eRapport

Oslo Breast Cancer Research Concortium

Prosjekt
Prosjektnummer
2011042
Ansvarlig person
Anne-Lise Børresen-Dale
Institusjon
Oslo universitetssykehus HF
Prosjektkategori
Helse Sør-Øst Forskningsgruppe
Helsekategori
Cancer
Forskningsaktivitet
4. Detection and Diagnosis
Rapporter
2014 - sluttrapport
The OSBREAC (The Oslo Breast Cancer Research consortium), which was funded by this project provided the initial collaborations necessary for the collection of a constitutive series of breast cancer from Oslo and Akershus area. In this group, researchers, surgeons and oncologists from the Oslo University Hospital (Norwegian Radium Hospital, Ullevål), Akershus University hospital and later also from Drammen and Fredrikstad joined forces to collect the sample material using fragmented funding from the Norwegian Cancer Society and Helse SørØst as well as local hospital grants. The OSBREAC iniative led to further funding from the K.G. Jebsen Foundation, which made it possible to melt these separate studies into a common study of the molecular profiling of breast cancer, which in size and depth of the analyses can be compared to the two largest and highly profiled similar studies on world basis (the TCGA, funded by the NCI, NIH and METABRIC, funded by Cancer Research UK), with whom we extensively collaborate. Profiled world wide as the Norwegian Breast Cancer study (NBCS), our study consists at present of close to 2000 cases and 2000 controls, characterised at different molecular levels, a core of which (approximately 700 cases) is profiled at every level. The project period was used for accumulation of patient material, isolation of DNA, RNA and protein, and the laboratory work on high throughput molecular analysis at all levels: somatic DNA copy number alterations (CNA), DNA methylation, mRNA expression, miRNA expression and protein levels by RPPA (reverse phase protein analysis). Data analyses were performed integrating miRNA, mRNA and CNA using various statistical methods. More importantly, we have in the project period performed and published promising results from the analyses of these patient cohorts, and have developed important analytical tools on our pilot dataset. These results and methodology we are exporting, in a collaborative setting, to the large international consortia. The generation of molecular data and high level of integration analyses will affect the strategy of how to perform analyses of both the primary tumors as well as single disseminated tumor cells (DTC) in the benefit of the best treatment for the patients. With the present project we illustrate good progress on our initial goals: develop validated stratification criteria based on phenotypic/genotypic profiling of breast tumors and use validated phenotypic and genotypic stratification criteria for assessing individual response and prognosis in patients with breast cancer. The main challenge is to identify with sufficient certainty the biological pathways responsible for the observed stratification and prognosis and interpret those also in terms of response to treatment. We have a great body of data on treatment response to conventional chemotherapy, but a great challenge and breakthrough will be to identify markers of response to targeted treatment longitudinally. This and the synthesis of our results in translatable molecular and imaging biomarkers from preclinical models into clinical trials such as the described below MetAction and I-BCT-1 The initiation of a new study exploring how to reduce the use of adjuvant systemic treatment to low risk breast cancer patients has recently started (RAST study). The study will include low risk patients, based on traditional clinicopathological parameters from several cohorts (Oslo1, Oslo2, OsloVal), with ability for genomic profiling and molecular analyses, aiming to identify characteristics of excellent outcome patients with no need of adjuvant systemic treatment (or adjuvant chemotherapy). In addition to the over 70 Scientific publications from OSBREAC, listed in the attached publication list, several of them in high profiled/ indexed journals such as Nature, Cell, Science TM, PNAS, the researchers in the consortium have been involved in writing book chapters and web tutorials for the developed methods. To stimulate translation of research data into clinical studies, we have established a close collaboration and integration with the Breast Cancer Clinical Research Group (headed by Bjørn Naume and Erik Wist). Also other key clinical researchers and pathologists (Olav Engebråten, Hege Russnes, Torill Sauer, Elin Borgen, Ellen Schlichting) are partners in OSBREAC. Our molecular and metabolic classification will be coupled to imaging techniques to hopefully refine diagnostics and improve treatment strategies (the EMIT trial, supported by HelseSørØst). A clinical neoadjuvant anti-angiogenic therapy study (NeoAva) has been conducted, which may also have impact in person-adapted treatment protocols. One of the most profound effects of molecular classification on clinical studies is that it leads inevitably to a paradigm shift from large randomized clinical trials tailored for stratified patient groups, down to N-of-1 trials, where a single patient is the entire trial. Thus, we will expand our approach from evaluating the response in randomized arms, using the other arm as a control, to also include evaluation of response to experimental and control interventions in each individual using the same individual as a control. Two spin-off projects from OSBREAC address new translational developments, 1) the N-of-1 concept: the MetAction project (PIs: GMM and ALBD); and 2) identification of DNA targeting treatment sensitivity by in-depth genomic aberration pattern analyses: the I-BCT-1 randomized study (PIs: OE, HKV, OCL), funded by NFR and Helse SørØst, respectively. In the clinical N-of-1 trial in the MetAction project we aim to offer approved targeted therapy to patients with metastases from solid tumors, including BC, where biopsies from the metastatic lesion has confirmed presence of the corresponding actionable target. This is the first clinical trial of this kind in Norway and the protocol was recently approved by the Medical Agency and the Regional Ethical Committee (Eudract No 2013-001363-23; National coordinator: Kjersti Flatmark, MD, PhD). The study centers are Oslo University Hospital and Akershus University Hospital. The work has been followed closely by the National Cancer Genome Consortium (http://kreftsatsing.no/persontilpasset-behandling/) and has received considerable interest from the public (eg. VG, April 5th 2013). The I-BCT-1 (Improved Breast Cancer Therapy) trial. Our work on allele specific analysis of CNA has resulted in a promising prognostic tool, and together with our previous work on total copy number architecture form the basis for a new neoadjuvant treatment trial in breast cancer: I-BCT-1. The purpose of this trial is to determine whether these parameters can be used for the selection of additional therapeutic measures targeting the DNA instability found in BC. Two cohorts are included in the trial: The neoadjuvant cohort will constitute the largest part of the study, with patients randomized to standard therapy alone or the addition of carboplatin to standard therapy. In the metastatic cohort, randomization will be performed between taxane therapy given alone, or taxane in combination with carboplatin. A more fundamental understanding of the biological dynamics of cancer will enable us to better identify risk factors, refine cancer diagnosis, predict therapeutic effects.
2013
In the Oslo Breast Cancer Research Consortium (OSBREAC) integration of data from high throughput molecular analyses of matched material from primary tumor, sentinel lymph nodes, peripheral blood, bone marrow and metastatic lesion are performed, and by integrated approaches we aim to reduce risk, improve prognosis, and tailor the treatment.The Consortium has formed the basis for the establishment and funding of the K.G Jebsen Center for Breast Cancer Research, and the activities continues in this Center (see http://ous-research.no/kgjebsen/ Midterm report). Several scientific papers are expected to be published in 2014 as a result of the funding to OSBREAC, and the final report will therefore be sent in February 2015. The concept of the research performed in OSBREAC and the K.G. Jebsen Center for Breast Cancer Research is to develop and validate the next generation risk stratification criteria based on breast tumour phenotypes/genotypes for more robust differentiation of the disease. This should lead to efficient diagnostic tools that increase management options in each phase of the disease. The research activities involve basic and clinical researchers at Oslo University Hospital (OUS, Ullevål and Radiumhospitalet), Akershus University Hospital (Ahus), NTNU/St. Olavs Hospital, Sykehuset Østfold HF and Sykehuset Buskerud HF. Collection of tumor samples and inclusion of patients are still ongoing at all centers. In 2013 two scientists, 2 research associates, two scientific nurses (each 50%), 1 visiting research fellow, and 2 PhD students that defended their thesis in 2013, were directly involved in the HSØ part of the project, all partly funded by OSBREAC . The project utilizes a number of previously and newly collected clinical cohorts and consists of several well integrated activities: 1) High throughput molecular characterization of primary tumors; 2) Detection and characterization of occult tumor cells in bone marrow (BM) (DTC), blood (CTC) and sentinel lymph nodes (SLN) as well as detection of cell free tumor DNA (ctDNA) in blood as a new development; 3) Functional studies in experimental model systems; 4) Metabolic and physiological characterization and 5) Data integration. Some few result are highlighted below: Data of miRNA, mRNA and CNA for > 800 patients (Oslo2 , Oslo3 (NeoAva), OsloVal) have been generated and will be integrated with clinical data. Deep sequencing of selected samples have identified new BC genes and novel mutational processes that evolve across the lifespan of a tumor, with cancer-specific signatures of point mutations and chromosomal instability contributing extensive genetic variation. Data from the OsloVal series with long term follow up was used as the main validation cohort in a worldwide computational competition to predict outcome. Single DTCs from two patients were analyzed by single-cell array CGH and deep-sequencing following whole-genome amplification based on methods developed in this project. Comparing copy-number profiles of the DTCs and the corresponding primary tumor revealed tumor clonality and DTC cell diversity. Orthotopic xenograft models have been established and utilized for assessment of therapeutic effects and for identification of biomarkers predicting response to anti-angiogenic treatment in combination with cytotoxic therapy. Drug/miRNA screens have identified miRNAs that modulate the response to HER2-targeted therapy, and miRNAs targeting HER2, B7-H3 and S100A4. Combined analyses of the molecular data generated in Activity 1 (CNA, mRNA and protein expression), and Activity 4 (metabolic profiles and imaging) point to biological functions and molecular pathways being deregulated in multiple cancers, and will be used to identify novel patient subgroups for tailored therapy and monitoring.
2012
In the Oslo Breast Cancer Research Consortium (OSBREAC) integration of high throughput molecular analyses of matched material from primary tumor, sentinel lymph nodes, peripheral blood, bone marrow and metastatic lesion are performed, and by integrated approaches we aim to reduce risk, improve prognosis, and tailor the treatment.The concept of the research performed in OSBREAC is to develop and validate the next generation risk stratification criteria based on breast tumour phenotypes/genotypes for more robust differentiation of the disease. This should lead to efficient diagnostic tools that increase the management options in each phase of the disease. The research activities involve basic as well as clinical researchers. Members of the OSBREAC are scientists and clinicians at Oslo University Hospital (OUS, Ullevål and Radiumhospitalet), Akershus University Hospital (Ahus), NTNU/St. Olavs Hospital, Sykehuset Østfold HF and Sykehuset Buskerud HF. Collection of tumor samples and inclusion of patients are ongoing at all centers. In 2012 two research associates, two scientific nurses (each 50%) and 1 postdoc has been working on several of the 5 main activities described below. Activity 1: Global characterization of the primary tumor and patients’ genetic background. In this activity we have completed analyses at 4 molecular levels (mRNA, miRNA, DNA copynumber and protein analyses using RPPA) for the first 450 samples from the Oslo2 study have been completed. Deep sequensing of selected samples have also been completed. These studies have identified new genes involved in breast cancer, and we could show that novel mutational processes evolve across the lifespan of a tumor, with cancer-specific signatures of point mutations and chromosomal instability often emerging late but contributing extensive genetic variation. Subclonal diversification was prominent, and every tumor studied had a dominant subclonal lineage, representing more than 50% of tumor cells. These studies have resulted in several publications in high profiled journals like Nature and Cell. Activity 2: Detection and characterization of occult tumor cells in BM (DTC), blood (CTC) and SLN. A single-cell array high-resolution comparative genomic hybridization (SCaCGH) method providing molecular aberration profiles of detected CTCs or DTCs, has been developed. More than two-third of the so far analyzed DTCs disclosed equivalent changes, both to each other and to the corresponding primary disease. Similar aberration patterns were visible in DTCs collected at diagnosis and at 3 years relapse-free follow-up. SCaCGH may be a powerful tool for the molecular characterization of DTCs. In a different study including patients from the Oslo1 cohort, a gene expression primary tumor signature predictive of the presence of CTCs (identified by a RT-PCR-based method), was detected. The "CTC profile" also provided prognostic information independent of the well-established and powerful '70-gene' prognostic breast cancer signature. Activity 3. Model systems and functional studies Tumors from several animal models, one basal-like and one luminal-like model from our own lab as well as 31 from collaborators in Paris (Curie Inst) have been analyzed and relevant models for our planned drug screens and image and MR analyses (Activity 4) have been selected and now established locally. The models are found to respond differently, thereby nicely representing the clinical situation. These models will be used for evaluating effect of various drugs based on different molecular profiles Activity 4. Metabolic and tumor physiological characterization by MR. Samples from 450 of the Oslo2 patients have been analyzed by HR MAS, and initial metabolic clustering and integrated analyses with other molecular data is ongoing. Activity 5. Identification of treatment induced side-effects This activity is reported in project 2012045 Activity 6. Integrated analyses The integrated analysis of all molecular levels of Oslo2 is on its way. Several different approaches are explored, ranging from the application of preexisting tools to the development of novel statistical models. These integrated molecular profiles have already given new insight into various signaling processes involved in the different groups of breast cancer, and we are now in a stage of evaluating the effects of these various processes on outcome.
2011
In the Oslo Breast Cancer Research Consortium (OSBREAC) integration of high throughput molecular analyses of matched material from primary tumor, sentinel lymph nodes, peripheral blood, bone marrow and metastatic lesion are performed, and by integrated approaches we aim to reduce risk, improve prognosis, and tailor the treatment.The concept of the research performed in OSBREAC is to develop and validate the next generation risk stratification criteria based on breast tumour phenotypes/genotypes for more robust differentiation of the disease. This should lead to efficient diagnostic tools that increase the management options in each phase of the disease. The research activities involve basic as well as clinical researchers. Members of the OSBREAC are scientists and clinicians at Oslo University Hospital (OUS, Ullevål and Radiumhospitalet), Akershus University Hospital (Ahus), NTNU/St. Olavs Hospital, Sykehuset Østfold HF and Sykehuset Buskerud HF. Collection of tumor samples and inclusion of patients are ongoing at all centers. Two research associates (each 50%) and 3 postdocs/scientists (each 50%) has been working on several of the 5 main activities in this first year as described below. Activity 1: Global characterization of the primary tumor and patients’ genetic background. In this activity we have performed analyses at 3 molecular levels for the first 450 samples from the Oslo2 study. Samples from several other cohorts are under extraction and will be analyzed over the next year. Effect of time to freezing has been investigated (Borgan et al). Large scale genotype analyses for risk estimates have been performed in several larger cohorts that are all part of international large efforts. Several multi-study papers in high profiled papers (like Nature Genetics and Cancer Res) are in press. Activity 2: Detection and characterization of occult tumor cells in BM (DTC), blood (CTC) and SLN. Methods for isolation of single cells from bone-marrow and blood have been developed and analyses to detect copy number aberration have been performed. In several of the isolated DTC's the same aberration as seen in the primary tumor as well as novel ones was found. This is important for detecting the heterogeneity and identification of aggressive subclones. (Mathiesen et al) Activity 3. Model systems and functional studies Tumors from several animal models from collaborators in Paris (Curie Inst) have been analyzed and relevant models for our planned drug screens and image and MR analyses (Activity 4) have been selected and now established locally. Functional screens on cell lines have started and will be a main focus in 2012. Activity 4. Metabolic and tumor physiological characterization by MR. Samples from Oslo2 and Oslo3 have been prepared for HR-MAS analyses, and the establish animal models will be analyzed during 2012. Activity 5. Identification of treatment induced side-effects Hege Landmark-Høyvik defended her thesis: Genomic studies of breast cancer survivors; Associations to treatment-induced late side effects. Re-collection of samples from the cohort analyzed in this thesis are ongoing and new analyses related to fibrosis and heart toxicity is planned for 2012. Activity 6. Integrated analyses Results of the first integration of data from DNA, mRNA ,miRNA and methylation using a pathway based approach was published in PNAS (Kristensen et al.) These integrated molecular profiles of invasive breast tumors and DCISs revealed differential vascular and interleukin signaling. The findings of the interleukin signaling will be followed up also in activity 2 and 3 in 2012.
Vitenskapelige artikler
Tahiri Andliena, Leivonen Suvi-Katri, Lüders Torben, Steinfeld Israel, Ragle Aure Miriam, Geisler Jürgen, Mäkelä Rami, Nord Silje, Riis Margit L H, Yakhini Zohar, Kleivi Sahlberg Kristine, Børresen-Dale Anne-Lise, Perälä Merja, Bukholm Ida R K, Kristensen Vessela N

Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors.

Carcinogenesis 2014 Jan;35(1):76-85. Epub 2013 okt 8

PMID: 24104550

Leivonen Suvi-Katri, Sahlberg Kristine Kleivi, Mäkelä Rami, Due Eldri Undlien, Kallioniemi Olli, Børresen-Dale Anne-Lise, Perälä Merja

High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth.

Mol Oncol 2014 Feb;8(1):93-104. Epub 2013 okt 11

PMID: 24148764

Liu Yanhong, Zhou Renke, Baumbusch Lars O, Tsavachidis Spyros, Brewster Abenaa M, Do Kim-Anh, Sahin Aysegul, Hortobagyi Gabriel N, Taube Joseph H, Mani Sendurai A, Aarøe Jørgen, Wärnberg Fredrik, Børresen-Dale Anne-Lise, Mills Gordon B, Thompson Patricia A, Bondy Melissa L

Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer.

Breast Cancer Res Treat 2014 Jan;143(1):189-201. Epub 2013 des 4

PMID: 24305980

Almendro Vanessa, Cheng Yu-Kang, Randles Amanda, Itzkovitz Shalev, Marusyk Andriy, Ametller Elisabet, Gonzalez-Farre Xavier, Muñoz Montse, Russnes Hege G, Helland Aslaug, Rye Inga H, Borresen-Dale Anne-Lise, Maruyama Reo, van Oudenaarden Alexander, Dowsett Mitchell, Jones Robin L, Reis-Filho Jorge, Gascon Pere, Gönen Mithat, Michor Franziska, Polyak Kornelia

Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.

Cell Rep 2014 Feb 13;6(3):514-27. Epub 2014 jan 23

PMID: 24462293

Milne Roger L, Herranz Jesús, Michailidou Kyriaki, Dennis Joe, Tyrer Jonathan P, Zamora M Pilar, Arias-Perez José Ignacio, González-Neira Anna, Pita Guillermo, Alonso M Rosario, Wang Qin, Bolla Manjeet K, Czene Kamila, Eriksson Mikael, Humphreys Keith, Darabi Hatef, Li Jingmei, Anton-Culver Hoda, Neuhausen Susan L, Ziogas Argyrios, Clarke Christina A, Hopper John L, Dite Gillian S, Apicella Carmel, Southey Melissa C, Chenevix-Trench Georgia, kConFab Investigators, Australian Ovarian Cancer Study Group, Swerdlow Anthony, Ashworth Alan, Orr Nicholas, Schoemaker Minouk, Jakubowska Anna, Lubinski Jan, Jaworska-Bieniek Katarzyna, Durda Katarzyna, Andrulis Irene L, Knight Julia A, Glendon Gord, Mulligan Anna Marie, Bojesen Stig E, Nordestgaard Børge G, Flyger Henrik, Nevanlinna Heli, Muranen Taru A, Aittomäki Kristiina, Blomqvist Carl, Chang-Claude Jenny, Rudolph Anja, Seibold Petra, Flesch-Janys Dieter, Wang Xianshu, Olson Janet E, Vachon Celine, Purrington Kristen, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Grip Mervi, Dunning Alison M, Shah Mitul, Guénel Pascal, Truong Thérèse, Sanchez Marie, Mulot Claire, Brenner Hermann, Dieffenbach Aida Karina, Arndt Volker, Stegmaier Christa, Lindblom Annika, Margolin Sara, Hooning Maartje J, Hollestelle Antoinette, Collée J Margriet, Jager Agnes, Cox Angela, Brock Ian W, Reed Malcolm W R, Devilee Peter, Tollenaar Robert A E M, Seynaeve Caroline, Haiman Christopher A, Henderson Brian E, Schumacher Fredrick, Le Marchand Loic, Simard Jacques, Dumont Martine, Soucy Penny, Dörk Thilo, Bogdanova Natalia V, Hamann Ute, Försti Asta, Rüdiger Thomas, Ulmer Hans-Ulrich, Fasching Peter A, Häberle Lothar, Ekici Arif B, Beckmann Matthias W, Fletcher Olivia, Johnson Nichola, dos Santos Silva Isabel, Peto Julian, Radice Paolo, Peterlongo Paolo, Peissel Bernard, Mariani Paolo, Giles Graham G, Severi Gianluca, Baglietto Laura, Sawyer Elinor, Tomlinson Ian, Kerin Michael, Miller Nicola, Marme Federik, Burwinkel Barbara, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Lambrechts Diether, Yesilyurt Betul T, Floris Giuseppe, Leunen Karin, Alnæs Grethe Grenaker, Kristensen Vessela, Børresen-Dale Anne-Lise, García-Closas Montserrat, Chanock Stephen J, Lissowska Jolanta, Figueroa Jonine D, Schmidt Marjanka K, Broeks Annegien, Verhoef Senno, Rutgers Emiel J, Brauch Hiltrud, Brüning Thomas, Ko Yon-Dschun, GENICA Network, Couch Fergus J, Toland Amanda E, TNBCC, Yannoukakos Drakoulis, Pharoah Paul D P, Hall Per, Benítez Javier, Malats Núria, Easton Douglas F

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.

Hum Mol Genet 2014 Apr 1;23(7):1934-46. Epub 2013 nov 15

PMID: 24242184

Fleischer Thomas, Edvardsen Hege, Solvang Hiroko K, Daviaud Christian, Naume Bjørn, Børresen-Dale Anne-Lise, Kristensen Vessela N, Tost Jörg

Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients.

Int J Cancer 2014 Jun 1;134(11):2615-25. Epub 2014 jan 6

PMID: 24395279

Silwal-Pandit Laxmi, Vollan Hans Kristian Moen, Chin Suet-Feung, Rueda Oscar M, McKinney Steven, Osako Tomo, Quigley David A, Kristensen Vessela N, Aparicio Samuel, Børresen-Dale Anne-Lise, Caldas Carlos, Langerød Anita

TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

Clin Cancer Res 2014 Jul 1;20(13):3569-80. Epub 2014 mai 6

PMID: 24803582

Saldova Radka, Asadi Shehni Akram, Haakensen Vilde D, Steinfeld Israel, Hilliard Mark, Kifer Ilona, Helland Aslaug, Yakhini Zohar, Børresen-Dale Anne-Lise, Rudd Pauline M

Association of N-glycosylation with breast carcinoma and systemic features using high-resolution quantitative UPLC.

J Proteome Res 2014 May 2;13(5):2314-27. Epub 2014 apr 11

PMID: 24669823

Grinde Maria T, Skrbo Nirma, Moestue Siver A, Rødland Einar A, Borgan Eldrid, Kristian Alexandr, Sitter Beathe, Bathen Tone F, Børresen-Dale Anne-Lise, Mælandsmo Gunhild M, Engebraaten Olav, Sørlie Therese, Marangoni Elisabetta, Gribbestad Ingrid S

Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.

