The molecular profile of breast cancer patients; the participation of Ahus in the K.G. Jebsen Centre for Breast Cancer Research
- Prosjektnummer
- 2012003
- Ansvarlig person
- Vessela N. Kristensen
- Institusjon
- Akershus universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst forskningsgruppe 4
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
Heterogeneous DNA Methylation Patterns in the GSTP1 Promoter Lead to Discordant Results between Assay Technologies and Impede Its Implementation as Epigenetic Biomarkers in Breast Cancer.
Genes (Basel) 2015;6(3):878-900. Epub 2015 sep 17
PMID: 26393654
DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.
Clin Epigenetics 2015;7(1):75. Epub 2015 jul 25
PMID: 26213588
Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas.
BMC Cancer 2015;15():524. Epub 2015 jul 17
PMID: 26183823
Breast-cancer screening--viewpoint of the IARC Working Group.
N Engl J Med 2015 Jun 11;372(24):2353-8. Epub 2015 jun 3
PMID: 26039523
Tumor expression, plasma levels and genetic polymorphisms of the coagulation inhibitor TFPI are associated with clinicopathological parameters and survival in breast cancer, in contrast to the coagulation initiator TF.
Breast Cancer Res 2015;17():44. Epub 2015 mar 26
PMID: 25882602
Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer.
Genome Med 2015;7(1):21. Epub 2015 feb 2
PMID: 25873999
Glycan-related gene expression signatures in breast cancer subtypes; relation to survival.
Mol Oncol 2015 Apr;9(4):861-76. Epub 2015 jan 14
PMID: 25655580
Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer.
Cancer Res 2015 Feb 15;75(4):698-708. Epub 2015 feb 3
PMID: 25649770
Targeted exploration and analysis of large cross-platform human transcriptomic compendia.
Nat Methods 2015 Mar;12(3):211-4, 3 p following 214. Epub 2015 jan 12
PMID: 25581801
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Hum Mol Genet 2015 Mar 1;24(5):1478-92. Epub 2014 nov 6
PMID: 25378557
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53.
Mol Cancer Res 2015 Mar;13(3):493-501. Epub 2014 okt 28
PMID: 25351767
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.
Mol Oncol 2015 Jan;9(1):115-27. Epub 2014 aug 8
PMID: 25169931
Predicting prognosis and therapeutic response from interactions between lymphocytes and tumor cells.
Mol Oncol 2015 Dec;9(10):2054-62. Epub 2015 okt 23
PMID: 26607741
Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression.
Am J Hum Genet 2015 Jul 2;97(1):22-34. Epub 2015 jun 11
PMID: 26073781
Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
Cancer Cell 2014 Dec 8;26(6):863-79.
PMID: 25490449
Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCR genes are associated with breast cancer: a case-control study.
BMC Cancer 2014;14():845. Epub 2014 nov 19
PMID: 25407022
DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.
Clin Cancer Res 2014 Dec 15;20(24):6357-66. Epub 2014 okt 7
PMID: 25294903
Long non-coding RNAs differentially expressed between normal versus primary breast tumor tissues disclose converse changes to breast cancer-related protein-coding genes.
PLoS One 2014;9(9):e106076. Epub 2014 sep 29
PMID: 25264628
Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.
Genome Biol 2014;15(8):435. Epub 2014 aug 22
PMID: 25146004
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.
Clin Cancer Res 2014 Jul 1;20(13):3569-80. Epub 2014 mai 6
PMID: 24803582
Principles and methods of integrative genomic analyses in cancer.
Nat Rev Cancer 2014 May;14(5):299-313.
PMID: 24759209
Differential DNA methylation analysis of breast cancer reveals the impact of immune signaling in radiation therapy.
Int J Cancer 2014 Nov 1;135(9):2085-95. Epub 2014 apr 5
PMID: 24658971
Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status.
BMC Cancer 2014;14():211. Epub 2014 mar 19
PMID: 24645668
Integrated analysis of high-resolution DNA methylation profiles, gene expression, germline genotypes and clinical end points in breast cancer patients.
Int J Cancer 2014 Jun 1;134(11):2615-25. Epub 2014 jan 6
PMID: 24395279
The 5p12 breast cancer susceptibility locus affects MRPS30 expression in estrogen-receptor positive tumors.
Mol Oncol 2014 Mar;8(2):273-84. Epub 2013 des 3
PMID: 24388359
Next-generation sequencing of disseminated tumor cells.
Front Oncol 2013;3():320. Epub 2013 des 31
PMID: 24427740
Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors.
Genome Biol 2013 Nov 20;14(11):R126. Epub 2013 nov 20
PMID: 24257477
Correction: miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in Primary Breast Tumors.
PLoS One 2013;8(9). Epub 2013 sep 10
PMID: 24098624
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors.
BMC Cancer 2013;13():456. Epub 2013 okt 5
PMID: 24093668
Genome-wide association study in breast cancer survivors reveals SNPs associated with gene expression of genes belonging to MHC class I and II.
Genomics 2013 Oct;102(4):278-87. Epub 2013 jul 21
PMID: 23880221
Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size.
J Med Genet 2013 Oct;50(10):666-73. Epub 2013 jul 3
PMID: 23825393
Improving breast cancer survival analysis through competition-based multidimensional modeling.
PLoS Comput Biol 2013;9(5):e1003047. Epub 2013 mai 9
PMID: 23671412
SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling.
Int J Radiat Oncol Biol Phys 2013 Jul 15;86(4):791-9. Epub 2013 apr 16
PMID: 23597419
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.
Sci Transl Med 2013 Apr 17;5(181):181re1.
