eRapport

TOP Study Group

Prosjekt
Prosjektnummer
2010074
Ansvarlig person
Ole A. Andreassen
Institusjon
Oslo universitetssykehus HF
Prosjektkategori
Miljøstøtte og regionale forskningsnettverk
Helsekategori
Mental Health
Forskningsaktivitet
2. Aetiology
Rapporter
2012 - sluttrapport
Formålet er å skaffe mer kunnskap om genetiske mekanismer for psykotiske lidelser i relasjon til miljøfaktorer. Vår har identifisert subgrupper av pasienter med spesifikke kliniske profiler inklusive biomarkører og andre objektivt målbare parametre, spesielt hjerne MRI-undersøkelser, og bruke disse fenotypene i genetiske analyser for å skaffe mer kunnskap om underliggende mekanismer. Midlene har blitt brukt til undersøkelser av et mange pasienter og til å vedlikeholde infrastruktur for klinisk karakterisering, hjerneavbildning (MRI) og molekylærgenetiske analyser – tre sentrale metoder innen psykiatrisk translasjonsforskning. Gjennom bl. annet samarbeid med Norske og utenlandske miljøer, har vi publisert en rekke funn omkring hjerneavbildnings- og molekylærgenetiske aspekter ved alvorlige psykiske lidelser, flere i prestisjetunge journaler, slik som Nature, Nature Genetics, New Engl Journal of Medicine. Videre har vi en serie med resultater omkring kliniske og nevrokognitive fenomener relatert til tidlig utvikling av alvorlig psykisk lidelse, og hvordan viktige kliniske karakteristika kan predikeres. Det pågår en serie med doktorgrads- og postdoktorprosjekter tilknyttet TOP forskergruppe, flere gjennom Nettverket tidlige psykoser. Alle disse benytter infrastruktur og får veiledning fra TOP miljøet. TOP gruppen er et ledende miljø i den nye nasjonale satsingen på alvorlige psykiske lidelser, samt i regional kjernefasilitet for hjerneavbildning. Alvorlige psykiske lidelser (schizofreni og bipolar lidelse) medfører stor lidelse, er vanskelige å behandle og legger beslag på store helseressurser. Sykdomsmekanismene er fremdeles ukjente, men arvelige faktorer spiller en viktig rolle. Forskningen hemmes av mangel på objektive kriterier og målbare parametre. TOP prosjektet har medført økt kunnskap om hvordan psykiske fenomener oppstår og utvikles hos pasienter med alvorlig psykisk lidelse. Vi har kartlagt tidlige tegn på alvorlige hendelser, slik som suicid. Dette har direkte nytte i klinisk hverdag. Nevropsykologiske dysfunksjon bidrar til forverret forløp, og ny kunnskap fra TOP prosjektet har direkte nytte i utredning og diagnostikk av alvorlig psykisk lidelser. Genetisk og hjerneavbildningsresultater fra prosjektet vil nok ikke ha noen direkte klinisk nytte, men kan brukes som utgangspunkt for å utvikle nye medikamenter.
2011
TOP gruppen har som mål å skaffe mer kunnskap om årsak og behandling ved alvorlige psykiske lidelser. Vi har infrastruktur og ekspertise innen kliniske og nevrokognitive aspekter, MRI-undersøkelser, molekylærgenetikk, samt biobank og database. Dette brukes av en serie forskningsprosjekter, som undersøker et stort, velkarakterisert klinisk materiale.Alvorlige psykiske lidelser (schizofreni og bipolar lidelse) medfører stor lidelse, er vanskelige å behandle og legger beslag på store helseressurser. Sykdomsmekanismene er fremdeles ukjente, men arvelige faktorer spiller en viktig rolle. Forskningen hemmes av mangel på objektive kriterier og målbare parametre. Formålet med satsingen er å skaffe mer kunnskap om genetiske mekanismer for psykotiske lidelser i relasjon til miljøfaktorer. Vår strategi er å identifisere subgrupper av pasienter med spesifikke kliniske profiler (fenotyper) inklusive biomarkører og andre objektivt målbare parametre, spesielt hjerne MRI-undersøkelser, og bruke disse fenotypene i genetiske analyser for å skaffe mer kunnskap om underliggende mekanismer. Vi har infrastruktur for storstilet undersøkelse av kliniske og nevrokognitiv karakteristika, hjerneavvik (MRI-teknologi), medikament- og klinisk kjemisk parametre, genetiske varianter (fra biobank), og storstilet data-analyser ved bruk av en felles database. Disse ressursene brukes av en rekke samkjørte subprosjekter og utvidet til en felles overordnet paraplystudie, TOP studien, som ledes fra Oslo universitetssykehus HF i samarbeid med forskningsmiljøer ved Universitetet i Oslo. Det er også konkrete samarbeidsprosjekter med NTNU, St. Olavs Hospital, UiB, Haukeland universitetssykehus og Stavanger universitetssjukehus, samt en rekke internasjonale partnere innen genetiske forhold ved alvorlige psykiske lidelser. Så langt er ressurser brukt til storstilet undersøkelser av et stort antall pasienter. Det er samlet inn ca 2200 pasientprøver samt ca 570 kontroller i TOP biobanken, og det er en serie med studier publisert på dette materialet. Vi har fremskaffet nye resultater om kliniske og nevrokognitive aspekter, hjernefunksjon og strukturelle avvik (MRI) ved alvorlige psykiske lidelser. Gjennom samarbeid med utenlandske miljøer, har vi publisert en rekke arbeider omkring hjerneavbildnings- og molekylærgenetiske aspekter ved alvorlige psykiske lidelser. Miljømidlene brukes til å vedlikeholde infrastruktur for klinisk karakterisering, hjerneavbildning (MRI) og molekylærgenetiske analyser – tre sentrale metoder innen psykiatrisk translasjonsforskning. Det pågår en serie med doktorgradsprosjekter tilknyttet TOP forskergruppe – mange kliniske (flere tilknyttet gjennom Nettverket tidlige psykoser), i tillegg til stipendiater innen molekylærgenetikk og hjerneavbildning, foruten 7 postdoktorprosjekt. Alle disse prosjektene benytter infrastruktur og får veiledning fra TOP miljøet. Det ble avlagt syv doktorgrader i 2011. TOP gruppen er et ledende miljø i den nye nasjonale satsingen på alvorlige psykiske lidelser, samt aktive deltakere i nasjonale forskningsnettverk. TOP miljøet har pågående internasjonalt samarbeid innen kliniske studier, molekylærgenetikk og MRI analyser, basert på metodeutvikling og innsamlet materiale. TOP har nå et translasjonsmiljø innen forskning på alvorlige psykisk lidelser, stort fokus på forskerutdannelse, og vil i de neste årene videreutvikle miljøet, og spisse forskningen mot spesifikke aspekter og har igangsatt intervensjonsstudier. Doktorgrader: 7 Publikasjoner: 57 totalt PubMed (2011)
2010
TOP prosjektet har som mål å skaffe mer kunnskap om årsak og behandling ved alvorlige psykiske lidelser. Det er opprettet infrastruktur og ekspertise innen kliniske og nevrokognitiv aspekter, MRI-teknologi, biobank og database. Dette brukes av en serie forskningsprosjekter på mange sykehus i regionen, og vi samler inn et stort, velkarakterisert materiale.Alvorlige psykiske lidelser (schizofreni og bipolar lidelse) medfører stor lidelse, er vanskelige å behandle og legger beslag på store helseressurser. Sykdomsmekanismene er fremdeles ukjente, men arvelige faktorer spiller en viktig rolle. Forskningen hemmes av mangel på objektive kriterier og målbare parametre. Formålet med satsingen var å skaffe mer kunnskap om genetiske mekanismer for psykotiske lidelser i relasjon til miljøfaktorer. Vår strategi har vært å identifisere subgrupper av pasienter med spesifikke kliniske profiler (fenotyper) inklusive biomarkører og andre objektivt målbare størrelser, spesielt MRI-undersøkelser, og bruke disse fenotypene i genetiske analyser. Vi har opprettet en infrastruktur for klinisk undersøkelse og diagnostikk, nevrokognitiv testing, MRI-undersøkelser, medikament- og klinisk kjemisk analyser, biobank og en felles database. Disse ressursene har blitt brukt av en rekke samkjørte subprosjekter og utvidet til en felles overordnet paraplystudie, TOP studien, som ledes fra Oslo universitetssykehus i samarbeid med forskningsmiljøer ved Universitetet i Oslo og Nasjonalt folkehelseinstitutt. Det er også konkrete samarbeidsprosjekter med NTNU,St. Olavs Hospital, UiB,Haukeland universitetssykehus og Stavanger universitetssjukehus, samt en rekke internasjonale studier innen genetiske forhold ved alvorlige psykiske lidelser. Så langt er ressurser brukt til undersøkelser av et stort antall pasienter. Det er samlet inn ca 2000 pasientprøver i TOP biobanken, samt ca 550 kontroller. En serie med studier om kliniske og nevrokognitive aspekter er publisert. Miljømidlene brukes til å vedlikeholde klinisk infrastruktur og slagkraftig hjerneavbildningsmiljø, og gruppe for psykiatriske molekylærgenetiske analyser – tre viktige metoder innen psykiatrisk translasjonsforskning. Gjennom samarbeid med utenlandske miljøer, har TOP gruppenpublisert en rekke arbeider omkring hjerneavbildnings- og molekylærgenetiske aspekter ved alvorlige psykiske lidelser. Det pågår en serie med doktorgradsprosjekter tilknyttet TOPs metodeplattformer – for tiden 26 kliniske (hvorav 9 tilknyttet gjennom Nettverket tidlige psykoser), i tillegg til 5 innen molekylærgenetikk og 6 innen hjerneavbildning, foruten 6 postdoktorprosjekt på TOP materialet. Alle disse prosjektene benytter infrastruktur og får veiledning fra TOP miljøet. Det ble avlagt tre doktorgrader i 2010. TOP gruppen er et ledende miljø i den nye nasjonale satsingen på alvorlige psykiske lidelser, samt aktive deltakere i nasjonale forskningsnettverk. TOP miljøet har pågående internasjonalt samarbeid innen kliniske studier, molekylærgenetikk og MRI analyser, basert på metodeutvikling og innsamlet materiale. TOP har nå et translasjonsmiljø innen forskning på alvorlige psykisk lidelser, stort fokus på forskerutdannelse, og vil i de neste årene videreutvikle miljøet, og spisse forskningen mot spesifikke aspekter og igangsette intervensjonsstudier. PubMed publikasjoner 2010: 48 totalt
Vitenskapelige artikler
Mattingsdal Morten, Brown Andrew Anand, Djurovic Srdjan, Sønderby Ida Elken, Server Andres, Melle Ingrid, Agartz Ingrid, Hovig Eivind, Jensen Jimmy, Andreassen Ole A

Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways.

Neuroimage 2013 Apr 15;70():143-9. Epub 2012 des 27

PMID: 23274185

Langeveld Johannes, Andreassen Ole A, Auestad Bjørn, Færden Ann, Hauge Lars Johan, Joa Inge, Johannessen Jan Olav, Melle Ingrid, Rund Bjorn Rishovd, Røssberg Jan Ivar, Simonsen Erik, Vaglum Per, Larsen Tor Ketil

Is there an optimal factor structure of the Positive and Negative Syndrome Scale in patients with first-episode psychosis?

Scand J Psychol 2013 Apr;54(2):160-5. Epub 2012 des 18

PMID: 23252448

Dieset Ingrid, Djurovic Srdjan, Tesli Martin, Hope Sigrun, Mattingsdal Morten, Michelsen Annika, Joa Inge, Larsen Tor Ketil, Agartz Ingrid, Melle Ingrid, Røssberg Jan Ivar, Aukrust Pål, Andreassen Ole A, Ueland Thor

Up-regulation of NOTCH4 gene expression in bipolar disorder.

Am J Psychiatry 2012 Dec;169(12):1292-300.

PMID: 23212060

Peleikis D E, Varga M, Sundet K, Lorentzen S, Agartz I, Andreassen O A

Schizophrenia patients with and without post-traumatic stress disorder (PTSD) have different mood symptom levels but same cognitive functioning.

Acta Psychiatr Scand 2013 Jun;127(6):455-63. Epub 2012 nov 26

PMID: 23176609

Steinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S, Pietiläinen O P H, Lin K, Papiol S, Huttenlocher J, Sigurdsson E, Vassos E, Giegling I, Breuer R, Fraser G, Walker N, Melle I, Djurovic S, Agartz I, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Olsen L, Hansen T, Ingason A, Pirinen M, Strengman E, GROUP, Hougaard D M, Orntoft T, Didriksen M, Hollegaard M V, Nordentoft M, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Etain B, Bellivier F, Méary A, Schürhoff F, Szoke A, Ribolsi M, Magni V, Siracusano A, Sperling S, Rossner M, Christiansen C, Kiemeney L A, Franke B, van den Berg L H, Veldink J, Curran S, Bolton P, Poot M, Staal W, Rehnstrom K, Kilpinen H, Freitag C M, Meyer J, Magnusson P, Saemundsen E, Martsenkovsky I, Bikshaieva I, Martsenkovska I, Vashchenko O, Raleva M, Paketchieva K, Stefanovski B, Durmishi N, Pejovic Milovancevic M, Lecic Tosevski D, Silagadze T, Naneishvili N, Mikeladze N, Surguladze S, Vincent J B, Farmer A, Mitchell P B, Wright A, Schofield P R, Fullerton J M, Montgomery G W, Martin N G, Rubino I A, van Winkel R, Kenis G, De Hert M, Réthelyi J M, Bitter I, Terenius L, Jönsson E G, Bakker S, van Os J, Jablensky A, Leboyer M, Bramon E, Powell J, Murray R, Corvin A, Gill M, Morris D, O'Neill F A, Kendler K, Riley B, Wellcome Trust Case Control Consortium 2, Craddock N, Owen M J, O'Donovan M C, Thorsteinsdottir U, Kong A, Ehrenreich H, Carracedo A, Golimbet V, Andreassen O A, Børglum A D, Mors O, Mortensen P B, Werge T, Ophoff R A, Nöthen M M, Rietschel M, Cichon S, Ruggeri M, Tosato S, Palotie A, St Clair D, Rujescu D, Collier D A, Stefansson H, Stefansson K

Common variant at 16p11.2 conferring risk of psychosis.

