Genes and the synapse in severe mental illnesses: from stem cells and in vivo brain function to clinical implications
- Prosjektnummer
- 2015078
- Ansvarlig person
- Ulrik F. Malt
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Postdoktorstipend
- Helsekategori
- Mental Health
- Forskningsaktivitet
- 1. Underpinning, 2. Aetiology
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Mismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity.
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bioRxiv 2023 Jun 14. Epub 2023 jun 14
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The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis.
medRxiv 2023 Sep 26. Epub 2023 sep 26
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Baseline long-term potentiation-like cortical plasticity is associated with longitudinal cortical thinning in healthy adults and in adults with bipolar disorder type II.
Eur J Neurosci 2023 Aug;58(3):2824. Epub 2023 jul 13
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Relationship between function and structure in the visual cortex in healthy individuals and in patients with severe mental disorders.
Psychiatry Res Neuroimaging 2023 Jul;332():111633. Epub 2023 mar 24
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Corrigendum to "Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling".
Neuroimage 2023 Apr 15;270():119939. Epub 2023 feb 24
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Elevated Systemic Levels of Markers Reflecting Intestinal Barrier Dysfunction and Inflammasome Activation Are Correlated in Severe Mental Illness.
Schizophr Bull 2023 May 03;49(3):635.
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Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation.
Biol Psychiatry 2023 Jan 15;93(2):187. Epub 2022 jul 2
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Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness.
Psychol Med 2023 Mar;53(4):1479. Epub 2021 aug 11
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A family study of symbolic learning and synaptic plasticity in autism spectrum disorder.
Front Hum Neurosci 2022;16():950922. Epub 2022 nov 24
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Long term potentiation-like neural plasticity and performance-based memory function.
Neurobiol Learn Mem 2022 Dec;196():107696. Epub 2022 nov 8
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Long-Term Potentiation-Like Visual Synaptic Plasticity Is Negatively Associated With Self-Reported Symptoms of Depression and Stress in Healthy Adults.
Front Hum Neurosci 2022;16():867675. Epub 2022 apr 22
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Evidence for widespread alterations in cortical microstructure after 32 h of sleep deprivation.
Transl Psychiatry 2022 Apr 14;12(1):161. Epub 2022 apr 14
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Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals.
Bipolar Disord 2022 Aug;24(5):509. Epub 2021 des 16
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Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group.
Biol Psychiatry 2022 Mar 15;91(6):582. Epub 2021 sep 16
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Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation.
Brain Behav Immun 2022 Jan;99():299. Epub 2021 nov 7
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Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study.
Schizophr Bull 2022 Jan 21;48(1):37.
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In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group.
Hum Brain Mapp 2022 Jan;43(1):385. Epub 2020 okt 19
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Reproducibility in the absence of selective reporting: An illustration from large-scale brain asymmetry research.
Hum Brain Mapp 2022 Jan;43(1):244. Epub 2020 aug 25
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What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group.
Hum Brain Mapp 2022 Jan;43(1):56. Epub 2020 jul 29
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ENIGMA-Sleep: Challenges, opportunities, and the road map.
J Sleep Res 2021 12;30(6):e13347. Epub 2021 apr 28
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Extensive bidirectional genetic overlap between bipolar disorder and cardiovascular disease phenotypes.
Transl Psychiatry 2021 07 23;11(1):407. Epub 2021 jul 23
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Heart rate variability is associated with disease severity in psychosis spectrum disorders.
Prog Neuropsychopharmacol Biol Psychiatry 2021 12 20;111():110108. Epub 2020 sep 15
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The genetic architecture of the human thalamus and its overlap with ten common brain disorders.
Nat Commun 2021 05 18;12(1):2909. Epub 2021 mai 18
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Exploring neurophysiological markers of visual perspective taking: Methodological considerations.
Int J Psychophysiol 2021 03;161():1-12. Epub 2020 des 31
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Association between body mass index and subcortical brain volumes in bipolar disorders-ENIGMA study in 2735 individuals.
Mol Psychiatry 2021 Nov;26(11):6806-6819. Epub 2021 apr 16
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Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms.
Transl Psychiatry 2021 01 05;11(1):3. Epub 2021 jan 5
PMID: 33414458
Telomeres are shorter and associated with number of suicide attempts in affective disorders.
J Affect Disord 2021 12 01;295():1032-1039. Epub 2021 sep 2
PMID: 34706411
Do visual and auditory stimulus-specific response modulation reflect different mechanisms of neocortical plasticity?
Eur J Neurosci 2021 02;53(4):1072-1085. Epub 2020 sep 21
PMID: 32897598
Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder.
Schizophr Bull 2021 10 21;47(6):1751-1760.
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Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.
Mol Psychiatry 2021 04;26(4):1286-1298. Epub 2019 nov 11
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Large-scale collaboration in ENIGMA-EEG: A perspective on the meta-analytic approach to link neurological and psychiatric liability genes to electrophysiological brain activity.
Brain Behav 2021 08;11(8):e02188. Epub 2021 jul 21
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Sleep and sleep deprivation differentially alter white matter microstructure: A mixed model design utilising advanced diffusion modelling.
