Integrating the connectome and the genome towards a brain based understanding of severe mental illness
- Prosjektnummer
- 2014097
- Ansvarlig person
- Lars T. Westlye
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Karrierestipend
- Helsekategori
- Mental Health
- Forskningsaktivitet
- 1. Underpinning, 4. Detection and Diagnosis
Mapping the Heterogeneous Phenotype of Schizophrenia and Bipolar Disorder Using Normative Models.
JAMA Psychiatry 2018 Nov 01;75(11):1146-1155.
PMID: 30304337
White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging.
Sci Rep 2018 Sep 20;8(1):14129. Epub 2018 sep 20
PMID: 30237410
Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls.
Mol Psychiatry 2018 Jun;23(6):1512-1520. Epub 2017 mai 16
PMID: 28507318
Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder.
Brain Imaging Behav 2018 Jun;12(3):640-652.
PMID: 28444556
Stability of the Brain Functional Connectome Fingerprint in Individuals With Schizophrenia.
JAMA Psychiatry 2018 Jul 01;75(7):749-751.
PMID: 29799905
Association of Heritable Cognitive Ability and Psychopathology With White Matter Properties in Children and Adolescents.
JAMA Psychiatry 2018 Mar 01;75(3):287-295.
PMID: 29365026
Probing Brain Developmental Patterns of Myelination and Associations With Psychopathology in Youths Using Gray/White Matter Contrast.
Biol Psychiatry 2019 03 01;85(5):389-398. Epub 2018 okt 9
PMID: 30447910
Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry.
PeerJ 2018;6():e5908. Epub 2018 nov 30
PMID: 30533290
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.
Mol Psychiatry 2020 11;25(11):3053-3065. Epub 2018 okt 2
PMID: 30279459
Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group.
Mol Psychiatry 2020 09;25(9):2130-2143. Epub 2018 aug 31
PMID: 30171211
Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence.
eNeuro 2018 Jul-Aug;5(4). Epub 2018 jul 11
PMID: 30073200
Widespread white matter changes in post-H1N1 patients with narcolepsy type 1 and first-degree relatives.
Sleep 2018 Oct 01;41(10).
PMID: 30016530
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
Biol Psychiatry 2018 Nov 01;84(9):644-654. Epub 2018 mai 14
PMID: 29960671
Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals.
Transl Psychiatry 2018 05 24;8(1):103. Epub 2018 mai 24
PMID: 29795193
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men.
Horm Behav 2018 Jun;102():85-92. Epub 2018 mai 16
PMID: 29750971
Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories.
Eur J Hum Genet 2018 07;26(7):1049-1059. Epub 2018 apr 27
PMID: 29700391
Restriction spectrum imaging of white matter and its relation to neurological disability in multiple sclerosis.
Mult Scler 2018 Mar 01. Epub 2018 mar 1
PMID: 29542336
An augmented aging process in brain white matter in HIV.
Hum Brain Mapp 2018 06;39(6):2532-2540. Epub 2018 feb 27
PMID: 29488278
A large, open source dataset of stroke anatomical brain images and manual lesion segmentations.
Sci Data 2018 02 20;5():180011. Epub 2018 feb 20
PMID: 29461514
White matter microstructure is associated with functional, cognitive and emotional symptoms 12 months after mild traumatic brain injury.
Sci Rep 2017 Oct 23;7(1):13795. Epub 2017 okt 23
PMID: 29061970
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group.
Mol Psychiatry 2018 May;23(5):1261-1269. Epub 2017 okt 17
PMID: 29038599
Increased default-mode variability is related to reduced task-performance and is evident in adults with ADHD.
Neuroimage Clin 2017;16():369-382. Epub 2017 mar 30
PMID: 28861338
Distinct multivariate brain morphological patterns and their added predictive value with cognitive and polygenic risk scores in mental disorders.