Mol Psychiatry 2014 Jan;19(1):108-14. Epub 2012 nov 20

PMID: 23164818

Bratlien Unni, Øie Merete, Lien Lars, Agartz Ingrid, Lie Romm Kristin, Vaskinn Anja, Ueland Torill, Andreassen Ole A, Melle Ingrid

Social dysfunction in first-episode psychosis and relations to neurocognition, duration of untreated psychosis and clinical symptoms.

Psychiatry Res 2013 May 15;207(1-2):33-9. Epub 2012 nov 13

PMID: 23153893

Holmén Aina, Juuhl-Langseth Monica, Thormodsen Rune, Ueland Torill, Agartz Ingrid, Sundet Kjetil, Andreassen Ole A, Rund Bjørn Rishovd, Melle Ingrid

Executive function in early- and adult onset schizophrenia.

Schizophr Res 2012 Dec;142(1-3):177-82. Epub 2012 okt 25

PMID: 23102692

Saetre Peter, Grove Jakob, Børglum Anders D, Mors Ole, Werge Thomas, Andreassen Ole A, Vares Maria, Agartz Ingrid, Terenius Lars, Jönsson Erik G

Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age at onset of schizophrenia: no consistent evidence for an association in the Nordic population.

Am J Med Genet B Neuropsychiatr Genet 2012 Dec;159B(8):981-6. Epub 2012 okt 17

PMID: 23076983

Tandberg Marte, Sundet Kjetil, Andreassen Ole A, Melle Ingrid, Ueland Torill

Occupational functioning, symptoms and neurocognition in patients with psychotic disorders: investigating subgroups based on social security status.

Soc Psychiatry Psychiatr Epidemiol 2013 Jun;48(6):863-74. Epub 2012 okt 13

PMID: 23064396

Finseth Per I, Morken Gunnar, Andreassen Ole A, Malt Ulrik F, Vaaler Arne E

Risk factors related to lifetime suicide attempts in acutely admitted bipolar disorder inpatients.

Bipolar Disord 2012 Nov;14(7):727-34. Epub 2012 sep 21

PMID: 22998124

Desikan R S, McEvoy L K, Holland D, Thompson W K, Brewer J B, Aisen P S, Andreassen O A, Hyman B T, Sperling R A, Dale A M, Alzheimer's Disease Neuroimaging Initiative

Apolipoprotein E epsilon4 does not modulate amyloid-ß-associated neurodegeneration in preclinical Alzheimer disease.

AJNR Am J Neuroradiol 2013 Mar;34(3):505-10. Epub 2012 sep 13

PMID: 22976236

Engedal Knut, Brækhus Anne, Andreassen Ole A, Nakstad Per Hj

Diagnosis of dementia--automatic quantification of brain structures.

Tidsskr Nor Laegeforen 2012 Aug;132(15):1747-51.

PMID: 22929941

Ousdal Olga Therese, Anand Brown Andrew, Jensen Jimmy, Nakstad Per H, Melle Ingrid, Agartz Ingrid, Djurovic Srdjan, Bogdan Ryan, Hariri Ahmad R, Andreassen Ole A

Associations between variants near a monoaminergic pathways gene (PHOX2B) and amygdala reactivity: a genome-wide functional imaging study.

Twin Res Hum Genet 2012 Jun;15(3):273-85.

PMID: 22856363

Wirgenes K V, Sønderby I E, Haukvik U K, Mattingsdal M, Tesli M, Athanasiu L, Sundet K, Røssberg J I, Dale A M, Brown A A, Agartz I, Melle I, Djurovic S, Andreassen O A

TCF4 sequence variants and mRNA levels are associated with neurodevelopmental characteristics in psychotic disorders.

Transl Psychiatry 2012;2():e112. Epub 2012 mai 8

PMID: 22832956

Brown A A, Jensen J, Nikolova Y S, Djurovic S, Agartz I, Server A, Ferrell R E, Manuck S B, Mattingsdal M, Melle I, Hariri A R, Frigessi A, Andreassen O A

Genetic variants affecting the neural processing of human facial expressions: evidence using a genome-wide functional imaging approach.

Transl Psychiatry 2012;2():e143. Epub 2012 jul 24

PMID: 22828495

Dieset Ingrid, Hope Sigrun, Ueland Thor, Bjella Thomas, Agartz Ingrid, Melle Ingrid, Aukrust Pål, Røssberg Jan-Ivar, Andreassen Ole A

Cardiovascular risk factors during second generation antipsychotic treatment are associated with increased C-reactive protein.

Schizophr Res 2012 Sep;140(1-3):169-74. Epub 2012 jul 18

PMID: 22817875

Kähler Anna K, Rimol Lars M, Brown Andrew Anand, Djurovic Srdjan, Hartberg Cecilie B, Melle Ingrid, Dale Anders M, Andreassen Ole A, Agartz Ingrid

Effect of DISC1 SNPs on brain structure in healthy controls and patients with a history of psychosis.

Am J Med Genet B Neuropsychiatr Genet 2012 Sep;159B(6):722-30. Epub 2012 jul 19

PMID: 22815203

Jonsson Thorlakur, Atwal Jasvinder K, Steinberg Stacy, Snaedal Jon, Jonsson Palmi V, Bjornsson Sigurbjorn, Stefansson Hreinn, Sulem Patrick, Gudbjartsson Daniel, Maloney Janice, Hoyte Kwame, Gustafson Amy, Liu Yichin, Lu Yanmei, Bhangale Tushar, Graham Robert R, Huttenlocher Johanna, Bjornsdottir Gyda, Andreassen Ole A, Jönsson Erik G, Palotie Aarno, Behrens Timothy W, Magnusson Olafur T, Kong Augustine, Thorsteinsdottir Unnur, Watts Ryan J, Stefansson Kari

A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

Nature 2012 Aug;488(7409):96-9.

PMID: 22801501

Derks Eske M, Vorstman Jacob A S, Ripke Stephan, Kahn Rene S, eUtils.ItemsChoiceType2[], Ophoff Roel A

Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.

PLoS One 2012;7(6):e37852. Epub 2012 jun 22

PMID: 22761660

Bauer Michael, Glenn Tasha, Alda Martin, Andreassen Ole A, Ardau Raffaella, Bellivier Frank, Berk Michael, Bjella Thomas D, Bossini Letizia, Del Zompo Maria, Dodd Seetal, Fagiolini Andrea, Frye Mark A, Gonzalez-Pinto Ana, Henry Chantal, Kapczinski Flávio, Kliwicki Sebastian, König Barbara, Kunz Mauricio, Lafer Beny, Lopez-Jaramillo Carlos, Manchia Mirko, Marsh Wendy, Martinez-Cengotitabengoa Mónica, Melle Ingrid, Morken Gunnar, Munoz Rodrigo, Nery Fabiano G, O'Donovan Claire, Pfennig Andrea, Quiroz Danilo, Rasgon Natalie, Reif Andreas, Rybakowski Janusz, Sagduyu Kemal, Simhandl Christian, Torrent Carla, Vieta Eduard, Zetin Mark, Whybrow Peter C

Impact of sunlight on the age of onset of bipolar disorder.

Bipolar Disord 2012 Sep;14(6):654-63. Epub 2012 mai 21

PMID: 22612720

Lindholm Carlström Eva, Saetre Peter, Rosengren Anders, Thygesen Johan H, Djurovic Srdjan, Melle Ingrid, Andreassen Ole A, Werge Thomas, Agartz Ingrid, Hall Håkan, Terenius Lars, Jönsson Erik G

Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia.

Behav Brain Funct 2012;8():24. Epub 2012 mai 17

PMID: 22594806

Vassos Evangelos, Steinberg Stacy, Cichon Sven, Breen Gerome, Sigurdsson Engilbert, Andreassen Ole A, Djurovic Srdjan, Morken Gunnar, Grigoroiu-Serbanescu Maria, Diaconu Carmen C, Czerski Piotr M, Hauser Joanna, Babadjanova Gulja, Abramova Lilia I, Mühleisen Thomas W, Nöthen Markus M, Rietschel Marcella, McGuffin Peter, St Clair David, Gustafsson Omar, Melle Ingrid, Pietiläinen Olli P H, Ruggeri Mirella, Tosato Sarah, Werge Thomas, Ophoff Roel A, eUtils.ItemsChoiceType2[], Rujescu Dan, Børglum Anders D, Mors Ole, Mortensen Preben B, Demontis Ditte, Hollegaard Mads V, van Winkel Ruud, Kenis Gunter, De Hert Marc, Réthelyi János M, Bitter István, Rubino I Alex, Golimbet Vera, Kiemeney Lambertus A, van den Berg Leonard H, Franke Barbara, Jönsson Erik G, Farmer Anne, Stefansson Hreinn, Stefansson Kari, Collier David A

Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder.

Biol Psychiatry 2012 Oct;72(8):645-50. Epub 2012 mai 5

PMID: 22560537

Mork Erlend, Mehlum Lars, Barrett Elizabeth A, Agartz Ingrid, Harkavy-Friedman Jill M, Lorentzen Steinar, Melle Ingrid, Andreassen Ole A, Walby Fredrik A

Self-harm in patients with schizophrenia spectrum disorders.

Arch Suicide Res 2012;16(2):111-23.

PMID: 22551042

Ousdal Olga Therese, Reckless Greg E, Server Andres, Andreassen Ole A, Jensen Jimmy

Effect of relevance on amygdala activation and association with the ventral striatum.

Neuroimage 2012 Aug;62(1):95-101. Epub 2012 apr 23

PMID: 22546319

Håvik Bjarte, Degenhardt Franziska A, Johansson Stefan, Fernandes Carla P D, Hinney Anke, Scherag André, Lybæk Helle, Djurovic Srdjan, Christoforou Andrea, Ersland Kari M, Giddaluru Sudheer, O'Donovan Michael C, Owen Michael J, Craddock Nick, Mühleisen Thomas W, Mattheisen Manuel, Schimmelmann Benno G, Renner Tobias, Warnke Andreas, Herpertz-Dahlmann Beate, Sinzig Judith, Albayrak Özgür, Rietschel Marcella, Nöthen Markus M, Bramham Clive R, Werge Thomas, Hebebrand Johannes, Haavik Jan, Andreassen Ole A, Cichon Sven, Steen Vidar M, Le Hellard Stéphanie

DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder.

PLoS One 2012;7(4):e35424. Epub 2012 apr 23

PMID: 22539971

Keller Matthew C, Simonson Matthew A, Ripke Stephan, Neale Ben M, Gejman Pablo V, Howrigan Daniel P, Lee Sang Hong, Lencz Todd, Levinson Douglas F, Sullivan Patrick F, eUtils.ItemsChoiceType2[]

Runs of homozygosity implicate autozygosity as a schizophrenia risk factor.

PLoS Genet 2012;8(4):e1002656. Epub 2012 apr 12

PMID: 22511889

Bis Joshua C, DeCarli Charles, Smith Albert Vernon, van der Lijn Fedde, Crivello Fabrice, Fornage Myriam, Debette Stephanie, Shulman Joshua M, Schmidt Helena, Srikanth Velandai, Schuur Maaike, Yu Lei, Choi Seung-Hoan, Sigurdsson Sigurdur, Verhaaren Benjamin F J, DeStefano Anita L, Lambert Jean-Charles, Jack Clifford R, Struchalin Maksim, Stankovich Jim, Ibrahim-Verbaas Carla A, Fleischman Debra, Zijdenbos Alex, den Heijer Tom, Mazoyer Bernard, Coker Laura H, Enzinger Christian, Danoy Patrick, Amin Najaf, Arfanakis Konstantinos, van Buchem Mark A, de Bruijn Renée F A G, Beiser Alexa, Dufouil Carole, Huang Juebin, Cavalieri Margherita, Thomson Russell, Niessen Wiro J, Chibnik Lori B, Gislason Gauti K, Hofman Albert, Pikula Aleksandra, Amouyel Philippe, Freeman Kevin B, Phan Thanh G, Oostra Ben A, Stein Jason L, Medland Sarah E, Vasquez Alejandro Arias, Hibar Derrek P, Wright Margaret J, Franke Barbara, Martin Nicholas G, Thompson Paul M, eUtils.ItemsChoiceType2[], Nalls Michael A, Uitterlinden Andre G, Au Rhoda, Elbaz Alexis, Beare Richard J, van Swieten John C, Lopez Oscar L, Harris Tamara B, Chouraki Vincent, Breteler Monique M B, De Jager Philip L, Becker James T, Vernooij Meike W, Knopman David, Fazekas Franz, Wolf Philip A, van der Lugt Aad, Gudnason Vilmundur, Longstreth W T, Brown Matthew A, Bennett David A, van Duijn Cornelia M, Mosley Thomas H, Schmidt Reinhold, Tzourio Christophe, Launer Lenore J, Ikram M Arfan, Seshadri Sudha, eUtils.ItemsChoiceType2[]

Common variants at 12q14 and 12q24 are associated with hippocampal volume.