Breast Cancer Res 2014;16(1):R5. Epub 2014 jan 21

PMID: 24447408

Quigley David A, Fiorito Elisa, Nord Silje, Van Loo Peter, Alnæs Grethe Grenaker, Fleischer Thomas, Tost Jorg, Moen Vollan Hans Kristian, Tramm Trine, Overgaard Jens, Bukholm Ida R, Hurtado Antoni, Balmain Allan, Børresen-Dale Anne-Lise, Kristensen Vessela

The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.

Mol Oncol 2014 Mar;8(2):273-84. Epub 2013 des 3

PMID: 24388359

Bjaanaes Maria Moksnes, Halvorsen Ann Rita, Solberg Steinar, Jørgensen Lars, Dragani Tommaso A, Galvan Antonella, Colombo Francesca, Anderlini Marco, Pastorino Ugo, Kure Elin, Børresen-Dale Anne-Lise, Brustugun Odd Terje, Helland Aslaug

Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas.

Int J Cancer 2014 Oct 15;135(8):1812-21. Epub 2014 mar 14

PMID: 24599520

Zhao Xi, Rødland Einar Andreas, Sørlie Therese, Vollan Hans Kristian Moen, Russnes Hege G, Kristensen Vessela N, Lingjærde Ole Christian, Børresen-Dale Anne-Lise

Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.

BMC Cancer 2014;14():211. Epub 2014 mar 19

PMID: 24645668

Cooke Susanna L, Shlien Adam, Marshall John, Pipinikas Christodoulos P, Martincorena Inigo, Tubio Jose M C, Li Yilong, Menzies Andrew, Mudie Laura, Ramakrishna Manasa, Yates Lucy, Davies Helen, Bolli Niccolo, Bignell Graham R, Tarpey Patrick S, Behjati Sam, Nik-Zainal Serena, Papaemmanuil Elli, Teixeira Vitor H, Raine Keiran, O'Meara Sarah, Dodoran Maryam S, Teague Jon W, Butler Adam P, Iacobuzio-Donahue Christine, Santarius Thomas, Grundy Richard G, Malkin David, Greaves Mel, Munshi Nikhil, Flanagan Adrienne M, Bowtell David, Martin Sancha, Larsimont Denis, Reis-Filho Jorge S, Boussioutas Alex, Taylor Jack A, Hayes Neil D, Janes Sam M, Futreal P Andrew, Stratton Michael R, McDermott Ultan, Campbell Peter J, ICGC Breast Cancer Group

Processed pseudogenes acquired somatically during cancer development.

Nat Commun 2014;5():3644. Epub 2014 apr 9

PMID: 24714652

Halvorsen Ann Rita, Helland Aslaug, Fleischer Thomas, Haug Karen Marie, Grenaker Alnaes Grethe Irene, Nebdal Daniel, Syljuåsen Randi G, Touleimat Nizar, Busato Florence, Tost Jörg, Saetersdal Anna B, Børresen-Dale Anne-Lise, Kristensen Vessela, Edvardsen Hege

Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy.

Int J Cancer 2014 Nov 1;135(9):2085-95. Epub 2014 apr 5

PMID: 24658971

Li Jingmei, Lindström Linda S, Foo Jia N, Rafiq Sajjad, Schmidt Marjanka K, Pharoah Paul D P, Michailidou Kyriaki, Dennis Joe, Bolla Manjeet K, Wang Qin, Van 't Veer Laura J, Cornelissen Sten, Rutgers Emiel, Southey Melissa C, Apicella Carmel, Dite Gillian S, Hopper John L, Fasching Peter A, Haeberle Lothar, Ekici Arif B, Beckmann Matthias W, Blomqvist Carl, Muranen Taru A, Aittomäki Kristiina, Lindblom Annika, Margolin Sara, Mannermaa Arto, Kosma Veli-Matti, Hartikainen Jaana M, Kataja Vesa, Chenevix-Trench Georgia, kConFab Investigators, Phillips Kelly-Anne, McLachlan Sue-Anne, Lambrechts Diether, Thienpont Bernard, Smeets Ann, Wildiers Hans, Chang-Claude Jenny, Flesch-Janys Dieter, Seibold Petra, Rudolph Anja, Giles Graham G, Baglietto Laura, Severi Gianluca, Haiman Christopher A, Henderson Brian E, Schumacher Fredrick, Le Marchand Loic, Kristensen Vessela, Alnæs Grethe I Grenaker, Borresen-Dale Anne-Lise, Nord Silje, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Grip Mervi, Andrulis Irene L, Knight Julia A, Glendon Gord, Tchatchou Sandrine, Devilee Peter, Tollenaar Robert, Seynaeve Caroline, Hooning Maartje, Kriege Mieke, Hollestelle Antoinette, van den Ouweland Ans, Li Yi, Hamann Ute, Torres Diana, Ulmer Hans U, Rüdiger Thomas, Shen Chen-Yang, Hsiung Chia-Ni, Wu Pei-Ei, Chen Shou-Tung, Teo Soo Hwang, Taib Nur Aishah Mohd, Har Yip Cheng, Fuang Ho Gwo, Matsuo Keitaro, Ito Hidemi, Iwata Hiroji, Tajima Kazuo, Kang Daehee, Choi Ji-Yeob, Park Sue K, Yoo Keun-Young, Maishman Tom, Tapper William J, Dunning Alison, Shah Mitul, Luben Robert, Brown Judith, Khor Chiea Chuen, Eccles Diana M, Nevanlinna Heli, Easton Douglas, Humphreys Keith, Liu Jianjun, Hall Per, Czene Kamila

2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy.

Nat Commun 2014;5():4051. Epub 2014 jun 17

PMID: 24937182

Sørlie Therese, Johnsen Hilde, Vu Phuong, Lind Guro Elisabeth, Lothe Ragnhild, Børresen-Dale Anne-Lise

Mutation screening of the TP53 gene by temporal temperature gel electrophoresis (TTGE).

Methods Mol Biol 2014;1105():315-24.

PMID: 24623239

Nygren M K, Tekle C, Ingebrigtsen V A, Mäkelä R, Krohn M, Aure M R, Nunes-Xavier C E, Perälä M, Tramm T, Alsner J, Overgaard J, Nesland J M, Borgen E, Børresen-Dale A-L, Fodstad Ø, Sahlberg K K, Leivonen S-K

Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c.

Br J Cancer 2014 Apr 15;110(8):2072-80. Epub 2014 feb 27

PMID: 24577056

Sternemalm J, Russnes H G, Zhao X, Risberg B, Nord S, Caldas C, Børresen-Dale A L, Stokke T, Patzke S

Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.

Br J Cancer 2014 Jul 15;111(2):326-38. Epub 2014 jun 5

PMID: 24901235

Tubio Jose M C, Li Yilong, Ju Young Seok, Martincorena Inigo, Cooke Susanna L, Tojo Marta, Gundem Gunes, Pipinikas Christodoulos P, Zamora Jorge, Raine Keiran, Menzies Andrew, Roman-Garcia Pablo, Fullam Anthony, Gerstung Moritz, Shlien Adam, Tarpey Patrick S, Papaemmanuil Elli, Knappskog Stian, Van Loo Peter, Ramakrishna Manasa, Davies Helen R, Marshall John, Wedge David C, Teague Jon W, Butler Adam P, Nik-Zainal Serena, Alexandrov Ludmil, Behjati Sam, Yates Lucy R, Bolli Niccolo, Mudie Laura, Hardy Claire, Martin Sancha, McLaren Stuart, O'Meara Sarah, Anderson Elizabeth, Maddison Mark, Gamble Stephen, ICGC Breast Cancer Group, ICGC Bone Cancer Group, ICGC Prostate Cancer Group, Foster Christopher, Warren Anne Y, Whitaker Hayley, Brewer Daniel, Eeles Rosalind, Cooper Colin, Neal David, Lynch Andy G, Visakorpi Tapio, Isaacs William B, van't Veer Laura, Caldas Carlos, Desmedt Christine, Sotiriou Christos, Aparicio Sam, Foekens John A, Eyfjörd Jórunn Erla, Lakhani Sunil R, Thomas Gilles, Myklebost Ola, Span Paul N, Børresen-Dale Anne-Lise, Richardson Andrea L, van de Vijver Marc, Vincent-Salomon Anne, Van den Eynden Gert G, Flanagan Adrienne M, Futreal P Andrew, Janes Sam M, Bova G Steven, Stratton Michael R, McDermott Ultan, Campbell Peter J

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug 1;345(6196):1251343.

PMID: 25082706

Askautrud Hanne A, Gjernes Elisabet, Gunnes Gjermund, Sletten Marit, Ross Douglas T, Børresen-Dale Anne Lise, Iversen Nina, Tranulis Michael A, Frengen Eirik

Global gene expression analysis reveals a link between NDRG1 and vesicle transport.

PLoS One 2014;9(1):e87268. Epub 2014 jan 31

PMID: 24498060

Johnson Nichola, Dudbridge Frank, Orr Nick, Gibson Lorna, Jones Michael E, Schoemaker Minouk J, Folkerd Elizabeth J, Haynes Ben P, Hopper John L, Southey Melissa C, Dite Gillian S, Apicella Carmel, Schmidt Marjanka K, Broeks Annegien, Van T Veer Laura J, Atsma Femke, Muir Kenneth, Lophatananon Artitaya, Fasching Peter A, Beckmann Matthias W, Ekici Arif B, Renner Stefan P, Sawyer Elinor, Tomlinson Ian, Kerin Michael, Miller Nicola, Burwinkel Barbara, Marme Frederik, Schneeweiss Andreas, Sohn Christof, Guénel Pascal, Truong Therese, Cordina Emilie, Menegaux Florence, Bojesen Stig E, Nordestgaard Børge G, Flyger Henrik, Milne Roger, Zamora M Pilar, Arias Perez Jose Ignacio, Benitez Javier, Bernstein Leslie, Anton-Culver Hoda, Ziogas Argyrios, Clarke Dur Christina, Brenner Hermann, Müller Heiko, Arndt Volker, Dieffenbach Aida Karina, Meindl Alfons, Heil Joerg, Bartram Claus R, Schmutzler Rita K, Brauch Hiltrud, Justenhoven Christina, Ko Yon-Dschun, Nevanlinna Heli, Muranen Taru A, Aittomäki Kristiina, Blomqvist Carl, Matsuo Keitaro, Dörk Thilo, Bogdanova Natalia V, Antonenkova Natalia N, Lindblom Annika, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Chenevix-Trench Georgia, Beesley Jonathan, Wu Anna H, Van Den Berg David, Tseng Chiu-Chen, Lambrechts Diether, Smeets Dominiek, Neven Patrick, Wildiers Hans, Chang-Claude Jenny, Rudolph Anja, Nickels Stefan, Flesch-Janys Dieter, Radice Paolo, Peterlongo Paolo, Bonanni Bernardo, Pensotti Valeria, Couch Fergus J, Olson Janet E, Wang Xianshu, Fredericksen Zachary, Pankratz Vernon S, Giles Graham G, Severi Gianluca, Baglietto Laura, Haiman Chris, Simard Jacques, Goldberg Mark S, Labrèche France, Dumont Martine, Soucy Penny, Teo Soo, Yip Cheng Har, Phuah Sze Yee, Cornes Belinda K, Kristensen Vessela N, Grenaker Alnæs Grethe, Børresen-Dale Anne-Lise, Zheng Wei, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Grip Mervi, Andrulis Irene L, Knight Julia A, Glendon Gord, Mulligan Anna Marie, Devillee Peter, Figueroa Jonine, Chanock Stephen J, Lissowska Jolanta, Sherman Mark E, Hall Per, Schoof Nils, Hooning Maartje, Hollestelle Antoinette, Oldenburg Rogier A, Tilanus-Linthorst Madeleine, Liu Jianjun, Cox Angie, Brock Ian W, Reed Malcolm Wr, Cross Simon S, Blot William, Signorello Lisa B, Pharoah Paul Dp, Dunning Alison M, Shah Mitul, Kang Daehee, Noh Dong-Young, Park Sue K, Choi Ji-Yeob, Hartman Mikael, Miao Hui, Lim Wei Yen, Tang Anthony, Hamann Ute, Försti Asta, Rüdiger Thomas, Ulmer Hans Ulrich, Jakubowska Anna, Lubinski Jan, Jaworska-Bieniek Katarzyna, Durda Katarzyna, Sangrajrang Suleeporn, Gaborieau Valerie, Brennan Paul, McKay James, Slager Susan, Toland Amanda E, Vachon Celine, Yannoukakos Drakoulis, Shen Chen-Yang, Yu Jyh-Cherng, Huang Chiun-Sheng, Hou Ming-Feng, González-Neira Anna, Tessier Daniel C, Vincent Daniel, Bacot Francois, Luccarini Craig, Dennis Joe, Michailidou Kyriaki, Bolla Manjeet K, Wang Jean, Easton Douglas F, García-Closas Montserrat, Dowsett Mitch, Ashworth Alan, Swerdlow Anthony J, Peto Julian, dos Santos Silva Isabel, Fletcher Olivia

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.

