attenuates Left Ventricular Remodeling after Myocardial Infarction
American Heart Association Scientific Sessions 2010, Circulation (Abstract Suppl. 2010)
Investigations on Signaling Pathways and Functions of CCN2 in The Heart.
- Disputert:
- februar 2015
- Hovedveileder:
- Håvard Attramadal
Cardioprotective Mechanisms in Ischemia-Reperfusion Injury and Heart Failure.
- Disputert:
- mai 2013
- Hovedveileder:
- Håvard Attramadal
Molecular Mechanisms of Myocardial Hypertrophy and Heart Failure
- Disputert:
- september 2009
- Hovedveileder:
- Håvard Attramadal
- Geir Florholmen Postdoktorstipendiat
- Ole Jørgen Kaasbøll Doktorgradsstipendiat
- Tuyet Anh Thi Pham Doktorgradsstipendiat
- Ingvild Tronstad Moe Doktorgradsstipendiat
- Else Marie Valbjørn Hagelin Prosjektdeltaker
- Jørgen A. Gravning Doktorgradsstipendiat
- Muhammad Shakil Ahmed Forsker (annen finansiering)
- Håvard Attramadal Prosjektleder
- Kenneth Dickstein Prosjektdeltaker
- Stein Ørn Prosjektdeltaker
- Thor Edvardsen Prosjektdeltaker
- Jan-Bjørn Osnes Prosjektdeltaker
- Tor Skomedal Prosjektdeltaker
- Finn Olav Levy Prosjektdeltaker
- Guro Valen Prosjektdeltaker
- Vladimir Nikolaev Martinov Postdoktorstipendiat
- Else Marie Hagelin Prosjektdeltaker
- Kurt Allen Krobert Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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