Oslo Breast Cancer Research Concortium
- Prosjektnummer
- 2011042
- Ansvarlig person
- Anne-Lise Børresen-Dale
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst Forskningsgruppe
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors.
Carcinogenesis 2014 Jan;35(1):76-85. Epub 2013 okt 8
PMID: 24104550
High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth.
Mol Oncol 2014 Feb;8(1):93-104. Epub 2013 okt 11
PMID: 24148764
Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer.
Breast Cancer Res Treat 2014 Jan;143(1):189-201. Epub 2013 des 4
PMID: 24305980
Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity.
Cell Rep 2014 Feb 13;6(3):514-27. Epub 2014 jan 23
PMID: 24462293
Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients.
Int J Cancer 2014 Jun 1;134(11):2615-25. Epub 2014 jan 6
PMID: 24395279
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.
Clin Cancer Res 2014 Jul 1;20(13):3569-80. Epub 2014 mai 6
PMID: 24803582
Association of N-glycosylation with breast carcinoma and systemic features using high-resolution quantitative UPLC.
J Proteome Res 2014 May 2;13(5):2314-27. Epub 2014 apr 11
PMID: 24669823
Interplay of choline metabolites and genes in patient-derived breast cancer xenografts.
Breast Cancer Res 2014;16(1):R5. Epub 2014 jan 21
PMID: 24447408
The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.
Mol Oncol 2014 Mar;8(2):273-84. Epub 2013 des 3
PMID: 24388359
Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas.
Int J Cancer 2014 Oct 15;135(8):1812-21. Epub 2014 mar 14
PMID: 24599520
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
BMC Cancer 2014;14():211. Epub 2014 mar 19
PMID: 24645668
Processed pseudogenes acquired somatically during cancer development.
Nat Commun 2014;5():3644. Epub 2014 apr 9
PMID: 24714652
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy.
Int J Cancer 2014 Nov 1;135(9):2085-95. Epub 2014 apr 5
PMID: 24658971
Mutation screening of the TP53 gene by temporal temperature gel electrophoresis (TTGE).
Methods Mol Biol 2014;1105():315-24.
PMID: 24623239
Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c.
Br J Cancer 2014 Apr 15;110(8):2072-80. Epub 2014 feb 27
PMID: 24577056
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.
Br J Cancer 2014 Jul 15;111(2):326-38. Epub 2014 jun 5
PMID: 24901235
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
Science 2014 Aug 1;345(6196):1251343.
PMID: 25082706
Global gene expression analysis reveals a link between NDRG1 and vesicle transport.
PLoS One 2014;9(1):e87268. Epub 2014 jan 31
PMID: 24498060
Development and validation of a gene profile predicting benefit of postmastectomy radiotherapy in patients with high-risk breast cancer: a study of gene expression in the DBCG82bc cohort.
Clin Cancer Res 2014 Oct 15;20(20):5272-80. Epub 2014 aug 22
PMID: 25149560
Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.
Genome Biol 2014;15(8):435. Epub 2014 aug 22
PMID: 25146004
Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo.
Br J Cancer 2014 Nov 25;111(11):2142-51. Epub 2014 sep 30
PMID: 25268374
Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
Cancer Cell 2014 Dec 8;26(6):863-79.
PMID: 25490449
A serum microRNA signature predicts tumor relapse and survival in triple-negative breast cancer patients.
Clin Cancer Res 2015 Mar 1;21(5):1207-14. Epub 2014 des 29
PMID: 25547678
Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors.
Genes Chromosomes Cancer 2015 Apr;54(4):235-48. Epub 2014 des 26
PMID: 25546585
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Hum Mol Genet 2015 Mar 1;24(5):1478-92. Epub 2014 nov 6
PMID: 25378557
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.
Mol Cancer Res 2015 Mar;13(3):493-501. Epub 2014 okt 28
PMID: 25351767
The multitude of molecular analyses in cancer: the opening of Pandora's box.
Genome Biol 2014 Sep 3;15(9):447. Epub 2014 sep 3
PMID: 25316146
Principles and methods of integrative genomic analyses in cancer.
Nat Rev Cancer 2014 May;14(5):299-313.
PMID: 24759209
Molecular signatures of mRNAs and miRNAs as prognostic biomarkers in pancreatobiliary and intestinal types of periampullary adenocarcinomas.
Mol Oncol 2014 Dec 19. Epub 2014 des 19
PMID: 25579086
Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts.