Breast Cancer Res 2014 May 26;16(3):R51. Epub 2014 mai 26

PMID: 24887515

Tramm Trine, Mohammed Hayat, Myhre Simen, Kyndi Marianne, Alsner Jan, Børresen-Dale Anne-Lise, Sørlie Therese, Frigessi Arnoldo, Overgaard Jens

Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort.

Clin Cancer Res 2014 Oct 15;20(20):5272-80. Epub 2014 aug 22

PMID: 25149560

Fleischer Thomas, Frigessi Arnoldo, Johnson Kevin C, Edvardsen Hege, Touleimat Nizar, Klajic Jovana, Riis Margit Lh, Haakensen Vilde D, Wärnberg Fredrik, Naume Bjørn, Helland Aslaug, Børresen-Dale Anne-Lise, Tost Jörg, Christensen Brock C, Kristensen Vessela N

Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.

Genome Biol 2014;15(8):435. Epub 2014 aug 22

PMID: 25146004

Winsel S, Mäki-Jouppila J, Tambe M, Aure M R, Pruikkonen S, Salmela A-L, Halonen T, Leivonen S-K, Kallio L, Børresen-Dale A-L, Kallio M J

Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo.

Br J Cancer 2014 Nov 25;111(11):2142-51. Epub 2014 sep 30

PMID: 25268374

Chaluvally-Raghavan Pradeep, Zhang Fan, Pradeep Sunila, Hamilton Mark P, Zhao Xi, Rupaimoole Rajesha, Moss Tyler, Lu Yiling, Yu Shuangxing, Pecot Chad V, Aure Miriam R, Peuget Sylvain, Rodriguez-Aguayo Cristian, Han Hee-Dong, Zhang Dong, Venkatanarayan Avinashnarayan, Krohn Marit, Kristensen Vessela N, Gagea Mihai, Ram Prahlad, Liu Wenbin, Lopez-Berestein Gabriel, Lorenzi Philip L, Børresen-Dale Anne-Lise, Chin Koei, Gray Joe, Dusetti Nelson J, McGuire Sean E, Flores Elsa R, Sood Anil K, Mills Gordon B

Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.

Cancer Cell 2014 Dec 8;26(6):863-79.

PMID: 25490449

Kleivi Sahlberg K, Bottai G, Naume B, Burwinkel B, Calin GA, Børresen-Dale AL, Santarpia L

A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.

Clin Cancer Res 2015 Mar 1;21(5):1207-14. Epub 2014 des 29

PMID: 25547678

Rye IH, Lundin P, Månér S, Fjelldal R, Naume B, Wigler M, Hicks J, Børresen-Dale AL, Zetterberg A, Russnes HG

Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors.

Genes Chromosomes Cancer 2015 Apr;54(4):235-48. Epub 2014 des 26

PMID: 25546585

Painter JN, O'Mara TA, Batra J, Cheng T, Lose FA, Dennis J, Michailidou K, Tyrer JP, Ahmed S, Ferguson K, Healey CS, Kaufmann S, Hillman KM, Walpole C, Moya L, Pollock P, Jones A, Howarth K, Martin L, Gorman M, Hodgson S, , , De Polanco MM, Sans M, Carracedo A, Castellvi-Bel S, Rojas-Martinez A, Santos E, Teixeira MR, Carvajal-Carmona L, Shu XO, Long J, Zheng W, Xiang YB, , Montgomery GW, Webb PM, Scott RJ, McEvoy M, Attia J, Holliday E, Martin NG, Nyholt DR, Henders AK, Fasching PA, Hein A, Beckmann MW, Renner SP, Dörk T, Hillemanns P, Dürst M, Runnebaum I, Lambrechts D, Coenegrachts L, Schrauwen S, Amant F, Winterhoff B, Dowdy SC, Goode EL, Teoman A, Salvesen HB, Trovik J, Njolstad TS, Werner HM, Ashton K, Proietto T, Otton G, Tzortzatos G, Mints M, Tham E, , Hall P, Czene K, Liu J, Li J, Hopper JL, Southey MC, , Ekici AB, Ruebner M, Johnson N, Peto J, Burwinkel B, Marme F, Brenner H, Dieffenbach AK, Meindl A, Brauch H, , Lindblom A, Depreeuw J, Moisse M, Chang-Claude J, Rudolph A, Couch FJ, Olson JE, Giles GG, Bruinsma F, Cunningham JM, Fridley BL, Børresen-Dale AL, Kristensen VN, Cox A, Swerdlow AJ, Orr N, Bolla MK, Wang Q, Weber RP, Chen Z, Shah M, French JD, Pharoah PD, Dunning AM, Tomlinson I, Easton DF, Edwards SL, Thompson DJ, Spurdle AB

Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.

Hum Mol Genet 2015 Mar 1;24(5):1478-92. Epub 2014 nov 6

PMID: 25378557

Quigley D, Silwal-Pandit L, Dannenfelser R, Langerød A, Vollan HK, Vaske C, Siegel JU, Troyanskaya O, Chin SF, Caldas C, Balmain A, Børresen-Dale AL, Kristensen V

Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.

Mol Cancer Res 2015 Mar;13(3):493-501. Epub 2014 okt 28

PMID: 25351767

Russnes Hege G, Lønning Per E, Børresen-Dale Anne-Lise, Lingjærde Ole C

The multitude of molecular analyses in cancer: the opening of Pandora's box.

Genome Biol 2014 Sep 3;15(9):447. Epub 2014 sep 3

PMID: 25316146

Kristensen Vessela N, Lingjærde Ole Christian, Russnes Hege G, Vollan Hans Kristian M, Frigessi Arnoldo, Børresen-Dale Anne-Lise

Principles and methods of integrative genomic analyses in cancer.

Nat Rev Cancer 2014 May;14(5):299-313.

PMID: 24759209

Sandhu V, Bowitz Lothe I M, Labori K J, Lingjærde O C, Buanes T, Dalsgaard A M, Skrede M L, Hamfjord J, Haaland T, Eide T J, Børresen-Dale A-L, Ikdahl T, Kure E H

Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas.

Mol Oncol 2014 Dec 19. Epub 2014 des 19

PMID: 25579086

Borgan Eldrid, Lindholm Evita M, Moestue Siver, Mælandsmo Gunhild M, Lingjærde Ole Christian, Gribbestad Ingrid S, Børresen-Dale Anne-Lise, Engebraaten Olav, Sørlie Therese

Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts.

Mol Oncol 2013 Feb;7(1):130-42. Epub 2012 okt 23

PMID: 23142657

Stavnes Helene Tuft, Nymoen Dag André, Langerød Anita, Holth Arild, Børresen Dale Anne-Lise, Davidson Ben

AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.

Virchows Arch 2013 Feb;462(2):163-73. Epub 2012 des 15

PMID: 23242172

Aure Miriam Ragle, Steinfeld Israel, Baumbusch Lars Oliver, Liestøl Knut, Lipson Doron, Nyberg Sandra, Naume Bjørn, Sahlberg Kristine Kleivi, Kristensen Vessela N, Børresen-Dale Anne-Lise, Lingjærde Ole Christian, Yakhini Zohar

Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data.

PLoS One 2013;8(1):e53014. Epub 2013 jan 30

PMID: 23382830

Sahlberg Kristine Kleivi, Hongisto Vesa, Edgren Henrik, Mäkelä Rami, Hellström Kirsi, Due Eldri U, Moen Vollan Hans Kristian, Sahlberg Niko, Wolf Maija, Børresen-Dale Anne-Lise, Perälä Merja, Kallioniemi Olli

The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells.

Mol Oncol 2013 Jun;7(3):392-401. Epub 2012 nov 24

PMID: 23253899

Baumbusch Lars O, Helland Åslaug, Wang Yun, Liestøl Knut, Schaner Marci E, Holm Ruth, Etemadmoghadam Dariush, Alsop Kathryn, Brown Pat, Australian Ovarian Cancer Study Group, Mitchell Gillian, Fereday Sian, deFazio Anna, Bowtell David D L, Kristensen Gunnar B, Lingjærde Ole Christian, Børresen-Dale Anne-Lise

High levels of genomic aberrations in serous ovarian cancers are associated with better survival.

PLoS One 2013;8(1):e54356. Epub 2013 jan 23

PMID: 23372714

Margolin Adam A, Bilal Erhan, Huang Erich, Norman Thea C, Ottestad Lars, Mecham Brigham H, Sauerwine Ben, Kellen Michael R, Mangravite Lara M, Furia Matthew D, Vollan Hans Kristian Moen, Rueda Oscar M, Guinney Justin, Deflaux Nicole A, Hoff Bruce, Schildwachter Xavier, Russnes Hege G, Park Daehoon, Vang Veronica O, Pirtle Tyler, Youseff Lamia, Citro Craig, Curtis Christina, Kristensen Vessela N, Hellerstein Joseph, Friend Stephen H, Stolovitzky Gustavo, Aparicio Samuel, Caldas Carlos, Børresen-Dale Anne-Lise

Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.

Sci Transl Med 2013 Apr 17;5(181):181re1.

PMID: 23596205

Bilal Erhan, Dutkowski Janusz, Guinney Justin, Jang In Sock, Logsdon Benjamin A, Pandey Gaurav, Sauerwine Benjamin A, Shimoni Yishai, Moen Vollan Hans Kristian, Mecham Brigham H, Rueda Oscar M, Tost Jorg, Curtis Christina, Alvarez Mariano J, Kristensen Vessela N, Aparicio Samuel, Børresen-Dale Anne-Lise, Caldas Carlos, Califano Andrea, Friend Stephen H, Ideker Trey, Schadt Eric E, Stolovitzky Gustavo A, Margolin Adam A

Improving breast cancer survival analysis through competition-based multidimensional modeling.

PLoS Comput Biol 2013;9(5):e1003047. Epub 2013 mai 9

PMID: 23671412

Edvardsen Hege, Landmark-Høyvik Hege, Reinertsen Kristin V, Zhao Xi, Grenaker-Alnæs Grethe Irene, Nebdal Daniel, Syvänen Ann-Christine, Rødningen Olaug, Alsner Jan, Overgaard Jens, Borresen-Dale Anne-Lise, Fosså Sophie D, Kristensen Vessela N

SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling.