Nat Genet 2012 May;44(5):545-51. Epub 2012 apr 15

PMID: 22504421

Stein Jason L, Medland Sarah E, Vasquez Alejandro Arias, Hibar Derrek P, Senstad Rudy E, Winkler Anderson M, Toro Roberto, Appel Katja, Bartecek Richard, Bergmann Ørjan, Bernard Manon, Brown Andrew A, Cannon Dara M, Chakravarty M Mallar, Christoforou Andrea, Domin Martin, Grimm Oliver, Hollinshead Marisa, Holmes Avram J, Homuth Georg, Hottenga Jouke-Jan, Langan Camilla, Lopez Lorna M, Hansell Narelle K, Hwang Kristy S, Kim Sungeun, Laje Gonzalo, Lee Phil H, Liu Xinmin, Loth Eva, Lourdusamy Anbarasu, Mattingsdal Morten, Mohnke Sebastian, Maniega Susana Muñoz, Nho Kwangsik, Nugent Allison C, O'Brien Carol, Papmeyer Martina, Pütz Benno, Ramasamy Adaikalavan, Rasmussen Jerod, Rijpkema Mark, Risacher Shannon L, Roddey J Cooper, Rose Emma J, Ryten Mina, Shen Li, Sprooten Emma, Strengman Eric, Teumer Alexander, Trabzuni Daniah, Turner Jessica, van Eijk Kristel, van Erp Theo G M, van Tol Marie-Jose, Wittfeld Katharina, Wolf Christiane, Woudstra Saskia, Aleman Andre, Alhusaini Saud, Almasy Laura, Binder Elisabeth B, Brohawn David G, Cantor Rita M, Carless Melanie A, Corvin Aiden, Czisch Michael, Curran Joanne E, Davies Gail, de Almeida Marcio A A, Delanty Norman, Depondt Chantal, Duggirala Ravi, Dyer Thomas D, Erk Susanne, Fagerness Jesen, Fox Peter T, Freimer Nelson B, Gill Michael, Göring Harald H H, Hagler Donald J, Hoehn David, Holsboer Florian, Hoogman Martine, Hosten Norbert, Jahanshad Neda, Johnson Matthew P, Kasperaviciute Dalia, Kent Jack W, Kochunov Peter, Lancaster Jack L, Lawrie Stephen M, Liewald David C, Mandl René, Matarin Mar, Mattheisen Manuel, Meisenzahl Eva, Melle Ingrid, Moses Eric K, Mühleisen Thomas W, Nauck Matthias, Nöthen Markus M, Olvera Rene L, Pandolfo Massimo, Pike G Bruce, Puls Ralf, Reinvang Ivar, Rentería Miguel E, Rietschel Marcella, Roffman Joshua L, Royle Natalie A, Rujescu Dan, Savitz Jonathan, Schnack Hugo G, Schnell Knut, Seiferth Nina, Smith Colin, Steen Vidar M, Valdés Hernández Maria C, Van den Heuvel Martijn, van der Wee Nic J, Van Haren Neeltje E M, Veltman Joris A, Völzke Henry, Walker Robert, Westlye Lars T, Whelan Christopher D, Agartz Ingrid, Boomsma Dorret I, Cavalleri Gianpiero L, Dale Anders M, Djurovic Srdjan, Drevets Wayne C, Hagoort Peter, Hall Jeremy, Heinz Andreas, Jack Clifford R, Foroud Tatiana M, Le Hellard Stephanie, Macciardi Fabio, Montgomery Grant W, Poline Jean Baptiste, Porteous David J, Sisodiya Sanjay M, Starr John M, Sussmann Jessika, Toga Arthur W, Veltman Dick J, Walter Henrik, Weiner Michael W, eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], Bis Joshua C, Ikram M Arfan, Smith Albert V, Gudnason Vilmundur, Tzourio Christophe, Vernooij Meike W, Launer Lenore J, DeCarli Charles, Seshadri Sudha, eUtils.ItemsChoiceType2[], Andreassen Ole A, Apostolova Liana G, Bastin Mark E, Blangero John, Brunner Han G, Buckner Randy L, Cichon Sven, Coppola Giovanni, de Zubicaray Greig I, Deary Ian J, Donohoe Gary, de Geus Eco J C, Espeseth Thomas, Fernández Guillén, Glahn David C, Grabe Hans J, Hardy John, Hulshoff Pol Hilleke E, Jenkinson Mark, Kahn René S, McDonald Colm, McIntosh Andrew M, McMahon Francis J, McMahon Katie L, Meyer-Lindenberg Andreas, Morris Derek W, Müller-Myhsok Bertram, Nichols Thomas E, Ophoff Roel A, Paus Tomas, Pausova Zdenka, Penninx Brenda W, Potkin Steven G, Sämann Philipp G, Saykin Andrew J, Schumann Gunter, Smoller Jordan W, Wardlaw Joanna M, Weale Michael E, Martin Nicholas G, Franke Barbara, Wright Margaret J, Thompson Paul M, eUtils.ItemsChoiceType2[]

Identification of common variants associated with human hippocampal and intracranial volumes.

Nat Genet 2012 May;44(5):552-61. Epub 2012 apr 15

PMID: 22504417

Aas Monica, Steen Nils E, Agartz Ingrid, Aminoff Sofie R, Lorentzen Steinar, Sundet Kjetil, Andreassen Ole A, Melle Ingrid

Is cognitive impairment following early life stress in severe mental disorders based on specific or general cognitive functioning?

Psychiatry Res 2012 Aug;198(3):495-500. Epub 2012 apr 1

PMID: 22472845

Andreou Dimitrios, Saetre Peter, Werge Thomas, Andreassen Ole A, Agartz Ingrid, Sedvall Göran C, Hall Håkan, Terenius Lars, Jönsson Erik G

D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians.

Eur Arch Psychiatry Clin Neurosci 2012 Oct;262(7):549-56. Epub 2012 mar 28

PMID: 22454242

Athanasiu Lavinia, Brown Andrew A, Birkenaes Astrid B, Mattingsdal Morten, Agartz Ingrid, Melle Ingrid, Steen Vidar M, Andreassen Ole A, Djurovic Srdjan

Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study.

Psychiatry Res 2012 May;197(3):327-36. Epub 2012 mar 13

PMID: 22417934

Aminoff Sofie Ragnhild, Jensen Jimmy, Lagerberg Trine Vik, Hellvin Tone, Sundet Kjetil, Andreassen Ole A, Melle Ingrid

An association between affective lability and executive functioning in bipolar disorder.

Psychiatry Res 2012 Jun;198(1):58-61. Epub 2012 mar 9

PMID: 22405635

Ersland Kari M, Christoforou Andrea, Stansberg Christine, Espeseth Thomas, Mattheisen Manuel, Mattingsdal Morten, Hardarson Gudmundur A, Hansen Thomas, Fernandes Carla P D, Giddaluru Sudheer, Breuer René, Strohmaier Jana, Djurovic Srdjan, Nöthen Markus M, Rietschel Marcella, Lundervold Astri J, Werge Thomas, Cichon Sven, Andreassen Ole A, Reinvang Ivar, Steen Vidar M, Le Hellard Stephanie

Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders.

PLoS One 2012;7(2):e31687. Epub 2012 feb 22

PMID: 22384057

Bakken Trygve E, Roddey J Cooper, Djurovic Srdjan, Akshoomoff Natacha, Amaral David G, Bloss Cinnamon S, Casey B J, Chang Linda, Ernst Thomas M, Gruen Jeffrey R, Jernigan Terry L, Kaufmann Walter E, Kenet Tal, Kennedy David N, Kuperman Joshua M, Murray Sarah S, Sowell Elizabeth R, Rimol Lars M, Mattingsdal Morten, Melle Ingrid, Agartz Ingrid, Andreassen Ole A, Schork Nicholas J, Dale Anders M, eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], Weiner Michael, Aisen Paul, Petersen Ronald, Jack Clifford R, Jagust William, Trojanowki John Q, Toga Arthur W, Beckett Laurel, Green Robert C, Saykin Andrew J, Morris John, Liu Enchi, Montine Tom, Gamst Anthony, Thomas Ronald G, Donohue Michael, Walter Sarah, Gessert Devon, Sather Tamie, Harvey Danielle, Kornak John, Dale Anders, Bernstein Matthew, Felmlee Joel, Fox Nick, Thompson Paul, Schuff Norbert, Alexander Gene, DeCarli Charles, Bandy Dan, Koeppe Robert A, Foster Norm, Reiman Eric M, Chen Kewei, Mathis Chet, Cairns Nigel J, Taylor-Reinwald Lisa, Trojanowki J Q, Shaw Les, Lee Virginia M Y, Korecka Magdalena, Crawford Karen, Neu Scott, Foroud Tatiana M, Potkin Steven, Shen Li, Kachaturian Zaven, Frank Richard, Snyder Peter J, Molchan Susan, Kaye Jeffrey, Quinn Joseph, Lind Betty, Dolen Sara, Schneider Lon S, Pawluczyk Sonia, Spann Bryan M, Brewer James, Vanderswag Helen, Heidebrink Judith L, Lord Joanne L, Johnson Kris, Doody Rachelle S, Villanueva-Meyer Javier, Chowdhury Munir, Stern Yaakov, Honig Lawrence S, Bell Karen L, Morris John C, Ances Beau, Carroll Maria, Leon Sue, Mintun Mark A, Schneider Stacy, Marson Daniel, Griffith Randall, Clark David, Grossman Hillel, Mitsis Effie, Romirowsky Aliza, deToledo-Morrell Leyla, Shah Raj C, Duara Ranjan, Varon Daniel, Roberts Peggy, Albert Marilyn, Onyike Chiadi, Kielb Stephanie, Rusinek Henry, de Leon Mony J, Glodzik Lidia, De Santi Susan, Doraiswamy P Murali, Petrella Jeffrey R, Coleman R Edward, Arnold Steven E, Karlawish Jason H, Wolk David, Smith Charles D, Jicha Greg, Hardy Peter, Lopez Oscar L, Oakley MaryAnn, Simpson Donna M, Porsteinsson Anton P, Goldstein Bonnie S, Martin Kim, Makino Kelly M, Ismail M Saleem, Brand Connie, Mulnard Ruth A, Thai Gaby, Mc-Adams-Ortiz Catherine, Womack Kyle, Mathews Dana, Quiceno Mary, Diaz-Arrastia Ramon, King Richard, Weiner Myron, Martin-Cook Kristen, DeVous Michael, Levey Allan I, Lah James J, Cellar Janet S, Burns Jeffrey M, Anderson Heather S, Swerdlow Russell H, Apostolova Liana, Lu Po H, Bartzokis George, Silverman Daniel H S, Graff-Radford Neill R, Parfitt Francine, Johnson Heather, Farlow Martin R, Hake Ann Marie, Matthews Brandy R, Herring Scott, van Dyck Christopher H, Carson Richard E, MacAvoy Martha G, Chertkow Howard, Bergman Howard, Hosein Chris, Black Sandra, Stefanovic Bojana, Caldwell Curtis, eUtils.ItemsChoiceType2[], Hsiung Robin, Feldman Howard, Mudge Benita, Assaly Michele, Kertesz Andrew, Rogers John, Trost Dick, Bernick Charles, Munic Donna, Kerwin Diana, Mesulam Marek-Marsel, Lipowski Kristina, Wu Chuang-Kuo, Johnson Nancy, Sadowsky Carl, Martinez Walter, Villena Teresa, Turner Raymond Scott, Johnson Kathleen, Reynolds Brigid, Sperling Reisa A, Johnson Keith A, Marshall Gad, Frey Meghan, Yesavage Jerome, Taylor Joy L, Lane Barton, Rosen Allyson, Tinklenberg Jared, Sabbagh Marwan, Belden Christine, Jacobson Sandra, Kowall Neil, Killiany Ronald, Budson Andrew E, Norbash Alexander, Johnson Patricia Lynn, Obisesan Thomas O, Wolday Saba, Bwayo Salome K, Lerner Alan, Hudson Leon, Ogrocki Paula, Fletcher Evan, Carmichael Owen, Olichney John, Kittur Smita, Borrie Michael, Lee T-Y, Bartha Rob, Johnson Sterling, Asthana Sanjay, Carlsson Cynthia M, Potkin Steven G, Preda Adrian, Nguyen Dana, Tariot Pierre, Fleisher Adam, Reeder Stephanie, Bates Vernice, Capote Horacio, Rainka Michelle, Scharre Douglas W, Kataki Maria, Zimmerman Earl A, Celmins Dzintra, Brown Alice D, Pearlson Godfrey D, Blank Karen, Anderson Karen, Santulli Robert B, Schwartz Eben S, Sink Kaycee M, Williamson Jeff D, Garg Pradeep, Watkins Franklin, Ott Brian R, Querfurth Henry, Tremont Geoffrey, Salloway Stephen, Malloy Paul, Correia Stephen, Rosen Howard J, Miller Bruce L, Mintzer Jacobo, Longmire Crystal Flynn, Spicer Kenneth, Finger Elizabether, Rachinsky Irina, Drost Dick, Jernigan Terry, McCabe Connor, Grant Ellen, Ernst Thomas, Kuperman Josh, Chung Yoon, Murray Sarah, Bloss Cinnamon, Darst Burcu, Pritchett Lexi, Saito Ashley, Amaral David, DiNino Mishaela, Eyngorina Bella, Sowell Elizabeth, Houston Suzanne, Soderberg Lindsay, Kaufmann Walter, van Zijl Peter, Rizzo-Busack Hilda, Javid Mohsin, Mehta Natasha, Ruberry Erika, Powers Alisa, Rosen Bruce, Gebhard Nitzah, Manigan Holly, Frazier Jean, Kennedy David, Yakutis Lauren, Hill Michael, Gruen Jeffrey, Bosson-Heenan Joan, Carlson Heatherly

Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.

Proc Natl Acad Sci U S A 2012 Mar;109(10):3985-90. Epub 2012 feb 16

PMID: 22343285

Tandberg Marte, Ueland Torill, Andreassen Ole A, Sundet Kjetil, Melle Ingrid

Factors associated with occupational and academic status in patients with first-episode psychosis with a particular focus on neurocognition.

Soc Psychiatry Psychiatr Epidemiol 2012 Nov;47(11):1763-73. Epub 2012 feb 7

PMID: 22310699

Rimol Lars M, Nesvåg Ragnar, Hagler Don J, Bergmann Orjan, Fennema-Notestine Christine, Hartberg Cecilie B, Haukvik Unn K, Lange Elisabeth, Pung Chris J, Server Andres, Melle Ingrid, Andreassen Ole A, Agartz Ingrid, Dale Anders M

Cortical volume, surface area, and thickness in schizophrenia and bipolar disorder.

Biol Psychiatry 2012 Mar;71(6):552-60. Epub 2012 jan 26

PMID: 22281121

Jönsson Erik G, Saetre Peter, Nyholm Helena, Djurovic Srdjan, Melle Ingrid, Andreassen Ole A, Skjødt Celina, Thygesen Johan H, Werge Thomas, Hall Håkan, Agartz Ingrid, Terenius Lars

Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia.

Psychiatr Genet 2012 Oct;22(5):263-4.

PMID: 22157635

Haug Elisabeth, Øie Merete, Melle Ingrid, Andreassen Ole A, Raballo Andrea, Bratlien Unni, Lien Lars, Møller Paul

The association between self-disorders and neurocognitive dysfunction in schizophrenia.

Schizophr Res 2012 Mar;135(1-3):79-83. Epub 2011 des 3

PMID: 22137461

Leblanc Marissa, Kulle Bettina, Sundet Kjetil, Agartz Ingrid, Melle Ingrid, Djurovic Srdjan, Frigessi Arnoldo, Andreassen Ole A

Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function.

J Psychiatr Res 2012 Feb;46(2):271-8. Epub 2011 nov 29

PMID: 22126837

Elvsåshagen Torbjørn, Moberget Torgeir, Bøen Erlend, Boye Birgitte, Englin Nils O A, Pedersen Per Ø, Andreassen Ole A, Dietrichs Espen, Malt Ulrik F, Andersson Stein

Evidence for impaired neocortical synaptic plasticity in bipolar II disorder.

Biol Psychiatry 2012 Jan;71(1):68-74. Epub 2011 okt 29

PMID: 22036034

Aas Monica, Djurovic Srdjan, Athanasiu Lavinia, Steen Nils Eiel, Agartz Ingrid, Lorentzen Steinar, Sundet Kjetil, Andreassen Ole A, Melle Ingrid

Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders.

Schizophr Bull 2012 Jan;38(1):15-22. Epub 2011 sep 9

PMID: 21908796

Haug Elisabeth, Melle Ingrid, Andreassen Ole A, Raballo Andrea, Bratlien Unni, Øie Merete, Lien Lars, Møller Paul

The association between anomalous self-experience and suicidality in first-episode schizophrenia seems mediated by depression.

Compr Psychiatry 2012 Jul;53(5):456-60. Epub 2011 aug 25

PMID: 21871617

Sullivan P, eUtils.ItemsChoiceType2[]

Don't give up on GWAS.

Mol Psychiatry 2012 Jan;17(1):2-3. Epub 2011 aug 9

PMID: 21826059

Romm Kristin Lie, Melle Ingrid, Thoresen Christian, Andreassen Ole A, Rossberg Jan Ivar

Severe social anxiety in early psychosis is associated with poor premorbid functioning, depression, and reduced quality of life.

Compr Psychiatry 2012 Jul;53(5):434-40. Epub 2011 aug 6

PMID: 21821242

Rietschel M, Mattheisen M, Degenhardt F, eUtils.ItemsChoiceType2[], Mühleisen T W, Kirsch P, Esslinger C, Herms S, Demontis D, Steffens M, Strohmaier J, Haenisch B, Breuer R, Czerski P M, Giegling I, Strengman E, Schmael C, Mors O, Mortensen P B, Hougaard D M, Ørntoft T, Kapelski P, Priebe L, Basmanav F F, Forstner A J, Hoffman P, Meier S, Nikitopoulos J, Moebus S, Alexander M, Mössner R, Wichmann H -E, Schreiber S, Rivandeneira F, Hofman A, Uitterlinden A G, Wienker T F, Schumacher J, Hauser J, Maier W, Cantor R M, Erk S, Schulze T G, eUtils.ItemsChoiceType2[], Craddock N, Owen M J, O'Donovan M C, Børglum A D, Rujescu D, Walter H, Meyer-Lindenberg A, Nöthen N M, Ophoff R A, Cichon S

Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe.

Mol Psychiatry 2012 Sep;17(9):906-17. Epub 2011 jul 12

PMID: 21747397

Holtze Maria, Saetre Peter, Engberg Göran, Schwieler Lilly, Werge Thomas, Andreassen Ole A, Hall Håkan, Terenius Lars, Agartz Ingrid, Jönsson Erik G, Schalling Martin, Erhardt Sophie

Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.

J Psychiatry Neurosci 2012 Jan;37(1):53-7.

PMID: 21693093

Mellerup Erling, Andreassen Ole, Bennike Bente, Dam Henrik, Durovic Srdjan, Hansen Thomas, Melle Ingrid, Møller Gert Lykke, Mors Ole, Koefoed Pernille

Connection between genetic and clinical data in bipolar disorder.

PLoS One 2012;7(9):e44623. Epub 2012 sep 20

PMID: 23028568

Fountoulakis Konstantinos N, Kasper Siegfried, Andreassen Ole, Blier Pierre, Okasha Ahmed, Severus Emanuel, Versiani Marcio, Tandon Rajiv, Möller Hans-Jürgen, Vieta Eduard

Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry.

Eur Arch Psychiatry Clin Neurosci 2012 Jun;262 Suppl 1():1-48.

PMID: 22622948

Juuhl-Langseth Monica, Rimol Lars M, Rasmussen Inge A, Thormodsen Rune, Holmén Aina, Emblem Kyrre E, Due-Tønnessen Paulina, Rund Bjørn Rishovd, Agartz Ingrid

Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities.

Psychiatry Res 2012 Jul;203(1):14-23. Epub 2012 aug 21

PMID: 22917502

Haahr Ulrik, Simonsen Erik, Røssberg Jan Ivar, Johannessen Jan Olav, Larsen T K, Melle Ingrid, Opjordsmoen Stein, Rund Bjørn Rishovd, Vaglum Per, Friis Svein, McGlashan Thomas

Patient satisfaction with treatment in first-episode psychosis.

Nord J Psychiatry 2012 Oct;66(5):329-35. Epub 2012 jan 18

PMID: 22250962

Evensen Julie, Røssberg Jan Ivar, Barder Helene, Haahr Ulrik, Hegelstad Wenche Ten Velden, Joa Inge, Johannessen Jan Olav, Larsen T K, Melle Ingrid, Opjordsmoen Stein, Rund Bjørn Rishovd, Simonsen Erik, Sundet Kjetil, Vaglum Per, Friis Svein, McGlashan Thomas

Apathy in first episode psychosis patients: a ten year longitudinal follow-up study.

Schizophr Res 2012 Apr;136(1-3):19-24. Epub 2012 jan 27

PMID: 22285655

Hegelstad Wenche Ten Velden, Larsen Tor K, Auestad Bjørn, Evensen Julie, Haahr Ulrik, Joa Inge, Johannesen Jan O, Langeveld Johannes, Melle Ingrid, Opjordsmoen Stein, Rossberg Jan Ivar, Rund Bjørn Rishovd, Simonsen Erik, Sundet Kjetil, Vaglum Per, Friis Svein, McGlashan Thomas

Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome.

Am J Psychiatry 2012 Apr;169(4):374-80.

PMID: 22407080

Holmén Aina, Juuhl-Langseth Monica, Thormodsen Rune, Sundet Kjetil, Melle Ingrid, Rund Bjørn Rishovd

Executive function tests in early-onset psychosis: which one to choose?

Scand J Psychol 2012 Jun;53(3):200-5. Epub 2012 mar 15

PMID: 22416819

Evensen Julie, Røssberg Jan Ivar, Barder Helene, Haahr Ulrik, Hegelstad Wenche Ten Velden, Joa Inge, Johannessen Jan Olav, Larsen T K, Melle Ingrid, Opjordsmoen Stein, Rund Bjørn Rishovd, Simonsen Erik, Vaglum Per, McGlashan Thomas, Friis Svein

Flat affect and social functioning: a 10 year follow-up study of first episode psychosis patients.

Schizophr Res 2012 Aug;139(1-3):99-104. Epub 2012 mai 23

PMID: 22627124

Friis Svein, Barder Helene, Evensen Julie Horgen, Haahr Ulrik, Hegelstad Wenche Ten Velden, Joa Inge, Johannessen Jan Olav, Langeveld Johannes, Larsen Tor K, Melle Ingrid, Opjordsmoen Stein, Rund Bjørn Rishovd, Røssberg Jan Ivar, Simonsen Erik, Sundet Kjetil, Vaglum Per, McGlashan Thomas

The TIPS study and bias: replies to Dr Amos.

Aust N Z J Psychiatry 2012 Sep;46(9):905-7.

PMID: 22956571

Haukvik U K, Schaer M, Nesvåg R, McNeil T, Hartberg C B, Jönsson E G, Eliez S, Agartz I

Cortical folding in Broca's area relates to obstetric complications in schizophrenia patients and healthy controls.

Psychol Med 2012 Jun;42(6):1329-37. Epub 2011 okt 26

PMID: 22029970

Espeseth Thomas, Christoforou Andrea, Lundervold Astri J, Steen Vidar M, Le Hellard Stephanie, Reinvang Ivar

Imaging and cognitive genetics: the Norwegian Cognitive NeuroGenetics sample.

Twin Res Hum Genet 2012 Jun;15(3):442-52.

PMID: 22856377

Saetre Peter, Vares Maria, Werge Thomas, Andreassen Ole A, Arinami Tadao, Ishiguro Hiroki, Nanko Shinichiro, Tan Ene Choo, Han Doug Hyun, Roffman Joshua L, Muntjewerff Jan-Willem, Jagodzinski Pawel P, Kempisty Bartosz, Hauser Joanna, Vilella Elisabet, Betcheva Elitza, Nakamura Yusuke, Regland Björn, Agartz Ingrid, Hall Håkan, Terenius Lars, Jönsson Erik G

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: A combined analysis of independent samples.

Am J Med Genet B Neuropsychiatr Genet 2011 Jan. Epub 2011 jan 13

PMID: 21234904

Lagerberg Trine V, Sundet Kjetil, Aminoff Sofie R, Berg Akiah O, Ringen Petter A, Andreassen Ole A, Melle Ingrid

Excessive cannabis use is associated with earlier age at onset in bipolar disorder.

Eur Arch Psychiatry Clin Neurosci 2011 Sep;261(6):397-405. Epub 2011 jan 26

PMID: 21267743

Johannessen Jan Olav, Joa Inge, Auestad Bjørn, Haahr Ulrik, Larsen Tor K, Melle Ingrid, Opjordsmoen Stein, Simonsen Per, Rund Bjørn R, Simonsen Erik, Vaglum Per, Friis Svein, McGlashan Thomas

First-episode psychosis patients recruited into treatment via early detection teams versus ordinary pathways: course and health service use during 5 years.

Early Interv Psychiatry 2011 Feb;5(1):70-5. Epub 2010 aug 13

PMID: 21272278

Barrett Elizabeth A, Sundet Kjetil, Simonsen Carmen, Agartz Ingrid, Lorentzen Steinar, Mehlum Lars, Mork Erlend, Andreassen Ole A, Melle Ingrid

Neurocognitive functioning and suicidality in schizophrenia spectrum disorders.

Compr Psychiatry 2011 Mar-Apr;52(2):156-63. Epub 2010 jul 29

PMID: 21295222

Andreou Dimitrios, Saetre Peter, Kähler Anna K, Werge Thomas, Andreassen Ole A, Agartz Ingrid, Sedvall Göran C, Hall Håkan, Terenius Lars, Jönsson Erik G

Dystrobrevin-binding protein 1 gene (DTNBP1) variants associated with cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentrations in healthy volunteers.

Eur Neuropsychopharmacol 2011 Sep;21(9):700-4. Epub 2011 feb 4

PMID: 21295953

Evensen Julie, Røssberg Jan Ivar, Haahr Ulrik, Ten Velden Hegelstad Wenche, Joa Inge, Johannessen Jan Olav, Langeveld Hans, Larsen T K, Melle Ingrid, Opjordsmoen Stein, Rund Bjørn Rishovd, Simonsen Erik, Sundet Kjetil, Vaglum Per, Friis Svein, McGlashan Thomas

Contrasting monosymptomatic patients with hallucinations and delusions in first-episode psychosis patients: a five-year longitudinal follow-up study.

Psychopathology 2011;44(2):90-7. Epub 2011 jan 13

PMID: 21228615

van Schijndel Jessica E, van Zweeden Martine, van Loo Karen M J, Djurovic Srdjan, Andreassen Ole A, Hansen Thomas, Werge Thomas, Nyegaard Mette, Sørensen Karina Meden, Nordentoft Merete, Mortensen Preben B, Mors Ole, Børglum Anders D, Del-Favero Jurgen, Norrback Karl-Fredrik, Adolfsson Rolf, De Hert Marc, Claes Stephan, Cichon Sven, Rietschel Marcella, Nöthen Markus M, Kallunki Pekka, Pedersen Jan T, Martens Gerard J M

Dual association of a TRKA polymorphism with schizophrenia.

Psychiatr Genet 2011 Jun;21(3):125-31.

PMID: 21317683

Ingason Andrés, Kirov George, Giegling Ina, Hansen Thomas, Isles Anthony R, Jakobsen Klaus D, Kristinsson Kari T, le Roux Louise, Gustafsson Omar, Craddock Nick, Möller Hans-Jürgen, McQuillin Andrew, Muglia Pierandrea, Cichon Sven, Rietschel Marcella, Ophoff Roel A, Djurovic Srdjan, Andreassen Ole A, Pietiläinen Olli P H, Peltonen Leena, Dempster Emma, Collier David A, St Clair David, Rasmussen Henrik B, Glenthøj Birte Y, Kiemeney Lambertus A, Franke Barbara, Tosato Sarah, Bonetto Chiara, Saemundsen Evald, Hreidarsson Stefán J, PubMed.ItemsChoiceType2[], Nöthen Markus M, Gurling Hugh, O'Donovan Michael C, Owen Michael J, Sigurdsson Engilbert, Petursson Hannes, Stefansson Hreinn, Rujescu Dan, Stefansson Kari, Werge Thomas

Maternally derived microduplications at 15q11-q13: implication of imprinted genes in psychotic illness.

Am J Psychiatry 2011 Apr;168(4):408-17. Epub 2011 feb 15

PMID: 21324950

Johansen Ragnhild, Hestad Knut, Iversen Valentina C, Agartz Ingrid, Sundet Kjetil, Andreassen Ole A, Melle Ingrid

Cognitive and clinical factors are associated with service engagement in early-phase schizophrenia spectrum disorders.

J Nerv Ment Dis 2011 Mar;199(3):176-82.

PMID: 21346488

Steen Nils Eiel, Methlie Paal, Lorentzen Steinar, Hope Sigrun, Barrett Elizabeth A, Larsson Sara, Mork Erlend, Almås Bjørg, Løvås Kristian, Agartz Ingrid, Melle Ingrid, Berg Jens P, Andreassen Ole A

Increased systemic cortisol metabolism in patients with schizophrenia and bipolar disorder: a mechanism for increased stress vulnerability?

J Clin Psychiatry 2011 Nov;72(11):1515-21. Epub 2011 feb 8

PMID: 21367348

Engh John A, Sundet Kjetil, Simonsen Carmen, Vaskinn Anja, Lagerberg Trine V, Opjordsmoen Stein, Friis Svein, Andreassen Ole A

Verbal learning contributes to cognitive insight in schizophrenia independently of affective and psychotic symptoms.

Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun;35(4):1059-63. Epub 2011 mar 15

PMID: 21392553

Hansen Thomas, Ingason Andrés, Djurovic Srdjan, Melle Ingrid, Fenger Mogens, Gustafsson Omar, Jakobsen Klaus D, Rasmussen Henrik B, Tosato Sarah, Rietschel Marcella, Frank Josef, Owen Mike, Bonetto Chiara, Suvisaari Jaana, Thygesen Johan Hilge, Pétursson Hannes, Lönnqvist Jouko, Sigurdsson Engilbert, Giegling Ina, Craddock Nick, O'Donovan Michael C, Ruggeri Mirella, Cichon Sven, Ophoff Roel A, Pietiläinen Olli, Peltonen Leena, Nöthen Markus M, Rujescu Dan, St Clair David, Collier David A, Andreassen Ole A, Werge Thomas

At-risk variant in TCF7L2 for type II diabetes increases risk of schizophrenia.

Biol Psychiatry 2011 Jul;70(1):59-63. Epub 2011 mar 16

PMID: 21414605

Steen Nils Eiel, Lorentzen Steinar, Barrett Elizabeth A, Lagerberg Trine V, Hope Sigrun, Larsson Sara, Berg Akiah O, Agartz Ingrid, Melle Ingrid, Berg Jens P, Andreassen Ole A

Sex-specific cortisol levels in bipolar disorder and schizophrenia during mental challenge--relationship to clinical characteristics and medication.

Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun;35(4):1100-7. Epub 2011 mar 21

PMID: 21420462

Håvik Bjarte, Le Hellard Stephanie, Rietschel Marcella, Lybæk Helle, Djurovic Srdjan, Mattheisen Manuel, Mühleisen Thomas W, Degenhardt Franziska, Priebe Lutz, Maier Wolfgang, Breuer Rene, Schulze Thomas G, Agartz Ingrid, Melle Ingrid, Hansen Thomas, Bramham Clive R, Nöthen Markus M, Stevens Beth, Werge Thomas, Andreassen Ole A, Cichon Sven, Steen Vidar M

The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia.

Biol Psychiatry 2011 Jul;70(1):35-42. Epub 2011 mar 24

PMID: 21439553

Schoeyen Helle K, Vaaler Arne E, Auestad Bjoern H, Malt Ulrik F, Melle Ingrid, Andreassen Ole A, Morken Gunnar

Despite clinical differences, bipolar disorder patients from acute wards and outpatient clinics have similar educational and disability levels compared to the general population.

J Affect Disord 2011 Jul;132(1-2):209-15. Epub 2011 mar 25

PMID: 21440307

Olsen Line, Hansen Thomas, Djurovic Srdjan, Haastrup Eva, Albrecthsen Anders, Hoeffding Louise K E, Secher Anna, Gustafsson Omar, Jakobsen Klaus D, Nielsen Finn C, Ullum Henrik, Morken Gunnar, Agartz Ingrid, Melle Ingrid, Gether Ulrik, Andreassen Ole A, Werge Thomas

Copy number variations in affective disorders and meta-analysis.

Psychiatr Genet 2011 Dec;21(6):319-22.

PMID: 21451435

Hartberg Cecilie B, Sundet Kjetil, Rimol Lars M, Haukvik Unn K, Lange Elisabeth H, Nesvåg Ragnar, Melle Ingrid, Andreassen Ole A, Agartz Ingrid

Subcortical brain volumes relate to neurocognition in schizophrenia and bipolar disorder and healthy controls.

Prog Neuropsychopharmacol Biol Psychiatry 2011 Jun;35(4):1122-30. Epub 2011 mar 30

PMID: 21457744

Vaskinn Anja, Sundet Kjetil, Simonsen Carmen, Hellvin Tone, Melle Ingrid, Andreassen Ole A

Sex differences in neuropsychological performance and social functioning in schizophrenia and bipolar disorder.

Neuropsychology 2011 Jul;25(4):499-510.

PMID: 21463042

Pers Tune H, Hansen Niclas Tue, Lage Kasper, Koefoed Pernille, Dworzynski Piotr, Miller Martin Lee, Flint Tracey J, Mellerup Erling, Dam Henrik, Andreassen Ole A, Djurovic Srdjan, Melle Ingrid, Børglum Anders D, Werge Thomas, Purcell Shaun, Ferreira Manuel A, Kouskoumvekaki Irene, Workman Christopher T, Hansen Torben, Mors Ole, Brunak Søren

Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes.

Genet Epidemiol 2011 Jul;35(5):318-32. Epub 2011 apr 11

PMID: 21484861

Agartz Ingrid, Brown Andrew Anand, Rimol Lars M, Hartberg Cecilie B, Dale Anders M, Melle Ingrid, Djurovic Srdjan, Andreassen Ole A

Common sequence variants in the major histocompatibility complex region associate with cerebral ventricular size in schizophrenia.

Biol Psychiatry 2011 Oct;70(7):696-8. Epub 2011 apr 22

PMID: 21514568

Tandberg Marte, Ueland Torill, Sundet Kjetil, Haahr Ulrik, Joa Inge, Johannessen Jan Olav, Larsen Tor Ketil, Opjordsmoen Stein, Rund Bjørn Rishovd, Røssberg Jan Ivar, Simonsen Erik, Vaglum Per, Melle Ingrid, Friis Svein, McGlashan Thomas

Neurocognition and occupational functioning in patients with first-episode psychosis: a 2-year follow-up study.

Psychiatry Res 2011 Aug;188(3):334-42. Epub 2011 mai 14

PMID: 21575993

Caprini Sara, Saetre Peter, Melle Ingrid, Djurovic Srdjan, Andreassen Ole A, Skjødt Celina, Duong Linh, Werge Thomas, Hall Hakan, Agartz Ingrid, Terenius Lars, Jönsson Erik G

Lack of association between two dopamine D2 receptor gene polymorphisms and schizophrenia.

Psychiatr Genet 2011 Aug;21(4):214-5.

PMID: 21712758

Steinberg Stacy, de Jong Simone, PubMed.ItemsChoiceType2[], Andreassen Ole A, Werge Thomas, Børglum Anders D, Mors Ole, Mortensen Preben B, Gustafsson Omar, Costas Javier, Pietiläinen Olli P H, Demontis Ditte, Papiol Sergi, Huttenlocher Johanna, Mattheisen Manuel, Breuer René, Vassos Evangelos, Giegling Ina, Fraser Gillian, Walker Nicholas, Tuulio-Henriksson Annamari, Suvisaari Jaana, Lönnqvist Jouko, Paunio Tiina, Agartz Ingrid, Melle Ingrid, Djurovic Srdjan, Strengman Eric, PubMed.ItemsChoiceType2[], Jürgens Gesche, Glenthøj Birte, Terenius Lars, Hougaard David M, Ørntoft Torben, Wiuf Carsten, Didriksen Michael, Hollegaard Mads V, Nordentoft Merete, van Winkel Ruud, Kenis Gunter, Abramova Lilia, Kaleda Vasily, Arrojo Manuel, Sanjuán Julio, Arango Celso, Sperling Swetlana, Rossner Moritz, Ribolsi Michele, Magni Valentina, Siracusano Alberto, Christiansen Claus, Kiemeney Lambertus A, Veldink Jan, van den Berg Leonard, Ingason Andres, Muglia Pierandrea, Murray Robin, Nöthen Markus M, Sigurdsson Engilbert, Petursson Hannes, Thorsteinsdottir Unnur, Kong Augustine, Rubino I Alex, De Hert Marc, Réthelyi János M, Bitter István, Jönsson Erik G, Golimbet Vera, Carracedo Angel, Ehrenreich Hannelore, Craddock Nick, Owen Michael J, O'Donovan Michael C, PubMed.ItemsChoiceType2[], Ruggeri Mirella, Tosato Sarah, Peltonen Leena, Ophoff Roel A, Collier David A, St Clair David, Rietschel Marcella, Cichon Sven, Stefansson Hreinn, Rujescu Dan, Stefansson Kari

Common variants at VRK2 and TCF4 conferring risk of schizophrenia.

Hum Mol Genet 2011 Oct;20(20):4076-81. Epub 2011 jul 26

PMID: 21791550

Bakken Trygve E, Bloss Cinnamon S, Roddey J Cooper, Joyner Alexander H, Rimol Lars M, Djurovic Srdjan, Melle Ingrid, Sundet Kjetil, Agartz Ingrid, Andreassen Ole A, Dale Anders M, Schork Nicholas J

Association of genetic variants on 15q12 with cortical thickness and cognition in schizophrenia.

Arch Gen Psychiatry 2011 Aug;68(8):781-90.

PMID: 21810643

Bolstad Albert, Andreassen Ole A, Røssberg Jan I, Agartz Ingrid, Melle Ingrid, Tanum Lars

Previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia.

BMC Psychiatry 2011;11():126. Epub 2011 aug 3

PMID: 21812996

Humphreys Keith, Grankvist Alexander, Leu Monica, Hall Per, Liu Jianjun, Ripatti Samuli, Rehnström Karola, Groop Leif, Klareskog Lars, Ding Bo, Grönberg Henrik, Xu Jianfeng, Pedersen Nancy L, Lichtenstein Paul, Mattingsdal Morten, Andreassen Ole A, O'Dushlaine Colm, Purcell Shaun M, Sklar Pamela, Sullivan Patrick F, Hultman Christina M, Palmgren Juni, Magnusson Patrik K E

The genetic structure of the Swedish population.

PLoS One 2011;6(8):e22547. Epub 2011 aug 4

PMID: 21829632

Romm Kristin Lie, Rossberg Jan Ivar, Hansen Charlotte Fredslund, Haug Elisabeth, Andreassen Ole A, Melle Ingrid

Self-esteem is associated with premorbid adjustment and positive psychotic symptoms in early psychosis.

BMC Psychiatry 2011;11():136. Epub 2011 aug 19

PMID: 21854599

Møller Paul, Haug Elisabeth, Raballo Andrea, Parnas Josef, Melle Ingrid

Examination of anomalous self-experience in first-episode psychosis: interrater reliability.

Psychopathology 2011;44(6):386-90. Epub 2011 aug 17

PMID: 21847006

Elvsåshagen Torbjørn, Vera Elsa, Bøen Erlend, Bratlie Jorunn, Andreassen Ole A, Josefsen Dag, Malt Ulrik F, Blasco Maria A, Boye Birgitte

The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder.

J Affect Disord 2011 Dec;135(1-3):43-50. Epub 2011 aug 30

PMID: 21880373

Koefoed Pernille, Andreassen Ole A, Bennike Bente, Dam Henrik, Djurovic Srdjan, Hansen Thomas, Jorgensen Martin Balslev, Kessing Lars Vedel, Melle Ingrid, Møller Gert Lykke, Mors Ole, Werge Thomas, Mellerup Erling

Combinations of SNPs related to signal transduction in bipolar disorder.

PLoS One 2011;6(8):e23812. Epub 2011 aug 29

PMID: 21897858

Hope Sigrun, Dieset Ingrid, Agartz Ingrid, Steen Nils E, Ueland Thor, Melle Ingrid, Aukrust Pål, Andreassen Ole A

Affective symptoms are associated with markers of inflammation and immune activation in bipolar disorders but not in schizophrenia.

J Psychiatr Res 2011 Dec;45(12):1608-16. Epub 2011 sep 1

PMID: 21889167

Sklar Pamela, Ripke Stephan, Scott Laura J, Andreassen Ole A, Cichon Sven, Craddock Nick, Edenberg Howard J, Nurnberger John I, Rietschel Marcella, Blackwood Douglas, Corvin Aiden, Flickinger Matthew, Guan Weihua, Mattingsdal Morten, McQuillin Andrew, Kwan Phoenix, Wienker Thomas F, Daly Mark, Dudbridge Frank, Holmans Peter A, Lin Danyu, Burmeister Margit, Greenwood Tiffany A, Hamshere Marian L, Muglia Pierandrea, Smith Erin N, Zandi Peter P, Nievergelt Caroline M, McKinney Rebecca, Shilling Paul D, Schork Nicholas J, Bloss Cinnamon S, Foroud Tatiana, Koller Daniel L, Gershon Elliot S, Liu Chunyu, Badner Judith A, Scheftner William A, Lawson William B, Nwulia Evaristus A, Hipolito Maria, Coryell William, Rice John, Byerley William, McMahon Francis J, Schulze Thomas G, Berrettini Wade, Lohoff Falk W, Potash James B, Mahon Pamela B, McInnis Melvin G, Zöllner Sebastian, Zhang Peng, Craig David W, Szelinger Szabocls, Barrett Thomas B, Breuer René, Meier Sandra, Strohmaier Jana, Witt Stephanie H, Tozzi Federica, Farmer Anne, McGuffin Peter, Strauss John, Xu Wei, Kennedy James L, Vincent John B, Matthews Keith, Day Richard, Ferreira Manuel A, O'Dushlaine Colm, Perlis Roy, Raychaudhuri Soumya, Ruderfer Douglas, Hyoun Phil L, Smoller Jordan W, Li Jun, Absher Devin, Thompson Robert C, Meng Fan Guo, Schatzberg Alan F, Bunney William E, Barchas Jack D, Jones Edward G, Watson Stanley J, Myers Richard M, Akil Huda, Boehnke Michael, Chambert Kim, Moran Jennifer, Scolnick Ed, Djurovic Srdjan, Melle Ingrid, Morken Gunnar, Gill Michael, Morris Derek, Quinn Emma, Mühleisen Thomas W, Degenhardt Franziska A, Mattheisen Manuel, Schumacher Johannes, Maier Wolfgang, Steffens Michael, Propping Peter, Nöthen Markus M, Anjorin Adebayo, Bass Nick, Gurling Hugh, Kandaswamy Radhika, Lawrence Jacob, McGhee Kevin, McIntosh Andrew, McLean Alan W, Muir Walter J, Pickard Benjamin S, Breen Gerome, St Clair David, Caesar Sian, Gordon-Smith Katherine, Jones Lisa, Fraser Christine, Green Elaine K, Grozeva Detelina, Jones Ian R, Kirov George, Moskvina Valentina, Nikolov Ivan, O'Donovan Michael C, Owen Michael J, Collier David A, Elkin Amanda, Williamson Richard, Young Allan H, Ferrier I Nicol, Stefansson Kari, Stefansson Hreinn, Thornorgeirsson Thornorgeir, Steinberg Stacy, Gustafsson Omar, Bergen Sarah E, Nimgaonkar Vishwajit, Hultman Christina, Landén Mikael, Lichtenstein Paul, Sullivan Patrick, Schalling Martin, Osby Urban, Backlund Lena, Frisén Louise, Langstrom Niklas, Jamain Stéphane, Leboyer Marion, Etain Bruno, Bellivier Frank, Petursson Hannes, Sigur Sson Engilbert, Müller-Mysok Bertram, Lucae Susanne, Schwarz Markus, Schofield Peter R, Martin Nick, Montgomery Grant W, Lathrop Mark, Oskarsson Högni, Bauer Michael, Wright Adam, Mitchell Philip B, Hautzinger Martin, Reif Andreas, Kelsoe John R, Purcell Shaun M, PubMed.ItemsChoiceType2[]

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

Nat Genet 2011 Oct;43(10):977-83. Epub 2011 sep 18

PMID: 21926972

Ripke Stephan, Sanders Alan R, Kendler Kenneth S, Levinson Douglas F, Sklar Pamela, Holmans Peter A, Lin Dan-Yu, Duan Jubao, Ophoff Roel A, Andreassen Ole A, Scolnick Edward, Cichon Sven, St Clair David, Corvin Aiden, Gurling Hugh, Werge Thomas, Rujescu Dan, Blackwood Douglas H R, Pato Carlos N, Malhotra Anil K, Purcell Shaun, Dudbridge Frank, Neale Benjamin M, Rossin Lizzy, Visscher Peter M, Posthuma Danielle, Ruderfer Douglas M, Fanous Ayman, Stefansson Hreinn, Steinberg Stacy, Mowry Bryan J, Golimbet Vera, De Hert Marc, Jönsson Erik G, Bitter István, Pietiläinen Olli P H, Collier David A, Tosato Sarah, Agartz Ingrid, Albus Margot, Alexander Madeline, Amdur Richard L, Amin Farooq, Bass Nicholas, Bergen Sarah E, Black Donald W, Børglum Anders D, Brown Matthew A, Bruggeman Richard, Buccola Nancy G, Byerley William F, Cahn Wiepke, Cantor Rita M, Carr Vaughan J, Catts Stanley V, Choudhury Khalid, Cloninger C Robert, Cormican Paul, Craddock Nicholas, Danoy Patrick A, Datta Susmita, de Haan Lieuwe, Demontis Ditte, Dikeos Dimitris, Djurovic Srdjan, Donnelly Peter, Donohoe Gary, Duong Linh, Dwyer Sarah, Fink-Jensen Anders, Freedman Robert, Freimer Nelson B, Friedl Marion, Georgieva Lyudmila, Giegling Ina, Gill Michael, Glenthøj Birte, Godard Stephanie, Hamshere Marian, Hansen Mark, Hansen Thomas, Hartmann Annette M, Henskens Frans A, Hougaard David M, Hultman Christina M, Ingason Andrés, Jablensky Assen V, Jakobsen Klaus D, Jay Maurice, Jürgens Gesche, Kahn René S, Keller Matthew C, Kenis Gunter, Kenny Elaine, Kim Yunjung, Kirov George K, Konnerth Heike, Konte Bettina, Krabbendam Lydia, Krasucki Robert, Lasseter Virginia K, Laurent Claudine, Lawrence Jacob, Lencz Todd, Lerer F Bernard, Liang Kung-Yee, Lichtenstein Paul, Lieberman Jeffrey A, Linszen Don H, Lönnqvist Jouko, Loughland Carmel M, Maclean Alan W, Maher Brion S, Maier Wolfgang, Mallet Jacques, Malloy Pat, Mattheisen Manuel, Mattingsdal Morten, McGhee Kevin A, McGrath John J, McIntosh Andrew, McLean Duncan E, McQuillin Andrew, Melle Ingrid, Michie Patricia T, Milanova Vihra, Morris Derek W, Mors Ole, Mortensen Preben B, Moskvina Valentina, Muglia Pierandrea, Myin-Germeys Inez, Nertney Deborah A, Nestadt Gerald, Nielsen Jimmi, Nikolov Ivan, Nordentoft Merete, Norton Nadine, Nöthen Markus M, O'Dushlaine Colm T, Olincy Ann, Olsen Line, O'Neill F Anthony, Orntoft Torben F, Owen Michael J, Pantelis Christos, Papadimitriou George, Pato Michele T, Peltonen Leena, Petursson Hannes, Pickard Ben, Pimm Jonathan, Pulver Ann E, Puri Vinay, Quested Digby, Quinn Emma M, Rasmussen Henrik B, Réthelyi János M, Ribble Robert, Rietschel Marcella, Riley Brien P, Ruggeri Mirella, Schall Ulrich, Schulze Thomas G, Schwab Sibylle G, Scott Rodney J, Shi Jianxin, Sigurdsson Engilbert, Silverman Jeremy M, Spencer Chris C A, Stefansson Kari, Strange Amy, Strengman Eric, Stroup T Scott, Suvisaari Jaana, Terenius Lars, Thirumalai Srinivasa, Thygesen Johan H, Timm Sally, Toncheva Draga, van den Oord Edwin, van Os Jim, van Winkel Ruud, Veldink Jan, Walsh Dermot, Wang August G, Wiersma Durk, Wildenauer Dieter B, Williams Hywel J, Williams Nigel M, Wormley Brandon, Zammit Stan, Sullivan Patrick F, O'Donovan Michael C, Daly Mark J, Gejman Pablo V, PubMed.ItemsChoiceType2[]

Genome-wide association study identifies five new schizophrenia loci.

Nat Genet 2011 Oct;43(10):969-76. Epub 2011 sep 18

PMID: 21926974

Jacquemont Sébastien, Reymond Alexandre, Zufferey Flore, Harewood Louise, Walters Robin G, Kutalik Zoltán, Martinet Danielle, Shen Yiping, Valsesia Armand, Beckmann Noam D, Thorleifsson Gudmar, Belfiore Marco, Bouquillon Sonia, Campion Dominique, de Leeuw Nicole, de Vries Bert B A, Esko Tõnu, Fernandez Bridget A, Fernández-Aranda Fernando, Fernández-Real José Manuel, Gratacòs Mònica, Guilmatre Audrey, Hoyer Juliane, Jarvelin Marjo-Riitta, Kooy R Frank, Kurg Ants, Le Caignec Cédric, Männik Katrin, Platt Orah S, Sanlaville Damien, Van Haelst Mieke M, Villatoro Gomez Sergi, Walha Faida, Wu Bai-Lin, Yu Yongguo, Aboura Azzedine, Addor Marie-Claude, Alembik Yves, Antonarakis Stylianos E, Arveiler Benoît, Barth Magalie, Bednarek Nathalie, Béna Frédérique, Bergmann Sven, Beri Mylène, Bernardini Laura, Blaumeiser Bettina, Bonneau Dominique, Bottani Armand, Boute Odile, Brunner Han G, Cailley Dorothée, Callier Patrick, Chiesa Jean, Chrast Jacqueline, Coin Lachlan, Coutton Charles, Cuisset Jean-Marie, Cuvellier Jean-Christophe, David Albert, de Freminville Bénédicte, Delobel Bruno, Delrue Marie-Ange, Demeer Bénédicte, Descamps Dominique, Didelot Gérard, Dieterich Klaus, Disciglio Vittoria, Doco-Fenzy Martine, Drunat Séverine, Duban-Bedu Bénédicte, Dubourg Christèle, El-Sayed Moustafa Julia S, Elliott Paul, Faas Brigitte H W, Faivre Laurence, Faudet Anne, Fellmann Florence, Ferrarini Alessandra, Fisher Richard, Flori Elisabeth, Forer Lukas, Gaillard Dominique, Gerard Marion, Gieger Christian, Gimelli Stefania, Gimelli Giorgio, Grabe Hans J, Guichet Agnès, Guillin Olivier, Hartikainen Anna-Liisa, Heron Délphine, Hippolyte Loyse, Holder Muriel, Homuth Georg, Isidor Bertrand, Jaillard Sylvie, Jaros Zdenek, Jiménez-Murcia Susana, Helas Géraldine Joly, Jonveaux Philippe, Kaksonen Satu, Keren Boris, Kloss-Brandstätter Anita, Knoers Nine V A M, Koolen David A, Kroisel Peter M, Kronenberg Florian, Labalme Audrey, Landais Emilie, Lapi Elisabetta, Layet Valérie, Legallic Solenn, Leheup Bruno, Leube Barbara, Lewis Suzanne, Lucas Josette, MacDermot Kay D, Magnusson Pall, Marshall Christian, Mathieu-Dramard Michèle, McCarthy Mark I, Meitinger Thomas, Mencarelli Maria Antonietta, Merla Giuseppe, Moerman Alexandre, Mooser Vincent, Morice-Picard Fanny, Mucciolo Mafalda, Nauck Matthias, Ndiaye Ndeye Coumba, Nordgren Ann, Pasquier Laurent, Petit Florence, Pfundt Rolph, Plessis Ghislaine, Rajcan-Separovic Evica, Ramelli Gian Paolo, Rauch Anita, Ravazzolo Roberto, Reis Andre, Renieri Alessandra, Richart Cristobal, Ried Janina S, Rieubland Claudine, Roberts Wendy, Roetzer Katharina M, Rooryck Caroline, Rossi Massimiliano, Saemundsen Evald, Satre Véronique, Schurmann Claudia, Sigurdsson Engilbert, Stavropoulos Dimitri J, Stefansson Hreinn, Tengström Carola, Thorsteinsdóttir Unnur, Tinahones Francisco J, Touraine Renaud, Vallée Louis, van Binsbergen Ellen, Van der Aa Nathalie, Vincent-Delorme Catherine, Visvikis-Siest Sophie, Vollenweider Peter, Völzke Henry, Vulto-van Silfhout Anneke T, Waeber Gérard, Wallgren-Pettersson Carina, Witwicki Robert M, Zwolinksi Simon, Andrieux Joris, Estivill Xavier, Gusella James F, Gustafsson Omar, Metspalu Andres, Scherer Stephen W, Stefansson Kari, Blakemore Alexandra I F, Beckmann Jacques S, Froguel Philippe

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus.

Nature 2011 Oct;478(7367):97-102. Epub 2011 aug 31

PMID: 21881559

Tesli Martin, Koefoed Pernille, Athanasiu Lavinia, Mattingsdal Morten, Gustafsson Omar, Agartz Ingrid, Rimol Lars M, Brown Andrew, Wirgenes Katrine V, Smorr Lisa-Lena, Kähler Anna K, Werge Thomas, Mors Ole, Mellerup Erling, Jönsson Erik G, Melle Ingrid, Morken Gunnar, Djurovic Srdjan, Andreassen Ole A

Association analysis of ANK3 gene variants in nordic bipolar disorder and schizophrenia case-control samples.

Am J Med Genet B Neuropsychiatr Genet 2011 Dec;156B(8):969-74. Epub 2011 okt 3

PMID: 21972176

Sulem Patrick, Gudbjartsson Daniel F, Walters G Bragi, Helgadottir Hafdis T, Helgason Agnar, Gudjonsson Sigurjon A, Zanon Carlo, Besenbacher Soren, Bjornsdottir Gyda, Magnusson Olafur T, Magnusson Gisli, Hjartarson Eirikur, Saemundsdottir Jona, Gylfason Arnaldur, Jonasdottir Adalbjorg, Holm Hilma, Karason Ari, Rafnar Thorunn, Stefansson Hreinn, Andreassen Ole A, Pedersen Jesper H, Pack Allan I, de Visser Marieke C H, Kiemeney Lambertus A, Geirsson Arni J, Eyjolfsson Gudmundur I, Olafsson Isleifur, Kong Augustine, Masson Gisli, Jonsson Helgi, Thorsteinsdottir Unnur, Jonsdottir Ingileif, Stefansson Kari

Identification of low-frequency variants associated with gout and serum uric acid levels.

Nat Genet 2011 Nov;43(11):1127-30. Epub 2011 okt 9

PMID: 21983786

Hartberg C B, Sundet K, Rimol L M, Haukvik U K, Lange E H, Nesvåg R, Dale A M, Melle I, Andreassen O A, Agartz I

Brain cortical thickness and surface area correlates of neurocognitive performance in patients with schizophrenia, bipolar disorder, and healthy adults.

J Int Neuropsychol Soc 2011 Nov;17(6):1080-93. Epub 2011 okt 3

PMID: 22013998

Thormodsen Rune, Jensen Jimmy, Holmèn Aina, Juuhl-Langseth Monica, Emblem Kyrre Eeg, Andreassen Ole Andreas, Rund Bjørn Rishovd

Prefrontal hyperactivation during a working memory task in early-onset schizophrenia spectrum disorders: an fMRI study.

Psychiatry Res 2011 Dec;194(3):257-62. Epub 2011 nov 12

PMID: 22079661

Berg Akiah O, Melle Ingrid, Rossberg Jan Ivar, Romm Kristin Lie, Larsson Sara, Lagerberg Trine V, Andreassen Ole A, Hauff Edvard

Perceived discrimination is associated with severity of positive and depression/anxiety symptoms in immigrants with psychosis: a cross-sectional study.

BMC Psychiatry 2011;11():77. Epub 2011 mai 6

PMID: 21548949

Romm K L, Rossberg J I, Berg A O, Hansen C F, Andreassen O A, Melle I

Assessment of social anxiety in first episode psychosis using the Liebowitz Social Anxiety scale as a self-report measure.

Eur Psychiatry 2011 Mar;26(2):115-21. Epub 2010 okt 30

PMID: 21036553

Holtze Maria, Saetre Peter, Erhardt Sophie, Schwieler Lilly, Werge Thomas, Hansen Thomas, Nielsen Jimmi, Djurovic Srdjan, Melle Ingrid, Andreassen Ole A, Hall Håkan, Terenius Lars, Agartz Ingrid, Engberg Göran, Jönsson Erik G, Schalling Martin

Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: an association study.

