The role of complement in human disease
- Prosjektnummer
- 2009087
- Ansvarlig person
- Tom Eirik Mollnes
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Nytt flerårig forskningsprosjekt
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 2. Aetiology
Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis.
Clin Physiol Funct Imaging 2011 Mar;31(2):151-8. Epub 2010 nov 18
PMID: 21087397
Biocompatibility and pathways of initial complement pathway activation with Phisio- and PMEA-coated cardiopulmonary bypass circuits during open-heart surgery.
Perfusion 2011 Mar;26(2):107-14. Epub 2010 des 22
PMID: 21177724
Artificial surface-induced inflammation relies on complement factor 5: proof from a deficient person.
Ann Thorac Surg 2011 Feb;91(2):527-33.
PMID: 21256307
Patient tolerance regarding different low-density lipoprotein apheresis columns: frequent minor side effects and high patient satisfaction.
J Clin Lipidol 2011 Jan-Feb;5(1):45-9. Epub 2010 nov 18
PMID: 21262506
Sun exposure induces rapid immunological changes in skin and peripheral blood in patients with psoriasis.
Br J Dermatol 2011 Feb;164(2):344-55.
PMID: 21271993
Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model.
Acta Biomater 2011 Jun;7(6):2566-78. Epub 2011 mar 12
PMID: 21402181
Development of ß-amino alcohol derivatives that inhibit Toll-like receptor 4 mediated inflammatory response as potential antiseptics.
J Med Chem 2011 Jul;54(13):4659-69. Epub 2011 jun 2
PMID: 21591694
Recurrent meningococcal sepsis in a presumptive immunocompetent host shown to be complement C5 deficient-a case report.
APMIS 2011 Jul;119(7):479-84. Epub 2011 apr 8
PMID: 21635555
Complement activation by candidate biomaterials of an implantable microfabricated medical device.
J Biomed Mater Res B Appl Biomater 2011 Aug;98B(2):323-9. Epub 2011 jun 6
PMID: 21648060
Advances in assay of complement function and activation.
Adv Drug Deliv Rev 2011 Sep;63(12):976-87. Epub 2011 jun 2
PMID: 21664392
Excessive innate immune response and mutant D222G/N in severe A (H1N1) pandemic influenza.
J Infect 2011 Oct;63(4):308-16. Epub 2011 jul 19
PMID: 21781987
Persisting thrombin activity in elderly patients with atrial fibrillation on oral anticoagulation is decreased by anti-inflammatory therapy with intensive cholesterol-lowering treatment.
J Clin Lipidol 2011 Jul-Aug;5(4):273-80. Epub 2011 mai 20
PMID: 21784372
Neisseria meningitidis and Escherichia coli are protected from leukocyte phagocytosis by binding to erythrocyte complement receptor 1 in human blood.
Mol Immunol 2011 Sep;48(15-16):2159-69. Epub 2011 aug 11
PMID: 21839519
The mild inflammatory response in febrile neutropenic lymphoma patients with low risk of complications is more pronounced in patients receiving tobramycin once daily compared with three times daily.
Scand J Immunol 2011 Dec;74(6):632-9.
PMID: 21883353
The role of bradykinin and the effect of the bradykinin receptor antagonist icatibant in porcine sepsis.
Shock 2011 Nov;36(5):517-23.
PMID: 21921836
Ornithodoros moubata complement inhibitor is an equally effective C5 inhibitor in pigs and humans.
J Immunol 2011 Nov;187(9):4913-9. Epub 2011 sep 30
PMID: 21964028
Staphylococcus epidermidis polysaccharide intercellular adhesin activates complement.
FEMS Immunol Med Microbiol 2011 Nov;63(2):269-80.
PMID: 22077230
Activation of polymorphonuclear leukocytes by candidate biomaterials for an implantable glucose sensor.
J Diabetes Sci Technol 2011 Nov;5(6):1490-8. Epub 2011 nov 1
PMID: 22226271
Anti-inflammatory effects of C1-Inhibitor in porcine and human whole blood are independent of its protease inhibition activity.
