Going “under the skin” of allergic skin inflammation
- Prosjektnummer
- 2015013
- Ansvarlig person
- Denis Khnykin
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Forskerstipend
- Helsekategori
- Skin
- Forskningsaktivitet
- 2. Aetiology
In accordance with the project plan, the project leader has been working three and half months at the Department of Dermatology, Brigham and Women’s Hospital, and Harvard Medical School (Boston, MA, USA) in the year 2017. The purpose of the visit was to study a humanized mouse model in attempt to elucidate the molecular and cellular mechanisms of human skin inflammation. Unfortunately, the extension of overseas visits was ultimately blocked by the group leader at the Department of Pathology.
The project leader spend in the year 2017 three months at the Department of Dermatology, Brigham and Women’s Hospital and Harvard Medical School (Boston, MA, USA) studying the generation of humanized mouse model to study the molecular and cellular mechanisms of the human skin inflammation.
Ichthyosis prematurity syndrome in two Omani siblings, caused by homozygous c.1A > G mutation in the FATP4 gene.
Int J Dermatol 2020 Dec 15. Epub 2020 des 15
PMID: 33319372
Methionine- and Choline-Deficient Diet Enhances Adipose Lipolysis and Leptin Release in aP2-Cre Fatp4-Knockout Mice.
Mol Nutr Food Res 2020 11;64(22):e2000361. Epub 2020 okt 12
PMID: 32991778
Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice.
Sci Rep 2020 04 15;10(1):6451. Epub 2020 apr 15
PMID: 32296080
Perspective: Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope.
J Invest Dermatol 2018 Nov 21. Epub 2018 nov 21
PMID: 30471252
Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines.
Am J Pathol 2018 Jun;188(6):1419-1429. Epub 2018 mar 13
PMID: 29548991
High-resolution antibody array analysis of proteins from primary human keratinocytes and leukocytes.
PLoS One 2018;13(12):e0209271. Epub 2018 des 27
PMID: 30589857
Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.
Contact Dermatitis 2017 Jul;77(1):1-16. Epub 2017 mai 12
PMID: 28497472
Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India.
Clin Case Rep 2016 Jan;4(1):87-9. Epub 2015 des 1
PMID: 26783444
Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences.
J Invest Dermatol 2015 Jul;135(7):1771-80. Epub 2015 mar 4
PMID: 25739051
High-resolution antibody array analysis of proteins from primary human keratinocytes and leukocytes
PLoS One . 2018 Dec 27
Hypo-osmotic Stress Drives IL-33 Production in Human Keratinocytes-An Epidermal Homeostatic Response
J Invest Dermatol . 2019 Jan;139(1):81-90.
Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope
J Invest Dermatol . 2019 Apr;139(4):760-768.
Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines
Am J Pathol . 2018 Jun;188(6):1419-1429.
Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis
Contact Dermatitis . 2017 Jul;77(1):1-16
Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India
Clin Case Rep . 2015 Dec 1;4(1):87-9.
Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences
J Invest Dermatol . 2015 Jul;135(7):1771-1780.
Ichthyosis Prematurity Syndrome in a French Canadian infant caused by 2 novel mutations in the fatty acid transport protein 4 gene.
NeoReview - Journal of American Academy of Pediatrics, January 2018
Vernix caseosa–like hyperkeratotic plaques in a french canadian infant
Neovision, January 2018
Interleukin-33 at human epidermal and endothelial barriers.
- Disputert:
- mars 2017
- Hovedveileder:
- Guttorm Haraldsen
Interleukin-33 in skin stress and inflammation.
- Disputert:
- oktober 2018
- Hovedveileder:
- Guttorm Haraldsen
- Guttorm Haraldsen Forsker (annen finansiering)
- Wojciech Pietka Doktorgradsstipendiat (annen finansiering)
- Olav Sundnes Doktorgradsstipendiat (annen finansiering)
- Frode Lars Jahnsen Forskningsgruppeleder
- Denis Khnykin Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
Alle henvendelser rettes til eRapport