Int J Radiat Oncol Biol Phys 2013 Jul 15;86(4):791-9. Epub 2013 apr 16

PMID: 23597419

Myhre Simen, Lingjærde Ole-Christian, Hennessy Bryan T, Aure Miriam R, Carey Mark S, Alsner Jan, Tramm Trine, Overgaard Jens, Mills Gordon B, Børresen-Dale Anne-Lise, Sørlie Therese

Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins.

Mol Oncol 2013 Jun;7(3):704-18. Epub 2013 mar 19

PMID: 23562353

Alexandrov Ludmil B, Nik-Zainal Serena, Wedge David C, Aparicio Samuel A J R, Behjati Sam, Biankin Andrew V, Bignell Graham R, Bolli Niccolò, Borg Ake, Børresen-Dale Anne-Lise, Boyault Sandrine, Burkhardt Birgit, Butler Adam P, Caldas Carlos, Davies Helen R, Desmedt Christine, Eils Roland, Eyfjörd Jórunn Erla, Foekens John A, Greaves Mel, Hosoda Fumie, Hutter Barbara, Ilicic Tomislav, Imbeaud Sandrine, Imielinski Marcin, Imielinsk Marcin, Jäger Natalie, Jones David T W, Jones David, Knappskog Stian, Kool Marcel, Lakhani Sunil R, López-Otín Carlos, Martin Sancha, Munshi Nikhil C, Nakamura Hiromi, Northcott Paul A, Pajic Marina, Papaemmanuil Elli, Paradiso Angelo, Pearson John V, Puente Xose S, Raine Keiran, Ramakrishna Manasa, Richardson Andrea L, Richter Julia, Rosenstiel Philip, Schlesner Matthias, Schumacher Ton N, Span Paul N, Teague Jon W, Totoki Yasushi, Tutt Andrew N J, Valdés-Mas Rafael, van Buuren Marit M, van 't Veer Laura, Vincent-Salomon Anne, Waddell Nicola, Yates Lucy R, Australian Pancreatic Cancer Genome Initiative, ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, ICGC PedBrain, Zucman-Rossi Jessica, Futreal P Andrew, McDermott Ultan, Lichter Peter, Meyerson Matthew, Grimmond Sean M, Siebert Reiner, Campo Elías, Shibata Tatsuhiro, Pfister Stefan M, Campbell Peter J, Stratton Michael R

Signatures of mutational processes in human cancer.

Nature 2013 Aug 22;500(7463):415-21. Epub 2013 aug 14

PMID: 23945592

Rajaram Megha, Zhang Jianping, Wang Tim, Li Jinyu, Kuscu Cem, Qi Huan, Kato Mamoru, Grubor Vladimir, Weil Robert J, Helland Aslaug, Borrenson-Dale Anne-Lise, Cho Kathleen R, Levine Douglas A, Houghton Alan N, Wolchok Jedd D, Myeroff Lois, Markowitz Sanford D, Lowe Scott W, Zhang Michael, Krasnitz Alex, Lucito Robert, Mu David, Powers R Scott

Two Distinct Categories of Focal Deletions in Cancer Genomes.

PLoS One 2013;8(6):e66264. Epub 2013 jun 21

PMID: 23805207

Klajic Jovana, Fleischer Thomas, Dejeux Emelyne, Edvardsen Hege, Warnberg Fredrik, Bukholm Ida, Lønning Per Eystein, Solvang Hiroko, Børresen-Dale Anne-Lise, Tost Jörg, Kristensen Vessela N

Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors.

BMC Cancer 2013;13():456. Epub 2013 okt 5

PMID: 24093668

Kalous Ondrej, Conklin Dylan, Desai Amrita J, Dering Judy, Goldstein Jennifer, Ginther Charles, Anderson Lee, Lu Ming, Kolarova Teodora, Eckardt Mark A, Langerød Anita, Børresen-Dale Anne-Lise, Slamon Dennis J, Finn Richard S

AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53.

Breast Cancer Res Treat 2013 Oct;141(3):397-408. Epub 2013 okt 5

PMID: 24091768

Landmark-Høyvik Hege, Dumeaux Vanessa, Nebdal Daniel, Lund Eiliv, Tost Jörg, Kamatani Yoichiro, Renault Victor, Børresen-Dale Anne-Lise, Kristensen Vessela, Edvardsen Hege

Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II.

Genomics 2013 Oct;102(4):278-87. Epub 2013 jul 21

PMID: 23880221

Møller Elen K, Kumar Parveen, Voet Thierry, Peterson April, Van Loo Peter, Mathiesen Randi R, Fjelldal Renathe, Grundstad Jason, Borgen Elin, Baumbusch Lars O, Naume Bjørn, Børresen-Dale Anne-Lise, White Kevin P, Nord Silje, Kristensen Vessela N

Next-generation sequencing of disseminated tumor cells.

Front Oncol 2013;3():320. Epub 2013 des 31

PMID: 24427740

Meyer Kerstin B, O'Reilly Martin, Michailidou Kyriaki, Carlebur Saskia, Edwards Stacey L, French Juliet D, Prathalingham Radhika, Dennis Joe, Bolla Manjeet K, Wang Qin, de Santiago Ines, Hopper John L, Tsimiklis Helen, Apicella Carmel, Southey Melissa C, Schmidt Marjanka K, Broeks Annegien, Van 't Veer Laura J, Hogervorst Frans B, Muir Kenneth, Lophatananon Artitaya, Stewart-Brown Sarah, Siriwanarangsan Pornthep, Fasching Peter A, Lux Michael P, Ekici Arif B, Beckmann Matthias W, Peto Julian, dos Santos Silva Isabel, Fletcher Olivia, Johnson Nichola, Sawyer Elinor J, Tomlinson Ian, Kerin Michael J, Miller Nicola, Marme Federick, Schneeweiss Andreas, Sohn Christof, Burwinkel Barbara, Guénel Pascal, Truong Thérèse, Laurent-Puig Pierre, Menegaux Florence, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Milne Roger L, Zamora M Pilar, Arias Jose I, Benitez Javier, Neuhausen Susan, Anton-Culver Hoda, Ziogas Argyrios, Dur Christina C, Brenner Hermann, Müller Heiko, Arndt Volker, Stegmaier Christa, Meindl Alfons, Schmutzler Rita K, Engel Christoph, Ditsch Nina, Brauch Hiltrud, Brüning Thomas, Ko Yon-Dschun, GENICA Network, Nevanlinna Heli, Muranen Taru A, Aittomäki Kristiina, Blomqvist Carl, Matsuo Keitaro, Ito Hidemi, Iwata Hiroji, Yatabe Yasushi, Dörk Thilo, Helbig Sonja, Bogdanova Natalia V, Lindblom Annika, Margolin Sara, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Chenevix-Trench Georgia, kConFab Investigators, Australian Ovarian Cancer Study Group, Wu Anna H, Tseng Chiu-Chen, Van Den Berg David, Stram Daniel O, Lambrechts Diether, Thienpont Bernard, Christiaens Marie-Rose, Smeets Ann, Chang-Claude Jenny, Rudolph Anja, Seibold Petra, Flesch-Janys Dieter, Radice Paolo, Peterlongo Paolo, Bonanni Bernardo, Bernard Loris, Couch Fergus J, Olson Janet E, Wang Xianshu, Purrington Kristen, Giles Graham G, Severi Gianluca, Baglietto Laura, McLean Catriona, Haiman Christopher A, Henderson Brian E, Schumacher Fredrick, Le Marchand Loic, Simard Jacques, Goldberg Mark S, Labrèche France, Dumont Martine, Teo Soo-Hwang, Yip Cheng-Har, Phuah Sze-Yee, Kristensen Vessela, Grenaker Alnæs Grethe, Børresen-Dale Anne-Lise, Zheng Wei, Deming-Halverson Sandra, Shrubsole Martha, Long Jirong, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Kauppila Saila, Andrulis Irene L, Knight Julia A, Glendon Gord, Tchatchou Sandrine, Devilee Peter, Tollenaar Robert A E M, Seynaeve Caroline M, García-Closas Montserrat, Figueroa Jonine, Chanock Stephen J, Lissowska Jolanta, Czene Kamila, Darabi Hartef, Eriksson Kimael, Hooning Maartje J, Martens John W M, van den Ouweland Ans M W, van Deurzen Carolien H M, Hall Per, Li Jingmei, Liu Jianjun, Humphreys Keith, Shu Xiao-Ou, Lu Wei, Gao Yu-Tang, Cai Hui, Cox Angela, Reed Malcolm W R, Blot William, Signorello Lisa B, Cai Qiuyin, Pharoah Paul D P, Ghoussaini Maya, Harrington Patricia, Tyrer Jonathan, Kang Daehee, Choi Ji-Yeob, Park Sue K, Noh Dong-Young, Hartman Mikael, Hui Miao, Lim Wei-Yen, Buhari Shaik A, Hamann Ute, Försti Asta, Rüdiger Thomas, Ulmer Hans-Ulrich, Jakubowska Anna, Lubinski Jan, Jaworska Katarzyna, Durda Katarzyna, Sangrajrang Suleeporn, Gaborieau Valerie, Brennan Paul, McKay James, Vachon Celine, Slager Susan, Fostira Florentia, Pilarski Robert, Shen Chen-Yang, Hsiung Chia-Ni, Wu Pei-Ei, Hou Ming-Feng, Swerdlow Anthony, Ashworth Alan, Orr Nick, Schoemaker Minouk J, Ponder Bruce A J, Dunning Alison M, Easton Douglas F

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.

Am J Hum Genet 2013 Dec 5;93(6):1046-60. Epub 2013 nov 27

PMID: 24290378

Stevens Kristen N, Fredericksen Zachary, Vachon Celine M, Wang Xianshu, Margolin Sara, Lindblom Annika, Nevanlinna Heli, Greco Dario, Aittomäki Kristiina, Blomqvist Carl, Chang-Claude Jenny, Vrieling Alina, Flesch-Janys Dieter, Sinn Hans-Peter, Wang-Gohrke Shan, Nickels Stefan, Brauch Hiltrud, eUtils.ItemsChoiceType2[], Ko Yon-Dschun, Fischer Hans-Peter, Schmutzler Rita K, Meindl Alfons, Bartram Claus R, Schott Sarah, Engel Christoph, Godwin Andrew K, Weaver Joellen, Pathak Harsh B, Sharma Priyanka, Brenner Hermann, Müller Heiko, Arndt Volker, Stegmaier Christa, Miron Penelope, Yannoukakos Drakoulis, Stavropoulou Alexandra, Fountzilas George, Gogas Helen J, Swann Ruth, Dwek Miriam, Perkins Annie, Milne Roger L, Benítez Javier, Zamora María Pilar, Pérez José Ignacio Arias, Bojesen Stig E, Nielsen Sune F, Nordestgaard Børge G, Flyger Henrik, Guénel Pascal, Truong Thérèse, Menegaux Florence, Cordina-Duverger Emilie, Burwinkel Barbara, Marmé Frederick, Schneeweiss Andreas, Sohn Christof, Sawyer Elinor, Tomlinson Ian, Kerin Michael J, Peto Julian, Johnson Nichola, Fletcher Olivia, dos Santos Silva Isabel, Fasching Peter A, Beckmann Matthias W, Hartmann Arndt, Ekici Arif B, Lophatananon Artitaya, Muir Kenneth, Puttawibul Puttisak, Wiangnon Surapon, Schmidt Marjanka K, Broeks Annegien, Braaf Linde M, Rosenberg Efraim H, Hopper John L, Apicella Carmel, Park Daniel J, Southey Melissa C, Swerdlow Anthony J, Ashworth Alan, Orr Nicholas, Schoemaker Minouk J, Anton-Culver Hoda, Ziogas Argyrios, Bernstein Leslie, Dur Christina Clarke, Shen Chen-Yang, Yu Jyh-Cherng, Hsu Huan-Ming, Hsiung Chia-Ni, Hamann Ute, Dünnebier Thomas, Rüdiger Thomas, Ulmer Hans Ulrich, Pharoah Paul P, Dunning Alison M, Humphreys Manjeet K, Wang Qin, Cox Angela, Cross Simon S, Reed Malcom W, Hall Per, Czene Kamila, Ambrosone Christine B, Ademuyiwa Foluso, Hwang Helena, Eccles Diana M, Garcia-Closas Montserrat, Figueroa Jonine D, Sherman Mark E, Lissowska Jolanta, Devilee Peter, Seynaeve Caroline, Tollenaar Rob A E M, Hooning Maartje J, Andrulis Irene L, Knight Julia A, Glendon Gord, Mulligan Anna Marie, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Grip Mervi, John Esther M, Miron Alexander, Alnæs Grethe Grenaker, Kristensen Vessela, Børresen-Dale Anne-Lise, Giles Graham G, Baglietto Laura, McLean Catriona A, Severi Gianluca, Kosel Matthew L, Pankratz V S, Slager Susan, Olson Janet E, Radice Paolo, Peterlongo Paolo, Manoukian Siranoush, Barile Monica, Lambrechts Diether, Hatse Sigrid, Dieudonne Anne-Sophie, Christiaens Marie-Rose, Chenevix-Trench Georgia, eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], Beesley Jonathan, Chen Xiaoqing, Mannermaa Arto, Kosma Veli-Matti, Hartikainen Jaana M, Soini Ylermi, Easton Douglas F, Couch Fergus J