Innate Immun 2010 Aug;16(4):254-64. Epub 2009 aug 26
PMID: 19710096
Perfusion temperature, thyroid hormones and inflammation during pediatric cardiac surgery.
Interact Cardiovasc Thorac Surg 2010 Jan;10(1):76-80. Epub 2009 okt 12
PMID: 19822605
Systemic mannose-binding lectin is not associated with Chronic Obstructive Pulmonary Disease.
Respir Med 2010 Feb;104(2):283-90.
PMID: 19836222
CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.
FASEB J 2010 Mar;24(3):712-22. Epub 2009 okt 19
PMID: 19841036
Critical roles of complement and antibodies in host defense mechanisms against Neisseria meningitidis as revealed by human complement genetic deficiencies.
Infect Immun 2010 Feb;78(2):802-9. Epub 2009 nov 23
PMID: 19933829
Meconium-induced release of cytokines is mediated by the TRL4/MD-2 complex in a CD14-dependent manner.
Mol Immunol 2010 Mar;47(6):1226-34. Epub 2010 jan 22
PMID: 20092898
The complement system is activated in a biphasic pattern after coronary artery bypass grafting.
Ann Thorac Surg 2010 Mar;89(3):710-6.
PMID: 20172115
Comparable biocompatibility of Phisio- and Bioline-coated cardiopulmonary bypass circuits indicated by the inflammatory response.
Perfusion 2010 Jan;25(1):9-16. Epub 2010 feb 19
PMID: 20172900
Selective inhibition of TNF-alpha or IL-1 beta does not affect E. coli-induced inflammation in human whole blood.
Mol Immunol 2010 May;47(9):1774-82. Epub 2010 mar 23
PMID: 20334922
Dissecting the effects of lipopolysaccharides from nonlipopolysaccharide molecules in experimental porcine meningococcal sepsis.
Crit Care Med 2010 Jun;38(6):1467-74.
PMID: 20400898
Body composition and plasma levels of inflammatory biomarkers in COPD.
Eur Respir J 2010 Nov;36(5):1027-33. Epub 2010 apr 22
PMID: 20413541
Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis.
Blood 2010 Jul;116(4):631-9. Epub 2010 apr 27
PMID: 20424189
Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis.
Blood 2010 Aug;116(6):1002-10. Epub 2010 mai 13
PMID: 20466856
Neutrophil gelatinase-associated lipocalin: a biomarker in COPD.
Chest 2010 Oct;138(4):888-95. Epub 2010 mai 21
PMID: 20495108
Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation.
J Perinat Med 2010 Sep;38(5):545-56.
PMID: 20629493
Toward an injectable continuous osmotic glucose sensor.
J Diabetes Sci Technol 2010 Jul;4(4):882-92. Epub 2010 jul 1
PMID: 20663452
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes.
Immunity 2010 Oct;33(4):583-96. Epub 2010 okt 7
PMID: 20933442
Hirudin versus heparin for use in whole blood in vitro biocompatibility models.
J Biomed Mater Res A 2009 Jun;89(4):951-9.
PMID: 18470919
Mechanisms of complement activation and effects of C1-inhibitor on the meconium-induced inflammatory reaction in human cord blood.
Mol Immunol 2009 Feb;46(4):688-94. Epub 2008 okt 31
PMID: 18950866
Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood.
Infect Immun 2009 Feb;77(2):725-32. Epub 2008 des 1
PMID: 19047409
Occupational exposure to bacterial single cell protein induces inflammation in lung and blood.
Inhal Toxicol 2009 Jul;21(8):674-81.
PMID: 19558225
A new dynamic porcine model of meningococcal shock.
Shock 2009 Sep;32(3):302-9.
PMID: 19174740
A helicopter flight does not induce significant changes in systemic biomarker profiles.
Scand J Clin Lab Invest 2009;69(4):462-74.
PMID: 19333819
Complement activation and plasma levels of C4b-binding protein in critical limb ischemia patients.