Neuroimage 2021 02 01;226():117540. Epub 2020 nov 10
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Differences in course of illness between patients with bipolar II disorder with and without epileptiform discharges or other sharp activity on electroencephalograms: a cross-sectional study.
BMC Psychiatry 2020 Dec 07;20(1):582. Epub 2020 des 7
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Experience-dependent modulation of the visual evoked potential: Testing effect sizes, retention over time, and associations with age in 415 healthy individuals.
Neuroimage 2020 12;223():117302. Epub 2020 aug 20
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The genetic architecture of human brainstem structures and their involvement in common brain disorders.
Nat Commun 2020 08 11;11(1):4016. Epub 2020 aug 11
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Borderline patients have difficulties describing feelings; bipolar II patients describe difficult feelings. An alexithymia study.
Acta Psychiatr Scand 2020 09;142(3):203-214. Epub 2020 jul 27
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Evidence for wakefulness-related changes to extracellular space in human brain white matter from diffusion-weighted MRI.
Neuroimage 2020 05 15;212():116682. Epub 2020 feb 28
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Using structural MRI to identify bipolar disorders - 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group.
Mol Psychiatry 2020 09;25(9):2130-2143. Epub 2018 aug 31
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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.
Cell 2019 Dec 12;179(7):1469-1482.e11.
PMID: 31835028
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.
Biol Psychiatry 2019 Nov 01. Epub 2019 nov 1
PMID: 31926635
Common brain disorders are associated with heritable patterns of apparent aging of the brain.
Nat Neurosci 2019 10;22(10):1617-1623. Epub 2019 sep 24
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Mood episodes are associated with increased cortical thinning: A longitudinal study of bipolar disorder type II.
Bipolar Disord 2019 09;21(6):525-538. Epub 2019 mar 31
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Biophysical Psychiatry-How Computational Neuroscience Can Help to Understand the Complex Mechanisms of Mental Disorders.
Front Psychiatry 2019;10():534. Epub 2019 aug 6
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Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade.
Acta Psychiatr Scand 2019 04;139(4):348-360. Epub 2019 feb 19
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Telomere length is associated with childhood trauma in patients with severe mental disorders.
Transl Psychiatry 2019 03 21;9(1):97. Epub 2019 mar 21
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Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes.
Front Neurosci 2019;13():220. Epub 2019 mar 13
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Patterns of altered regional brain glucose metabolism in borderline personality disorder and bipolar II disorder.
Acta Psychiatr Scand 2019 03;139(3):256-268. Epub 2019 jan 6
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Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations.
Cereb Cortex 2019 02 01;29(2):875-891.
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Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.
Cell 2018 Jun 14;173(7):1705-1715.e16.
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Longitudinal and cross-sectional investigations of long-term potentiation-like cortical plasticity in bipolar disorder type II and healthy individuals.
Transl Psychiatry 2018 05 24;8(1):103. Epub 2018 mai 24
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Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium.
Proc Natl Acad Sci U S A 2018 05 29;115(22):E5154-E5163. Epub 2018 mai 15
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Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.
Mol Psychiatry 2018 04;23(4):932-942. Epub 2017 mai 2
PMID: 28461699
Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial.
Transl Psychiatry 2017 May 23;7(5):e1136. Epub 2017 mai 23
PMID: 28534875
Evidence for cortical structural plasticity in humans after a day of waking and sleep deprivation.
Neuroimage 2017 Aug 01;156():214-223. Epub 2017 mai 17
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Diurnal Variation and Twenty-Four Hour Sleep Deprivation Do Not Alter Supine Heart Rate Variability in Healthy Male Young Adults.
PLoS One 2017;12(2):e0170921. Epub 2017 feb 2
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Oxytocin system dysfunction as a common mechanism underlying metabolic syndrome and psychiatric symptoms in schizophrenia and bipolar disorders.
Front Neuroendocrinol 2017 04;45():1-10. Epub 2017 jan 1
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Dentate gyrus-cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross-sectional analyses.
Bipolar Disord 2016 Dec;18(8):657-668. Epub 2016 des 20
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Subcortical volumetric abnormalities in bipolar disorder.
Mol Psychiatry 2016 Dec;21(12):1710-1716. Epub 2016 feb 9
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The brain functional connectome is robustly altered by lack of sleep.
Neuroimage 2016 Feb 15;127():324-32. Epub 2015 des 19
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- Clara Timpe Forsker (annen finansiering)
- Daniel Roelfs Forsker (annen finansiering)
- Nora Slapø Forsker (annen finansiering)
- Torgeir Moberget Postdoktorstipendiat (annen finansiering)
- Erik Gunnar Jönsson Forskningsgruppeleder
- Mathias Valstad Doktorgradsstipendiat (annen finansiering)
- Srdjan Djurovic Forskningsgruppeleder
- Torbjørn Elvsåshagen Postdoktorstipendiat (finansiert av denne bevilgning)
- Ole Andreas Andreassen Forskningsgruppeleder
- Ulrik Fredrik Malt Prosjektleder
- Nathalia Zak Doktorgradsstipendiat (annen finansiering)
- Lars Tjelta Westlye Forsker (annen finansiering)
- Jeff Daskalakis Medveileder
- Gaute Einevoll Prosjektdeltaker
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