From Cilia to Cytokinesis – Impact of Centrosome Dysfunction in Cancer beyond Cell Division
- Prosjektnummer
- 2011095
- Ansvarlig person
- Sebastian Patzke
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Forskerstipend
- Helsekategori
- Cancer, Congenital Disorders
- Forskningsaktivitet
- 1. Underpinning, 2. Aetiology
Targeted Cancer Therapy with a Novel Anti-CD37 Beta-Particle Emitting Radioimmunoconjugate for Treatment of Non-Hodgkin Lymphoma.
PLoS One 2015;10(6):e0128816. Epub 2015 jun 11
PMID: 26066655
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation.
PLoS One 2015;10(8):e0134789. Epub 2015 aug 4
PMID: 26241740
Replication-induced DNA damage after PARP inhibition causes G2 delay, and cell line-dependent apoptosis, necrosis and multinucleation.
Cell Cycle 2015;14(20):3248-60.
PMID: 26312527
New distinct compartments in the G2 phase of the cell cycle defined by the levels of ?H2AX.
Cell Cycle 2015;14(20):3261-9.
PMID: 26317799
Design of an EGFR-targeting toxin for photochemical delivery: in vitro and in vivo selectivity and efficacy.
Oncogene 2015 Oct 29;34(44):5582-92. Epub 2015 feb 16
PMID: 25684137
Nuclear CSPP1 expression defined subtypes of basal-like breast cancer.
Br J Cancer 2014 Jul 15;111(2):326-38. Epub 2014 jun 5
PMID: 24901235
PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule.
Radiother Oncol 2014 Feb;110(2):355-61. Epub 2014 feb 4
PMID: 24502970
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption.
Mol Cell Biol 2012 Oct;32(20):4226-36. Epub 2012 aug 20
PMID: 22907750
Three independent mechanisms for arrest in G2 after ionizing radiation.
Cell Cycle 2011 Mar 1;10(5):819-29. Epub 2011 mar 1
PMID: 21325885
Hypoxia-induced alterations of G2 checkpoint regulators.
Mol Oncol. 2016 Jan 8. pii: S1574-7891(16)00003-X. doi: 10.1016/j.molonc.2015.12.015. [Epub ahead of print] PubMed PMID: 26791779.
Cell type dependent sub-cellular localization and expression of CSPP in normal and malignant mammary epithelia (poster)
2nd Annual NordForsk Nordic Cilia and Centrosome Network Meeting (Hankø, Norway 2012)
Role of CSPP-L in recruitment of ciliopathy proteins to the centriolar satellites and the ciliary transition zone (talk)
2nd Annual NordForsk Nordic Cilia and Centrosome Network Meeting (Hankø, Norway 2012)
Cell type dependent sub-cellular localization and expression of CSPP in normal and malignant mammary epithelia (poster)
GAP 2012 (Oslo, Norway 2012)
Role of CSPP-L in recruitment of ciliopathy proteins to the centriolar satellites and the ciliary transition zone (poster)
CILIA 2012 Conference: Cilia in development and disease (London, U.K. 2012)
Functional characterization of CSPP1 proteins and their evaluation as biomarkers in breast cancer
- Disputert:
- mars 2015
- Hovedveileder:
- Sebastian Patzke
- Kari-Anne Myrum Frikstad Prosjektdeltaker
- Marianne Thoresen Prosjektdeltaker
- Hege Elisabeth Giercksky Russnes Forsker (annen finansiering)
- Anne-Lise Børresen-Dale Medveileder
- Trond Stokke Forskningsgruppeleder
- Anders Johan Wilhelm Sternemalm Doktorgradsstipendiat
- Sebastian Patzke Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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