Mol Oncol 2013 Feb;7(1):130-42. Epub 2012 okt 23
PMID: 23142657
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.
Virchows Arch 2013 Feb;462(2):163-73. Epub 2012 des 15
PMID: 23242172
Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data.
PLoS One 2013;8(1):e53014. Epub 2013 jan 30
PMID: 23382830
The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells.
Mol Oncol 2013 Jun;7(3):392-401. Epub 2012 nov 24
PMID: 23253899
High levels of genomic aberrations in serous ovarian cancers are associated with better survival.
PLoS One 2013;8(1):e54356. Epub 2013 jan 23
PMID: 23372714
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.
Sci Transl Med 2013 Apr 17;5(181):181re1.
PMID: 23596205
Improving breast cancer survival analysis through competition-based multidimensional modeling.
PLoS Comput Biol 2013;9(5):e1003047. Epub 2013 mai 9
PMID: 23671412
SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling.
Int J Radiat Oncol Biol Phys 2013 Jul 15;86(4):791-9. Epub 2013 apr 16
PMID: 23597419
Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins.
Mol Oncol 2013 Jun;7(3):704-18. Epub 2013 mar 19
PMID: 23562353
Two Distinct Categories of Focal Deletions in Cancer Genomes.
PLoS One 2013;8(6):e66264. Epub 2013 jun 21
PMID: 23805207
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors.
BMC Cancer 2013;13():456. Epub 2013 okt 5
PMID: 24093668
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53.
Breast Cancer Res Treat 2013 Oct;141(3):397-408. Epub 2013 okt 5
PMID: 24091768
Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II.
Genomics 2013 Oct;102(4):278-87. Epub 2013 jul 21
PMID: 23880221
Next-generation sequencing of disseminated tumor cells.
Front Oncol 2013;3():320. Epub 2013 des 31
PMID: 24427740
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Cell 2012 Jan;148(1-2):244-58.
PMID: 22265415
Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity.
Proc Natl Acad Sci U S A 2012 Apr;109(16):6124-9. Epub 2012 mar 27
PMID: 22454501
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Nature 2012 Jun;486(7403):346-52. Epub 2012 apr 18
PMID: 22522925
The landscape of cancer genes and mutational processes in breast cancer.
Nature 2012 Jun;486(7403):400-4. Epub 2012 mai 16
PMID: 22722201
Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.
Cancer Epidemiol Biomarkers Prev 2012 Jul;21(7):1156-66. Epub 2012 mar 27
PMID: 22454379
Mutational processes molding the genomes of 21 breast cancers.
Cell 2012 May;149(5):979-93. Epub 2012 mai 17
PMID: 22608084
The life history of 21 breast cancers.
Cell 2012 May;149(5):994-1007. Epub 2012 mai 17
PMID: 22608083
Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers.
PLoS One 2012;7(6):e38575. Epub 2012 jun 13
PMID: 22719901
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.
J Clin Oncol 2012 Dec;30(35):4308-16. Epub 2012 okt 29
PMID: 23109706
Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway.
Br J Cancer 2012 Nov;107(10):1722-8. Epub 2012 okt 18
PMID: 23079576
Gefitinib in Combination with Weekly Docetaxel in Patients with Metastatic Breast Cancer Caused Unexpected Toxicity: Results from a Randomized Phase II Clinical Trial.
ISRN Oncol 2012;2012():176789. Epub 2012 mai 14
PMID: 22666610
Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts.
Mol Oncol 2012 Aug;6(4):418-27. Epub 2012 mar 31
PMID: 22521242
In vivo MRI and histopathological assessment of tumor microenvironment in luminal-like and basal-like breast cancer xenografts.
J Magn Reson Imaging 2012 May;35(5):1098-107. Epub 2011 des 14
PMID: 22170753
High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer.
Int J Cancer 2012 Aug;131(4):E405-15. Epub 2011 nov 9
PMID: 21935921
A prognostic gene expression profile that predicts circulating tumor cell presence in breast cancer patients.
PLoS One 2012;7(2):e32426. Epub 2012 feb 23
PMID: 22384245
Persistence of disseminated tumor cells after neoadjuvant treatment for locally advanced breast cancer predicts poor survival.
Breast Cancer Res 2012 Aug;14(4):R117. Epub 2012 aug 14
PMID: 22889108
Weekly Paclitaxel plus Capecitabine versus Docetaxel Every 3 Weeks plus Capecitabine in Metastatic Breast Cancer.
