Harnessing NK Cell Repertoire Diversity in Immunotherapy Against Cancer
- Prosjektnummer
- 2014027
- Ansvarlig person
- Karl Johan Malmberg
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Cancer
- Forskningsaktivitet
- 5. Treatment Developement
CD56bright NK cells exhibit potent antitumor responses following IL-15 priming.
J Clin Invest 2017 Nov 01;127(11):4042-4058. Epub 2017 okt 3
PMID: 28972539
Natural killer cell-mediated immunosurveillance of human cancer.
Semin Immunol 2017 Jun;31():20-29. Epub 2017 sep 6
PMID: 28888619
Bioinformatics Approaches to Profile the Tumor Microenvironment for Immunotherapeutic Discovery.
Curr Pharm Des 2017;23(32):4716-4725.
PMID: 28699527
Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition.
Immunogenetics 2017 08;69(8-9):547-556. Epub 2017 jul 11
PMID: 28699110
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells.
Cancer Immunol Res 2017 Aug;5(8):654-665. Epub 2017 jun 21
PMID: 28637877
Class I HLA haplotypes form two schools that educate NK cells in different ways.
Sci Immunol 2016 Sep;1(3). Epub 2016 sep 9
PMID: 27868107
Cognate HLA absence in trans diminishes human NK cell education.
J Clin Invest 2016 Oct 03;126(10):3772-3782. Epub 2016 aug 29
PMID: 27571408
Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA.
Oncoimmunology 2016 May;5(5):e1138199. Epub 2016 feb 18
PMID: 27467957
Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.
Cell Rep 2016 05 03;15(5):1088-99. Epub 2016 apr 21
PMID: 27117418
Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.
J Immunol 2016 Feb 01;196(3):1400-11. Epub 2016 jan 8
PMID: 26746188
Harnessing adaptive natural killer cells in cancer immunotherapy.
Mol Oncol 2015 Dec;9(10):1904-17. Epub 2015 okt 20
PMID: 26604011
Polyclonal Expansion of NKG2C(+) NK Cells in TAP-Deficient Patients.
Front Immunol 2015;6():507. Epub 2015 okt 6
PMID: 26500647
Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome.
Oncotarget 2015 Oct 27;6(33):34178-90.
PMID: 26497557
Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells.
J Immunol 2015 Oct 1;195(7):3374-81. Epub 2015 aug 28
PMID: 26320254
Newtonian cell interactions shape natural killer cell education.
Immunol Rev 2015 Sep;267(1):197-213.
PMID: 26284479
Increased incidence of chronic GvHD and CMV disease in patients with vitamin D deficiency before allogeneic stem cell transplantation.
Bone Marrow Transplant 2015 Sep;50(9):1217-23. Epub 2015 jun 1
PMID: 26030049
Impact of KIR and HLA Genotypes on Outcomes after Reduced-Intensity Conditioning Hematopoietic Cell Transplantation.
Biol Blood Marrow Transplant 2015 Sep;21(9):1589-96. Epub 2015 mai 8
PMID: 25960307
Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.
J Immunol 2015 May 1;194(9):4518-27. Epub 2015 mar 30
PMID: 25825444
Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.
Immunity 2015 Mar 17;42(3):443-56.
PMID: 25786176
Effects of HDV infection and pegylated interferon a treatment on the natural killer cell compartment in chronically infected individuals.
Gut 2015 Mar;64(3):469-82. Epub 2014 apr 10
PMID: 24721903
Role for early-differentiated natural killer cells in infectious mononucleosis.
Blood 2014 Oct 16;124(16):2533-43. Epub 2014 sep 9
PMID: 25205117
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.
Blood 2014 Jul 31;124(5):812-21. Epub 2014 mai 22
PMID: 24855210
Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation.
Eur J Immunol 2014 Jul;44(7):2192-6. Epub 2014 mai 7
PMID: 24723455
Independent skewing of the T cell and NK cell compartments associated with cytomegalovirus infection suggests division of labor between innate and adaptive immunity.
Age (Dordr) 2014 Apr;36(2):571-82. Epub 2013 sep 25
PMID: 24065293
- Hanna Julie Hoel Prosjektdeltaker
- Merete Thune Wiiger Prosjektdeltaker
- Karl-Johan Malmberg Forskningsgruppeleder
- Jodie Goodridge Forsker (annen finansiering)
- Michelle Lu Sætersmoen Prosjektdeltaker
- Axel Berg-Larsen Prosjektdeltaker
- Kishankumar Chudasama Prosjektdeltaker
- Trevor Clancy Forsker (annen finansiering)
- Vincent Oei Sheng Doktorgradsstipendiat
- Benedikt Jakobs Postdoktorstipendiat
- Michelle Sætersmoen Doktorgradsstipendiat
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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