PMID: 23596205
Gene expression profile analysis of t1 and t2 breast cancer reveals different activation pathways.
ISRN Oncol 2013;2013():924971. Epub 2013 feb 28
PMID: 23533813
Identifying in-trans process associated genes in breast cancer by integrated analysis of copy number and expression data.
PLoS One 2013;8(1):e53014. Epub 2013 jan 30
PMID: 23382830
Molecular profiles of pre- and postoperative breast cancer tumours reveal differentially expressed genes.
ISRN Oncol 2012;2012():450267. Epub 2012 nov 26
PMID: 23227362
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.
J Clin Oncol 2012 Dec;30(35):4308-16. Epub 2012 okt 29
PMID: 23109706
Detection of frequent ABCB1 polymorphisms by high-resolution melting curve analysis and their effect on breast carcinoma prognosis.
Clin Chem Lab Med 2012 Nov;50(11):1999-2007.
PMID: 23093106
Overrepresentation of transcription factor families in the genesets underlying breast cancer subtypes.
BMC Genomics 2012;13():199. Epub 2012 mai 22
PMID: 22616941
Common breast cancer susceptibility variants in LSP1 and RAD51L1 are associated with mammographic density measures that predict breast cancer risk.
Cancer Epidemiol Biomarkers Prev 2012 Jul;21(7):1156-66. Epub 2012 mar 27
PMID: 22454379
Analyzing cancer samples with SNP arrays.
Methods Mol Biol 2012;802():57-72.
PMID: 22130873
Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival.
Breast Cancer Res Treat 2012 Jun;133(3):865-80. Epub 2011 nov 3
PMID: 22048815
Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling.
Proc Natl Acad Sci U S A 2012 Feb;109(8):2802-7. Epub 2011 sep 9
PMID: 21908711
Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway.
Br J Cancer 2012 Nov;107(10):1722-8. Epub 2012 okt 18
PMID: 23079576
From normal breast to invasive carcinoma: DNA methylation profiling of stage and response to chemotherapy.
- Disputert:
- januar 2015
- Hovedveileder:
- Vessela N. Kristensen
Genomic alterations and heterogeneity in progression of breast carcinomas
- Disputert:
- mars 2015
- Hovedveileder:
- Vessela N. Kristensen
Towards pathway and network-based medicine in breast cancer.
- Disputert:
- januar 2015
- Hovedveileder:
- Arnoldo Frigessi
Molecular Analysis of Pre- and Postoperative Biopsies in Breast Cancer Progression.
- Disputert:
- januar 2015
- Hovedveileder:
- Vessela N. Kristensen
From normal breast to invasive carcinoma: DNA methylation profiling of stage and response to chemotherapy.
- Disputert:
- juni 2014
- Hovedveileder:
- Vessela N. Kristensen
Towards pathway and network-based medicine in breast cancer.
- Disputert:
- april 2014
- Hovedveileder:
- Vessela N. Kristensen
Towards pathway and network- based medicine in breast cancer
- Disputert:
- november 2013
- Hovedveileder:
- Vessela N. Kristensen
From normal breast to invasive carcinoma: DNA methylation profiling of stage and response to chemotherapy
- Disputert:
- desember 2013
- Hovedveileder:
- Vessela N. Kristensen
From DNA to RNA to protein: Integrated analyses of high-throughput molecular data from primary breast carcinomas
- Disputert:
- juni 2013
- Hovedveileder:
- Vessela N. Kristensen
Genomic signatures in progression of breast cancer with reference to gynecological carcinomas
- Disputert:
- mai 2013
- Hovedveileder:
- Vessela N. Kristensen
Molecular Analysis of Pre- and Postoperative Biopsies in Breast Carcinomas
- Disputert:
- april 2013
- Hovedveileder:
- Vessela N. Kristensen
MOLECULAR ANALYSIS OF PRE- AND POSTOPERATIVE BIOPSIES IN BREAST CANCER PROGRESSION
- Disputert:
- desember 2012
- Hovedveileder:
- Vessela N. Kristensen
- Arnoldo Frigessi Medveileder
- Margit Riis Prosjektdeltaker
- Marianne Eikhom Nome Doktorgradsstipendiat
- Jovana Klajic Postdoktorstipendiat
- Shakila Jabeen Doktorgradsstipendiat
- Andliena Tahiri Postdoktorstipendiat
- Torben Luders Forsker (annen finansiering)
- Mev Dominguez Valentin Postdoktorstipendiat
- Marie Fongaard Forsker (annen finansiering)
- Xavier Tekpli Postdoktorstipendiat
- Sunniva Maria Stordal Bjørklund Postdoktorstipendiat
- Miriam Ragle Aure Postdoktorstipendiat
- Daniel J.H. Nebdal Prosjektdeltaker
- Thomas Fleischer Postdoktorstipendiat
- Grethe Irene Grenaker Alnæs Forsker (annen finansiering)
- Surendra Kumar Postdoktorstipendiat
- Olav Engebråten Prosjektdeltaker
- Bjørn Naume Prosjektdeltaker
- Torill Sauer Prosjektdeltaker
- Jürgen Geisler Prosjektdeltaker
- Ida Rashida Khan Bukholm Prosjektdeltaker
- Anne-Lise Børresen-Dale Forskningsgruppeleder
- Vessela N. Kristensen Prosjektleder
- Himanshu Joshi Doktorgradsstipendiat
- Kristine Kleivi Sahlberg Prosjektdeltaker
- Silje Nord Prosjektdeltaker
- Anna Brzozowska Frengen Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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