The OxyTarget Study – Merging Functional MRI and Circulating Biomarkers for Biopsy-Free Detection of Chemoradiotherapy Resistant Rectal Cancer
- Prosjektnummer
- 2013002
- Ansvarlig person
- Kathrine Røe
- Institusjon
- Akershus universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Cancer
- Forskningsaktivitet
- 4. Detection and Diagnosis
Systemic immune response induced by oxaliplatin-based neoadjuvant therapy favours survival without metastatic progression in high-risk rectal cancer.
Br J Cancer 2018 May;118(10):1322-1328. Epub 2018 apr 26
PMID: 29695770 - Inngår i doktorgradsavhandlingen
Circulating proteins in response to combined-modality therapy in rectal cancer identified by antibody array screening.
BMC Cancer 2016 Jul 26;16():536. Epub 2016 jul 26
PMID: 27461255
Systemic release of osteoprotegerin during oxaliplatin-containing induction chemotherapy and favorable systemic outcome of sequential radiotherapy in rectal cancer.
Oncotarget 2016 Jun 07;7(23):34907-17.
PMID: 27145458 - Inngår i doktorgradsavhandlingen
Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor Ktrans and ΔR2* peak are significantly associated with lymph node metastasis.
J Magn Reson Imaging 2017 Jul;46(1):194-206. Epub 2016 des 21
PMID: 28001320
High tumor glycine concentration is an adverse prognostic factor in locally advanced rectal cancer.
Radiother Oncol 2016 Feb;118(2):393-8. Epub 2015 des 17
PMID: 26705680
Sulfamate inhibitor S4 influences carbonic anhydrase IX ectodomain shedding in colorectal carcinoma cells.
J Enzyme Inhib Med Chem 2016 Oct;31(5):779-86. Epub 2015 aug 5
PMID: 26244271
Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer.
BMC Cancer 2015;15():543. Epub 2015 jul 24
PMID: 26205955
Personalized radiotherapy: concepts, biomarkers and trial design.
Br J Radiol 2015 Jul;88(1051):20150009. Epub 2015 mai 20
PMID: 25989697
MRI volumetry for prediction of tumour response to neoadjuvant chemotherapy followed by chemoradiotherapy in locally advanced rectal cancer.
Br J Radiol 2015 Jul;88(1051):20150097. Epub 2015 apr 22
PMID: 25899892
Tumor phosphatidylinositol 3-kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: opportunities for signaling-adapted therapies.
Crit Rev Oncol Hematol 2015 Jul;95(1):114-24. Epub 2015 jan 12
PMID: 25624177
Biomarkers of treatment toxicity in combined-modality cancer therapies with radiation and systemic drugs: study design, multiplex methods, molecular networks.
Int J Mol Sci 2014;15(12):22835-56. Epub 2014 des 9
PMID: 25501337 - Inngår i doktorgradsavhandlingen
Reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage in tumor hypoxia, poor radiotherapy response, and metastatic progression of rectal cancer.
Cancer Research 2017; 77(13): 1782
Low release of exosomal miR-663a from hypoxic tumor cells and poor tumor response to neoadjuvant radiotherapy in rectal cancer patients
Cancer Research 2017; 77(13: 4514
Oxaliplatin-induced immune factors and long-term disease control in rectal cancer-a reflection of immunogenic tumor cell death?
AACR Annual Meeting 2016
Nytt håp i gammel kreftmedisin
forskning.no, 2.9 2016 (http://forskning.no/kreft/2016/08/nytt-hap-i-gammel-kreftmedisin)
Nye MR-teknikker for evaluering og prediksjon av respons på neoadjuvant behandling ved rektumcancer.
BestPractice Onkologi/Hematologi 2014,16:14–17.
Circulating markers of immunogenicity and metastasis in combined-modality treatment of rectal cancer
- Disputert:
- desember 2017
- Hovedveileder:
- Kathrine Røe Redalen
- Ert Kalanxhi Medveileder
- Kathrine Røe Redalen Prosjektleder
- Sebastian Meltzer Doktorgradsstipendiat (finansiert av denne bevilgning)
- Endre Grøvik Prosjektdeltaker
- Anne Hansen Ree Forskningsgruppeleder
- Anne Negard Prosjektdeltaker
- Stein Harald Holmedal Prosjektdeltaker
- Kjell-Inge Gjesdal Prosjektdeltaker
- Lars Gustav Lyckander Prosjektdeltaker
- Christin Johansen Prosjektdeltaker
- Marius Bornstein Prosjektdeltaker
- Arne Sigmund Borthne Prosjektdeltaker
- Kine Mari Bakke Doktorgradsstipendiat
- Solveig Norheim Andersen Prosjektdeltaker
- Arne Engebret Færden Prosjektdeltaker
- Anne Negård Prosjektdeltaker
- Monica Chahal-Kummen Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport