Translational research with goal to identify T-cells that support and expand B cell lymphoma in humans
- Prosjektnummer
- 2010057
- Ansvarlig person
- Geir Tjønnfjord
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Blood, Cancer, Inflammatory and Immune System
- Forskningsaktivitet
- 5. Treatment Developement
Nei
Nei
Nei
The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function.
J Immunol 2019 03 01;202(5):1397-1405. Epub 2019 jan 28
PMID: 30692213
Richter syndrome epidemiology in a large population based chronic lymphocytic leukemia cohort from Norway.
Cancer Epidemiol 2019 06;60():128-133. Epub 2019 apr 12
PMID: 30986631
Cold agglutinin disease: current challenges and future prospects.
J Blood Med 2019;10():93-103. Epub 2019 apr 9
PMID: 31114413
Inheritance of Susceptibility to Malignant Blood Disorders.
Sci Rep 2019 Feb 21;9(1):2444. Epub 2019 feb 21
PMID: 30792429
Cryopreservation of primary B cells minimally influences their signaling responses.
Sci Rep 2018 Dec 05;8(1):17651. Epub 2018 des 5
PMID: 30518828
Cytokinesis arrest and multiple centrosomes in B cell chronic lymphocytic leukaemia.
J Cell Mol Med 2018 May;22(5):2846-2855. Epub 2018 mar 7
PMID: 29516674
Single cell profiling of phospho-protein levels in chronic lymphocytic leukemia.
Oncotarget 2018 Feb 06;9(10):9273-9284. Epub 2018 jan 4
PMID: 29507689
Bone marrow T helper cells with a Th1 phenotype induce activation and proliferation of leukemic cells in precursor B acute lymphoblastic leukemia patients.
Oncogene 2019 03;38(13):2420-2431. Epub 2018 des 7
PMID: 30532071
Phospho Flow Cytometry with Fluorescent Cell Barcoding for Single Cell Signaling Analysis and Biomarker Discovery.
J Vis Exp 2018 10 04. Epub 2018 okt 4
PMID: 30346411
Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice.
Leukemia 2017 Oct;31(10):2114-2121. Epub 2017 feb 24
PMID: 28232741
Spleen tyrosine kinase inhibitors reduce CD40L-induced proliferation of chronic lymphocytic leukemia cells but not normal B cells.
Haematologica 2016 Feb;101(2):e59-62. Epub 2015 nov 20
PMID: 26589914
Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-? by a T-bet-dependent mechanism.
J Immunol 2015 Jan 15;194(2):827-35. Epub 2014 des 10
PMID: 25505279
Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells.
Cell Rep 2013 Aug 15;4(3):566-77. Epub 2013 aug 8
PMID: 23933259
Richter syndrome presenting as a solitary cerebellar tumor during first-line treatment for chronic lymphocytic leukemia.
Leuk Lymphoma 2011 Oct;52(10):2007-9. Epub 2011 jun 12
PMID: 21663503
Familial chronic lymphocytic leukemia in Norway and Denmark. Comments on pleiotropy and birth order.
In Vivo 2010 Jan-Feb;24(1):85-95.
PMID: 20133982
High response rate and durable remissions following fludarabine and rituximab combination therapy for chronic cold agglutinin disease.
Blood 2010 Oct;116(17):3180-4. Epub 2010 jul 15
PMID: 20634373
Chronic Lymphocytic Leukemia Cells Express CD38 in Response to Th1 Cell-Derived IFN-? by a T-bet-Dependent Mechanism
Journal of Immunology, Epub 2014 Dec 10
Leukemic B cells receive help from autologous T helper cells through a mechanism involving recognition of endogenous antigen
World Immune Regulation Meeting V, Davos, Switzerland, March 2012, poster presentation
T cells in CLL
UK-CLL forum, London March 2012. Invited lecture.
Leukemic B Cells Can Collaborate with Antigen-specific T Helper Cells and Receive Help to Proliferate
FOCIS 2012 Trainee Satellite Symposium, in Vancouver, Canada, June 2012, oral presentation
Leukemic B Cells Can Collaborate with Antigen-specific T Helper Cells and Receive Help to Proliferate
12th Annual Meeting of the Federation of Clinical Immunology Societies (FOCIS 2012), in Vancouver, Canada, June 2012, poster presentation
What makes the B cell lymphomas grow?
Global Academic Programs - (GAP). MD Anderson Cancer Center. Oslo, May 2012. Lecture.
Unravelling the role of the microenvironment in chronic lymphocytic leukemia. T helper cell support of cancer cells.
- Disputert:
- mai 2018
- Hovedveileder:
- Ludvig A. Munthe
CD4+ T cell-induced macrophage cytotoxicity against tumor cells
- Disputert:
- juni 2016
- Hovedveileder:
- Bjarne Bogen
T cells specific for endogenous B cell antigen: Consequencies for autoimmunity and mature B cell malignancies
- Disputert:
- desember 2011
- Hovedveileder:
- Ludvig Munthe
- Viggo Jønsson Prosjektdeltaker
- Tom Børge Johannesen Prosjektdeltaker
- Kjetil Tasken Prosjektdeltaker
- Andrea Lenartova Doktorgradsstipendiat (annen finansiering)
- Xue-Yan Cui Forsker (annen finansiering)
- Anna Maria Parente Ribes Doktorgradsstipendiat (annen finansiering)
- Sigrid Strand Skånland Postdoktorstipendiat (annen finansiering)
- Dong Wang Postdoktorstipendiat (annen finansiering)
- Fredrik Hellem Schjesvold Postdoktorstipendiat (annen finansiering)
- Ludvig Andre Munthe Forsker (annen finansiering)
- Anders Tveita Forsker (annen finansiering)
- Geir Erland Tjønnfjord Prosjektleder
- Bjarne Bogen Forskningsgruppeleder
- Yngvar Fløisand Forsker (annen finansiering)
- Stephen Devereux Prosjektdeltaker
- Audun Os Prosjektdeltaker
- Simone Bürgler Forsker (annen finansiering)
- Ludvig MUnthe Forsker (annen finansiering)
- Simone Burgler Postdoktorstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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