19p13.1 is a triple-negative-specific breast cancer susceptibility locus.

Cancer Res 2012 Apr;72(7):1795-803. Epub 2012 feb 13

PMID: 22331459

Ghoussaini Maya, Fletcher Olivia, Michailidou Kyriaki, Turnbull Clare, Schmidt Marjanka K, Dicks Ed, Dennis Joe, Wang Qin, Humphreys Manjeet K, Luccarini Craig, Baynes Caroline, Conroy Don, Maranian Melanie, Ahmed Shahana, Driver Kristy, Johnson Nichola, Orr Nicholas, dos Santos Silva Isabel, Waisfisz Quinten, Meijers-Heijboer Hanne, Uitterlinden Andre G, Rivadeneira Fernando, eUtils.ItemsChoiceType2[], Hall Per, Czene Kamila, Irwanto Astrid, Liu Jianjun, Nevanlinna Heli, Aittomäki Kristiina, Blomqvist Carl, Meindl Alfons, Schmutzler Rita K, Müller-Myhsok Bertram, Lichtner Peter, Chang-Claude Jenny, Hein Rebecca, Nickels Stefan, Flesch-Janys Dieter, Tsimiklis Helen, Makalic Enes, Schmidt Daniel, Bui Minh, Hopper John L, Apicella Carmel, Park Daniel J, Southey Melissa, Hunter David J, Chanock Stephen J, Broeks Annegien, Verhoef Senno, Hogervorst Frans B L, Fasching Peter A, Lux Michael P, Beckmann Matthias W, Ekici Arif B, Sawyer Elinor, Tomlinson Ian, Kerin Michael, Marme Frederik, Schneeweiss Andreas, Sohn Christof, Burwinkel Barbara, Guénel Pascal, Truong Thérèse, Cordina-Duverger Emilie, Menegaux Florence, Bojesen Stig E, Nordestgaard Børge G, Nielsen Sune F, Flyger Henrik, Milne Roger L, Alonso M Rosario, González-Neira Anna, Benítez Javier, Anton-Culver Hoda, Ziogas Argyrios, Bernstein Leslie, Dur Christina Clarke, Brenner Hermann, Müller Heiko, Arndt Volker, Stegmaier Christa, eUtils.ItemsChoiceType2[], Justenhoven Christina, Brauch Hiltrud, Brüning Thomas, eUtils.ItemsChoiceType2[], Wang-Gohrke Shan, Eilber Ursula, Dörk Thilo, Schürmann Peter, Bremer Michael, Hillemanns Peter, Bogdanova Natalia V, Antonenkova Natalia N, Rogov Yuri I, Karstens Johann H, Bermisheva Marina, Prokofieva Darya, Khusnutdinova Elza, Lindblom Annika, Margolin Sara, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Lambrechts Diether, Yesilyurt Betul T, Floris Giuseppe, Leunen Karin, Manoukian Siranoush, Bonanni Bernardo, Fortuzzi Stefano, Peterlongo Paolo, Couch Fergus J, Wang Xianshu, Stevens Kristen, Lee Adam, Giles Graham G, Baglietto Laura, Severi Gianluca, McLean Catriona, Alnaes Grethe Grenaker, Kristensen Vessela, Børrensen-Dale Anne-Lise, John Esther M, Miron Alexander, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Kauppila Saila, Andrulis Irene L, Glendon Gord, Mulligan Anna Marie, Devilee Peter, van Asperen Christie J, Tollenaar Rob A E M, Seynaeve Caroline, Figueroa Jonine D, Garcia-Closas Montserrat, Brinton Louise, Lissowska Jolanta, Hooning Maartje J, Hollestelle Antoinette, Oldenburg Rogier A, van den Ouweland Ans M W, Cox Angela, Reed Malcolm W R, Shah Mitul, Jakubowska Ania, Lubinski Jan, Jaworska Katarzyna, Durda Katarzyna, Jones Michael, Schoemaker Minouk, Ashworth Alan, Swerdlow Anthony, Beesley Jonathan, Chen Xiaoqing, eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], Muir Kenneth R, Lophatananon Artitaya, Rattanamongkongul Suthee, Chaiwerawattana Arkom, Kang Daehee, Yoo Keun-Young, Noh Dong-Young, Shen Chen-Yang, Yu Jyh-Cherng, Wu Pei-Ei, Hsiung Chia-Ni, Perkins Annie, Swann Ruth, Velentzis Louiza, Eccles Diana M, Tapper Will J, Gerty Susan M, Graham Nikki J, Ponder Bruce A J, Chenevix-Trench Georgia, Pharoah Paul D P, Lathrop Mark, Dunning Alison M, Rahman Nazneen, Peto Julian, Easton Douglas F

Genome-wide association analysis identifies three new breast cancer susceptibility loci.

Nat Genet 2012 Mar;44(3):312-8. Epub 2012 jan 22

PMID: 22267197

Freed-Pastor William A, Mizuno Hideaki, Zhao Xi, Langerød Anita, Moon Sung-Hwan, Rodriguez-Barrueco Ruth, Barsotti Anthony, Chicas Agustin, Li Wencheng, Polotskaia Alla, Bissell Mina J, Osborne Timothy F, Tian Bin, Lowe Scott W, Silva Jose M, Børresen-Dale Anne-Lise, Levine Arnold J, Bargonetti Jill, Prives Carol

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.

Cell 2012 Jan;148(1-2):244-58.

PMID: 22265415

Kim Jiyoung, Villadsen René, Sørlie Therese, Fogh Louise, Grønlund Signe Z, Fridriksdottir Agla J, Kuhn Irene, Rank Fritz, Wielenga Vera Timmermans, Solvang Hiroko, Edwards Paul A W, Børresen-Dale Anne-Lise, Rønnov-Jessen Lone, Bissell Mina J, Petersen Ole William

Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity.

Proc Natl Acad Sci U S A 2012 Apr;109(16):6124-9. Epub 2012 mar 27

PMID: 22454501

Curtis Christina, Shah Sohrab P, Chin Suet-Feung, Turashvili Gulisa, Rueda Oscar M, Dunning Mark J, Speed Doug, Lynch Andy G, Samarajiwa Shamith, Yuan Yinyin, Gräf Stefan, Ha Gavin, Haffari Gholamreza, Bashashati Ali, Russell Roslin, McKinney Steven, eUtils.ItemsChoiceType2[], Langerød Anita, Green Andrew, Provenzano Elena, Wishart Gordon, Pinder Sarah, Watson Peter, Markowetz Florian, Murphy Leigh, Ellis Ian, Purushotham Arnie, Børresen-Dale Anne-Lise, Brenton James D, Tavaré Simon, Caldas Carlos, Aparicio Samuel

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

Nature 2012 Jun;486(7403):346-52. Epub 2012 apr 18

PMID: 22522925

Stephens Philip J, Tarpey Patrick S, Davies Helen, Van Loo Peter, Greenman Chris, Wedge David C, Nik-Zainal Serena, Martin Sancha, Varela Ignacio, Bignell Graham R, Yates Lucy R, Papaemmanuil Elli, Beare David, Butler Adam, Cheverton Angela, Gamble John, Hinton Jonathan, Jia Mingming, Jayakumar Alagu, Jones David, Latimer Calli, Lau King Wai, McLaren Stuart, McBride David J, Menzies Andrew, Mudie Laura, Raine Keiran, Rad Roland, Chapman Michael Spencer, Teague Jon, Easton Douglas, Langerød Anita, eUtils.ItemsChoiceType2[], Lee Ming Ta Michael, Shen Chen-Yang, Tee Benita Tan Kiat, Huimin Bernice Wong, Broeks Annegien, Vargas Ana Cristina, Turashvili Gulisa, Martens John, Fatima Aquila, Miron Penelope, Chin Suet-Feung, Thomas Gilles, Boyault Sandrine, Mariani Odette, Lakhani Sunil R, van de Vijver Marc, van 't Veer Laura, Foekens John, Desmedt Christine, Sotiriou Christos, Tutt Andrew, Caldas Carlos, Reis-Filho Jorge S, Aparicio Samuel A J R, Salomon Anne Vincent, Børresen-Dale Anne-Lise, Richardson Andrea L, Campbell Peter J, Futreal P Andrew, Stratton Michael R

The landscape of cancer genes and mutational processes in breast cancer.

