Elucidating the TP53 network in breast cancer
- Prosjektnummer
- 2011079
- Ansvarlig person
- Anita Langerød
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Forskerstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 1. Underpinning, 4. Detection and Diagnosis
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TP53 Mutations in Breast and Ovarian Cancer.
Cold Spring Harb Perspect Med 2017 Jan 03;7(1). Epub 2017 jan 3
PMID: 27815305
Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk.
Hum Mutat 2017 Mar;38(3):265-268. Epub 2017 jan 23
PMID: 27957778
Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.
Cancer Res 2017 Mar 15;77(6):1250-1260.
PMID: 28254861
The Longitudinal Transcriptional Response to Neoadjuvant Chemotherapy with and without Bevacizumab in Breast Cancer.
Clin Cancer Res 2017 Aug 15;23(16):4662-4670. Epub 2017 mai 9
PMID: 28487444
Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
Nature 2016 06 02;534(7605):47-54.
PMID: 27135926
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.
Cell Rep 2016 Aug 16;16(7):2032-46. Epub 2016 aug 4
PMID: 27498871
Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration.
Nat Commun 2016 Sep 26;7():12910. Epub 2016 sep 26
PMID: 27666519
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.
Mol Cancer Res 2015 Mar;13(3):493-501. Epub 2014 okt 28
PMID: 25351767
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.
Genome Res 2015 Jun;25(6):814-24. Epub 2015 mai 11
PMID: 25963125
The Sub-Cellular Localization of WRAP53 Has Prognostic Impact in Breast Cancer.
PLoS One 2015;10(10):e0139965. Epub 2015 okt 13
PMID: 26460974
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.
Clin Cancer Res 2014 Jul 1;20(13):3569-80. Epub 2014 mai 6
PMID: 24803582
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.
Science 2014 Aug 1;345(6196):1251343.
PMID: 25082706
Processed pseudogenes acquired somatically during cancer development.
Nat Commun 2014;5():3644. Epub 2014 apr 9
PMID: 24714652
AZGP1 and SPDEF mRNA expression differentiates breast carcinoma from ovarian serous carcinoma.
Virchows Arch 2013 Feb;462(2):163-73. Epub 2012 des 15
PMID: 23242172
AMG 900, pan-Aurora kinase inhibitor, preferentially inhibits the proliferation of breast cancer cell lines with dysfunctional p53.
Breast Cancer Res Treat 2013 Oct;141(3):397-408. Epub 2013 okt 5
PMID: 24091768
Functional characterization of the 19q12 amplicon in grade III breast cancers.
Breast Cancer Res 2012;14(2):R53. Epub 2012 mar 20
PMID: 22433433
The life history of 21 breast cancers.
Cell 2012 May;149(5):994-1007. Epub 2012 mai 17
PMID: 22608083
Mutational processes molding the genomes of 21 breast cancers.
Cell 2012 May;149(5):979-93. Epub 2012 mai 17
PMID: 22608084
The landscape of cancer genes and mutational processes in breast cancer.
Nature 2012 Jun;486(7403):400-4. Epub 2012 mai 16
PMID: 22722201
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.
Nature 2012 Jun;486(7403):346-52. Epub 2012 apr 18
PMID: 22522925
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Cell 2012 Jan;148(1-2):244-58.
PMID: 22265415
Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups.
Breast Cancer Res Treat 2011 Nov;130(2):599-608. Epub 2011 jun 11
PMID: 21667122
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters.
Nat Genet 2011 Jul;43(7):621-9. Epub 2011 jun 5
PMID: 21642992
Combining gene signatures improves prediction of breast cancer survival.
PLoS One 2011;6(3):e17845. Epub 2011 mar 10
PMID: 21423775
p53-Dependent repression of focal adhesion kinase in response to estradiol in breast cancer cell-lines.
Cancer Lett 2011 Jan;300(2):215-24. Epub 2010 nov 10
PMID: 21071137
Ultra-deep sequencing of TP53 in breast cancer uncovers additional mutations with clinical impact
UK Interdisciplinary Breast Cancer Symposium, Birmingham 2020
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic implication
6th International Mutant p53 Workshop, 2013
Cellular sub-localization of WRAP53 has prognostic impact in breast cancer
EACR conferance, Barcelona 2012
Assessing TP53 status in human tumors: lessons from breast cancer
Book chapter; p53 in the Clinics. Springer, 2012 (ISBN 978-1-4614-3675-1).
TP53 mutations and molecular profiles of breast cancer - prognostic and therapeutic implications
- Disputert:
- juni 2015
- Hovedveileder:
- Anita Langerød
- Anita Langerød Prosjektleder
- Anne-Lise Børresen-Dale Forskningsgruppeleder
- Laxmi Silwal-Pandit Postdoktorstipendiat (annen finansiering)
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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