Photochemical internalization of EGFR-targeted toxins for treatment of head and neck cancer
- Prosjektnummer
- 2011029
- Ansvarlig person
- Kristian Berg
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer.
Oncotarget 2015 May 20;6(14):12436-51.
PMID: 26002552 - Inngår i doktorgradsavhandlingen
Photochemical activation of drugs for the treatment of therapy-resistant cancers.
Photochem Photobiol Sci 2015 Aug;14(8):1465-75. Epub 2015 apr 7
PMID: 25849953
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy.
Oncogene 2015 Oct 29;34(44):5582-92. Epub 2015 feb 16
PMID: 25684137 - Inngår i doktorgradsavhandlingen
The photosensitizer disulfonated aluminum phthalocyanine reduces uptake and alters trafficking of fluid phase endocytosed drugs in vascular endothelial cells--impact on efficacy of photochemical internalization.
Biochem Pharmacol 2013 Sep 15;86(6):748-58. Epub 2013 jul 20
PMID: 23876343
Vascular endothelial cells as targets for photochemical internalization (PCI).
Photochem Photobiol 2013 Sep-Oct;89(5):1185-92. Epub 2013 aug 17
PMID: 23819771
Photochemical internalization (PCI) of HER2-targeted toxins: synergy is dependent on the treatment sequence.
Biochim Biophys Acta 2012 Dec;1820(12):1849-58. Epub 2012 sep 8
PMID: 22981913 - Inngår i doktorgradsavhandlingen
Sustained EKR inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy.
Biochim Biophys Acta 2012 Nov. Epub 2012 nov 28
PMID: 23201195
Strongly amphiphilic photosensitizers are not substrates of the cancer stem cell marker ABCG2 and provides specific and efficient light-triggered drug delivery of an EGFR-targeted cytotoxic drug.
J Control Release 2012 Apr;159(2):197-203. Epub 2012 feb 10
PMID: 22349185
Design of an EGFR-targeting toxin for photochemical delivery; in vitro and in vivo selectivity and efficacy
Oncogene, manuscript in press 2015
Photochemical internalization of recombinant toxins targeting RGFR an HER2 for treatment of aggressive and resistant tumors
- Disputert:
- april 2015
- Hovedveileder:
- Anette Weyergang
- Maria Elisabeth Brandal Berstad Doktorgradsstipendiat
- Anette Weyergang Hovedveileder
- Alf Kristian Berg Medveileder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport