5-HT4 serotonin receptor signalling in heart failure: Compartmentation of cAMP signalling
- Prosjektnummer
- 2011025
- Ansvarlig person
- Finn Olav Levy
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
PLoS One 2015;10(3):e0115547. Epub 2015 mar 4
PMID: 25738589
Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis.
Front Behav Neurosci 2015;9():92. Epub 2015 mai 8
PMID: 26005408
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.
ACS Chem Neurosci 2015 Jul 15;6(7):1206-18. Epub 2015 apr 20
PMID: 25706089 - Inngår i doktorgradsavhandlingen
The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors.
Br J Pharmacol 2015 Aug;172(15):3846-60. Epub 2015 jun 12
PMID: 25884989 - Inngår i doktorgradsavhandlingen
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle.
J Pharmacol Exp Ther 2014 Sep;350(3):681-90. Epub 2014 jul 14
PMID: 25022512
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium.
Naunyn Schmiedebergs Arch Pharmacol 2014 May;387(5):407-17. Epub 2014 jan 15
PMID: 24424715
Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists.
Bioorg Med Chem Lett 2014 Sep 15;24(18):4598-602. Epub 2014 jul 5
PMID: 25149506
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists.
Bioorg Med Chem 2013 Nov 15;21(22):7134-45. Epub 2013 sep 11
PMID: 24113240
PDE3, but not PDE4, reduces ß1 - and ß2 -adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients.
Br J Pharmacol 2013 Jun;169(3):528-38.
PMID: 23489141
Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility.
Naunyn Schmiedebergs Arch Pharmacol 2013 Aug;386(8):665-70. Epub 2013 mai 7
PMID: 23649864
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist.
Eur J Med Chem 2013 Jun;64():629-37. Epub 2013 apr 9
PMID: 23711770
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.
Br J Pharmacol 2013 Sep;170(2):366-79.
PMID: 23808942
Prostaglandin E1 facilitates inotropic effects of 5-HT4 serotonin receptors and ß-adrenoceptors in failing human heart.
Basic Res Cardiol 2012 Sep;107(5):295. Epub 2012 aug 25
PMID: 22923058
Receptor-mediated signalling mechanisms. Functional selectivity and trafficking of serotonin receptors and compartmentation
- Disputert:
- desember 2015
- Hovedveileder:
- Finn Olav Levy
- Finn Olav Levy Hovedveileder
- Kjetil Wessel Andressen Medveileder
- Ornella Manfra Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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