Heart failure mechanisms - a multilevel approach
- Prosjektnummer
- 2011131
- Ansvarlig person
- Ole M. Sejersted
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst forskningsgruppe
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning
Hypokalaemia induces Ca2+ overload and Ca2+ waves in ventricular myocytes by reducing Na+,K+-ATPase a2 activity.
J Physiol 2014 Oct 17. Epub 2014 okt 17
PMID: 25326449
Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle.
J Pharmacol Exp Ther 2014 Sep;350(3):681-90. Epub 2014 jul 14
PMID: 25022512
The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure.
J Intern Med 2014 Jun;275(6):621-30. Epub 2014 jan 9
PMID: 24330105
ß-blockade abolishes the augmented cardiac tPA release induced by transactivation of heterodimerised bradykinin receptor-2 and ß2-adrenergic receptor in vivo.
Thromb Haemost 2014 Nov;112(5):951-9. Epub 2014 jul 31
PMID: 25078038
The molecular basis of emerin-emerin and emerin-BAF interactions.
J Cell Sci 2014 Sep 15;127(Pt 18):3956-69. Epub 2014 jul 22
PMID: 25052089
Impaired left ventricular mechanical and energetic function in mice after cardiomyocyte-specific excision of Serca2.
Am J Physiol Heart Circ Physiol 2014 Apr 1;306(7):H1018-24. Epub 2014 jan 31
PMID: 24486508
Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5.
J Mol Cell Cardiol 2014 Nov;76():148-57. Epub 2014 aug 26
PMID: 25169971
Unwrapping eddy current compensation: improved compensation of eddy current induced baseline shifts in high-resolution phase-contrast MRI at 9.4 Tesla.
Magn Reson Med 2014 Oct;72(4):1096-102. Epub 2013 nov 21
PMID: 24264935
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling.
PLoS One 2014;9(11):e112172. Epub 2014 nov 14
PMID: 25398010
Variable t-tubule organization and Ca2+ homeostasis across the atria.
Am J Physiol Heart Circ Physiol 2014 Aug 15;307(4):H609-20. Epub 2014 jun 20
PMID: 24951751
CaMKII comes of age in cardiac health and disease.
Front Pharmacol 2014;5():154. Epub 2014 jul 3
PMID: 25071573
Downregulation of L-type Ca2+ channel in rat mesenteric arteries leads to loss of smooth muscle contractile phenotype and inward hypertrophic remodeling.
Am J Physiol Heart Circ Physiol 2014 May;306(9):H1287-301. Epub 2014 feb 21
PMID: 24561864
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying ß-adrenergic stimulation in the rat left ventricle.
Am J Physiol Heart Circ Physiol 2014 Nov 15;307(10):H1487-96. Epub 2014 sep 19
PMID: 25239804
Calcium signalling in developing cardiomyocytes: implications for model systems and disease.
J Physiol 2015 Mar 1;593(5):1047-63. Epub 2015 feb 9
PMID: 25641733
Reduced visfatin levels in aortic stenosis increase after aortic valve replacement and may contribute to reverse left ventricular remodelling.
J Cardiovasc Surg (Torino) 2015 Jun;56(3):483-92. Epub 2014 jan 16
PMID: 24429804
Non-classical regulation of ß1- and ß 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi.
Naunyn Schmiedebergs Arch Pharmacol 2014 Dec;387(12):1177-86. Epub 2014 sep 13
PMID: 25216690
Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium.
Naunyn Schmiedebergs Arch Pharmacol 2014 May;387(5):407-17. Epub 2014 jan 15
PMID: 24424715
A computational pipeline for quantification of mouse myocardial stiffness parameters.
Comput Biol Med 2014 Oct;53():65-75. Epub 2014 aug 2
PMID: 25129018
Identifying pathogenic processes by integrating microarray data with prior knowledge.
BMC Bioinformatics 2014;15():115. Epub 2014 apr 24
PMID: 24758699
Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis.
PLoS One 2014;9(3):e91812. Epub 2014 mar 13
PMID: 24626394
In active juvenile dermatomyositis, elevated eotaxin and MCP-1 and cholesterol levels in the upper normal range are associated with cardiac dysfunction.
Rheumatology (Oxford) 2014 Dec;53(12):2214-22. Epub 2014 jul 4
PMID: 24996906
In juvenile dermatomyositis, cardiac systolic dysfunction is present after long-term follow-up and is predicted by sustained early skin activity.