Nature 2012 Jun;486(7403):400-4. Epub 2012 mai 16

PMID: 22722201

Lambrechts Diether, Truong Therese, Justenhoven Christina, Humphreys Manjeet K, Wang Jean, Hopper John L, Dite Gillian S, Apicella Carmel, Southey Melissa C, Schmidt Marjanka K, Broeks Annegien, Cornelissen Sten, van Hien Richard, Sawyer Elinor, Tomlinson Ian, Kerin Michael, Miller Nicola, Milne Roger L, Zamora M Pilar, Pérez José Ignacio Arias, Benítez Javier, Hamann Ute, Ko Yon-Dschun, Brüning Thomas, eUtils.ItemsChoiceType2[], Chang-Claude Jenny, Eilber Ursel, Hein Rebecca, Nickels Stefan, Flesch-Janys Dieter, Wang-Gohrke Shan, John Esther M, Miron Alexander, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Grip Mervi, Chenevix-Trench Georgia, Beesley Jonathan, Chen Xiaoqing, eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], Menegaux Florence, Cordina-Duverger Emilie, Shen Chen-Yang, Yu Jyh-Cherng, Wu Pei-Ei, Hou Ming-Feng, Andrulis Irene L, Selander Teresa, Glendon Gord, Mulligan Anna Marie, Anton-Culver Hoda, Ziogas Argyrios, Muir Kenneth R, Lophatananon Artitaya, Rattanamongkongul Suthee, Puttawibul Puttisak, Jones Michael, Orr Nicholas, Ashworth Alan, Swerdlow Anthony, Severi Gianluca, Baglietto Laura, Giles Graham, Southey Melissa, Marmé Federik, Schneeweiss Andreas, Sohn Christof, Burwinkel Barbara, Yesilyurt Betul T, Neven Patrick, Paridaens Robert, Wildiers Hans, Brenner Hermann, Müller Heiko, Arndt Volker, Stegmaier Christa, Meindl Alfons, Schott Sarah, Bartram Claus R, Schmutzler Rita K, Cox Angela, Brock Ian W, Elliott Graeme, Cross Simon S, Fasching Peter A, Schulz-Wendtland Ruediger, Ekici Arif B, Beckmann Matthias W, Fletcher Olivia, Johnson Nichola, Silva Isabel Dos Santos, Peto Julian, Nevanlinna Heli, Muranen Taru A, Aittomäki Kristiina, Blomqvist Carl, Dörk Thilo, Schürmann Peter, Bremer Michael, Hillemanns Peter, Bogdanova Natalia V, Antonenkova Natalia N, Rogov Yuri I, Karstens Johann H, Khusnutdinova Elza, Bermisheva Marina, Prokofieva Darya, Gancev Shamil, Jakubowska Anna, Lubinski Jan, Jaworska Katarzyna, Durda Katarzyna, Nordestgaard Børge G, Bojesen Stig E, Lanng Charlotte, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana M, Radice Paolo, Peterlongo Paolo, Manoukian Siranoush, Bernard Loris, Couch Fergus J, Olson Janet E, Wang Xianshu, Fredericksen Zachary, Alnaes Grethe Grenaker, Kristensen Vessela, Børresen-Dale Anne-Lise, Devilee Peter, Tollenaar Robert A E M, Seynaeve Caroline M, Hooning Maartje J, García-Closas Montserrat, Chanock Stephen J, Lissowska Jolanta, Sherman Mark E, Hall Per, Liu Jianjun, Czene Kamila, Kang Daehee, Yoo Keun-Young, Noh Dong-Young, Lindblom Annika, Margolin Sara, Dunning Alison M, Pharoah Paul D P, Easton Douglas F, Guénel Pascal, Brauch Hiltrud

11q13 is a susceptibility locus for hormone receptor positive breast cancer.

Hum Mutat 2012 Jul;33(7):1123-32. Epub 2012 apr 30

PMID: 22461340

Vachon Celine M, Scott Christopher G, Fasching Peter A, Hall Per, Tamimi Rulla M, Li Jingmei, Stone Jennifer, Apicella Carmel, Odefrey Fabrice, Gierach Gretchen L, Jud Sebastian M, Heusinger Katharina, Beckmann Matthias W, Pollan Marina, Fernández-Navarro Pablo, Gonzalez-Neira Anna, Benitez Javier, van Gils Carla H, Lokate Mariëtte, Onland-Moret N Charlotte, Peeters Petra H M, Brown Judith, Leyland Jean, Varghese Jajini S, Easton Douglas F, Thompson Deborah J, Luben Robert N, Warren Ruth M L, Wareham Nicholas J, Loos Ruth J F, Khaw Kay-Tee, Ursin Giske, Lee Eunjung, Gayther Simon A, Ramus Susan J, Eeles Rosalind A, Leach Martin O, Kwan-Lim Gek, Couch Fergus J, Giles Graham G, Baglietto Laura, Krishnan Kavitha, Southey Melissa C, Le Marchand Loic, Kolonel Laurence N, Woolcott Christy, Maskarinec Gertraud, Haiman Christopher A, Walker Kate, Johnson Nichola, McCormack Valeria A, Biong Margarethe, Alnaes Grethe I G, Gram Inger Torhild, Kristensen Vessela N, Børresen-Dale Anne-Lise, Lindström Sara, Hankinson Susan E, Hunter David J, Andrulis Irene L, Knight Julia A, Boyd Norman F, Figuero Jonine D, Lissowska Jolanta, Wesolowska Ewa, Peplonska Beata, Bukowska Agnieszka, Reszka Edyta, Liu Jianjun, Eriksson Louise, Czene Kamila, Audley Tina, Wu Anna H, Pankratz V Shane, Hopper John L, dos-Santos-Silva Isabel

Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.

Cancer Epidemiol Biomarkers Prev 2012 Jul;21(7):1156-66. Epub 2012 mar 27

PMID: 22454379

Nik-Zainal Serena, Alexandrov Ludmil B, Wedge David C, Van Loo Peter, Greenman Christopher D, Raine Keiran, Jones David, Hinton Jonathan, Marshall John, Stebbings Lucy A, Menzies Andrew, Martin Sancha, Leung Kenric, Chen Lina, Leroy Catherine, Ramakrishna Manasa, Rance Richard, Lau King Wai, Mudie Laura J, Varela Ignacio, McBride David J, Bignell Graham R, Cooke Susanna L, Shlien Adam, Gamble John, Whitmore Ian, Maddison Mark, Tarpey Patrick S, Davies Helen R, Papaemmanuil Elli, Stephens Philip J, McLaren Stuart, Butler Adam P, Teague Jon W, Jönsson Göran, Garber Judy E, Silver Daniel, Miron Penelope, Fatima Aquila, Boyault Sandrine, Langerød Anita, Tutt Andrew, Martens John W M, Aparicio Samuel A J R, Borg Åke, Salomon Anne Vincent, Thomas Gilles, Børresen-Dale Anne-Lise, Richardson Andrea L, Neuberger Michael S, Futreal P Andrew, Campbell Peter J, Stratton Michael R, eUtils.ItemsChoiceType2[]

Mutational processes molding the genomes of 21 breast cancers.

Cell 2012 May;149(5):979-93. Epub 2012 mai 17

PMID: 22608084

Nik-Zainal Serena, Van Loo Peter, Wedge David C, Alexandrov Ludmil B, Greenman Christopher D, Lau King Wai, Raine Keiran, Jones David, Marshall John, Ramakrishna Manasa, Shlien Adam, Cooke Susanna L, Hinton Jonathan, Menzies Andrew, Stebbings Lucy A, Leroy Catherine, Jia Mingming, Rance Richard, Mudie Laura J, Gamble Stephen J, Stephens Philip J, McLaren Stuart, Tarpey Patrick S, Papaemmanuil Elli, Davies Helen R, Varela Ignacio, McBride David J, Bignell Graham R, Leung Kenric, Butler Adam P, Teague Jon W, Martin Sancha, Jönsson Goran, Mariani Odette, Boyault Sandrine, Miron Penelope, Fatima Aquila, Langerød Anita, Aparicio Samuel A J R, Tutt Andrew, Sieuwerts Anieta M, Borg Åke, Thomas Gilles, Salomon Anne Vincent, Richardson Andrea L, Børresen-Dale Anne-Lise, Futreal P Andrew, Stratton Michael R, Campbell Peter J, eUtils.ItemsChoiceType2[]

The life history of 21 breast cancers.

Cell 2012 May;149(5):994-1007. Epub 2012 mai 17

PMID: 22608083

Bilal Erhan, Vassallo Kristen, Toppmeyer Deborah, Barnard Nicola, Rye Inga H, Almendro Vanessa, Russnes Hege, Børresen-Dale Anne-Lise, Levine Arnold J, Bhanot Gyan, Ganesan Shridar

Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers.

PLoS One 2012;7(6):e38575. Epub 2012 jun 13

PMID: 22719901

Weischer Maren, Nordestgaard Børge G, Pharoah Paul, Bolla Manjeet K, Nevanlinna Heli, Van't Veer Laura J, Garcia-Closas Montserrat, Hopper John L, Hall Per, Andrulis Irene L, Devilee Peter, Fasching Peter A, Anton-Culver Hoda, Lambrechts Diether, Hooning Maartje, Cox Angela, Giles Graham G, Burwinkel Barbara, Lindblom Annika, Couch Fergus J, Mannermaa Arto, Grenaker Alnæs Grethe, John Esther M, Dörk Thilo, Flyger Henrik, Dunning Alison M, Wang Qin, Muranen Taru A, van Hien Richard, Figueroa Jonine, Southey Melissa C, Czene Kamila, Knight Julia A, Tollenaar Rob A E M, Beckmann Matthias W, Ziogas Argyrios, Christiaens Marie-Rose, Collée Johanna Margriet, Reed Malcolm W R, Severi Gianluca, Marme Frederik, Margolin Sara, Olson Janet E, Kosma Veli-Matti, Kristensen Vessela N, Miron Alexander, Bogdanova Natalia, Shah Mitul, Blomqvist Carl, Broeks Annegien, Sherman Mark, Phillips Kelly-Anne, Li Jingmei, Liu Jianjun, Glendon Gord, Seynaeve Caroline, Ekici Arif B, Leunen Karin, Kriege Mieke, Cross Simon S, Baglietto Laura, Sohn Christof, Wang Xianshu, Kataja Vesa, Børresen-Dale Anne-Lise, Meyer Andreas, Easton Douglas F, Schmidt Marjanka K, Bojesen Stig E

CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.

J Clin Oncol 2012 Dec;30(35):4308-16. Epub 2012 okt 29

PMID: 23109706

Hein Rebecca, Maranian Melanie, Hopper John L, Kapuscinski Miroslaw K, Southey Melissa C, Park Daniel J, Schmidt Marjanka K, Broeks Annegien, Hogervorst Frans B L, Bueno-de-Mesquit H Bas, Muir Kenneth R, Lophatananon Artitaya, Rattanamongkongul Suthee, Puttawibul Puttisak, Fasching Peter A, Hein Alexander, Ekici Arif B, Beckmann Matthias W, Fletcher Olivia, Johnson Nichola, dos Santos Silva Isabel, Peto Julian, Sawyer Elinor, Tomlinson Ian, Kerin Michael, Miller Nicola, Marmee Frederick, Schneeweiss Andreas, Sohn Christof, Burwinkel Barbara, Guénel Pascal, Cordina-Duverger Emilie, Menegaux Florence, Truong Thérèse, Bojesen Stig E, Nordestgaard Børge G, Flyger Henrik, Milne Roger L, Perez Jose Ignacio Arias, Zamora M Pilar, Benítez Javier, Anton-Culver Hoda, Ziogas Argyrios, Bernstein Leslie, Clarke Christina A, Brenner Hermann, Müller Heiko, Arndt Volker, Stegmaier Christa, Rahman Nazneen, Seal Sheila, Turnbull Clare, Renwick Anthony, Meindl Alfons, Schott Sarah, Bartram Claus R, Schmutzler Rita K, Brauch Hiltrud, Hamann Ute, Ko Yon-Dschun, eUtils.ItemsChoiceType2[], Wang-Gohrke Shan, Dörk Thilo, Schürmann Peter, Karstens Johann H, Hillemanns Peter, Nevanlinna Heli, Heikkinen Tuomas, Aittomäki Kristiina, Blomqvist Carl, Bogdanova Natalia V, Zalutsky Iosif V, Antonenkova Natalia N, Bermisheva Marina, Prokovieva Darya, Farahtdinova Albina, Khusnutdinova Elza, Lindblom Annika, Margolin Sara, Mannermaa Arto, Kataja Vesa, Kosma Veli-Matti, Hartikainen Jaana, Chen Xiaoqing, Beesley Jonathan, eUtils.ItemsChoiceType2[], eUtils.ItemsChoiceType2[], Lambrechts Diether, Zhao Hui, Neven Patrick, Wildiers Hans, Nickels Stefan, Flesch-Janys Dieter, Radice Paolo, Peterlongo Paolo, Manoukian Siranoush, Barile Monica, Couch Fergus J, Olson Janet E, Wang Xianshu, Fredericksen Zachary, Giles Graham G, Baglietto Laura, McLean Catriona A, Severi Gianluca, Offit Kenneth, Robson Mark, Gaudet Mia M, Vijai Joseph, Alnæs Grethe Grenaker, Kristensen Vessela, Børresen-Dale Anne-Lise, John Esther M, Miron Alexander, Winqvist Robert, Pylkäs Katri, Jukkola-Vuorinen Arja, Grip Mervi, Andrulis Irene L, Knight Julia A, Glendon Gord, Mulligan Anna Marie, Figueroa Jonine D, García-Closas Montserrat, Lissowska Jolanta, Sherman Mark E, Hooning Maartje, Martens John W M, Seynaeve Caroline, Collée Margriet, Hall Per, Humpreys Keith, Czene Kamila, Liu Jianjun, Cox Angela, Brock Ian W, Cross Simon S, Reed Malcolm W R, Ahmed Shahana, Ghoussaini Maya, Pharoah Paul D P, Kang Daehee, Yoo Keun-Young, Noh Dong-Young, Jakubowska Anna, Jaworska Katarzyna, Durda Katarzyna, Zlowocka Elzbieta, Sangrajrang Suleeporn, Gaborieau Valerie, Brennan Paul, McKay James, Shen Chen-Yang, Yu Jyh-Cherng, Hsu Huan-Ming, Hou Ming-Feng, Orr Nick, Schoemaker Minouk, Ashworth Alan, Swerdlow Anthony, Trentham-Dietz Amy, Newcomb Polly A, Titus Linda, Egan Kathleen M, Chenevix-Trench Georgia, Antoniou Antonis C, Humphreys Manjeet K, Morrison Jonathan, Chang-Claude Jenny, Easton Douglas F, Dunning Alison M