J Vasc Surg 2009 Jul;50(1):100-6.
PMID: 19563958
Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation.
Brain Res 2009 Mar;1259():80-9. Epub 2008 des 31
PMID: 19146835
In vitro evaluation of PHISIO-coated sets for pediatric cardiac surgery.
Scand Cardiovasc J 2009 Apr;43(2):129-35.
PMID: 19294579
The soluble terminal complement complex (SC5b-9) up-regulates osteoprotegerin expression and release by endothelial cells: implications in rheumatoid arthritis.
Rheumatology (Oxford) 2009 Mar;48(3):293-8. Epub 2009 jan 23
PMID: 19168833
C-reactive protein, infarct size, microvascular obstruction, and left-ventricular remodelling following acute myocardial infarction.
Eur Heart J 2009 May;30(10):1180-6. Epub 2009 mar 19
PMID: 19299430
Pathway-specific complement activity in pigs evaluated with a human functional complement assay.
Mol Immunol 2009 May;46(8-9):1620-5. Epub 2009 mar 27
PMID: 19328551
In situ deposition of complement in human acute brain ischaemia.
Scand J Immunol 2009 Jun;69(6):555-62.
PMID: 19439017
Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis.
Scand J Immunol 2009 Jun;69(6):479-91.
PMID: 19439008
Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians.
Clin Exp Immunol 2009 Jul;157(1):98-103.
PMID: 19659775
The effect of exercise on serum levels of interleukin-18 and components of the metabolic syndrome.
Metab Syndr Relat Disord 2009 Dec;7(6):579-84.
PMID: 19900154
Human genetic deficiencies reveal the roles of complement in the inflammatory network: lessons from nature.
Proc Natl Acad Sci U S A 2009 Sep;106(37):15861-6. Epub 2009 aug 26
PMID: 19717455
Mannose-binding lectin is a critical factor in systemic complement activation during meningococcal septic shock.
Clin Infect Dis 2009 Nov;49(9):1380-6.
PMID: 19793001
Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system.
Mol Immunol 2009 Oct;46(16):3388-98. Epub 2009 aug 11
PMID: 19674792
The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification.
Mol Immunol 2009 Dec;47(2-3):373-80. Epub 2009 okt 1
PMID: 19800125
The chemokine network in relation to infarct size and left ventricular remodeling following acute myocardial infarction.
Am J Cardiol 2009 Nov;104(9):1179-83. Epub 2009 sep 16
PMID: 19840558
Selective inhibition of TNF-a and IL-1ß do not affect E. coli-induced inflammation in human whole blood, in contrast to combined
Mol Immunol 46:2838. 2009.
Transcription of key components of complement and the TLR-signaling system is down-regulated by LPS in a porcine model of mening
Mol Immunol 46:2853-4. 2009.
Analysis of the complement system in human lymph.
Mol Immunol 46:2858. 2009.
Mechanisms of meconium-induced innate immune-reactions: Role of complement and CD14/TLR4/MD-2.
Mol Immunol 46:2865-6. 2009.
Complement activation by proposed biomaterials intended for composition of a glucose sensor.
Mol Immunol 46:2868. 2009.
Key role of complement receptor 1 in the initial binding of Escherichia coli and Neisseria meningitidis to erythrocytes in human
Mol Immunol 46:2824. 2009.
29. Meningococcal sepsis: Beneficial and harmful inflammatory mechanisms
- Disputert:
- juni 2011
- Hovedveileder:
- Petter Brandtzaeg
28. Improvement in technology and biocompatibility of extracorporeal circuits
- Disputert:
- juni 2011
- Hovedveileder:
- Arnt E. Fiane
MD, PhD
- Disputert:
- juni 2010
- Hovedveileder:
- Tom Eirik Mollnes
Complement and CD14: Roles in Escherichia coli-induced inflammation in the pig.
- Disputert:
- desember 2009
- Hovedveileder:
- Tom Eirik Mollnes
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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