Genome Repair and Regulation
- Prosjektnummer
- 2011009
- Ansvarlig person
- Arne Klungland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Ekstraordinære driftsmidler
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.
Proc Natl Acad Sci U S A 2011 Oct;108(43):17815-20. Epub 2011 okt 11
PMID: 21990350
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction.
Brain 2011 Nov;134(Pt 11):3369-83. Epub 2011 sep 29
PMID: 21964919
Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10).
Glia 2011 Nov;59(11):1635-42. Epub 2011 jul 11
PMID: 21748805
The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.
Biochem Biophys Res Commun 2011 Jul;411(1):40-3. Epub 2011 jun 15
PMID: 21703242
Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.
J Bacteriol 2011 Sep;193(17):4495-508. Epub 2011 jun 10
PMID: 21665970
Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses.
DNA Repair (Amst) 2011 Jun;10(6):639-53. Epub 2011 mai 7
PMID: 21550321
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond.
Mech Ageing Dev 2011 Aug;132(8-9):424-8. Epub 2011 feb 25
PMID: 21354441
A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.
Nucleic Acids Res 2011 Apr;39(8):e55. Epub 2011 feb 7
PMID: 21300643
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.
Nat Commun 2011;2():172. Epub 2011 feb 1
PMID: 21285950
Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.
Proc Natl Acad Sci U S A 2011 Jan;108(2):846-51. Epub 2010 des 27
PMID: 21187412
Excision repair deficiencies in man and mice; lessons from CSA and Fen1 mutants.
- Disputert:
- desember 2011
- Hovedveileder:
- Arne Klunglnad
Alkbh8-mediated formation of wobble uridine modifications.
- Disputert:
- oktober 2011
- Hovedveileder:
- Arne Klungland
Mitochondrial DNA damage in forebrain neurons of mice
- Disputert:
- februar 2011
- Hovedveileder:
- Arne Klungland
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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