A novel treatment regimen for inflammatory diseases: Targeting the interaction between the complement system and CD14.
- Prosjektnummer
- 2015032
- Ansvarlig person
- Tom Eirik Mollnes
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Åpen prosjektstøtte
- Helsekategori
- Inflammatory and Immune System
- Forskningsaktivitet
- 2. Aetiology
NEI
Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood.
J Immunol 2019 09 15;203(6):1571-1578. Epub 2019 aug 14
PMID: 31413105
The Role of Complement in Liver Injury, Regeneration, and Transplantation.
Hepatology 2019 Aug;70(2):725-736. Epub 2019 jul 15
PMID: 30653682
Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.
Neonatology 2018;113(4):322-330. Epub 2018 feb 27
PMID: 29486477
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.
J Leukoc Biol 2017 01;101(1):193-204. Epub 2016 aug 31
PMID: 27581539
Complement activation by cholesterol crystals triggers a subsequent cytokine response.
Mol Immunol 2017 Apr;84():43-50. Epub 2016 sep 28
PMID: 27692470
Properdin binding to complement activating surfaces depends on initial C3b deposition.
Proc Natl Acad Sci U S A 2017 Jan 24;114(4):E534-E539. Epub 2017 jan 9
PMID: 28069958
The alternative complement pathway is dysregulated in patients with chronic heart failure.
Sci Rep 2017 Feb 14;7():42532. Epub 2017 feb 14
PMID: 28195242
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function.
Basic Res Cardiol 2017 May;112(3):20. Epub 2017 mar 3
PMID: 28258298
Combined inhibition of C5 and CD14 efficiently attenuated the inflammatory response in a porcine model of meningococcal sepsis.
J Intensive Care 2017;5():21. Epub 2017 feb 27
PMID: 28261486
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome: A case report.
Medicine (Baltimore) 2017 Mar;96(11):e6338.
PMID: 28296762
Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes.
Nat Nanotechnol 2017 Jul;12(6):589-594. Epub 2017 apr 10
PMID: 28396605
Complement in clinical medicine: Clinical trials, case reports and therapy monitoring.
Mol Immunol 2017 Sep;89():10-21. Epub 2017 mai 31
PMID: 28576323
Iron oxide nanoparticles induce cytokine secretion in a complement-dependent manner in a human whole blood model.
Int J Nanomedicine 2017;12():3927-3940. Epub 2017 mai 23
PMID: 28579778
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses.
Mol Immunol 2017 Sep;89():111-114. Epub 2017 jun 10
PMID: 28610663
Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis.
Proc Natl Acad Sci U S A 2017 Jul 18. Epub 2017 jul 18
PMID: 28720697
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.
J Immunol 2017 10 15;199(8):2910-2920. Epub 2017 aug 30
PMID: 28855312
Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery.
Blood 2016 Jan 21;127(3):365-7. Epub 2015 des 7
PMID: 26644452
Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1ß Secondarily to Activation of C5 and CD14 in Whole Blood.
J Immunol 2016 Mar 01;196(5):2293-9. Epub 2016 jan 22
PMID: 26800874
Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation.
J Control Release 2016 May 10;229():58-69. Epub 2016 mar 16
PMID: 26993426
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome.
Rheumatology (Oxford) 2016 Jul;55(7):1337-9. Epub 2016 apr 22
PMID: 27105662
Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis.
J Immunol 2016 Jun 15;196(12):5064-74. Epub 2016 mai 16
PMID: 27183610
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo.
Clin Microbiol Infect 2016 Aug;22(8):734.e1-6. Epub 2016 mai 20
PMID: 27217049
Eculizumab treatment during pregnancy does not affect the complement system activity of the newborn.
Immunobiology 2015 Apr;220(4):452-9. Epub 2014 nov 13
PMID: 25468724
CD14 and complement crosstalk and largely mediate the transcriptional response to Escherichia coli in human whole blood as revealed by DNA microarray.
PLoS One 2015;10(2):e0117261. Epub 2015 feb 23
PMID: 25706641
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14.
Immunobiology 2015 Aug;220(8):999-1005. Epub 2015 apr 27
PMID: 25956456
Eculizumab treatment efficiently prevents C5 cleavage without C5a generation in vivo.
Blood 2015 Jul 9;126(2):278-9.
PMID: 26160188
- Mathew Thomas Anub Doktorgradsstipendiat (finansiert av denne bevilgning)
- Per Nilsson Medveileder
- Andreas Barratt-Due Hovedveileder
- Tom Eirik Mollnes Prosjektleder
eRapport er utarbeidet av Sølvi Lerfald og Reidar Thorstensen, Regionalt kompetansesenter for klinisk forskning, Helse Vest RHF, og videreutvikles av de fire RHF-ene i fellesskap, med støtte fra Helse Vest IKT
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