Neuroimage Clin 2017;15():719-731. Epub 2017 jun 9
PMID: 28702349
Distinguishing early and late brain aging from the Alzheimer's disease spectrum: consistent morphological patterns across independent samples.
Neuroimage 2017 Sep;158():282-295. Epub 2017 jun 27
PMID: 28666881
Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial.
Transl Psychiatry 2017 May 23;7(5):e1136. Epub 2017 mai 23
PMID: 28534875
Evidence for cortical structural plasticity in humans after a day of waking and sleep deprivation.
Neuroimage 2017 Aug 01;156():214-223. Epub 2017 mai 17
PMID: 28526620
Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.
Mol Psychiatry 2018 04;23(4):932-942. Epub 2017 mai 2
PMID: 28461699
Predicting Outcome 12 Months after Mild Traumatic Brain Injury in Patients Admitted to a Neurosurgery Service.
Front Neurol 2017;8():125. Epub 2017 apr 10
PMID: 28443058
The correlation between central and peripheral oxytocin concentrations: A systematic review and meta-analysis.
Neurosci Biobehav Rev 2017 Jul;78():117-124. Epub 2017 apr 23
PMID: 28442403
Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables.
Brain Inj 2017;31(5):674-685. Epub 2017 apr 17
PMID: 28414250
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium.
Acta Psychiatr Scand 2017 May;135(5):439-447. Epub 2017 mar 29
PMID: 28369804
Dissociable diffusion MRI patterns of white matter microstructure and connectivity in Alzheimer's disease spectrum.
Sci Rep 2017 Mar 24;7():45131. Epub 2017 mar 24
PMID: 28338052
Delayed stabilization and individualization in connectome development are related to psychiatric disorders.
Nat Neurosci 2017 Apr;20(4):513-515. Epub 2017 feb 20
PMID: 28218917
Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults.
PLoS One 2017;12(2):e0170921. Epub 2017 feb 2
PMID: 28151944
Increased sensitivity to age-related differences in brain functional connectivity during continuous multiple object tracking compared to resting-state.
Neuroimage 2017 Mar 01;148():364-372. Epub 2017 jan 20
PMID: 28111190
A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue.
Schizophr Bull 2017 Jul 01;43(4):881-890.
PMID: 28049760
Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders.
Front Neuroendocrinol 2017 04;45():1-10. Epub 2017 jan 1
PMID: 28049009
Brain connectivity aberrations in anabolic-androgenic steroid users.
Neuroimage Clin 2017;13():62-69. Epub 2016 nov 17
PMID: 27942448
Brain volume change in first-episode psychosis: an effect of antipsychotic medication independent of BMI change.
Acta Psychiatr Scand 2017 Feb;135(2):117-126. Epub 2016 des 7
PMID: 27925164
Reliability of basal plasma vasopressin concentrations in healthy male adults.
Acta Neuropsychiatr 2017 Oct;29(5):315-321. Epub 2016 des 7
PMID: 27923411
Task modulations and clinical manifestations in the brain functional connectome in 1615 fMRI datasets.
Neuroimage 2017 Feb 15;147():243-252. Epub 2016 des 1
PMID: 27916665
Consistent Functional Connectivity Alterations in Schizophrenia Spectrum Disorder: A Multisite Study.
Schizophr Bull 2017 Jul 01;43(4):914-924.
PMID: 27872268
Childhood trauma is associated with increased brain responses to emotionally negative as compared with positive faces in patients with psychotic disorders.
Psychol Med 2017 Mar;47(4):669-679. Epub 2016 nov 11
PMID: 27834153
Volumetric and morphometric MRI findings in patients with mild traumatic brain injury.
Brain Inj 2016;30(13-14):1683-1691. Epub 2016 okt 24
PMID: 27996331
Dentate gyrus-cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross-sectional analyses.
Bipolar Disord 2016 Dec;18(8):657-668. Epub 2016 des 20
PMID: 27995733
The impact of oxytocin administration on brain activity: a systematic review and meta-analysis protocol.
