Inflammatory mechanisms in cardiovascular disorders
- Prosjektnummer
- 2011078
- Ansvarlig person
- Pål Aukrust
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst forskningsgruppe
- Helsekategori
- Cardiovascular, Inflammatory and Immune System
- Forskningsaktivitet
- 5. Treatment Developement
Secreted Wnt antagonists during eradication of cytomegalovirus infection in solid organ transplant recipients.
Am J Transplant 2014 Jan;14(1):210-5. Epub 2013 nov 13
PMID: 24224707
Low level of inflammatory marker in hyperhomocysteinemic patients on statin therapy.
Scand J Clin Lab Invest 2014 Jan;74(1):1-7. Epub 2013 nov 18
PMID: 24236948
The relationship between markers of extracellular cardiac matrix turnover: infarct healing and left ventricular remodelling following primary PCI in patients with first-time STEMI.
Eur Heart J 2014 Feb;35(6):395-402. Epub 2013 nov 18
PMID: 24255130
Prognostic effect of high-sensitive troponin T assessment in elderly patients with chronic heart failure: results from the CORONA trial.
Circ Heart Fail 2014 Jan;7(1):96-103. Epub 2013 nov 27
PMID: 24284025
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.
J Intern Med 2014 Jun;275(6):621-30. Epub 2014 jan 9
PMID: 24330105
Matrix metalloproteinase 7 is associated with symptomatic lesions and adverse events in patients with carotid atherosclerosis.
PLoS One 2014;9(1):e84935. Epub 2014 jan 6
PMID: 24400123
Interleukin-6 signaling, soluble glycoprotein 130, and inflammation in heart failure.
Curr Heart Fail Rep 2014 Jun;11(2):146-55.
PMID: 24477903
Increased levels of CCR7 ligands in carotid atherosclerosis: different effects in macrophages and smooth muscle cells.
Cardiovasc Res 2014 Apr 1;102(1):148-56. Epub 2014 feb 11
PMID: 24518141
Plasma NGAL and glomerular filtration rate in cardiac transplant recipients treated with standard or reduced calcineurin inhibitor levels.
Biomark Med 2014;8(2):239-45.
PMID: 24521021
Subjects with familial hypercholesterolemia are characterized by an inflammatory phenotype despite long-term intensive cholesterol lowering treatment.
Atherosclerosis 2014 Apr;233(2):561-7. Epub 2014 jan 24
PMID: 24530965
The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial.
PLoS One 2014;9(2):e89732. Epub 2014 feb 25
PMID: 24586994
The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions.
J Intern Med 2014 Nov;276(5):525-36. Epub 2014 mar 24
PMID: 24588843
Activated platelets promote increased monocyte expression of CXCR5 through prostaglandin E2-related mechanisms and enhance the anti-inflammatory effects of CXCL13.
Atherosclerosis 2014 Jun;234(2):352-9. Epub 2014 mar 31
PMID: 24732574
CXCR4 blockade induces atherosclerosis by affecting neutrophil function.
J Mol Cell Cardiol 2014 Sep;74():44-52. Epub 2014 mai 8
PMID: 24816217
A salmon protein hydrolysate exerts lipid-independent anti-atherosclerotic activity in ApoE-deficient mice.
PLoS One 2014;9(5):e97598. Epub 2014 mai 19
PMID: 24840793
Markers of atherosclerotic development in children with familial hypercholesterolemia: a literature review.
Atherosclerosis 2014 Aug;235(2):299-309. Epub 2014 mai 20
PMID: 24908240
Interleukin-10 increases reverse cholesterol transport in macrophages through its bidirectional interaction with liver X receptor a.
Biochem Biophys Res Commun 2014 Aug 8;450(4):1525-30. Epub 2014 jul 15
PMID: 25035925
Circulating dickkopf-1 in diabetes mellitus: association with platelet activation and effects of improved metabolic control and low-dose aspirin.
J Am Heart Assoc 2014 Aug;3(4). Epub 2014 jul 18
PMID: 25037197
A vital role for complement in heart disease.
Mol Immunol 2014 Oct;61(2):126-34. Epub 2014 jul 16
PMID: 25037633
Toll-like receptor 9 mediated responses in cardiac fibroblasts.
PLoS One 2014;9(8):e104398. Epub 2014 aug 15
PMID: 25126740
Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension.
PLoS One 2014;9(8):e104407. Epub 2014 aug 15
PMID: 25126943
Inflammatory cytokines as biomarkers in heart failure.
Clin Chim Acta 2015 Mar 30;443():71-7. Epub 2014 sep 6
PMID: 25199849
Adipose tissue distribution in relation to insulin sensitivity and inflammation in Pakistani and Norwegian subjects with type 2 diabetes.
