Innate immune mechanisms in cardiac injury and heart failure
- Prosjektnummer
- 2012037
- Ansvarlig person
- Arne Yndestad
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Utvidet forskerstipend/karrierestipend 1
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.
PLoS One 2017;12(11):e0188387. Epub 2017 nov 27
PMID: 29176764
Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy.
Sci Rep 2017 Jun 14;7(1):3490. Epub 2017 jun 14
PMID: 28615692
Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice.
Mediators Inflamm 2017;2017():9450439. Epub 2017 apr 11
PMID: 28490840
Leukocyte Overexpression of Intracellular NAMPT Attenuates Atherosclerosis by Regulating PPARγ-Dependent Monocyte Differentiation and Function.
Arterioscler Thromb Vasc Biol 2017 Jun;37(6):1157-1167. Epub 2017 apr 13
PMID: 28408371
Limited Added Value of Circulating Inflammatory Biomarkers in Chronic Heart Failure.
JACC Heart Fail 2017 Apr;5(4):256-264.
PMID: 28359413
Wnt5a is elevated in heart failure and affects cardiac fibroblast function.
J Mol Med (Berl) 2017 Jul;95(7):767-777. Epub 2017 mar 30
PMID: 28357477
The alternative complement pathway is dysregulated in patients with chronic heart failure.
Sci Rep 2017 Feb 14;7():42532. Epub 2017 feb 14
PMID: 28195242
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell Rep 2017 01 03;18(1):82-92.
PMID: 28052262
Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.
Biochim Biophys Acta 2017 02;1862(2):234-245. Epub 2016 nov 12
PMID: 27845246
Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure.
J Card Fail 2016 Oct;22(10):823-8. Epub 2016 jun 24
PMID: 27349571
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis.
J Am Heart Assoc 2016 May 20;5(5). Epub 2016 mai 20
PMID: 27207962
NLRP3 inflammasome activation during myocardial ischemia reperfusion is cardioprotective.
Biochem Biophys Res Commun 2016 Jan 22;469(4):1012-20. Epub 2015 des 17
PMID: 26706279
Circulating nucleosomes in chronic heart failure.
Int J Cardiol 2016 Jan 15;203():742-3. Epub 2015 okt 28
PMID: 26595779
Sustained Toll-Like Receptor 9 Activation Promotes Systemic and Cardiac Inflammation, and Aggravates Diastolic Heart Failure in SERCA2a KO Mice.
PLoS One 2015;10(10):e0139715. Epub 2015 okt 13
PMID: 26461521
Altered Levels of Fatty Acids and Inflammatory and Metabolic Mediators in Epicardial Adipose Tissue in Patients With Systolic Heart Failure.
J Card Fail 2015 Nov;21(11):916-23. Epub 2015 jul 29
PMID: 26231517
The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis.
Atherosclerosis 2015 Aug;241(2):480-94. Epub 2015 jun 5
PMID: 26086357
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.
Am J Physiol Lung Cell Mol Physiol 2015 Aug 15;309(4):L378-87. Epub 2015 jun 12
PMID: 26071556
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.
J Intern Med 2015 Jun;277(6):717-26. Epub 2014 des 1
PMID: 25382824
Inflammatory cytokines as biomarkers in heart failure.
Clin Chim Acta 2015 Mar 30;443():71-7. Epub 2014 sep 6
PMID: 25199849
Early Upregulation of NLRP3 in the Brain of Neonatal Mice Exposed to Hypoxia-Ischemia: No Early Neuroprotective Effects of NLRP3 Deficiency.
Neonatology 2015;108(3):211-9. Epub 2015 aug 13
PMID: 26279061
The homeostatic chemokine CCL21 predicts mortality in aortic stenosis patients and modulates left ventricular remodeling.
PLoS One 2014;9(11):e112172. Epub 2014 nov 14
PMID: 25398010
Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension.
PLoS One 2014;9(8):e104407. Epub 2014 aug 15
PMID: 25126943
Toll-like receptor 9 mediated responses in cardiac fibroblasts.
PLoS One 2014;9(8):e104398. Epub 2014 aug 15
PMID: 25126740
A vital role for complement in heart disease.
Mol Immunol 2014 Oct;61(2):126-34. Epub 2014 jul 16
PMID: 25037633
The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial.