Syst Rev 2016 Nov 29;5(1):205. Epub 2016 nov 29
PMID: 27899138
Resting-state high-frequency heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls.
Sci Rep 2016 Nov 17;6():37212. Epub 2016 nov 17
PMID: 27853244
Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders.
BJPsych Open 2016 Nov;2(6):353-358. Epub 2016 nov 3
PMID: 27847593
Age-related differences in brain network activation and co-activation during multiple object tracking.
Brain Behav 2016 Nov;6(11):e00533. Epub 2016 sep 7
PMID: 27843692
Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders.
Neuroimage Clin 2016;12():389-96. Epub 2016 aug 12
PMID: 27622135
Conservation of Distinct Genetically-Mediated Human Cortical Pattern.
PLoS Genet 2016 Jul;12(7):e1006143. Epub 2016 jul 26
PMID: 27459196
Clinical Utility of Mindfulness Training in the Treatment of Fatigue After Stroke, Traumatic Brain Injury and Multiple Sclerosis: A Systematic Literature Review and Meta-analysis.
Front Psychol 2016;7():912. Epub 2016 jun 23
PMID: 27445888
Random Projection for Fast and Efficient Multivariate Correlation Analysis of High-Dimensional Data: A New Approach.
Front Genet 2016;7():102. Epub 2016 jun 7
PMID: 27375677
Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial.
Psychoneuroendocrinology 2016 Jul;69():180-8. Epub 2016 apr 22
PMID: 27107209
Increased MRI-based cortical grey/white-matter contrast in sensory and motor regions in schizophrenia and bipolar disorder.
Psychol Med 2016 Jul;46(9):1971-85. Epub 2016 apr 6
PMID: 27049014
The relationship between central and peripheral oxytocin concentrations: a systematic review and meta-analysis protocol.
Syst Rev 2016 Mar 31;5():49. Epub 2016 mar 31
PMID: 27037015
Subcortical volumetric abnormalities in bipolar disorder.
Mol Psychiatry 2016 Dec;21(12):1710-1716. Epub 2016 feb 9
PMID: 26857596
Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders.
J Psychiatry Neurosci 2016 Aug;41(5):331-41.
PMID: 26854755
Genetics of structural connectivity and information processing in the brain.
Brain Struct Funct 2016 Dec;221(9):4643-4661. Epub 2016 feb 6
PMID: 26852023
The brain functional connectome is robustly altered by lack of sleep.
Neuroimage 2016 Feb 15;127():324-32. Epub 2015 des 19
PMID: 26712339
The promise and pitfalls of intranasally administering psychopharmacological agents for the treatment of psychiatric disorders.
Mol Psychiatry 2016 Jan;21(1):29-38. Epub 2015 nov 10
PMID: 26552590
Reduced heart rate variability in schizophrenia and bipolar disorder compared to healthy controls.
Acta Psychiatr Scand 2016 Jan;133(1):44-52. Epub 2015 sep 15
PMID: 26371411
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
Mol Psychiatry 2016 Apr;21(4):585. Epub 2015 aug 18
PMID: 26283641
Association between cytokine levels, verbal memory and hippocampus volume in psychotic disorders and healthy controls.
Acta Psychiatr Scand 2016 Jan;133(1):53-62. Epub 2015 jul 20
PMID: 26189721
Mild Cognitive Impairment is Associated With White Matter Integrity Changes in Late-Myelinating Regions Within the Corpus Callosum.
Am J Alzheimers Dis Other Demen 2016 Feb;31(1):68-75. Epub 2015 apr 22
PMID: 25904759
Intracortical Posterior Cingulate Myelin Content Relates to Error Processing: Results from T1- and T2-Weighted MRI Myelin Mapping and Electrophysiology in Healthy Adults.
Cereb Cortex 2016 Jun;26(6):2402-10. Epub 2015 apr 2
PMID: 25840423
Attentional load modulates large-scale functional brain connectivity beyond the core attention networks.
Neuroimage 2015 Apr 1;109():260-72. Epub 2015 jan 13
PMID: 25595500
Long-term supratentorial brain structure and cognitive function following cerebellar tumour resections in childhood.
Neuropsychologia 2015 Mar;69():218-31. Epub 2015 feb 7
PMID: 25665770
Cognitive Effort and Schizophrenia Modulate Large-Scale Functional Brain Connectivity.
Schizophr Bull 2015 Nov;41(6):1360-9. Epub 2015 mar 1
PMID: 25731885
Brain structure characteristics in intellectually superior schizophrenia.
Psychiatry Res 2015 Apr 30;232(1):123-9. Epub 2015 feb 24
PMID: 25754688
Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease.
Nat Genet 2015 May;47(5):445-7. Epub 2015 mar 25
PMID: 25807283
Lithium treatment and hippocampal subfields and amygdala volumes in bipolar disorder.
Bipolar Disord 2015 Aug;17(5):496-506. Epub 2015 mar 24
PMID: 25809287
Genome-wide analysis of attention deficit hyperactivity disorder in Norway.
PLoS One 2015;10(4):e0122501. Epub 2015 apr 13
PMID: 25875332
Disintegration of Sensorimotor Brain Networks in Schizophrenia.
Schizophr Bull 2015 Nov;41(6):1326-35. Epub 2015 mai 4
PMID: 25943122
Inflammatory markers are associated with general cognitive abilities in schizophrenia and bipolar disorder patients and healthy controls.
Schizophr Res 2015 Jul;165(2-3):188-94. Epub 2015 mai 5
PMID: 25956633
Widespread changes in white matter microstructure after a day of waking and sleep deprivation.
PLoS One 2015;10(5):e0127351. Epub 2015 mai 28
PMID: 26020651
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium.
Mol Psychiatry 2015 Jun 2. Epub 2015 jun 2
PMID: 26033243
Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment.
Transl Psychiatry 2015;5():e602. Epub 2015 jul 14
PMID: 26171983
Large-scale genomics unveil polygenic architecture of human cortical surface area.
Nat Commun 2015;6():7549. Epub 2015 jul 20
PMID: 26189703
Altered Brain Activation during Emotional Face Processing in Relation to Both Diagnosis and Polygenic Risk of Bipolar Disorder.
PLoS One 2015;10(7):e0134202. Epub 2015 jul 29
PMID: 26222050
Functional connectivity indicates differential roles for the intraparietal sulcus and the superior parietal lobule in multiple object tracking.
Neuroimage 2015 Dec;123():129-37. Epub 2015 aug 21
PMID: 26299796
To the editors: Reply to Anna R. Docherty.
Psychiatry Res 2015 Sep 30;233(3):497.
PMID: 26319295
Assessing brain structural associations with working-memory related brain patterns in schizophrenia and healthy controls using linked independent component analysis.
Neuroimage Clin 2015;9():253-63. Epub 2015 aug 21
PMID: 26509112
A common brain network links development, aging, and vulnerability to disease.
Proc Natl Acad Sci U S A 2014 Dec 9;111(49):17648-53. Epub 2014 nov 24
PMID: 25422429
Polygenic risk for schizophrenia associated with working memory-related prefrontal brain activation in patients with schizophrenia and healthy controls.
Schizophr Bull 2015 May;41(3):736-43. Epub 2014 nov 11
PMID: 25392519
- Aldo Córdova Palomera Prosjektdeltaker
- Nhat Trung Doan Prosjektdeltaker
- Srdjan Djurovic Prosjektdeltaker
- Ingrid Agartz Prosjektdeltaker
- Tobias Kaufmann Forsker (annen finansiering)
- Ole Andreas Andreassen Prosjektdeltaker
- Lars Tjelta Westlye Prosjektleder
- Dag Alnæs Postdoktorstipendiat (finansiert av denne bevilgning)
- Tobias Kaufmann Prosjektdeltaker
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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