Ann Rheum Dis 2014 Oct;73(10):1805-10. Epub 2013 jul 23
PMID: 23881732
Toward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.
Front Pharmacol 2014;5():110. Epub 2014 mai 16
PMID: 24994983
Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding.
PLoS One 2014;9(3):e89621. Epub 2014 mar 3
PMID: 24595230
Molecular basis of calpain cleavage and inactivation of the sodium-calcium exchanger 1 in heart failure.
J Biol Chem 2014 Dec 5;289(49):33984-98. Epub 2014 okt 21
PMID: 25336645
Cardiac sodium transport and excitation-contraction coupling.
J Mol Cell Cardiol 2013 Aug;61():11-9. Epub 2013 jun 14
PMID: 23774049
The N-terminal cytoplasmic region of NCBE displays features of an intrinsic disordered structure and represents a novel target for specific drug screening.
Front Physiol 2013;4():320. Epub 2013 nov 7
PMID: 24223558
Improved MR phase-contrast velocimetry using a novel nine-point balanced motion-encoding scheme with increased robustness to eddy current effects.
Magn Reson Med 2013 Jan;69(1):48-61. Epub 2012 mar 5
PMID: 22392844
Novel insight into the detailed myocardial motion and deformation of the rodent heart using high-resolution phase contrast cardiovascular magnetic resonance.
J Cardiovasc Magn Reson 2013;15():82. Epub 2013 sep 14
PMID: 24034168
Prominent heart organ-level performance deficits in a genetic model of targeted severe and progressive SERCA2 deficiency.
PLoS One 2013;8(11):e79609. Epub 2013 nov 4
PMID: 24223976
Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress.
J Mol Cell Cardiol 2013 Jan;54():73-81. Epub 2012 nov 22
PMID: 23178899
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the Serca2 gene.
J Appl Physiol (1985) 2013 Nov;115(10):1572-80. Epub 2013 sep 26
PMID: 24072410
Multiple causes of fatigue during shortening contractions in rat slow twitch skeletal muscle.
PLoS One 2013;8(8):e71700. Epub 2013 aug 16
PMID: 23977116
The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.
J Mol Cell Cardiol 2013 Mar;56():129-38. Epub 2012 des 7
PMID: 23220156
Beta-adrenergic stimulation maintains cardiac function in Serca2 knockout mice.
Biophys J 2013 Mar 19;104(6):1349-56. Epub 2013 mar 19
PMID: 23528094
Integrating multi-scale data to create a virtual physiological mouse heart.
Interface Focus 2013 Apr 6;3(2):20120076.
PMID: 24427525
Mind the store: modulating Ca(2+) reuptake with a leaky sarcoplasmic reticulum.
Cardiovasc Res 2013 May 1;98(2):165-8. Epub 2013 mar 21
PMID: 23524302
Slow Ca²? sparks de-synchronize Ca²? release in failing cardiomyocytes: evidence for altered configuration of Ca²? release units?
J Mol Cell Cardiol 2013 May;58():41-52. Epub 2013 jan 30
PMID: 23376034
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.
Br J Pharmacol 2013 Sep;170(2):366-79.
PMID: 23808942
Effect of short- and long-term physical activities on circulating granin protein levels.
Regul Pept 2013 Aug 10;185():14-9. Epub 2013 jun 28
PMID: 23816467
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Cardiovasc Res 2013 Jul 1;99(1):164-74. Epub 2013 apr 10
PMID: 23580606
Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload.
Matrix Biol 2013 Mar 11;32(2):133-42. Epub 2012 des 7
PMID: 23220517
Deletion of mouse Alkbh7 leads to obesity.
J Mol Cell Biol 2013 Jun;5(3):194-203. Epub 2013 apr 8
PMID: 23572141
I(CaL) inhibition prevents arrhythmogenic Ca(2+) waves caused by abnormal Ca(2+) sensitivity of RyR or SR Ca(2+) accumulation.
Cardiovasc Res 2013 May 1;98(2):315-25. Epub 2013 feb 14
PMID: 23417043
Innate immune signaling induces expression and shedding of the heparan sulfate proteoglycan syndecan-4 in cardiac fibroblasts and myocytes, affecting inflammation in the pressure-overloaded heart.
