A novel glio-vascular pathway for brain fluid circulation and waste clearance studied by in vivo two-photon laser scanning microscopy
- Prosjektnummer
- 2013021
- Ansvarlig person
- Erlend Arnulf Nagelhus
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Doktorgradsstipend
- Helsekategori
- Neurological
- Forskningsaktivitet
- 1. Underpinning, 2. Aetiology
Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
J Neurosci 2015 Feb 18;35(7):3016-21.
PMID: 25698739 - Inngår i doktorgradsavhandlingen
Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy.
Front Cell Neurosci 2015;9():49. Epub 2015 feb 25
PMID: 25762896 - Inngår i doktorgradsavhandlingen
Dynamics of Ionic Shifts in Cortical Spreading Depression.
Cereb Cortex 2015 Nov;25(11):4469-76. Epub 2015 apr 2
PMID: 25840424 - Inngår i doktorgradsavhandlingen
Research into glia and epilepsy.
Tidsskr Nor Laegeforen 2014 Jan 14;134(1):6.
PMID: 24429739
Deletion of aquaporin-4 increases extracellular K(+) concentration during synaptic stimulation in mouse hippocampus.
Brain Struct Funct 2014 Apr 18. Epub 2014 apr 18
PMID: 24744149
Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering.
Nat Med 2013 Dec;19(12):1643-8. Epub 2013 nov 17
PMID: 24240184
The glia doctrine: Addressing the role of glial cells in healthy brain ageing.
Mech Ageing Dev 2013 Oct;134(10):449-59. Epub 2013 okt 17
PMID: 24141107
Physiological roles of aquaporin-4 in brain.
Physiol Rev 2013 Oct;93(4):1543-62.
PMID: 24137016
Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.
Sci Rep 2013;3():2582.
PMID: 24002448
Evidence that pericytes regulate aquaporin-4 polarization in mouse cortical astrocytes.
Brain Struct Funct 2013 Aug 28. Epub 2013 aug 28
PMID: 23982198
In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression.
J Cereb Blood Flow Metab 2013 Jul;33(7):996-9. Epub 2013 apr 24
PMID: 23611872
Deletion of aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice
Cerebral Cortex, 2016; https://doi.org/10.1093/cercor/bhw359
The Neuroimaging Revolution: Shedding Light on Neuron-Glia Interactions in Health and Disease
- Disputert:
- juni 2016
- Hovedveileder:
- Erlend Arnulf Nagelhus
Roles of aquaporin-4 in brain fluid dynamics
- Disputert:
- juni 2013
- Hovedveileder:
- Erlend Arnulf Nagelhus
- Rune Enger Doktorgradsstipendiat (finansiert av denne bevilgning)
- Erlend Arnulf Nagelhus Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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