Scand J Clin Lab Invest 2014 Nov;74(8):700-7. Epub 2014 sep 16
PMID: 25223599
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.
J Intern Med 2015 Jun;277(6):717-26. Epub 2014 des 1
PMID: 25382824
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling.
PLoS One 2014;9(11):e112172. Epub 2014 nov 14
PMID: 25398010
Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure: analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Circ Heart Fail 2013 Jan;6(1):91-8. Epub 2012 des 10
PMID: 23230311
Tetradecylthioacetic acid increases fat metabolism and improves cardiac function in experimental heart failure.
Lipids 2013 Feb;48(2):139-54. Epub 2012 des 25
PMID: 23266898
Cardiac resynchronization therapy improves minute ventilation/carbon dioxide production slope and skeletal muscle capillary density without reversal of skeletal muscle pathology or inflammation.
Europace 2013 Jun;15(6):857-64. Epub 2013 jan 15
PMID: 23322010
Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH.
Circ Heart Fail 2013 Mar;6(2):219-26. Epub 2013 feb 8
PMID: 23395934
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse.
J Appl Physiol (1985) 2013 Apr;114(8):988-97. Epub 2013 feb 14
PMID: 23412898
CCL21 is associated with fatal outcomes in chronic heart failure: data from CORONA and GISSI-HF trials.
Eur J Heart Fail 2013 Jul;15(7):747-55. Epub 2013 mar 13
PMID: 23487539
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Cardiovasc Res 2013 Jul 1;99(1):164-74. Epub 2013 apr 10
PMID: 23580606
Association of ficolin-3 with severity and outcome of chronic heart failure.
PLoS One 2013;8(4):e60976. Epub 2013 apr 15
PMID: 23596511
Prognostic value of CXCL16 in patients with left ventricular systolic dysfunction and heart failure.
Int J Cardiol 2013 Oct 9;168(4):4427-9. Epub 2013 mai 26
PMID: 23714594
An Immunomodulating Fatty Acid Analogue Targeting Mitochondria Exerts Anti-Atherosclerotic Effect beyond Plasma Cholesterol-Lowering Activity in apoE(-/-) Mice.
PLoS One 2013;8(12):e81963. Epub 2013 des 4
PMID: 24324736
Subjects with low plasma HDL cholesterol levels are characterized by an inflammatory and oxidative phenotype.
PLoS One 2013;8(11):e78241. Epub 2013 nov 11
PMID: 24244297
Soluble CXCL16 and long-term outcome in acute ischemic stroke.
Atherosclerosis 2012 Jan;220(1):244-9. Epub 2011 okt 12
PMID: 22055341
Antibodies to common infectious agents in coronary artery disease patients with and without rheumatic conditions.
Rheumatology (Oxford) 2012 Apr;51(4):679-85. Epub 2011 des 11
PMID: 22157685
Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies.
Eur J Endocrinol 2012 Mar;166(3):503-10. Epub 2011 des 14
PMID: 22170794
Increased interleukin-1ß levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
J Intern Med 2012 Sep;272(3):267-76. Epub 2012 feb 26
PMID: 22243053
Activin A and cardiovascular disease in type 2 diabetes mellitus.
Diab Vasc Dis Res 2012 Jul;9(3):234-7. Epub 2012 jan 10
PMID: 22234949
The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*.
J Intern Med 2012 May;271(5):436-43. Epub 2012 jan 16
PMID: 22211640
NT-proBNP predicts myocardial recovery after non-ST-elevation acute coronary syndrome.
Scand Cardiovasc J 2012 Apr;46(2):65-71. Epub 2012 jan 23
PMID: 22191851
Serum levels of neutrophil gelatinase-associated lipocalin are associated with microalbuminuria in HIV-infected patients.
J Acquir Immune Defic Syndr 2012 Feb;59(2):e24-5.
PMID: 22245717
Soluble ST2 is associated with adverse outcome in patients with heart failure of ischaemic aetiology.
Eur J Heart Fail 2012 Mar;14(3):268-77. Epub 2012 feb 2
PMID: 22302661
Adipocytes as a source of increased circulating levels of nicotinamide phosphoribosyltransferase/visfatin in active acromegaly.
J Clin Endocrinol Metab 2012 Apr;97(4):1355-62. Epub 2012 feb 8
PMID: 22319029
Improvement in renal function after everolimus introduction and calcineurin inhibitor reduction in maintenance thoracic transplant recipients: the significance of baseline glomerular filtration rate.
J Heart Lung Transplant 2012 Mar;31(3):259-65.
PMID: 22333403
Plasma levels of soluble CD36, platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients.
Free Radic Biol Med 2012 Apr;52(8):1318-24. Epub 2012 feb 15
PMID: 22343420
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle.
J Appl Physiol 2012 Apr;112(8):1372-82. Epub 2012 feb 16
PMID: 22345433
High levels of S100A12 are associated with recent plaque symptomatology in patients with carotid atherosclerosis.
Stroke 2012 May;43(5):1347-53. Epub 2012 mar 1
PMID: 22382154
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure.
PLoS One 2012;7(3):e33038. Epub 2012 mar 12
PMID: 22427939
TNF revisited: osteoprotegerin and TNF-related molecules in heart failure.
Curr Heart Fail Rep 2012 Jun;9(2):92-100.
PMID: 22453763
Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology.
Annu Rev Nutr 2012 Aug;32():229-43. Epub 2012 mar 29
PMID: 22462624
Galectin-3 predicts response to statin therapy in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Eur Heart J 2012 Sep;33(18):2290-6. Epub 2012 apr 17
PMID: 22513778
Increased circulating mitochondrial DNA after myocardial infarction.
Int J Cardiol 2012 Jun;158(1):132-4. Epub 2012 mai 10
PMID: 22578950
Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure.
PLoS One 2012;7(5):e36815. Epub 2012 mai 15
PMID: 22615818
Inflammatory cytokines in heart failure: mediators and markers.
Cardiology 2012;122(1):23-35. Epub 2012 jun 12
PMID: 22699305
LDL-apheresis affects markers of endothelial function in patients with homozygous familial hypercholesterolemia.
Thromb Res 2012 Nov;130(5):823-5. Epub 2012 jun 22
PMID: 22728023
Pentraxin-3 in chronic heart failure: the CORONA and GISSI-HF trials.
Eur J Heart Fail 2012 Sep;14(9):992-9. Epub 2012 jun 27
PMID: 22740508
The prediction of adverse cardiac remodelling following myocardial infarction: defining the need for a dynamic multimarker approach.
Heart 2012 Aug;98(15):1112-3.
PMID: 22773683
Visfatin/NAMPT - a hot spot in thrombosis?
Thromb Res 2012 Sep;130(3):289-90. Epub 2012 jul 17
PMID: 22809845
Statins affect the presentation of endothelial chemokines by targeting to multivesicular bodies.
PLoS One 2012;7(7):e40673. Epub 2012 jul 16
PMID: 22815786
Cardiovascular risk factors during second generation antipsychotic treatment are associated with increased C-reactive protein.
Schizophr Res 2012 Sep;140(1-3):169-74. Epub 2012 jul 18
PMID: 22817875
Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis - Potential role in plaque stabilization.
Atherosclerosis 2012 Sep;224(1):266-73. Epub 2012 jul 20
PMID: 22840692
Heart failure biomarkers: focus on interleukin-1 receptor-like 1-based blood tests.
Drugs Today (Barc) 2012 Jul;48(7):479-91.
PMID: 22844659
High-intensity interval training improves peak oxygen uptake and muscular exercise capacity in heart transplant recipients.
Am J Transplant 2012 Nov;12(11):3134-42. Epub 2012 aug 17
PMID: 22900793
Virtual histology assessment of cardiac allograft vasculopathy following introduction of everolimus--results of a multicenter trial.
Am J Transplant 2012 Oct;12(10):2700-9. Epub 2012 sep 7
PMID: 22958738
Multimarker risk assessment including osteoprotegerin and CXCL16 in acute coronary syndromes.
Arterioscler Thromb Vasc Biol 2012 Dec;32(12):3041-9. Epub 2012 sep 27
PMID: 23023373
Highly sensitive troponin T in patients with acute ischemic stroke.
Eur Neurol 2012;68(5):287-93. Epub 2012 okt 5
PMID: 23051820
The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Am Heart J 2012 Dec;164(6):878-83. Epub 2012 okt 29
PMID: 23194488
Secreted wnt modulators in symptomatic aortic stenosis.
J Am Heart Assoc 2012 Dec;1(6):e002261. Epub 2012 des 19
PMID: 23316316
Inflammatory response to percutaneous coronary intervention in stable coronary artery disease.
J Thromb Thrombolysis 2011 Jan;31(1):92-8.
PMID: 20373128
Tumor necrosis factor superfamily molecules in acute coronary syndromes.
Ann Med 2011 Mar;43(2):90-103. Epub 2010 nov 2
PMID: 21039303
Interleukin 1 receptor antagonist is associated with changes in body composition during physiological GH substitution in patients with adult-onset growth hormone deficiency.
Clin Endocrinol (Oxf) 2011 Jan;74(1):60-6.
PMID: 21039720
Children with familial hypercholesterolemia are characterized by an inflammatory imbalance between the tumor necrosis factor a system and interleukin-10.
Atherosclerosis 2011 Jan;214(1):163-8. Epub 2010 nov 1
PMID: 21040915
Osteoprotegerin predicts progression of chronic heart failure: results from CORONA.