FEBS J 2013 May;280(10):2228-47. Epub 2013 feb 24
PMID: 23374111
Lack of pro-inflammatory cytokine mobilization predicts poor prognosis in patients with acute heart failure.
Cytokine 2013 Mar;61(3):962-9. Epub 2013 feb 14
PMID: 23415671
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.
J Med Chem 2013 Apr 11;56(7):3012-23. Epub 2013 mar 29
PMID: 23473363
Synchrony of cardiomyocyte Ca(2+) release is controlled by T-tubule organization, SR Ca(2+) content, and ryanodine receptor Ca(2+) sensitivity.
Biophys J 2013 Apr 16;104(8):1685-97.
PMID: 23601316
Lumican is increased in experimental and clinical heart failure, and its production by cardiac fibroblasts is induced by mechanical and proinflammatory stimuli.
FEBS J 2013 May;280(10):2382-98. Epub 2013 apr 2
PMID: 23480731
Decorin, lumican, and their GAG chain-synthesizing enzymes are regulated in myocardial remodeling and reverse remodeling in the mouse.
J Appl Physiol (1985) 2013 Apr;114(8):988-97. Epub 2013 feb 14
PMID: 23412898
No rest for the weary: diastolic calcium homeostasis in the normal and failing myocardium.
Physiology (Bethesda) 2012 Oct;27(5):308-23.
PMID: 23026754
Sodium accumulation in SERCA knockout-induced heart failure.
Biophys J 2012 May;102(9):2039-48.
PMID: 22824267
From global to local: a new understanding of cardiac electromechanical coupling.
Tidsskr Nor Laegeforen 2012 Jun;132(12-13):1457-60.
PMID: 22766818
An analysis of deformation-dependent electromechanical coupling in the mouse heart.
J Physiol 2012 Sep;590(Pt 18):4553-69. Epub 2012 mai 21
PMID: 22615436
Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout.
Proc Natl Acad Sci U S A 2012 Mar;109(10):3997-4001. Epub 2012 feb 21
PMID: 22355118
Intrinsic skeletal muscle alterations in chronic heart failure patients: a disease-specific myopathy or a result of deconditioning?
Heart Fail Rev 2012 May;17(3):421-36.
PMID: 21996779
Preserved metabolic reserve capacity in skeletal muscle of post-infarction heart failure patients.
Scand J Med Sci Sports 2012 Apr;22(2):199-206. Epub 2010 sep 28
PMID: 20874858
Different cardiac tissue plasminogen activator release patterns by local stimulation of the endothelium and sympathetic nerves in pigs.
Blood Coagul Fibrinolysis 2012 Dec;23(8):714-22.
PMID: 22964765
The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.
PLoS One 2012;7(9):e45489. Epub 2012 sep 20
PMID: 23029047
Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy.
J Cell Biol 2012 Nov;199(5):783-98. Epub 2012 nov 19
PMID: 23166348
Dephosphorylation of cardiac proteins in vitro - a matter of phosphatase specificity.
Proteomics 2012 Apr;12(7):973-8.
PMID: 22522803
Phospholamban ablation in hearts expressing the high affinity SERCA2b isoform normalizes global Ca²? homeostasis but not Ca²?-dependent hypertrophic signaling.
Am J Physiol Heart Circ Physiol 2012 Jun;302(12):H2574-82. Epub 2012 apr 13
PMID: 22505640
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.
Physiol Genomics 2012 Feb;44(2):162-72. Epub 2011 nov 29
PMID: 22128088
Endothelin-1 in the human myocardium and circulating plasma: evaluation before, during and after correction of aortic stenosis with aortic valve replacement.
Cardiology 2012;123(1):1-10. Epub 2012 aug 17
PMID: 22907118
Calcium release units in heart failure: that's about the size of it.
Cardiovasc Res 2012 Sep;95(4):397-8. Epub 2012 jul 24
PMID: 22832099
Chemokines regulate small leucine-rich proteoglycans in the extracellular matrix of the pressure-overloaded right ventricle.
J Appl Physiol 2012 Apr;112(8):1372-82. Epub 2012 feb 16
PMID: 22345433
The homeostatic chemokine CCL21 predicts mortality and may play a pathogenic role in heart failure.
PLoS One 2012;7(3):e33038. Epub 2012 mar 12
PMID: 22427939
ACE inhibition prevents diastolic Ca2+ overload and loss of myofilament Ca2+ sensitivity after myocardial infarction.