J Oncol 2012;2012():862921. Epub 2012 jan 15
PMID: 22291703
Combining gene signatures improves prediction of breast cancer survival.
PLoS One 2011;6(3):e17845. Epub 2011 mar 10
PMID: 21423775
Linear and non-linear dependencies between copy number aberrations and mRNA expression reveal distinct molecular pathways in breast cancer.
BMC Bioinformatics 2011;12():197. Epub 2011 mai 24
PMID: 21609452
Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue.
Mol Oncol 2011 Dec;5(6):564-76. Epub 2011 aug 29
PMID: 21917534
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling.
Proc Natl Acad Sci U S A 2012 Feb;109(8):2802-7. Epub 2011 sep 9
PMID: 21908711
The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.
Cancer Cell 2011 Feb;19(2):273-82.
PMID: 21316605
Allele-specific disparity in breast cancer.
BMC Med Genomics 2011 Dec;4(1):85. Epub 2011 des 21
PMID: 22188678
Paired distribution of molecular subtypes in bilateral breast carcinomas.
Cancer Genet 2011 Feb;204(2):96-102.
PMID: 21504707
Insight into the heterogeneity of breast cancer through next-generation sequencing
J.Clin Invest.2011 Oct 3:121(10):3810-8
Epigenetic alterations in breast cancer: implications on classification and prognosis.
- Disputert:
- juni 2014
- Hovedveileder:
- Vessela N. Kristensen
The search for therapeutic targets in breast cancer by genome analyses
- Disputert:
- desember 2014
- Hovedveileder:
- Kristine Kleivi Sahlberg
From normal breast to invasive carcinoma: DNA methylation profiling of stage and response to chemotherapy.
- Disputert:
- januar 2014
- Hovedveileder:
- Vessela N. Kristensen
Rewiring of Genetic Networks in Breast and Skin Cancer Progression.
- Disputert:
- oktober 2014
- Hovedveileder:
- Anne-Lise Børresen-Dale
From DNA to RNA to protein: Integrated analysies of high-throughput molecular data from primary breast carcinomas
- Disputert:
- november 2013
- Hovedveileder:
- Vessela N. Kristensen
Genomic signatures in the progression of breast cancer with reference to gynecological carcinomas
- Disputert:
- oktober 2013
- Hovedveileder:
- Vessela N. Kristensen
A molecular study of breast carcinomas in relation to patient outcome and tumor characteristics
- Disputert:
- september 2011
- Hovedveileder:
- Anne-Lise Børresen-Dale
Genomic studies of breast cancer survivors; Associations to treatment-induced late side effects
- Disputert:
- desember 2011
- Hovedveileder:
- Anne-Lise Børresen-Dale
Systems biology and genomics of breast cancer through mining multi-level molecular profiles
- Disputert:
- desember 2011
- Hovedveileder:
- Anne-Lise Børresen-Dale
- Jahn M Nesland Prosjektdeltaker
- Ida Rashida Khan Bukholm Prosjektdeltaker
- Kristine Kleivi Sahlberg Prosjektdeltaker
- Lisbeth Winger Prosjektdeltaker
- Mette Kjeldsen Willet Prosjektdeltaker
- Kristin Høimyr Prosjektdeltaker
- Ole Christian Lingjærde Prosjektdeltaker
- Tone Frost Bathen Prosjektdeltaker
- Gunhild Mælandsmo Prosjektdeltaker
- Øystein Fodstad Prosjektdeltaker
- Vessela N. Kristensen Forskningsgruppeleder
- Anne-Lise Børresen-Dale Prosjektleder
- Bjørn Naume Prosjektdeltaker
- Olav Engebråten Prosjektdeltaker
- Erik Wist Prosjektdeltaker
- Hege Elisabeth Giercksky Russnes Prosjektdeltaker
- Elin Borgen Prosjektdeltaker
- Torill Sauer Prosjektdeltaker
- Rolf Kåresen Prosjektdeltaker
- Ellen Schlichting Prosjektdeltaker
- Silje Nord Prosjektdeltaker
- Miriam Ragle Aure Doktorgradsstipendiat
- Ingrid Gribbestad Prosjektdeltaker
- Quirina Thio Prosjektdeltaker
- Laila Jansen Prosjektdeltaker
- Cathrine Pedersen Prosjektdeltaker
- Fatemeh Kaveh Doktorgradsstipendiat
- Hege Edvardsen Forsker (annen finansiering)
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