Schizophr Res 2011 Apr;127(1-3):270-2. Epub 2010 okt 27

PMID: 21030213

Kähler Anna K, Djurovic Srdjan, Rimol Lars M, Brown Andrew Anand, Athanasiu Lavinia, Jönsson Erik G, Hansen Thomas, Gústafsson Omar, Hall Håkan, Giegling Ina, Muglia Pierandrea, Cichon Sven, Rietschel Marcella, Pietiläinen Olli P H, Peltonen Leena, Bramon Elvira, Collier David, St Clair David, Sigurdsson Engilbert, Petursson Hannes, Rujescu Dan, Melle Ingrid, Werge Thomas, Steen Vidar M, Dale Anders M, Matthews Russell T, Agartz Ingrid, Andreassen Ole A

Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.

Biol Psychiatry 2011 Jan;69(1):90-6. Epub 2010 okt 15

PMID: 20950796

Chen X, Lee G, Maher B S, Fanous A H, Chen J, Zhao Z, Guo A, van den Oord E, Sullivan P F, Shi J, Levinson D F, Gejman P V, Sanders A, Duan J, Owen M J, Craddock N J, O'Donovan M C, Blackman J, Lewis D, Kirov G K, Qin W, Schwab S, Wildenauer D, Chowdari K, Nimgaonkar V, Straub R E, Weinberger D R, O'Neill F A, Walsh D, Bronstein M, Darvasi A, Lencz T, Malhotra A K, Rujescu D, Giegling I, Werge T, Hansen T, Ingason A, Nöethen M M, Rietschel M, Cichon S, Djurovic S, Andreassen O A, Cantor R M, Ophoff R, Corvin A, Morris D W, Gill M, Pato C N, Pato M T, Macedo A, Gurling H M D, McQuillin A, Pimm J, Hultman C, Lichtenstein P, Sklar P, Purcell S M, Scolnick E, St Clair D, Blackwood D H R, Kendler K S, PubMed.ItemsChoiceType2[], PubMed.ItemsChoiceType2[]

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.

Mol Psychiatry 2011 Nov;16(11):1117-29. Epub 2010 sep 14

PMID: 20838396

Schoeyen Helle K, Birkenaes Astrid B, Vaaler Arne E, Auestad Bjoern H, Malt Ulrik F, Andreassen Ole A, Morken Gunnar

Bipolar disorder patients have similar levels of education but lower socio-economic status than the general population.

J Affect Disord 2011 Mar;129(1-3):68-74. Epub 2010 sep 15

PMID: 20832866

Aminoff Sofie R, Jensen Jimmy, Lagerberg Trine V, Andreassen Ole A, Melle Ingrid

Decreased self-reported arousal in schizophrenia during aversive picture viewing compared to bipolar disorder and healthy controls.

Psychiatry Res 2011 Feb;185(3):309-14. Epub 2010 aug 17

PMID: 20724003

Saetre Peter, Vares Maria, Werge Thomas, Andreassen Ole A, Arinami Tadao, Ishiguro Hiroki, Nanko Shinichiro, Tan Ene Choo, Han Doug Hyun, Roffman Joshua L, Muntjewerff Jan-Willem, Jagodzinski Pawel P, Kempisty Bartosz, Hauser Joanna, Vilella Elisabet, Betcheva Elitza, Nakamura Yusuke, Regland Björn, Agartz Ingrid, Hall Håkan, Terenius Lars, Jönsson Erik G

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples.

Am J Med Genet B Neuropsychiatr Genet 2011 Mar;156(2):215-24. Epub 2011 jan 13

PMID: 21302350

PubMed.ItemsChoiceType2[], Nalls Michael A, Plagnol Vincent, Hernandez Dena G, Sharma Manu, Sheerin Una-Marie, Saad Mohamad, Simón-Sánchez J, Schulte Claudia, Lesage Suzanne, Sveinbjörnsdóttir Sigurlaug, Stefánsson Kári, Martinez Maria, Hardy John, Heutink Peter, Brice Alexis, Gasser Thomas, Singleton Andrew B, Wood Nicholas W

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

Lancet 2011 Feb;377(9766):641-9. Epub 2011 feb 1

PMID: 21292315

PubMed.ItemsChoiceType2[], PubMed.ItemsChoiceType2[]

A two-stage meta-analysis identifies several new loci for Parkinson's disease.

PLoS Genet 2011 Jun;7(6):e1002142. Epub 2011 jun 30

PMID: 21738488

Yu Yi, Bhangale Tushar R, Fagerness Jesen, Ripke Stephan, Thorleifsson Gudmar, Tan Perciliz L, Souied Eric H, Richardson Andrea J, Merriam Joanna E, Buitendijk Gabriëlle H S, Reynolds Robyn, Raychaudhuri Soumya, Chin Kimberly A, Sobrin Lucia, Evangelou Evangelos, Lee Phil H, Lee Aaron Y, Leveziel Nicolas, Zack Donald J, Campochiaro Betsy, Campochiaro Peter, Smith R Theodore, Barile Gaetano R, Guymer Robyn H, Hogg Ruth, Chakravarthy Usha, Robman Luba D, Gustafsson Omar, Sigurdsson Haraldur, Ortmann Ward, Behrens Timothy W, Stefansson Kari, Uitterlinden André G, van Duijn Cornelia M, Vingerling Johannes R, Klaver Caroline C W, Allikmets Rando, Brantley Milam A, Baird Paul N, Katsanis Nicholas, Thorsteinsdottir Unnur, Ioannidis John P A, Daly Mark J, Graham Robert R, Seddon Johanna M

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.

Hum Mol Genet 2011 Sep;20(18):3699-709. Epub 2011 jun 10

PMID: 21665990

Walhovd Kristine B, Westlye Lars T, Amlien Inge, Espeseth Thomas, Reinvang Ivar, Raz Naftali, Agartz Ingrid, Salat David H, Greve Doug N, Fischl Bruce, Dale Anders M, Fjell Anders M

Consistent neuroanatomical age-related volume differences across multiple samples.

Neurobiol Aging 2011 May;32(5):916-32. Epub 2009 jun 30

PMID: 19570593

Faerden Ann, Finset Arnstein, Friis Svein, Agartz Ingrid, Barrett Elizabeth Ann, Nesvåg Ragnar, Andreassen Ole A, Marder Stephen R, Melle Ingrid

Apathy in first episode psychosis patients: one year follow up.

Schizophr Res 2010 Jan;116(1):20-6.

PMID: 19948392

Ingason Andrés, Giegling Ina, Cichon Sven, Hansen Thomas, Rasmussen Henrik B, Nielsen Jimmi, Jürgens Gesche, Muglia Pierandrea, Hartmann Annette M, Strengman Eric, Vasilescu Catalina, Mühleisen Thomas W, Djurovic Srdjan, Melle Ingrid, Lerer Bernard, Möller Hans-Jürgen, Francks Clyde, Pietiläinen Olli P H, Lonnqvist Jouko, Suvisaari Jaana, Tuulio-Henriksson Annamari, Walshe Muriel, Vassos Evangelos, Di Forti Marta, Murray Robin, Bonetto Chiara, Tosato Sarah, PubMed.ItemsChoiceType2[], Cantor Rita M, Rietschel Marcella, Craddock Nick, Owen Michael J, Peltonen Leena, Andreassen Ole A, Nöthen Markus M, St Clair David, Ophoff Roel A, O'Donovan Michael C, Collier David A, Werge Thomas, Rujescu Dan

A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.

Hum Mol Genet 2010 Apr;19(7):1379-86. Epub 2010 jan 12

PMID: 20071346

Rimol Lars M, Agartz Ingrid, Djurovic Srdjan, Brown Andrew A, Roddey J Cooper, Kähler Anna K, Mattingsdal Morten, Athanasiu Lavinia, Joyner Alexander H, Schork Nicholas J, Halgren Eric, Sundet Kjetil, Melle Ingrid, Dale Anders M, Andreassen Ole A, PubMed.ItemsChoiceType2[]

Sex-dependent association of common variants of microcephaly genes with brain structure.

Proc Natl Acad Sci U S A 2010 Jan;107(1):384-8. Epub 2009 des 22

PMID: 20080800

Lagerberg Trine V, Andreassen Ole A, Ringen Petter A, Berg Akiah O, Larsson Sara, Agartz Ingrid, Sundet Kjetil, Melle Ingrid

Excessive substance use in bipolar disorder is associated with impaired functioning rather than clinical characteristics, a descriptive study.

BMC Psychiatry 2010;10():9. Epub 2010 jan 27

PMID: 20105311

Romm Kristin Lie, Rossberg Jan Ivar, Berg Akiah Ottesen, Barrett Elizabeth Ann, Faerden Ann, Agartz Ingrid, Andreassen Ole A, Melle Ingrid

Depression and depressive symptoms in first episode psychosis.

J Nerv Ment Dis 2010 Jan;198(1):67-71.

PMID: 20061872

Opjordsmoen S, Friis S, Melle I, Haahr U, Johannessen J O, Larsen T K, Røssberg J I, Rund B R, Simonsen E, Vaglum P, McGlashan T H

A 2-year follow-up of involuntary admission's influence upon adherence and outcome in first-episode psychosis.

Acta Psychiatr Scand 2010 May;121(5):371-6. Epub 2010 jan 19

PMID: 20085554

Nesvåg Ragnar, Lange Elisabeth H, Faerden Ann, Barrett Elizabeth Ann, Emilsson Björn, Ringen Petter Andreas, Andreassen Ole A, Melle Ingrid, Agartz Ingrid

The use of screening instruments for detecting alcohol and other drug use disorders in first-episode psychosis.

Psychiatry Res 2010 May;177(1-2):228-34. Epub 2010 feb 23

PMID: 20178887

Haukvik Unn Kristin, Agartz Ingrid

[Do obstetric complications increase the risk of schizophrenia?].

Tidsskr Nor Laegeforen 2010 Feb;130(3):270-2.

PMID: 20160770

Athanasiu Lavinia, Mattingsdal Morten, Kähler Anna K, Brown Andrew, Gustafsson Omar, Agartz Ingrid, Giegling Ina, Muglia Pierandrea, Cichon Sven, Rietschel Marcella, Pietiläinen Olli P H, Peltonen Leena, Bramon Elvira, Collier David, Clair David St, Sigurdsson Engilbert, Petursson Hannes, Rujescu Dan, Melle Ingrid, Steen Vidar M, Djurovic Srdjan, Andreassen Ole A

Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.

J Psychiatr Res 2010 Sep;44(12):748-53. Epub 2010 feb 24

PMID: 20185149

Rimol Lars M, Panizzon Matthew S, Fennema-Notestine Christine, Eyler Lisa T, Fischl Bruce, Franz Carol E, Hagler Donald J, Lyons Michael J, Neale Michael C, Pacheco Jennifer, Perry Michele E, Schmitt J Eric, Grant Michael D, Seidman Larry J, Thermenos Heidi W, Tsuang Ming T, Eisen Seth A, Kremen William S, Dale Anders M

Cortical thickness is influenced by regionally specific genetic factors.

Biol Psychiatry 2010 Mar;67(5):493-9. Epub 2009 des 6

PMID: 19963208

Haukvik Unn Kristin, McNeil Thomas, Nesvåg Ragnar, Söderman Erik, Jönsson Erik, Agartz Ingrid

No effect of obstetric complications on basal ganglia volumes in schizophrenia.

Prog Neuropsychopharmacol Biol Psychiatry 2010 May;34(4):619-23. Epub 2010 mar 1

PMID: 20193725

Haatveit Beathe C, Sundet Kjetil, Hugdahl Kenneth, Ueland Torill, Melle Ingrid, Andreassen Ole A

The validity of d prime as a working memory index: results from the "Bergen n-back task".

J Clin Exp Neuropsychol 2010 Oct;32(8):871-80. Epub 2010 apr 9

PMID: 20383801

Barrett Elizabeth A, Sundet Kjetil, Faerden Ann, Nesvåg Ragnar, Agartz Ingrid, Fosse Roar, Mork Erlend, Steen Nils Eiel, Andreassen Ole A, Melle Ingrid

Suicidality before and in the early phases of first episode psychosis.

Schizophr Res 2010 Jun;119(1-3):11-7.

PMID: 20399077

Berg Akiah Ottesen, Melle Ingrid, Torjesen Peter A, Lien Lars, Hauff Edvard, Andreassen Ole A

A cross-sectional study of vitamin D deficiency among immigrants and Norwegians with psychosis compared to the general population.

J Clin Psychiatry 2010 Dec;71(12):1598-604. Epub 2010 apr 6

PMID: 20441728

Djurovic Srdjan, Gustafsson Omar, Mattingsdal Morten, Athanasiu Lavinia, Bjella Thomas, Tesli Martin, Agartz Ingrid, Lorentzen Steinar, Melle Ingrid, Morken Gunnar, Andreassen Ole A

A genome-wide association study of bipolar disorder in Norwegian individuals, followed by replication in Icelandic sample.

J Affect Disord 2010 Oct;126(1-2):312-6. Epub 2010 mai 7

PMID: 20451256

Melle Ingrid, Johannessen Jan Olav, Friis Svein, Haahr Ulrik, Joa Inge, Larsen Tor K, Opjordsmoen Stein, Rund Bjørn R, Simonsen Erik, Vaglum Per, McGlashan Thomas

Course and predictors of suicidality over the first two years of treatment in first-episode schizophrenia spectrum psychosis.

Arch Suicide Res 2010 Apr;14(2):158-70.

PMID: 20455151

Hartberg Cecilie Bhandari, Lawyer Glenn, Nyman Håkan, Jönsson Erik G, Haukvik Unn K, Saetre Peter, Bjerkan Petr S, Andreassen Ole A, Hall Håkan, Agartz Ingrid

Investigating relationships between cortical thickness and cognitive performance in patients with schizophrenia and healthy adults.

Psychiatry Res 2010 May;182(2):123-33. Epub 2010 apr 24

PMID: 20456929

Rossberg Jan Ivar, Johannessen J O, Klungsoyr O, Opjordsmoen S, Evensen J, Fjell A, Haahr U, Joa I, Langeveld J, Larsen T K, Melle I, Rund B R, Simonsen E, ten Velden W, Vaglum P, Friis S, McGlashan T

Are multi family groups appropriate for patients with first episode psychosis? A 5-year naturalistic follow-up study.

Acta Psychiatr Scand 2010 Nov;122(5):384-94.

