Novel effects of natriuretic peptides in normal and failing hearts. Implications for treatment of heart failure
- Prosjektnummer
- 2012114
- Ansvarlig person
- Finn Olav Levy
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Cardiovascular
- Forskningsaktivitet
- 1. Underpinning, 5. Treatment Developement
CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes.
Biochem Biophys Res Commun 2016 Feb 26;471(1):219-25. Epub 2016 jan 22
PMID: 26809094
CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes.
Biochem Biophys Res Commun 2016 Aug 12;477(1):14-9. Epub 2016 mai 27
PMID: 27237977
Functional pharmacological characterization of SER100 in cardiovascular health and disease.
Br J Pharmacol 2016 Sep 25. Epub 2016 sep 25
PMID: 27667485
The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.
PLoS One 2015;10(3):e0115547. Epub 2015 mar 4
PMID: 25738589
Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure.
Naunyn Schmiedebergs Arch Pharmacol 2014 Jan;387(1):5-14. Epub 2013 des 3
PMID: 24297249
Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility.
Naunyn Schmiedebergs Arch Pharmacol 2013 Aug;386(8):665-70. Epub 2013 mai 7
PMID: 23649864
SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.
Br J Pharmacol 2013 Sep;170(2):366-79.
PMID: 23808942
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist.
Eur J Med Chem 2013 Jun;64():629-37. Epub 2013 apr 9
PMID: 23711770
Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists.
Bioorg Med Chem 2013 Nov 15;21(22):7134-45. Epub 2013 sep 11
PMID: 24113240
- Finn Olav Levy Prosjektleder
- Trond Bach Postdoktorstipendiat (finansiert av denne bevilgning)
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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