Circ Heart Fail 2011 Mar;4(2):145-52. Epub 2011 jan 7
PMID: 21216833
Elevated serum osteoprotegerin levels measured early after acute ST-elevation myocardial infarction predict final infarct size.
Heart 2011 Mar;97(6):460-5. Epub 2011 jan 26
PMID: 21270073
Circulating levels of non-phosphorylated undercarboxylated matrix Gla protein are associated with disease severity in patients with chronic heart failure.
Clin Sci (Lond) 2011 Aug;121(3):119-27.
PMID: 21294711
Persistently raised plasma levels of platelet-derived inflammatory mediators in HIV-infected patients during highly active anti-retroviral therapy.
J Thromb Haemost 2011 May;9(5):1075-7.
PMID: 21324059
Anti-inflammatory and hypolipidemic effects of the modified fatty acid tetradecylthioacetic acid in psoriasis--a pilot study.
Scand J Clin Lab Invest 2011 Jul;71(4):269-73. Epub 2011 feb 21
PMID: 21338276
Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages.
Eur J Clin Invest 2011 Oct;41(10):1098-104. Epub 2011 mar 22
PMID: 21426336
Activin A in nonalcoholic fatty liver disease.
Vitam Horm 2011;85():323-42.
PMID: 21353887
No inflammatory response related to pulmonary hemodynamics in children with systemic to pulmonary shunts.
Congenit Heart Dis 2011 Jul-Aug;6(4):338-46. Epub 2011 mar 31
PMID: 21450032
High intensity interval training reduces systemic inflammation in post-PCI patients.
Eur J Cardiovasc Prev Rehabil 2011 Dec;18(6):850-7. Epub 2011 feb 18
PMID: 21450602
Activin A levels are associated with abnormal glucose regulation in patients with myocardial infarction: potential counteracting effects of activin A on inflammation.
Diabetes 2011 May;60(5):1544-51. Epub 2011 apr 4
PMID: 21464440
Fatty acid composition in chronic heart failure: low circulating levels of eicosatetraenoic acid and high levels of vaccenic acid are associated with disease severity and mortality.
J Intern Med 2011 Sep;270(3):263-72. Epub 2011 mai 3
PMID: 21466599
Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation.
Am J Physiol Lung Cell Mol Physiol 2011 Jul;301(1):L50-9. Epub 2011 apr 15
PMID: 21498626
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.
PLoS One 2011;6(4):e18668. Epub 2011 apr 18
PMID: 21533157
Osteoprotegerin levels predict mortality in patients with symptomatic aortic stenosis.
J Intern Med 2011 Nov;270(5):452-60. Epub 2011 mai 30
PMID: 21623962
Galectin-3 in heart failure: high levels are associated with all-cause mortality.
Int J Cardiol 2011 Aug;150(3):361-4. Epub 2011 jun 8
PMID: 21641051
Prognostic value of cardiac troponin T in patients with moderate to severe heart failure scheduled for cardiac resynchronization therapy.
Am Heart J 2011 Jun;161(6):1031-7. Epub 2011 mai 11
PMID: 21641347
Increased serum and bone matrix levels of transforming growth factor {beta}1 in patients with GH deficiency in response to GH treatment.
Eur J Endocrinol 2011 Sep;165(3):393-400. Epub 2011 jun 8
PMID: 21653735
Effect of everolimus introduction on cardiac allograft vasculopathy--results of a randomized, multicenter trial.
Transplantation 2011 Jul;92(2):235-43.
PMID: 21677600
Activated leukocyte cell adhesion molecule and prognosis in acute ischemic stroke.
Stroke 2011 Sep;42(9):2453-8. Epub 2011 jul 14
PMID: 21757661
Effect of eptifibatide on platelet-mediated inflammation in acute coronary syndromes.
Int J Cardiol 2011 Sep;151(3):385-7. Epub 2011 jul 22
PMID: 21782261
Plasmacytoid dendritic cells protect against atherosclerosis by tuning T-cell proliferation and activity.
Circ Res 2011 Dec;109(12):1387-95. Epub 2011 okt 20
PMID: 22021930
Fatty Acid binding protein 4 is associated with carotid atherosclerosis and outcome in patients with acute ischemic stroke.
PLoS One 2011;6(12):e28785. Epub 2011 des 9
PMID: 22174896
The innate immune system. A paradoxical mediator of host defense, tissue repair and collateral damage
- Disputert:
- november 2012
- Hovedveileder:
- Terje Espevik og Arne Yndestad
- Arne Yndestad Forskningsgruppeleder
- Pål Aukrust Prosjektleder
- Thor Ueland Forskningsgruppeleder
- Bente Evy Halvorsen Forskningsgruppeleder
- Filip Segers Postdoktorstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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