Novel therapeutic concepts in thrombosis.
- Prosjektnummer
- 2013114
- Ansvarlig person
- Sandip Kanse
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Stroke
- Forskningsaktivitet
- 5. Treatment Developement
Post-transcriptional, post-translational and pharmacological regulation of tissue factor pathway inhibitor.
Blood Coagul Fibrinolysis 2018 Dec;29(8):668-682.
PMID: 30439766
Genetics of the thrombomodulin-endothelial cell protein C receptor system and the risk of early-onset ischemic stroke.
PLoS One 2018;13(11):e0206554. Epub 2018 nov 1
PMID: 30383853
Altered structure and function of fibrinogen after cleavage by Factor VII Activating Protease (FSAP).
Biochim Biophys Acta Mol Basis Dis 2018 Oct;1864(10):3397-3406. Epub 2018 aug 1
PMID: 30076961
Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity.
J Thromb Haemost 2018 Oct;16(10):2024-2034. Epub 2018 aug 24
PMID: 30070759
Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion.
Arterioscler Thromb Vasc Biol 2018 04;38(4):829-842. Epub 2018 jan 25
PMID: 29371242
Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs).
Thromb Res 2018 01;161():36-42. Epub 2017 nov 21
PMID: 29178989
A Positively Charged Surface Triggers Coagulation Activation Through Factor VII Activating Protease (FSAP).
ACS Appl Mater Interfaces 2017 Nov 22;9(46):40107-40116. Epub 2017 nov 9
PMID: 29091393
Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells.
Atherosclerosis 2017 Oct;265():133-139. Epub 2017 aug 25
PMID: 28881271
A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7.
Thromb Res 2017 Sep;157():111-116. Epub 2017 jul 14
PMID: 28734156
Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates.
Thromb Haemost 2017 Aug 30;117(9):1750-1760. Epub 2017 jul 20
PMID: 28726978
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages.
Biochem Biophys Res Commun 2017 09 16;491(2):442-448. Epub 2017 jul 13
PMID: 28712870
Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model.
Am J Transl Res 2017;9(6):3084-3095. Epub 2017 jun 15
PMID: 28670395
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
EMBO J 2017 Feb 01;36(3):260-273. Epub 2016 des 22
PMID: 28007894
Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function.
Cell Rep 2016 Aug 23;16(8):2197-207. Epub 2016 aug 11
PMID: 27524614
Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation.
J Thromb Haemost 2016 Oct;14(10):2058-2067. Epub 2016 sep 7
PMID: 27431088
Transforming Growth Factor-ß (TGF-ß) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes.
J Biol Chem 2016 Sep 30;291(40):21020-21028. Epub 2016 jul 26
PMID: 27462075
Factor seven activating protease (FSAP) predicts response to intravenous thrombolysis in acute ischemic stroke.
Int J Stroke 2016 Aug;11(6):646-55. Epub 2016 apr 12
PMID: 27073188
Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2.
Stroke 2016 Feb;47(2):307-16. Epub 2016 jan 5
PMID: 26732560
Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer.
J Thromb Haemost 2016 Feb;14(2):387-96. Epub 2016 jan 30
PMID: 26598923
Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects.
PLoS One 2015;10(2):e0116883. Epub 2015 feb 6
PMID: 25658820
Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP).
Thromb Haemost 2015 Apr;113(4):870-80. Epub 2014 nov 27
PMID: 25427855
Deficiency of Factor VII activating protease alters the outcome of ischemic stroke in mice.
Eur J Neurosci 2015 Apr;41(7):965-75. Epub 2015 jan 23
PMID: 25615590
Regulation of monocyte/macrophage function by factor VII activating protease (FSAP).
Atherosclerosis 2013 Oct;230(2):365-72. Epub 2013 aug 16
PMID: 24075769
Association of circulating factor seven activating protease (FSAP) and of oral Omega-3 fatty acids supplements with clinical outcome in patients with atrial fibrillation: the OMEGA-AF study.
J Thromb Thrombolysis 2013 Apr 11. Epub 2013 apr 11
PMID: 23575879
Identifying Factor VII activating protease (FSAP) substrate specificity by phage display
- Disputert:
- november 2018
- Hovedveileder:
- Sandip Kanse
The pathophysiological significance of Factor VII activating protease (FSAP) in ischemic stroke
- Disputert:
- juni 2014
- Hovedveileder:
- Sandip Kanse
Factor VII activating protease (FSAP) in thrombosis and haemostasis in vivo
- Disputert:
- september 2014
- Hovedveileder:
- Sandip Kanse
- Sandip Kanse Prosjektleder
- Sebastian Seidl Postdoktorstipendiat (finansiert av denne bevilgning)
- Sandra Espada Serrano Postdoktorstipendiat (finansiert av denne bevilgning)
- Emrah Kara Doktorgradsstipendiat (finansiert av denne bevilgning)
- Sebastian Seidl Postdoktorstipendiat
- Sandip Kanse Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport