Advanced Electron Microscopy
- Prosjektnummer
- 2015093
- Ansvarlig person
- Andreas Brech
- Institusjon
- Oslo universitetssykehus HF
- Prosjektkategori
- Regional teknologisk kjernefasilitet
- Helsekategori
- Cardiovascular, Eye, Inflammatory and Immune System, Generic Health Relevance
- Forskningsaktivitet
- 1. Underpinning
Endocytic trafficking of connexins in cancer pathogenesis.
Biochim Biophys Acta Mol Basis Dis 2023 Oct;1869(7):166812. Epub 2023 jul 16
PMID: 37454772
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes.
Nat Commun 2023 Sep 27;14(1):6035. Epub 2023 sep 27
PMID: 37758698
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk.
J Immunol 2023 Nov 01;211(9):1348.
PMID: 37737664
Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis.
Cell Mol Life Sci 2023 Jul 31;80(8):235. Epub 2023 jul 31
PMID: 37523003
siRNA screening reveals that SNAP29 contributes to exosome release.
Cell Mol Life Sci 2023 Jun 07;80(7):177. Epub 2023 jun 7
PMID: 37285022
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.
Circ Res 2023 May 26;132(11):e188. Epub 2023 mai 4
PMID: 37139790
TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1.
FEBS J 2023 Feb;290(4):1096. Epub 2022 sep 24
PMID: 36111389
Osteocyte-Like Cells Differentiated From Primary Osteoblasts in an Artificial Human Bone Tissue Model.
JBMR Plus 2023 Sep;7(9):e10792. Epub 2023 jun 28
PMID: 37701151
Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells.
Biomedicines 2022 Jan 21;10(2). Epub 2022 jan 21
PMID: 35203441
Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.
EMBO J 2022 Dec 15;41(24):e112677. Epub 2022 nov 21
PMID: 36408828
Adaptation to hypoxia in
Autophagy 2022 Apr;18(4):909. Epub 2021 nov 18
PMID: 34793268
Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use.
Clin J Am Soc Nephrol 2022 Apr;17(4):518. Epub 2022 mar 16
PMID: 35296512
Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy.
Biochem Pharmacol 2021 12;194():114837. Epub 2021 nov 12
PMID: 34780750
Host autophagy mediates organ wasting and nutrient mobilization for tumor growth.
EMBO J 2021 09 15;40(18):e107336. Epub 2021 jul 26
PMID: 34309071
JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes.
J Cell Sci 2021 07 15;134(14). Epub 2021 jul 20
PMID: 34109410
Wetting regulates autophagy of phase-separated compartments and the cytosol.
Nature 2021 03;591(7848):142-146. Epub 2021 jan 20
PMID: 33473217
Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation.
Autophagy 2021 04;17(4):1046-1048. Epub 2021 feb 25
PMID: 33629888
The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy.
J Cell Sci 2021 02 10;134(3). Epub 2021 feb 10
PMID: 33468622
Scaffold-Free Engineering of Human Cartilage Implants.
Cartilage 2021 12;13(1_suppl):1237S-1249S. Epub 2021 apr 15
PMID: 33858229
Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.
iScience 2020 Jun 26;23(6):101154. Epub 2020 mai 11
PMID: 32450518
Hsp90 inhibition and co-incubation with pertuzumab induce internalization and degradation of trastuzumab: Implications for use of T-DM1.
J Cell Mol Med 2020 Sep;24(17):10258-10262. Epub 2020 jul 16
PMID: 32672902
International consensus guideline for reporting transmission electron microscopy results in the diagnosis of primary ciliary dyskinesia (BEAT PCD TEM Criteria).
Eur Respir J 2020 04;55(4). Epub 2020 apr 16
PMID: 32060067
Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles.
Proc Natl Acad Sci U S A 2020 11 17;117(46):28614-28624. Epub 2020 nov 2
PMID: 33139578
RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism.
Curr Biol 2020 04 06;30(7):1177-1188.e5. Epub 2020 feb 13
PMID: 32059769
Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.
Nat Commun 2020 01 23;11(1):440. Epub 2020 jan 23
PMID: 31974402
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Nat Cell Biol 2020 07;22(7):856-867. Epub 2020 jun 29
PMID: 32601372
ESCRT-mediated phagophore sealing during mitophagy.
Autophagy 2020 05;16(5):826-841. Epub 2019 aug 1
PMID: 31366282
Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.
EMBO J 2020 Nov 23. Epub 2020 nov 23
PMID: 33226137
Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites.
Nat Commun 2019 09 13;10(1):4176. Epub 2019 sep 13
PMID: 31519908
The FMRpolyGlycine Protein Mediates Aggregate Formation and Toxicity Independent of the CGG mRNA Hairpin in a Cellular Model for FXTAS.
Front Genet 2019;10():249. Epub 2019 mar 28
PMID: 30984240
The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress.
J Biol Chem 2019 05 17;294(20):8197-8217. Epub 2019 mar 29
PMID: 30926605
Remodeling of secretory lysosomes during education tunes functional potential in NK cells.
Nat Commun 2019 01 31;10(1):514. Epub 2019 jan 31
PMID: 30705279
Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation.
Autophagy 2019 01;15(1):182-183. Epub 2018 okt 25
PMID: 30295124
Protein kinase C regulates ErbB3 turnover.
Exp Cell Res 2019 Sep 15;382(2):111473. Epub 2019 jun 21
PMID: 31233741
Short-term perioperative parecoxib is not detrimental to shaft fracture healing in a rat model.
Bone Joint Res 2019 Oct;8(10):472-480. Epub 2019 nov 2
PMID: 31728186
Effects of marine n-3 fatty acid supplementation in renal transplantation: A randomized controlled trial.
Am J Transplant 2019 03;19(3):790-800. Epub 2018 sep 22
PMID: 30125457
Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation.
Nat Commun 2018 07 26;9(1):2932. Epub 2018 jul 26
PMID: 30050131
Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy.
J Cell Biol 2018 Oct 01;217(10):3640-3655. Epub 2018 jul 17
PMID: 30018090
Centrosomal ALIX regulates mitotic spindle orientation by modulating astral microtubule dynamics.
EMBO J 2018 Jul 02;37(13). Epub 2018 jun 1
PMID: 29858227
The tankyrase inhibitor G007-LK inhibits small intestine LGR5
Biol Res 2018 Jan 09;51(1):3. Epub 2018 jan 9
PMID: 29316982
Machine learning for intraoperative prediction of viability in ischemic small intestine.
Physiol Meas 2018 Oct 24;39(10):105011. Epub 2018 okt 24
PMID: 30207981
Activation of the vitamin D receptor transcription factor stimulates the growth of definitive erythroid progenitors.
Blood Adv 2018 06 12;2(11):1207-1219.
PMID: 29844206
Ischemia/reperfusion injury in porcine intestine - Viability assessment.
World J Gastroenterol 2018 May 14;24(18):2009-2023.
PMID: 29760544
Negative effect of zoledronic acid on tendon-to-bone healing.
Acta Orthop 2018 Jun;89(3):360-366. Epub 2018 mar 1
PMID: 29493345
Kidney allograft subclinical rejection modulates systemic inflammation measured by C-reactive protein at 1 year after transplantation.
Clin Transplant 2018 Mar;32(3):e13196. Epub 2018 jan 30
PMID: 29380890
Development of Kidney Transplant Fibrosis Is Inversely Associated With Plasma Marine Fatty Acid Level.
J Ren Nutr 2018 Mar;28(2):118-124. Epub 2017 nov 14
PMID: 29146138
Protein kinase C mediated internalization of ErbB2 is independent of clathrin, ubiquitination and Hsp90 dissociation.
Exp Cell Res 2018 Oct 01;371(1):139-150. Epub 2018 aug 8
PMID: 30098331
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation.
Biochim Biophys Acta 2017 12;1864(12):2241-2252. Epub 2017 sep 1
PMID: 28867611
Outer membrane vesicles extracted from Neisseria meningitidis serogroup X for prevention of meningococcal disease in Africa.
Pharmacol Res 2017 Jul;121():194-201. Epub 2017 mai 8
PMID: 28495657
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.
Cell Rep 2017 01 03;18(1):82-92.
PMID: 28052262
Tacrolimus and mycophenolate regimen and subclinical tubulo-interstitial inflammation in low immunological risk renal transplants.
Transpl Int 2017 Nov;30(11):1119-1131. Epub 2017 jul 27
PMID: 28667664
Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis.
Traffic 2017 03;18(3):176-191. Epub 2017 jan 30
PMID: 28067430
Microenvironmental autophagy promotes tumour growth.
Nature 2017 01 19;541(7637):417-420. Epub 2017 jan 11
PMID: 28077876
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites.
Nucleus 2017 Jul 04;8(4):404-420. Epub 2017 apr 12
PMID: 28402725
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.
J Cell Sci 2017 Sep 01;130(17):2867-2882. Epub 2017 jul 21
PMID: 28733455
Development of resistance to photodynamic therapy (PDT) in human breast cancer cells is photosensitizer-dependent: Possible mechanisms and approaches for overcoming PDT-resistance.
Biochem Pharmacol 2017 11 15;144():63-77. Epub 2017 aug 5
PMID: 28784290
Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation.
Nat Cell Biol 2017 Dec;19(12):1412-1423. Epub 2017 okt 30
PMID: 29084199
2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection.
Am J Transplant 2016 Jun 07. Epub 2016 jun 7
PMID: 27273869
Total inflammation in early protocol kidney graft biopsies does not predict progression of fibrosis at one year post-transplant.
Clin Transplant 2016 Jul;30(7):802-9. Epub 2016 mai 18
PMID: 27101801
Inflammation in Early Kidney Allograft Surveillance Biopsies With and Without Associated Tubulointerstitial Chronic Damage as a Predictor of Fibrosis Progression and Development of De Novo Donor Specific Antibodies.
Transplantation 2017 06;101(6):1410-1415.
PMID: 27163535
Ichthyosis prematurity syndrome caused by a novel missense mutation in FATP4 gene-a case report from India.
Clin Case Rep 2016 Jan;4(1):87-9. Epub 2015 des 1
PMID: 26783444
CTGF/CCN2 Postconditioning Increases Tolerance of Murine Hearts towards Ischemia-Reperfusion Injury.
PLoS One 2016;11(2):e0149000. Epub 2016 feb 12
PMID: 26872261
Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3.
Biochim Biophys Acta 2016 Jun;1863(6 Pt A):1179-88. Epub 2016 mar 11
PMID: 26975582
Autologous cell sources in therapeutic vasculogenesis: In vitro and in vivo comparison of endothelial colony-forming cells from peripheral blood and endothelial cells isolated from adipose tissue.
Cytotherapy 2016 Feb;18(2):242-52. Epub 2015 des 3
PMID: 26669908
PIKfyve inhibition increases exosome release and induces secretory autophagy.
Cell Mol Life Sci 2016 Dec;73(24):4717-4737. Epub 2016 jul 20
PMID: 27438886
Identification of p62/SQSTM1 as a component of non-canonical Wnt VANGL2-JNK signalling in breast cancer.
Nat Commun 2016 Jan 12;7():10318. Epub 2016 jan 12
PMID: 26754771
Mitotic cells form actin-based bridges with adjacent cells to provide intercellular communication during rounding.
Cell Cycle 2016 Nov;15(21):2943-2957. Epub 2016 sep 13
PMID: 27625181
Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline.
Development 2015 Dec 1;142(23):4107-18.
PMID: 26628094
Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.
Mol Cancer Res 2015 Nov;13(11):1487-501. Epub 2015 jun 29
PMID: 26124443
Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.
Nature 2015 Jun 11;522(7555):231-5. Epub 2015 jun 3
PMID: 26040712
Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth.
Nature 2015 Apr 9;520(7546):234-8.
PMID: 25855459
The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells.
J Biol Chem 2015 Feb 13;290(7):4225-37. Epub 2014 des 17
PMID: 25519911
Glomerular Collagen V Codeposition and Hepatic Perisinusoidal Collagen III Accumulation in Canine Collagen Type III Glomerulopathy.
Vet Pathol 2015 Nov;52(6):1134-41. Epub 2014 des 8
PMID: 25487411
Tartrate-resistant acid phosphatase (TRAP) co-localizes with receptor activator of NF-KB ligand (RANKL) and osteoprotegerin (OPG) in lysosomal-associated membrane protein 1 (LAMP1)-positive vesicles in rat osteoblasts and osteocytes.
Histochem Cell Biol 2015 Feb;143(2):195-207. Epub 2014 sep 9
PMID: 25201349
Effects of restoring normoglycemia in type 1 diabetes on inflammatory profile and renal extracellular matrix structure after simultaneous pancreas and kidney transplantation.
Diabetes Res Clin Pract 2015 Jan;107(1):46-53. Epub 2014 okt 28
PMID: 25467621
Tendon to bone tunnel healing--a study on the time-dependent changes in biomechanics, bone remodeling, and histology in a rat model.
J Orthop Res 2015 Feb;33(2):216-23. Epub 2014 nov 3
PMID: 25367445
Syndecan-4 Regulates Muscle Differentiation and Is Internalized from the Plasma Membrane during Myogenesis.
PLoS One 2015;10(6):e0129288. Epub 2015 jun 12
PMID: 26068620
Membrane Remodeling in Macropinocytosis
- Disputert:
- oktober 2021
- Hovedveileder:
- Kay Oliver Schink
Effects of inhibition of bone resorption and cyclooxygenase on bone and tendon to bone healing.
- Disputert:
- mai 2020
- Hovedveileder:
- Sigmund Dimmen
Assessment of small bowel intestinal viability – a bioimpedance approach
- Disputert:
- april 2019
- Hovedveileder:
- Tor Inge Tønnesen
Molecular mechanisms regulating expression of the oncoproteins ErbB2 and ErbB3
- Disputert:
- februar 2018
- Hovedveileder:
- Espen Stang
Molecular mechanisms involved in the internalization and degradation of the receptor tyrosine kinases ErbB2 and ErbB3
- Disputert:
- januar 2017
- Hovedveileder:
- Espen Stang
Endocytic downregulation of the oncoproteins ErbB2 and ErbB3.
- Disputert:
- februar 2016
- Hovedveileder:
- Espen Stang
Focal cartilage lesions in anterior cruciate ligament-injured knees.
- Disputert:
- mars 2015
- Hovedveileder:
- Asbjørn Aarøen
- Eystein Hellstrøm Hoddevik Prosjektleder
- Rosa Linn Andersen Prosjektdeltaker
- Marianne Smestad Prosjektdeltaker
- Catherine E Sem Wegner Prosjektdeltaker
- Ingrid Kjos Prosjektdeltaker
- Ulrikke Brinch Dahl Prosjektdeltaker
- Espen Stang Forsker (annen finansiering)
- Sverre Henning Brorson Forsker (annen finansiering)
- Linn Furebotten Kymre Prosjektdeltaker
- Finn P. Reinholt Prosjektleder
- Andreas John Carl Brech Prosjektleder
- Linn Kymre Prosjektdeltaker
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