Curr Mol Med 2012 Feb;12(2):206-17.
PMID: 22280358
A mouse model of reverse cardiac remodelling following banding-debanding of the ascending aorta.
Acta Physiol (Oxf) 2012 May;205(1):92-102. Epub 2011 okt 28
PMID: 21974781
Inhibition of SMAD2 phosphorylation preserves cardiac function during pressure overload.
Cardiovasc Res 2012 Jan;93(1):100-10. Epub 2011 nov 2
PMID: 22049534
IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung.
Exp Lung Res 2012 Oct;38(8):406-19. Epub 2012 aug 21
PMID: 22908875
Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties.
PLoS One 2012;7(5):e37401. Epub 2012 mai 24
PMID: 22655045
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathway.
PLoS One 2011;6(12):e28302. Epub 2011 des 2
PMID: 22164265
Mechanism of prolonged electromechanical delay in late activated myocardium during left bundle branch block.
Am J Physiol Heart Circ Physiol 2011 Dec;301(6):H2334-43. Epub 2011 okt 7
PMID: 21984549
Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle.
Naunyn Schmiedebergs Arch Pharmacol 2011 Dec;384(6):543-53. Epub 2011 sep 8
PMID: 21901315
Attenuated fatigue in slow twitch skeletal muscle during isotonic exercise in rats with chronic heart failure.
PLoS One 2011;6(7):e22695. Epub 2011 jul 25
PMID: 21799933
Lack of chemokine signaling through CXCR5 causes increased mortality, ventricular dilatation and deranged matrix during cardiac pressure overload.
PLoS One 2011;6(4):e18668. Epub 2011 apr 18
PMID: 21533157
Lack of CCR7 induces pulmonary hypertension involving perivascular leukocyte infiltration and inflammation.
Am J Physiol Lung Cell Mol Physiol 2011 Jul;301(1):L50-9. Epub 2011 apr 15
PMID: 21498626
Ca(2+) wave probability is determined by the balance between SERCA2-dependent Ca(2+) reuptake and threshold SR Ca(2+) content.
Cardiovasc Res 2011 Jun;90(3):503-12. Epub 2011 jan 17
PMID: 21242164
Cardiac dysfunction in juvenile dermatomyositis: a case-control study.
Ann Rheum Dis 2011 May;70(5):766-71. Epub 2011 jan 7
PMID: 21216816
Differential regulation of ß2 -adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle.
Br J Pharmacol 2011 Jan;162(1):54-71.
PMID: 21133887
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle.
Br J Pharmacol 2011 Feb;162(4):908-16.
PMID: 21039419
Pulmonary outcome in juvenile dermatomyositis: a case-control study.
Ann Rheum Dis 2011 Jan;70(1):86-91. Epub 2010 aug 30
PMID: 20805295
Collagen isoform shift during the early phase of reverse left ventricular remodelling after relief of pressure overload.
Eur Heart J 2011 Jan;32(2):236-45. Epub 2010 jun 5
PMID: 20525982
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle.
J Physiol 2011 Dec;589(Pt 24):6139-55. Epub 2011 sep 26
PMID: 21946846
Calcium controls cardiac function--by all means!
J Physiol 2011 Jun;589(Pt 12):2919-20.
PMID: 21676882
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A.
Am J Physiol Cell Physiol 2011 May;300(5):C989-97. Epub 2011 feb 2
PMID: 21289289
Calcium dynamics in the ventricular myocytes of SERCA2 knockout mice: A modeling study.
Biophys J 2011 Jan;100(2):322-31.
PMID: 21244828
Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes.
J Appl Physiol 2011 Nov;111(5):1278-89. Epub 2011 apr 7
PMID: 21474694
Methods in cardiomyocyte isolation, culture, and gene transfer.
J Mol Cell Cardiol 2011 Sep;51(3):288-98. Epub 2011 jun 24
PMID: 21723873
Strange bedfellows: biologists and mathematical modelers tie the knot on cardiomyocyte calcium homeostasis
2014, doi:doi:10.1016/j.ddmod.2014.05.001
Measuring in vivo regional myocardial function using high-field MRI.