PMID: 20491714

Simonsen Carmen, Sundet Kjetil, Vaskinn Anja, Ueland Torill, Romm Kristin Lie, Hellvin Tone, Melle Ingrid, Friis Svein, Andreassen Ole A

Psychosocial function in schizophrenia and bipolar disorder: Relationship to neurocognition and clinical symptoms.

J Int Neuropsychol Soc 2010 Sep;16(5):771-83. Epub 2010 mai 28

PMID: 20509984

Jónsdóttir Halldóra, Opjordsmoen Stein, Birkenaes Astrid B, Engh John A, Ringen Petter Andreas, Vaskinn Anja, Aamo Trond O, Friis Svein, Andreassen Ole A

Medication adherence in outpatients with severe mental disorders: relation between self-reports and serum level.

J Clin Psychopharmacol 2010 Apr;30(2):169-75.

PMID: 20520290

Hope Sigrun, Melle Ingrid, Aukrust Pål, Agartz Ingrid, Lorentzen Steinar, Steen Nils Eiel, Djurovic Srdjan, Ueland Thor, Andreassen Ole A

Osteoprotegerin levels in patients with severe mental disorders.

J Psychiatry Neurosci 2010 Sep;35(5):304-10.

PMID: 20569643

Andreou Dimitrios, Saetre Peter, Werge Thomas, Andreassen Ole A, Agartz Ingrid, Sedvall Göran C, Hall Håkan, Terenius Lars, Jönsson Erik G

Tryptophan hydroxylase gene 1 (TPH1) variants associated with cerebrospinal fluid 5-hydroxyindole acetic acid and homovanillic acid concentrations in healthy volunteers.

Psychiatry Res 2010 Dec;180(2-3):63-7. Epub 2010 mai 23

PMID: 20580984

Wirgenes Katrine V, Djurovic Srdjan, Sundet Kjetil, Agartz Ingrid, Mattingsdal Morten, Athanasiu Lavinia, Melle Ingrid, Andreassen Ole A

Catechol O-methyltransferase variants and cognitive performance in schizophrenia and bipolar disorder versus controls.

Schizophr Res 2010 Sep;122(1-3):31-7. Epub 2010 jun 1

PMID: 20605701

Rimol Lars M, Hartberg Cecilie B, Nesvåg Ragnar, Fennema-Notestine Christine, Hagler Donald J, Pung Chris J, Jennings Robin G, Haukvik Unn K, Lange Elisabeth, Nakstad Per H, Melle Ingrid, Andreassen Ole A, Dale Anders M, Agartz Ingrid

Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder.

Biol Psychiatry 2010 Jul;68(1):41-50.

PMID: 20609836

Haukvik Unn Kristin, Saetre Peter, McNeil Thomas, Bjerkan Petr S, Andreassen Ole A, Werge Thomas, Jönsson Erik G, Agartz Ingrid

An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes.

Prog Neuropsychopharmacol Biol Psychiatry 2010 Oct;34(7):1259-65. Epub 2010 jul 16

PMID: 20638435

Hellvin Tone, Sundet Kjetil, Vaskinn Anja, Simonsen Carmen, Ueland Torill, Andreassen Ole A, Melle Ingrid

Validation of the Norwegian version of the Social Functioning Scale (SFS) for schizophrenia and bipolar disorder.

Scand J Psychol 2010 Dec;51(6):525-33.

PMID: 20642739

Barrett Elizabeth A, Sundet Kjetil, Faerden Ann, Agartz Ingrid, Bratlien Unni, Romm Kristin Lie, Mork Erlend, Rossberg Jan Ivar, Steen Nils Eiel, Andreassen Ole A, Melle Ingrid

Suicidality in first episode psychosis is associated with insight and negative beliefs about psychosis.

Schizophr Res 2010 Nov;123(2-3):257-62. Epub 2010 aug 3

PMID: 20685083

Simonsen Erik, Friis S, Opjordsmoen S, Mortensen E L, Haahr U, Melle I, Joa I, Johannessen J O, Larsen T K, Røssberg J I, Rund B R, Vaglum P, McGlashan T H

Early identification of non-remission in first-episode psychosis in a two-year outcome study.

Acta Psychiatr Scand 2010 Nov;122(5):375-83. Epub 2010 aug 18

PMID: 20722632

Steen Nils Eiel, Tesli Martin, Kähler Anna K, Methlie Paal, Hope Sigrun, Barrett Elizabeth A, Larsson Sara, Mork Erlend, Løvås Kristian, Røssberg Jan Ivar, Agartz Ingrid, Melle Ingrid, Djurovic Srdjan, Lorentzen Steinar, Berg Jens P, Andreassen Ole A

SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders.

Prog Neuropsychopharmacol Biol Psychiatry 2010 Dec;34(8):1500-6. Epub 2010 aug 25

PMID: 20800085

Lagerberg Trine Vik, Larsson Sara, Sundet Kjetil, Hansen Charlotte B, Hellvin Tone, Andreassen Ole A, Melle Ingrid

Treatment delay and excessive substance use in bipolar disorder.

J Nerv Ment Dis 2010 Sep;198(9):628-33.

PMID: 20823723

Tesli Martin, Athanasiu Lavinia, Mattingsdal Morten, Kähler Anna K, Gustafsson Omar, Andreassen Bettina K, Werge Thomas, Hansen Thomas, Mors Ole, Mellerup Erling, Koefoed Pernille, Jönsson Erik G, Agartz Ingrid, Melle Ingrid, Morken Gunnar, Djurovic Srdjan, Andreassen Ole A

Association analysis of PALB2 and BRCA2 in bipolar disorder and schizophrenia in a scandinavian case-control sample.

Am J Med Genet B Neuropsychiatr Genet 2010 Oct;153B(7):1276-82.

PMID: 20872766

Larsen T K, Melle I, Auestad B, Haahr U, Joa I, Johannessen J O, Opjordsmoen S, Rund B R, Rossberg J I, Simonsen E, Vaglum P, Friis S, McGlashan T

Early detection of psychosis: positive effects on 5-year outcome.

Psychol Med 2011 Jul;41(7):1461-9. Epub 2010 okt 14

PMID: 20942996

Melle Ingrid, Røssberg Jan Ivar, Joa Inge, Friis Svein, Haahr Ulrik, Johannessen Jan Olav, Larsen Tor Ketil, Opjordsmoen Stein, Rund Bjørn Rishovd, Simonsen Erik, Vaglum Per, McGlashan Thomas

The development of subjective quality of life over the first 2 years in first-episode psychosis.

J Nerv Ment Dis 2010 Dec;198(12):864-9.

PMID: 21135636

Saetre Peter, Lundmark Per, Wang August, Hansen Thomas, Rasmussen Henrik B, Djurovic Srdjan, Melle Ingrid, Andreassen Ole A, Werge Thomas, Agartz Ingrid, Hall Håkan, Terenius Lars, Jönsson Erik G

The tryptophan hydroxylase 1 (TPH1) gene, schizophrenia susceptibility, and suicidal behavior: a multi-centre case-control study and meta-analysis.

Am J Med Genet B Neuropsychiatr Genet 2010 Mar;153B(2):387-96.

PMID: 19526457

Vares Maria, Saetre Peter, Deng Hong, Cai Guiqing, Liu Xiehe, Hansen Thomas, Rasmussen Henrik B, Werge Thomas, Melle Ingrid, Djurovic Srdjan, Andreassen Ole A, Agartz Ingrid, Hall Håkan, Terenius Lars, Jönsson Erik G

Association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and age of onset in schizophrenia.

Am J Med Genet B Neuropsychiatr Genet 2010 Mar;153B(2):610-8.

PMID: 19746410

Ringen P A, Vaskinn A, Sundet K, Engh J A, Jónsdóttir H, Simonsen C, Friis S, Opjordsmoen S, Melle I, Andreassen O A

Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia.

Psychol Med 2010 Aug;40(8):1337-47. Epub 2009 nov 6

PMID: 19891810

Sagen Ulrike, Faerden Ann, Haug Tonje, Melle Ingrid, Finset Arnstein, Dammen Toril

Are there common core features of apathy in different neuropsychiatric samples as assessed by the Apathy Evaluation Scale?

Nord J Psychiatry 2010;64(1):49-57.

PMID: 19883192

Larsson Sara, Lorentzen Steinar, Mork Erlend, Barrett Elizabeth A, Steen Nils Eiel, Lagerberg Trine Vik, Berg Akiah Ottesen, Aminoff Sofie R, Agartz Ingrid, Melle Ingrid, Andreassen Ole A

Age at onset of bipolar disorder in a Norwegian catchment area sample.

J Affect Disord 2010 Jul;124(1-2):174-7. Epub 2009 nov 22

PMID: 19931918

Lawyer Glenn, Bjerkan Petr S, Hammarberg Anders, Jayaram-Lindström Nitya, Franck Johan, Agartz Ingrid

Amphetamine dependence and co-morbid alcohol abuse: associations to brain cortical thickness.

BMC Pharmacol 2010;10():5. Epub 2010 mai 20

PMID: 20487539

Kähler Anna K, Otnaess Mona K, Wirgenes Katrine V, Hansen Thomas, Jönsson Erik G, Agartz Ingrid, Hall Håkan, Werge Thomas, Morken Gunnar, Mors Ole, Mellerup Erling, Dam Henrik, Koefod Pernille, Melle Ingrid, Steen Vidar M, Andreassen Ole A, Djurovic Srdjan

Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples.

Am J Med Genet B Neuropsychiatr Genet 2010 Jan;153B(1):86-96.

PMID: 19350560

Holmén Aina, Juuhl-Langseth Monica, Thormodsen Rune, Melle Ingrid, Rund Bjørn Rishovd

Neuropsychological profile in early-onset schizophrenia-spectrum disorders: measured with the MATRICS battery.

Schizophr Bull 2010 Jul;36(4):852-9. Epub 2009 feb 17

PMID: 19223656

Kessler Ute, Vaaler Arne E, Schøyen Helle, Oedegaard Ketil J, Bergsholm Per, Andreassen Ole A, Malt Ulrik F, Morken Gunnar

The study protocol of the Norwegian randomized controlled trial of electroconvulsive therapy in treatment resistant depression in bipolar disorder.

BMC Psychiatry 2010;10():16. Epub 2010 feb 23

PMID: 20178636

Engh John A, Friis Svein, Birkenaes Astrid B, Jónsdóttir Halldóra, Klungsøyr Ole, Ringen Petter A, Simonsen Carmen, Vaskinn Anja, Opjordsmoen Stein, Andreassen Ole A

Delusions are associated with poor cognitive insight in schizophrenia.

Schizophr Bull 2010 Jul;36(4):830-5. Epub 2009 jan 27

PMID: 19176474

Le Hellard S, Mühleisen T W, Djurovic S, Fernø J, Ouriaghi Z, Mattheisen M, Vasilescu C, Raeder M B, Hansen T, Strohmaier J, Georgi A, Brockschmidt F F, Melle I, Nenadic I, Sauer H, Rietschel M, Nöthen M M, Werge T, Andreassen O A, Cichon S, Steen V M

Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.

Mol Psychiatry 2010 May;15(5):463-72. Epub 2008 okt 21

PMID: 18936756

Doktorgrader
Lavinia Athanasiu

Whole genome analysis of genetic susceptibility factors in psychotic disorders

Disputert:
januar 2012
Hovedveileder:
Srdjan Djurovic
Halldóra Jónsdóttir

Adherence to pharmacological treatment in patients with severe mental disorders

Disputert:
februar 2012
Hovedveileder:
Ole A. Andreassen
Sigrun Hope

Inflammatory profile in schizophrenia and bipolar disorder. Relation to affective state

Disputert:
april 2012
Hovedveileder:
Ole A. Andreassen
Sofie Ragnhild Aminoff

Emotion processing in bipolar disorder and its relationship to neurocognitive and clinical characteristics

Disputert:
mai 2012
Hovedveileder:
Ingrid Melle
Tone Hellvin

Neurocognition and social functioning in bipolar disorder at first treatment contact

Disputert:
juni 2012
Hovedveileder:
Kjetil Sundet
Elisabeth Haug

Anomalous Self-Experience in Schizophrenia: associations with diagnosis, suicidality and neurocognition

Disputert:
august 2012
Hovedveileder:
Paul Møller
Martin Steen Tesli

Susceptibility genes for bipolar disorder, with focus on pleiotropy and amygdala activity

Disputert:
august 2012
Hovedveileder:
Ole A. Andreassen
Olga T. Ousdal

On the role of the human amygdala. Mapping functions and individual variations using fMRI.

Disputert:
desember 2012
Hovedveileder:
Ole A. Andreassen
Unn Haukvik

Effects of obstetric complications on brain morphology in schizophrenia

Disputert:
januar 2011
Hovedveileder:
Ingrid Agartz
John Abel Engh

Cognitive insight and clinical insight in schizophrenia - methodological, neurocognitive and psychopathological aspects and comp

Disputert:
februar 2011
Hovedveileder:
Svein Friis
Trine Vik Lagerberg

Substance use in bipolar disorder - associations with age at onset, treatment delay and outcome

Disputert:
februar 2011
Hovedveileder:
Ingrid Melle
Akiah O. Berg

Psychosis in Immigrants: A Cross-Sectional Study of Symptom Profile and Environmental Stressors

Disputert:
juni 2011
Hovedveileder:
Edvard Hauff
Nils Eiel Steen

Cortisol metabolism and release in bipolar disorder and schizophrenia spectrum disorders

Disputert:
oktober 2011
Hovedveileder:
Ole A. Andreassen
Cecilie B. Hartberg

Brain structure and the relationship with neurocognitive functioning in schizophrenia and bipolar disorder – MRI studies

Disputert:
september 2011
Hovedveileder:
Ingrid Agartz
Kristin Lie Romm

Depression, social anxiety and self-esteem in first episode psychosis – a cross-sectional study

Disputert:
august 2011
Hovedveileder:
Jan Ivar Røssberg
Carmen Simonsen

Neurocognition and psychosocial function across bipolar disorder and schizophrenia

Disputert:
juni 2010
Hovedveileder:
Kjetil Sundet
Ann Færden

Apathy in first episode psychosis patients. One year follow-up and clinical characteristics

Disputert:
februar 2010
Hovedveileder:
Ingrid Melle
Elisabeth Ann Barrett

Suicidality in psychotic disorders; demographical, clinical and neurocognitive correlates

Disputert:
desember 2010
Hovedveileder:
Ingrid Melle

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