New therapeutics and diagnostics for Alzheimer's disease - targeting Abeta oligomers
- Prosjektnummer
- 2013016
- Ansvarlig person
- Lars Nilsson
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Neurological
- Forskningsaktivitet
- 2. Aetiology, 4. Detection and Diagnosis
NEI
Glial activation and inflammation along the Alzheimer's disease continuum.
J Neuroinflammation 2019 Feb 21;16(1):46. Epub 2019 feb 21
PMID: 30791945
Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression.
Sci Rep 2019 Mar 14;9(1):4600. Epub 2019 mar 14
PMID: 30872722
CSF sTREM2 and Tau Work Together in Predicting Increased Temporal Lobe Atrophy in Older Adults.
Cereb Cortex 2020 04 14;30(4):2295-2306.
PMID: 31812991
CSF sTREM2 in delirium-relation to Alzheimer's disease CSF biomarkers Aβ42, t-tau and p-tau.
J Neuroinflammation 2018 Nov 03;15(1):304. Epub 2018 nov 3
PMID: 30390679 - Inngår i doktorgradsavhandlingen
An improved CPRG colorimetric ligand-receptor signal transduction assay based on beta-galactosidase activity in mammalian BWZ-reporter cells.
J Pharmacol Toxicol Methods 2017 Dec 01;90():67-75. Epub 2017 des 1
PMID: 29203451
The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway.
J Neuroinflammation 2017 Mar 21;14(1):59. Epub 2017 mar 21
PMID: 28320424
Cerebrospinal fluid soluble TREM2 in aging and Alzheimer's disease.
Alzheimers Res Ther 2016 Apr 27;8(1):17. Epub 2016 apr 27
PMID: 27121148 - Inngår i doktorgradsavhandlingen
Isobaric Quantification of Cerebrospinal Fluid Amyloid-ß Peptides in Alzheimer's Disease: C-Terminal Truncation Relates to Early Measures of Neurodegeneration.
J Proteome Res 2015 Nov 6;14(11):4834-43. Epub 2015 okt 16
PMID: 26452689
Identification of amyloid beta mid-domain fragments in human cerebrospinal fluid.
Biochimie 2015 Jun;113():86-92. Epub 2015 apr 10
PMID: 25866191
Overexpression of heparanase lowers the amyloid burden in amyloid-ß precursor protein transgenic mice.
J Biol Chem 2015 Feb 20;290(8):5053-64. Epub 2014 des 29
PMID: 25548284 - Inngår i doktorgradsavhandlingen
Elevated mRNA-levels of gonadotropin-releasing hormone and its receptor in plaque-bearing Alzheimer's disease transgenic mice.
PLoS One 2014;9(8):e103607. Epub 2014 aug 4
PMID: 25089901
Brainwide distribution and variance of amyloid-beta deposits in tg-ArcSwe mice.
Neurobiol Aging 2014 Mar;35(3):556-64. Epub 2013 okt 12
PMID: 24126157
Elevated MARK2-dependent phosphorylation of Tau in Alzheimer's disease.
J Alzheimers Dis 2013;33(3):699-713.
PMID: 23001711
Specific uptake of an amyloid-ß protofibril-binding antibody-tracer in AßPP transgenic mouse brain.
J Alzheimers Dis 2013 Jan 1;37(1):29-40.
PMID: 23780660
Transient OGG1, APE1, PARP1 and Polß expression in an Alzheimer's disease mouse model.
Mech Ageing Dev 2013 Oct;134(10):467-77. Epub 2013 okt 11
PMID: 24121118
The Arctic AßPP mutation leads to Alzheimer's disease pathology with highly variable topographic deposition of differentially truncated Aß.
Acta Neuropathol Commun 2013;1(1):60. Epub 2013 sep 10
PMID: 24252272
Lack of exon 10 in the murine tau gene results in mild sensorimotor defects with aging.
BMC Neurosci 2013;14():148. Epub 2013 nov 22
PMID: 24261309
Analyzing Aβ in AβPP-transgenic mice with a mid-domain Aβ-antibody
-Inngår i doktorgradsavhandlingen
Analyzing Aβ-clearance in AβPP-transgenic mice with a mid-domain Aβ-antibody
In manuscript (planeras ingå i doktorsavhandlingen)
CSF soluble TREM2 in delirium
In manuscript (planeras ingå I doktorsavhandlingen)
Analyzing Aß-clearance in AßPP-transgenic mice with a mid-domain Abeta-antibody
in manuscript (planeras ingå i doktorsavhandling)
11C and 18F radiolabeling of tetra- and pentathiophenes as PET-ligands for amyloid protein aggregates.
ACS Medical Chemistry Letters 7(4):368-73. 2016 (ej i doktorsavhandling)
Microglia and soluble TREM2 in Alzheimer's disease and delirium - biomarker and model studies
- Disputert:
- juni 2019
- Hovedveileder:
- Lars Nilsson
Aß aggression and clearance in alzheimer`s disease
- Disputert:
- desember 2017
- Hovedveileder:
- Lars Nilsson
- Lars Nilsson Prosjektleder
- Kristi Henjum Doktorgradsstipendiat (finansiert av denne bevilgning)
- Charlotte Bille Jendresen Doktorgradsstipendiat (annen finansiering)
- Vibeke Helen Årskog Forsker (annen finansiering)
- Lars Nilsson Prosjektleder
- Helena Kjeldgaard Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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