- Disputert:
- juni 2014
- Hovedveileder:
- Ivar Sjaastad
SERCA2-function in cardiomyocytes. Regulation of activity and pathophysiological role
- Disputert:
- mai 2014
- Hovedveileder:
- Ivar Sjaastad
Cardiac function and cytokine profile in juvenile dermatomyositis
- Disputert:
- juni 2014
- Hovedveileder:
- Ivar Sjaastad
Cytokines and extracellular matrix in heart failure
- Disputert:
- november 2012
- Hovedveileder:
- Geir Christensen
Chemokines in cardiac remodelling and heart failure, and their role in regulation of small leucine-rich proteoglycans in the ext
- Disputert:
- februar 2012
- Hovedveileder:
- Geir Christensen
The granin protein family in cardiac disease
- Disputert:
- mai 2012
- Hovedveileder:
- Torbjørn Omland
Molecular mechanisms of heart failure; nuclear factor of activated T-cell (NFAT) signaling in myocardial hypertrophy and dysfunc
- Disputert:
- mars 2012
- Hovedveileder:
- Geir Christensen
SERCA2-RyR2 interplay at the heart of Ca2+ wave development. Experimental studies on mechanisms underlying triggered arrythmias
- Disputert:
- juni 2011
- Hovedveileder:
- Ivar Sjaastad
The TGF-b/SMAD signalling system and extracellular matrix changes in myocardial remodelling and reverse remodelling following co
- Disputert:
- juni 2011
- Hovedveileder:
- Theis Tønnessen
- Karina Hougen Doktorgradsstipendiat
- Kristin V Thunheim Engebretsen Doktorgradsstipendiat
- Bård Andre Bendiksen Prosjektdeltaker
- Lili Zhang Prosjektdeltaker
- Roy Trondsen Prosjektdeltaker
- Kristine Skårdal Prosjektdeltaker
- Vidar Magne Skulberg Prosjektdeltaker
- Solveig Sirnes Prosjektdeltaker
- Per Andreas Norseng Prosjektdeltaker
- Jørn Bodvar Sande Prosjektdeltaker
- Marita Martinsen Prosjektdeltaker
- Marianne Lunde Prosjektdeltaker
- Heidi Kvaløy Prosjektdeltaker
- Solveig Bjærum Haugstad Prosjektdeltaker
- Almira Hasic Prosjektdeltaker
- Morten Eriksen Prosjektdeltaker
- Ulla Helene Enger Prosjektdeltaker
- Hilde Dishington Prosjektdeltaker
- Dina Behmen Prosjektdeltaker
- Bjørg Austbø Prosjektdeltaker
- Birgit Nomeland Witczak Doktorgradsstipendiat
- Pimthanya Wanichawan Doktorgradsstipendiat
- Nils Tovsrud Doktorgradsstipendiat
- Mari Elen Strand Doktorgradsstipendiat
- Thomas Schwartz Prosjektdeltaker
- Marianne Ruud Doktorgradsstipendiat
- Anett Hellebø Ottesen Doktorgradsstipendiat
- Arne Olav Melleby Doktorgradsstipendiat
- Ravinea Manotheepan Doktorgradsstipendiat
- David Bruce Lipsett Doktorgradsstipendiat
- Terje R Selnes Kolstad Doktorgradsstipendiat
- Kristin Halvorsen Hortemo Doktorgradsstipendiat
- Vigdis Hillestad Prosjektdeltaker
- Kate Louise Møller Herum Doktorgradsstipendiat
- Tandekile Lubelwana Doktorgradsstipendiat
- Michael Frisk Doktorgradsstipendiat
- Emil Knut Stenersen Espe Postdoktorstipendiat
- Tore Kristian Danielsen Doktorgradsstipendiat
- Cero Fadila Doktorgradsstipendiat
- Jan Magnus Aronsen Doktorgradsstipendiat
- Mathis Korseberg Stokke Postdoktorstipendiat
- Helge Røsjø Postdoktorstipendiat
- Ståle Nygård Postdoktorstipendiat
- Ida Gjervold Lunde Postdoktorstipendiat
- Kjetil Hodne Postdoktorstipendiat
- Per Kristian Lunde Forsker (annen finansiering)
- William Edward Louch Forsker (annen finansiering)
- Cathrine Rein Carlson Forsker (annen finansiering)
- Geir Arve Christensen Forskningsgruppeleder
- Ivar Sjaastad Forskningsgruppeleder
- Ole M Sejersted Prosjektleder
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