Comparison of 6q25 breast cancer hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC).

PLoS One 2012;7(8):e42380. Epub 2012 aug 7

PMID: 22879957

Joshi H, Bhanot G, Børresen-Dale A-L, Kristensen V

Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway.

Br J Cancer 2012 Nov;107(10):1722-8. Epub 2012 okt 18

PMID: 23079576

Engebraaten Olav, Edvardsen Hege, Løkkevik Erik, Naume Bjørn, Kristensen Vessela, Ottestad Lars, Natarajan Vasanti

Gefitinib in Combination with Weekly Docetaxel in Patients with Metastatic Breast Cancer Caused Unexpected Toxicity: Results from a Randomized Phase II Clinical Trial.

ISRN Oncol 2012;2012():176789. Epub 2012 mai 14

PMID: 22666610

Lindholm Evita M, Kristian Alexandr, Nalwoga Hawa, Krüger Kristi, Nygård Ståle, Akslen Lars A, Mælandsmo Gunhild M, Engebraaten Olav

Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts.

Mol Oncol 2012 Aug;6(4):418-27. Epub 2012 mar 31

PMID: 22521242

Huuse Else M, Moestue Siver A, Lindholm Evita M, Bathen Tone F, Nalwoga Hawa, Krüger Kristi, Bofin Anna, Maelandsmo Gunhild M, Akslen Lars A, Engebraaten Olav, Gribbestad Ingrid S

In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts.

J Magn Reson Imaging 2012 May;35(5):1098-107. Epub 2011 des 14

PMID: 22170753

Mathiesen Randi R, Fjelldal Renathe, Liestøl Knut, Due Eldri U, Geigl Jochen B, Riethdorf Sabine, Borgen Elin, Rye Inga H, Schneider Ida J, Obenauf Anna C, Mauermann Oliver, Nilsen Gro, Christian Lingjaerde Ole, Børresen-Dale Anne-Lise, Pantel Klaus, Speicher Michael R, Naume Bjørn, Baumbusch Lars O

High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer.

Int J Cancer 2012 Aug;131(4):E405-15. Epub 2011 nov 9

PMID: 21935921

Molloy Timothy J, Roepman Paul, Naume Bjørn, Van't Veer Laura J

A prognostic gene expression profile that predicts circulating tumor cell presence in breast cancer patients.

PLoS One 2012;7(2):e32426. Epub 2012 feb 23

PMID: 22384245

Mathiesen Randi R, Borgen Elin, Renolen Anne, Løkkevik Erik, Nesland Jahn M, Anker Gun, Ostenstad Bjørn, Lundgren Steinar, Risberg Terje, Mjaaland Ingvil, Kvalheim Gunnar, Lønning Per Eystein, Naume Bjørn

Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival.

Breast Cancer Res 2012 Aug;14(4):R117. Epub 2012 aug 14

PMID: 22889108

Wist E A, Mjaaland I, Løkkevik E, Sommer H H

Weekly Paclitaxel plus Capecitabine versus Docetaxel Every 3 Weeks plus Capecitabine in Metastatic Breast Cancer.

J Oncol 2012;2012():862921. Epub 2012 jan 15

PMID: 22291703

Zhao Xi, Rødland Einar Andreas, Sørlie Therese, Naume Bjørn, Langerød Anita, Frigessi Arnoldo, Kristensen Vessela N, Børresen-Dale Anne-Lise, Lingjærde Ole Christian

Combining gene signatures improves prediction of breast cancer survival.

PLoS One 2011;6(3):e17845. Epub 2011 mar 10

PMID: 21423775

Solvang Hiroko K, Lingjærde Ole Christian, Frigessi Arnoldo, Børresen-Dale Anne-Lise, Kristensen Vessela N

Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer.

BMC Bioinformatics 2011;12():197. Epub 2011 mai 24

PMID: 21609452

Borgan Eldrid, Navon Roy, Vollan Hans Kristian Moen, Schlichting Ellen, Sauer Torill, Yakhini Zohar, Lingjærde Ole Christian, Sørlie Therese, Børresen-Dale Anne-Lise

Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue.

Mol Oncol 2011 Dec;5(6):564-76. Epub 2011 aug 29

PMID: 21917534

Kristensen Vessela N, Vaske Charles J, Ursini-Siegel Josie, Van Loo Peter, Nordgard Silje H, Sachidanandam Ravi, Sørlie Therese, Wärnberg Fredrik, Haakensen Vilde D, Helland Åslaug, Naume Bjørn, Perou Charles M, Haussler David, Troyanskaya Olga G, Børresen-Dale Anne-Lise

Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling.

Proc Natl Acad Sci U S A 2012 Feb;109(8):2802-7. Epub 2011 sep 9

PMID: 21908711

Knappskog Stian, Bjørnslett Merete, Myklebust Line M, Huijts Petra E A, Vreeswijk Maaike P, Edvardsen Hege, Guo Yongli, Zhang Xuemei, Yang Ming, Ylisaukko-Oja Sanna K, Alhopuro Pia, Arola Johanna, Tollenaar Rob A E M, van Asperen Christi J, Seynaeve Caroline, Staalesen Vidar, Chrisanthar Ranjan, Løkkevik Erik, Salvesen Helga B, Evans D Gareth, Newman William G, Lin Dongxin, Aaltonen Lauri A, Børresen-Dale Anne-Lise, Tell Grethe S, Stoltenberg Camilla, Romundstad Pål, Hveem Kristian, Lillehaug Johan R, Vatten Lars, Devilee Peter, Dørum Anne, Lønning Per E

The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.

Cancer Cell 2011 Feb;19(2):273-82.

PMID: 21316605

Kaveh Fatemeh, Edvardsen Hege, Borresen-Dale Anne-Lise, Kristensen Vessela N, Solvang Hiroko K

Allele-specific disparity in breast cancer.

BMC Med Genomics 2011 Dec;4(1):85. Epub 2011 des 21

PMID: 22188678

Russnes Hege G, Kuligina Ekatherina Sh, Suspitsin Evgeny N, Voskresenskiy Dmitry A, Jordanova Ekaterina S, Cornelisse Cees J, Borresen-Dale Anne-Lise, Imyanitov Evgeny N

Paired distribution of molecular subtypes in bilateral breast carcinomas.

Cancer Genet 2011 Feb;204(2):96-102.

PMID: 21504707

Russnes HG, Navin N, Hicks J, Børresen-Dale AL

Insight into the heterogeneity of breast cancer through next-generation sequencing

J.Clin Invest.2011 Oct 3:121(10):3810-8

Doktorgrader
Thomas Fleischer

Epigenetic alterations in breast cancer: implications on classification and prognosis.

Disputert:
juni 2014
Hovedveileder:
Vessela N. Kristensen
Sandra Johanna Nyberg

The search for therapeutic targets in breast cancer by genome analyses

Disputert:
desember 2014
Hovedveileder:
Kristine Kleivi Sahlberg
Jovana Jovanovic

From normal breast to invasive carcinoma: DNA methylation profiling of stage and response to chemotherapy.

Disputert:
januar 2014
Hovedveileder:
Vessela N. Kristensen
David Quigley

Rewiring of Genetic Networks in Breast and Skin Cancer Progression.

Disputert:
oktober 2014
Hovedveileder:
Anne-Lise Børresen-Dale
Miriam Ragle Aure

From DNA to RNA to protein: Integrated analysies of high-throughput molecular data from primary breast carcinomas

Disputert:
november 2013
Hovedveileder:
Vessela N. Kristensen
Fatemeh Kaveh

Genomic signatures in the progression of breast cancer with reference to gynecological carcinomas

Disputert:
oktober 2013
Hovedveileder:
Vessela N. Kristensen
Simen Myhre

A molecular study of breast carcinomas in relation to patient outcome and tumor characteristics

Disputert:
september 2011
Hovedveileder:
Anne-Lise Børresen-Dale
Hege Benedicte Knutsen Landmark-Høyvik

Genomic studies of breast cancer survivors; Associations to treatment-induced late side effects

Disputert:
desember 2011
Hovedveileder:
Anne-Lise Børresen-Dale
Xi Zhao

Systems biology and genomics of breast cancer through mining multi-level molecular profiles

Disputert:
desember 2011
Hovedveileder:
Anne-Lise Børresen-Dale
Deltagere
  • Jahn M Nesland Prosjektdeltaker
  • Ida Rashida Khan Bukholm Prosjektdeltaker
  • Kristine Kleivi Sahlberg Prosjektdeltaker
  • Lisbeth Winger Prosjektdeltaker
  • Mette Kjeldsen Willet Prosjektdeltaker
  • Kristin Høimyr Prosjektdeltaker
  • Ole Christian Lingjærde Prosjektdeltaker
  • Tone Frost Bathen Prosjektdeltaker
  • Gunhild Mælandsmo Prosjektdeltaker
  • Øystein Fodstad Prosjektdeltaker
  • Vessela N. Kristensen Forskningsgruppeleder
  • Anne-Lise Børresen-Dale Prosjektleder
  • Bjørn Naume Prosjektdeltaker
  • Olav Engebråten Prosjektdeltaker
  • Erik Wist Prosjektdeltaker
  • Hege Elisabeth Giercksky Russnes Prosjektdeltaker
  • Elin Borgen Prosjektdeltaker
  • Torill Sauer Prosjektdeltaker
  • Rolf Kåresen Prosjektdeltaker
  • Ellen Schlichting Prosjektdeltaker
  • Silje Nord Prosjektdeltaker
  • Miriam Ragle Aure Doktorgradsstipendiat
  • Ingrid Gribbestad Prosjektdeltaker
  • Quirina Thio Prosjektdeltaker
  • Laila Jansen Prosjektdeltaker
  • Cathrine Pedersen Prosjektdeltaker
  • Fatemeh Kaveh Doktorgradsstipendiat
  • Hege Edvardsen Forsker (annen finansiering)

eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT

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