Novel and known DNA modifications - role in disease
- Prosjektnummer
- 2012082
- Ansvarlig person
- Arne Klungland
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Helse Sør-Øst forskningsgruppe 4
- Helsekategori
- Disputed aetiology and other
- Forskningsaktivitet
- 1. Underpinning
Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015.
Genomics Proteomics Bioinformatics 2016 Jun;14(3):122-5. Epub 2015 des 12
PMID: 26689322
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.
PLoS One 2015;10(11):e0141472. Epub 2015 nov 6
PMID: 26544960
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes Dev 2015 Oct 1;29(19):2037-53. Epub 2015 sep 24
PMID: 26404942
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes.
Genome Res 2015 Jun;25(6):897-906. Epub 2015 mar 23
PMID: 25800674
Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.
Cell Rep 2015 Dec 29;13(12):2671-8. Epub 2015 des 17
PMID: 26711335
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.
Nucleic Acids Res 2014 Dec 1;42(21):13280-93. Epub 2014 okt 29
PMID: 25355512
Dynamic RNA modifications in disease.
Curr Opin Genet Dev 2014 Jun;26():47-52. Epub 2014 jul 5
PMID: 25005745
Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.
PLoS One 2014;9(6):e98729. Epub 2014 jun 10
PMID: 24914785
Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells.
Stem Cell Res 2013 Nov;11(3):1264-71. Epub 2013 aug 27
PMID: 24041806
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Nat Commun 2013;4():1832.
PMID: 23673617
Tzfp represses the androgen receptor in mouse testis.
PLoS One 2013;8(4):e62314. Epub 2013 apr 25
PMID: 23634227
Sprouts of RNA epigenetics: the discovery of mammalian RNA demethylases.
RNA Biol 2013 Jun;10(6):915-8. Epub 2013 apr 17
PMID: 23619745
Deletion of mouse Alkbh7 leads to obesity.
J Mol Cell Biol 2013 Jun;5(3):194-203. Epub 2013 apr 8
PMID: 23572141
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.
Mol Cell 2013 Jan 10;49(1):18-29. Epub 2012 nov 21
PMID: 23177736
Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes.
Nucleic Acids Res 2012 Nov;40(21):10950-63. Epub 2012 sep 10
PMID: 22965116
ALKBH1 is a histone H2A dioxygenase involved in neural differentiation.
Stem Cells 2012 Dec;30(12):2672-82.
PMID: 22961808
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.
Hum Mol Genet 2012 Nov;21(22):4939-47. Epub 2012 aug 21
PMID: 22914735
Kinetics of endogenous mouse FEN1 in base excision repair.
Nucleic Acids Res 2012 Oct;40(18):9044-59. Epub 2012 jul 18
PMID: 22810208
DNA repair is indispensable for survival after acute inflammation.
J Clin Invest 2012 Jul;122(7):2680-9. Epub 2012 jun 11
PMID: 22684101
The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.
Nucleic Acids Res 2012 Aug;40(14):6620-31. Epub 2012 apr 24
PMID: 22532610
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.
Nat Protoc 2012 Feb;7(2):340-50. Epub 2012 jan 26
PMID: 22281869
Physiological Roles of Mouse Alkbh7: Implications in Obesity and Running Endurance.
- Disputert:
- august 2013
- Hovedveileder:
- Arne Klungland
- Miriam Landfors Doktorgradsstipendiat
- Dominique Ober Doktorgradsstipendiat
- John Arne Dahl Forsker (annen finansiering)
- Håvard Aanes Postdoktorstipendiat
- Xu Zhao Postdoktorstipendiat
- Endalkachew Ashenafi Alemu Postdoktorstipendiat
- Miaomiao Li Doktorgradsstipendiat
- Ida Jonson Doktorgradsstipendiat
- Arne Klungland Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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