PLoS One 2014;9(2):e89732. Epub 2014 feb 25
PMID: 24586994
Inflammatory cytokines in chronic heart failure: interleukin-8 is associated with adverse outcome. Results from CORONA.
Eur J Heart Fail 2014 Jan;16(1):68-75. Epub 2013 des 3
PMID: 23918775
Interleukin-6 signaling, soluble glycoprotein 130, and inflammation in heart failure.
Curr Heart Fail Rep 2014 Jun;11(2):146-55.
PMID: 24477903
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Cardiovasc Res 2013 Jul 1;99(1):164-74. Epub 2013 apr 10
PMID: 23580606
Association of ficolin-3 with severity and outcome of chronic heart failure.
PLoS One 2013;8(4):e60976. Epub 2013 apr 15
PMID: 23596511
CCL21 is associated with fatal outcomes in chronic heart failure: data from CORONA and GISSI-HF trials.
Eur J Heart Fail 2013 Jul;15(7):747-55. Epub 2013 mar 13
PMID: 23487539
Soluble glycoprotein 130 predicts fatal outcomes in chronic heart failure: analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA).
Circ Heart Fail 2013 Jan;6(1):91-8. Epub 2012 des 10
PMID: 23230311
The early transcriptomic response to interleukin 1ß and interleukin 33 in rat neonatal cardiomyocytes.
Cytokine 2013 Feb;61(2):340-4. Epub 2012 des 7
PMID: 23219998
Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction.
Int J Cardiol 2013 Sep 20;168(1):212-8. Epub 2012 okt 6
PMID: 23046599
Increased interleukin-1ß levels are associated with left ventricular hypertrophy and remodelling following acute ST segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
J Intern Med 2012 Sep;272(3):267-76. Epub 2012 feb 26
PMID: 22243053
The association between neutrophil gelatinase-associated lipocalin and clinical outcome in chronic heart failure: results from CORONA*.
J Intern Med 2012 May;271(5):436-43. Epub 2012 jan 16
PMID: 22211640
Heart failure biomarkers: focus on interleukin-1 receptor-like 1-based blood tests.
Drugs Today (Barc) 2012 Jul;48(7):479-91.
PMID: 22844659
Increased circulating mitochondrial DNA after myocardial infarction.
Int J Cardiol 2012 Jun;158(1):132-4. Epub 2012 mai 10
PMID: 22578950
Inflammatory Biomarkers in Cardiovascular diseases
- Disputert:
- mars 2017
- Hovedveileder:
- Arne Yndestad
Cardiac Toll-like receptor 9 signalling
- Disputert:
- november 2014
- Hovedveileder:
- Leif Erik Vinge
The innate immune system - A paradoxical mediator of host defense, tissue repair and collateral damage
- Disputert:
- november 2012
- Hovedveileder:
- Arne Yndestad
- Knut Husø Lauritzen Postdoktorstipendiat (annen finansiering)
- Ivar Sjaastad Prosjektdeltaker
- Ståle Haugset Nymo Doktorgradsstipendiat (finansiert av denne bevilgning)
- Marina Sokolova Doktorgradsstipendiat (finansiert av denne bevilgning)
- Trine Ranheim Prosjektdeltaker
- Maria Cornelia Louwe Postdoktorstipendiat (annen finansiering)
- Lars Gullestad Prosjektdeltaker
- Pål Aukrust Prosjektdeltaker
- Arne Yndestad Prosjektleder
- Kuan Yang Doktorgradsstipendiat (annen finansiering)
- Håvard Attramadal Prosjektdeltaker
- Yangchen Dhondup Doktorgradsstipendiat (annen finansiering)
- Øystein Sandanger Postdoktorstipendiat (annen finansiering)
- Leif Erik Vinge Prosjektdeltaker
- Kåre-Olav Stensløkken Prosjektdeltaker
- Maria Belland Olsen Doktorgradsstipendiat
- Alexandra Vanessa Finsen Forsker (annen finansiering)
- Mieke Louwe Postdoktorstipendiat
- Katrine Alfsnes Prosjektdeltaker
- Ingrid Kristine Ohm Doktorgradsstipendiat
- Marte Bliksøen Postdoktorstipendiat
- Ståle Nymo Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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