Genome Repair and Regulation

Prosjektnummer: 2011009
Ansvarlig person: Arne Klungland
Institusjon: Oslo universitetssykehus HF
Prosjektkategori: Ekstraordinære driftsmidler
Helsekategori: Cancer
Forskningsaktivitet: 1. Underpinning

2011 - sluttrapport

Vi har etablert og analysert flere spennende biologiske modeller som magler gen som er innvolvert i reprogrammering. I tillegg har vi søkt tre patenter, hvorav en er lisensiert av "ZYMO research" og produktet er kommet ut som produkt. Vi utarbeider en ny patent for bruk innen diagnostikk.

Vitenskapelige artikler

Haj-Yasein Nadia Nabil, Vindedal Gry Fluge, Eilert-Olsen Martine, Gundersen Georg Andreas, Skare Øivind, Laake Petter, Klungland Arne, Thorén Anna Elisabeth, Burkhardt John Michael, Ottersen Ole Petter, Nagelhus Erlend Arnulf

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.

Proc Natl Acad Sci U S A 2011 Oct;108(43):17815-20. Epub 2011 okt 11

PMID: 21990350

Strømme Petter, Dobrenis Kostantin, Sillitoe Roy V, Gulinello Maria, Ali Nafeeza F, Davidson Cristin, Micsenyi Matthew C, Stephney Gloria, Ellevog Linda, Klungland Arne, Walkley Steven U

X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction.

Brain 2011 Nov;134(Pt 11):3369-83. Epub 2011 sep 29

PMID: 21964919

Haj-Yasein Nadia Nabil, Jensen Vidar, Vindedal Gry Fluge, Gundersen Georg Andreas, Klungland Arne, Ottersen Ole Petter, Hvalby Oivind, Nagelhus Erlend Arnulf

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10).

Glia 2011 Nov;59(11):1635-42. Epub 2011 jul 11

PMID: 21748805

Robertson Julia, Robertson Adam B, Klungland Arne

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression.

Biochem Biophys Res Commun 2011 Jul;411(1):40-3. Epub 2011 jun 15

PMID: 21703242

Moen Marivi N, Knævelsrud Ingeborg, Haugland Gyri T, Grøsvik Kristin, Birkeland Nils-Kåre, Klungland Arne, Bjelland Svein

Uracil-DNA glycosylase of Thermoplasma acidophilum directs long-patch base excision repair, which is promoted by deoxynucleoside triphosphates and ATP/ADP, into short-patch repair.

J Bacteriol 2011 Sep;193(17):4495-508. Epub 2011 jun 10

PMID: 21665970

Lauritzen Knut H, Cheng Chang, Wiksen Hege, Bergersen Linda H, Klungland Arne

Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses.

DNA Repair (Amst) 2011 Jun;10(6):639-53. Epub 2011 mai 7

PMID: 21550321

Lauritzen Knut H, Dalhus Bjørn, Storm Johan F, Bjørås Magnar, Klungland Arne

Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond.

Mech Ageing Dev 2011 Aug;132(8-9):424-8. Epub 2011 feb 25

PMID: 21354441

Robertson Adam B, Dahl John A, Vågbø Cathrine B, Tripathi Pankaj, Krokan Hans E, Klungland Arne

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.

Nucleic Acids Res 2011 Apr;39(8):e55. Epub 2011 feb 7

PMID: 21300643

van den Born Erwin, Vågbø Cathrine B, Songe-Møller Lene, Leihne Vibeke, Lien Guro F, Leszczynska Grazyna, Malkiewicz Andrzej, Krokan Hans E, Kirpekar Finn, Klungland Arne, Falnes Pål Ø

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.

Nat Commun 2011;2():172. Epub 2011 feb 1

PMID: 21285950

Thrane Alexander S, Rappold Phillip M, Fujita Takumi, Torres Arnulfo, Bekar Lane K, Takano Takahiro, Peng Weiguo, Wang Fushun, Thrane Vinita Rangroo, Enger Rune, Haj-Yasein Nadia N, Skare Øivind, Holen Torgeir, Klungland Arne, Ottersen Ole P, Nedergaard Maiken, Nagelhus Erlend A

Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Proc Natl Acad Sci U S A 2011 Jan;108(2):846-51. Epub 2010 des 27

PMID: 21187412

Doktorgrader

Liv Kleppa

Excision repair deficiencies in man and mice; lessons from CSA and Fen1 mutants.

Disputert:: desember 2011
Hovedveileder:: Arne Klunglnad

Lene Songe-Møller

Alkbh8-mediated formation of wobble uridine modifications.

Disputert:: oktober 2011
Hovedveileder:: Arne Klungland

Knut Lauritzen

Mitochondrial DNA damage in forebrain neurons of mice

Disputert:: februar 2011
Hovedveileder:: Arne Klungland

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

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