Common variable immunodefiency: autoimmunity and persistent inflammation
- Prosjektnummer
- 2012063
- Ansvarlig person
- Pål Aukrust
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 4. Detection and Diagnosis
TLR9 stimulation of B-cells induces transcription of p53 and prevents spontaneous and irradiation-induced cell death independent of DNA damage responses. Implications for Common variable immunodeficiency.
PLoS One 2017;12(10):e0185708. Epub 2017 okt 3
PMID: 28973009
Defective IL-4 signaling in T cells defines severe common variable immunodeficiency.
J Autoimmun 2017 Jul;81():110-119. Epub 2017 mai 3
PMID: 28476239
CVID and Celiac Disease.
Am J Gastroenterol 2017 Feb;112(2):393.
PMID: 28154406
Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency.
Clin Immunol 2017 Feb;175():69-74. Epub 2016 des 3
PMID: 27919819
Liver transplantation in patients with primary antibody deficiency.
J Allergy Clin Immunol 2017 May;139(5):1708-1710.e2. Epub 2016 des 6
PMID: 27931972
A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency.
Am J Gastroenterol 2016 Oct;111(10):1467-1475. Epub 2016 aug 16
PMID: 27527747 - Inngår i doktorgradsavhandlingen
Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation.
Mucosal Immunol 2016 Nov;9(6):1455-1465. Epub 2016 mar 16
PMID: 26982597 - Inngår i doktorgradsavhandlingen
A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction.
Mol Genet Genomic Med 2016 Nov;4(6):604-616. Epub 2016 sep 17
PMID: 27896283
Activating PI3Kd mutations in a cohort of 669 patients with primary immunodeficiency.
Clin Exp Immunol 2016 Feb;183(2):221-9. Epub 2015 nov 9
PMID: 26437962
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
Nat Commun 2015;6():6804. Epub 2015 apr 20
PMID: 25891430 - Inngår i doktorgradsavhandlingen
IRF4 Is a Critical Gene in Retinoic Acid-Mediated Plasma Cell Formation and Is Deregulated in Common Variable Immunodeficiency-Derived B Cells.
J Immunol 2015 Sep 15;195(6):2601-11. Epub 2015 aug 14
PMID: 26276871
Rare variants at 16p11.2 are associated with common variable immunodeficiency.
J Allergy Clin Immunol 2015 Jun;135(6):1569-77. Epub 2015 feb 10
PMID: 25678086
- Henrik Mikael Reims Prosjektdeltaker
- Knut Erik Aslaksen Lundin Prosjektdeltaker
- Johannes Espolin Roksund Hov Prosjektdeltaker
- Tom Hemming Karlsen Medveileder
- Børre Fevang Medveileder
- Pål Aukrust Hovedveileder
- Silje Fjellgård Jørgensen Doktorgradsstipendiat (annen finansiering)
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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